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Q556U6

- BIP1_DICDI

UniProt

Q556U6 - BIP1_DICDI

Protein

Luminal-binding protein 1

Gene

bip1-1

more
Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 60 (01 Oct 2014)
      Sequence version 1 (02 May 2006)
      Previous versions | rss
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    Functioni

    Probably plays a role in facilitating the assembly of multimeric protein complexes inside the ER.By similarity

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW

    Keywords - Molecular functioni

    Chaperone

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    ReactomeiREACT_218739. XBP1(S) activates chaperone genes.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Luminal-binding protein 1
    Short name:
    BiP 1
    Alternative name(s):
    78 kDa glucose-regulated protein homolog
    Short name:
    GRP-78
    Gene namesi
    Name:bip1-1
    ORF Names:DDB_G0273093
    AND
    Name:bip1-2
    ORF Names:DDB_G0273813
    OrganismiDictyostelium discoideum (Slime mold)
    Taxonomic identifieri44689 [NCBI]
    Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
    ProteomesiUP000002195: Chromosome 2, UP000002195: Unassembled WGS sequence

    Organism-specific databases

    dictyBaseiDDB_G0273093.
    DDB_G0273813.

    Subcellular locationi

    Endoplasmic reticulum lumen PROSITE-ProRule annotation

    GO - Cellular componenti

    1. endoplasmic reticulum lumen Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Endoplasmic reticulum

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2626Sequence AnalysisAdd
    BLAST
    Chaini27 – 926900Luminal-binding protein 1PRO_0000327977Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi120 – 1201N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi136 – 1361N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi216 – 2161N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi249 – 2491N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi311 – 3111N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi468 – 4681N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi544 – 5441N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi584 – 5841N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi596 – 5961N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi649 – 6491N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi797 – 7971N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi881 – 8811N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PRIDEiQ556U6.

    Interactioni

    Protein-protein interaction databases

    STRINGi44689.DDBDRAFT_0217320.

    Structurei

    3D structure databases

    ProteinModelPortaliQ556U6.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi923 – 9264Prevents secretion from ERPROSITE-ProRule annotation

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi474 – 4796Poly-Gln
    Compositional biasi618 – 6225Poly-Gln
    Compositional biasi623 – 6297Poly-Glu
    Compositional biasi856 – 8605Poly-Lys
    Compositional biasi896 – 9005Poly-Gln

    Sequence similaritiesi

    Belongs to the heat shock protein 70 family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiCOG0443.
    KOiK09486.
    OMAiNDNTETE.
    PhylomeDBiQ556U6.

