ID HALL_DICDI Reviewed; 529 AA. AC Q556V9; Q86AJ4; DT 24-NOV-2009, integrated into UniProtKB/Swiss-Prot. DT 02-MAY-2006, sequence version 1. DT 22-FEB-2012, entry version 40. DE RecName: Full=hal-like protein DDB_G0273787/DDB_G0273081; DE EC=4.3.1.3; GN ORFNames=DDB_G0273787; GN and GN ORFNames=DDB_G0273081; OS Dictyostelium discoideum (Slime mold). OC Eukaryota; Amoebozoa; Mycetozoa; Dictyosteliida; Dictyostelium. OX NCBI_TaxID=44689; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=AX4; RX MEDLINE=22092622; PubMed=12097910; DOI=10.1038/nature00847; RA Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., RA Bankier A.T., Dear P.H., Lehmann R., Baumgart C., Parra G., RA Abril J.F., Guigo R., Kumpf K., Tunggal B., Cox E.C., Quail M.A., RA Platzer M., Rosenthal A., Noegel A.A.; RT "Sequence and analysis of chromosome 2 of Dictyostelium discoideum."; RL Nature 418:79-85(2002). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=AX4; RX PubMed=15875012; DOI=10.1038/nature03481; RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., RA Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., RA Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., RA Bankier A.T., Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., RA Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., RA Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., RA Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., RA Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., RA Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., RA Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., RA Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., RA Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., RA Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., RA Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., RA Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., RA Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., RA Kuspa A.; RT "The genome of the social amoeba Dictyostelium discoideum."; RL Nature 435:43-57(2005). CC -!- CATALYTIC ACTIVITY: L-histidine = urocanate + NH(3). CC -!- PATHWAY: Amino-acid degradation; L-histidine degradation into L- CC glutamate; N-formimidoyl-L-glutamate from L-histidine: step 1/3. CC -!- SUBCELLULAR LOCATION: Cytoplasm (Potential). CC -!- PTM: Contains an active site 4-methylidene-imidazol-5-one (MIO), CC which is formed autocatalytically by cyclization and dehydration CC of residues Ala-Ser-Gly (By similarity). CC -!- SIMILARITY: Belongs to the PAL/histidase family. CC -!- CAUTION: The gene for this protein is duplicated in strains AX3 CC and AX4. These strains contain a duplication of a segment of 750 CC kb of chromosome 2 compared to the corresponding sequence in CC strain AX2. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AAFI02000011; EAL70584.1; -; Genomic_DNA. DR EMBL; AAFI02000009; EAL70758.1; -; Genomic_DNA. DR RefSeq; XP_644510.1; XM_639418.1. DR RefSeq; XP_644740.1; XM_639648.1. DR ProteinModelPortal; Q556V9; -. DR STRING; Q556V9; -. DR EnsemblProtists; DDB0231725; DDB0231725; DDB_G0273081. DR EnsemblProtists; DDB0304843; DDB0304843; DDB_G0273787. DR GeneID; 8618840; -. DR GeneID; 8619136; -. DR KEGG; ddi:DDB_G0273081; -. DR KEGG; ddi:DDB_G0273787; -. DR dictyBase; DDB_G0273081; -. DR dictyBase; DDB_G0273787; -. DR eggNOG; COG2986; -. DR HOGENOM; HBG510887; -. DR InParanoid; Q556V9; -. DR OMA; HIARIMD; -. DR PhylomeDB; Q556V9; -. DR ProtClustDB; CLSZ2429936; -. DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. DR GO; GO:0004397; F:histidine ammonia-lyase activity; IEA:EC. DR GO; GO:0009058; P:biosynthetic process; IEA:InterPro. DR GO; GO:0006547; P:histidine metabolic process; IEA:UniProtKB-KW. DR InterPro; IPR008948; L-Aspartase-like. DR InterPro; IPR024083; L-Aspartase-like_N. DR InterPro; IPR001106; Phe/His_NH3-lyase. DR InterPro; IPR022313; Phe/His_NH3-lyase_AS. DR Gene3D; G3DSA:1.10.275.10; G3DSA:1.10.275.10; 1. DR Pfam; PF00221; PAL; 1. DR SUPFAM; SSF48557; L-Aspartase-like; 1. DR PROSITE; PS00488; PAL_HISTIDASE; 1. PE 3: Inferred from homology; KW Complete proteome; Cytoplasm; Histidine metabolism; Lyase; KW Reference proteome. FT CHAIN 1 529 hal-like protein FT DDB_G0273787/DDB_G0273081. FT /FTId=PRO_0000389023. FT MOD_RES 152 152 2,3-didehydroalanine (Ser) (By FT similarity). FT CROSSLNK 151 153 5-imidazolinone (Ala-Gly) (By FT similarity). SQ SEQUENCE 529 AA; 58568 MW; DCB8EF3CEE11587B CRC64; MIETNHKDNF LIDGENKNLE INDIISISKG EKNIIFTNEL LEFLQKGRDQ LENKLKENVA IYGINTGFGG NGDLIIPFDK LDYHQSNLLD FLTCGTGDFF NDQYVRGIQF IIIIALSRGW SGVRPMVIQT LAKHLNKGII PQVPMHGSVG ASGDLVPLSY IANVLCGKGM VKYNEKLMNA SDALKITSIE PLVLKSKEGL ALVNGTRVMS SVSCISINKF ETIFKAAIGS IALAVEGLLA SKDHYDMRIH NLKNHPGQIL IAQILNKYFN TSDNNTKSSN ITFNQSENVQ KLDKSVQEVY SLRCAPQILG IISENISNAK IVIKREILSV NDNPLIDPYY GDVLSGGNFM GNHIARIMDG IKLDISLVAN HLHSLVALMM HSEFSKGLPN SLSPNPGIYQ GYKGMQISQT SLVVWLRQEA APACIHSLTT EQFNQDIVSL GLHSANGAAS MLIKLCDIVS MTLIIAFQAI SLRMKSIENF KLPNKVQKLY SSIIKIIPIL ENDRRTDIDV REITNAILQD KLDFINLNL //