    Family and domain databases

    Gene3Di1.20.1270.10. 1 hit.
    InterProiIPR029048. HSP70_C.
    IPR013126. Hsp_70_fam.
    [Graphical view]
    PfamiPF00012. HSP70. 1 hit.
    [Graphical view]
    PRINTSiPR00301. HEATSHOCK70.
    SUPFAMiSSF100934. SSF100934. 1 hit.
    PROSITEiPS00014. ER_TARGET. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q556U6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVKNIKIFLS LFFVVVLGLL ATTANSMVIG IDLGSQTFKV SLIKPGAFET    50
    VLNEQSGRKT ISSVGWFKDE RLFSSDSFSV WARNPKQNYN LIQAFLGIKY 100
    KEGLVEEISN GLPLGFKVKN DTVRNTVSIV YDDDTNYSAE ELTGMLLRRV 150
    KDMASSYAGS SIKDCAITIP PYFTQQQRQA LLDAAQLAGL NVLSLIHDVN 200
    AAALSFAMDR TFLEKNESVI FYDMGARHTS VSLVEFESHN EQIKGVKKNK 250
    TVSSASVKGI EWDEKLGGFD FDMVIVNHLK TLLKKQIPSA NVDDIKITIK 300
    LLKEVGKMKE NLSVNQQAQI FIGSLVDDHD FQATISKQQF EELSQSLIER 350
    SLLPLKKLIL STGIKLKDIE YFEVIGGGVR IPFIQQALKD YLKRDTLDKH 400
    LNGDEAMSNG AAFYAASLTH YFKVKEIKLK DILLNSVDVE INNNIINSGG 450
    AGETLLEETE DNEDNELNNS GNEQQQQQQP TINQGGLKDK KIQLFKVNSK 500
    LGIKKTVSFS SENGFSLFLN NPTINNPLAT YTVSNVPTPG EKYNFTGKPK 550
    IHCSFRLTTS GIVVLEKAEA EITVSLIKPQ PQQNKTSSST STTKKNTTTI 600
    ETTDGGSEET TDETTTKQQQ QQEKEEEEEV VVVEKVIEYI QKTIRVPLNF 650
    TIKYNGCVEP LSKELSQESN DRINKLDQVD RILRELRQER NNLESFIYET 700
    KDKLESNEEY LKCSTQQERD QLVEELDKTS AWLSDALDND NTETEEYRKQ 750
    LKDIKKKADK IVNRVSQYQL VPVALEELED TVDKVKPMFE IASKDLNVTA 800
    EELKETTDKI QSVSDWVQEK KSEFKLADYS KDLQTSSFDI KFKLYDLERT 850
    IKEILKKKKK PVKPSSSKKD KSSKSSKGKS NSTDEKDQKQ KEQKEQQQQQ 900
    KEESQFQNDG AEEQQFEDDH KVHDEL 926
    Length:926
    Mass (Da):104,792
    Last modified:May 2, 2006 - v1
    Checksum:iEEA198A7B6B5E111
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AAFI02000011 Genomic DNA. Translation: EAL70597.1.
    AAFI02000009 Genomic DNA. Translation: EAL70764.1.
    RefSeqiXP_644523.1. XM_639431.1.
    XP_644727.1. XM_639635.1.

    Genome annotation databases

    EnsemblProtistsiDDB0266529; DDB0266529; DDB_G0273093.
    DDB0266530; DDB0266530; DDB_G0273813.
    GeneIDi8618827.
    8619149.
    KEGGiddi:DDB_G0273093.
    ddi:DDB_G0273813.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AAFI02000011 Genomic DNA. Translation: EAL70597.1 .
    AAFI02000009 Genomic DNA. Translation: EAL70764.1 .
    RefSeqi XP_644523.1. XM_639431.1.
    XP_644727.1. XM_639635.1.

    3D structure databases

    ProteinModelPortali Q556U6.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 44689.DDBDRAFT_0217320.

    Proteomic databases

    PRIDEi Q556U6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblProtistsi DDB0266529 ; DDB0266529 ; DDB_G0273093 .
    DDB0266530 ; DDB0266530 ; DDB_G0273813 .
    GeneIDi 8618827.
    8619149.
    KEGGi ddi:DDB_G0273093.
    ddi:DDB_G0273813.

    Organism-specific databases

    dictyBasei DDB_G0273093.
    DDB_G0273813.

    Phylogenomic databases

    eggNOGi COG0443.
    KOi K09486.
    OMAi NDNTETE.
    PhylomeDBi Q556U6.

    Enzyme and pathway databases

    Reactomei REACT_218739. XBP1(S) activates chaperone genes.

    Family and domain databases

    Gene3Di 1.20.1270.10. 1 hit.
    InterProi IPR029048. HSP70_C.
    IPR013126. Hsp_70_fam.
    [Graphical view ]
    Pfami PF00012. HSP70. 1 hit.
    [Graphical view ]
    PRINTSi PR00301. HEATSHOCK70.
    SUPFAMi SSF100934. SSF100934. 1 hit.
    PROSITEi PS00014. ER_TARGET. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: AX4.
    2. "The genome of the social amoeba Dictyostelium discoideum."
      Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N.
      , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
      Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: AX4.

    Entry informationi

    Entry nameiBIP1_DICDI
    AccessioniPrimary (citable) accession number: Q556U6
    Secondary accession number(s): Q86JV8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 8, 2008
    Last sequence update: May 2, 2006
    Last modified: October 1, 2014
    This is version 60 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Caution

    The gene for this protein is duplicated in strains AX3 and AX4. These strains contain a duplication of a segment of 750 kb of chromosome 2 compared to the corresponding sequence in strain AX2.Curated

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Dictyostelium discoideum
      Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3