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Q556U6 (BIP1_DICDI) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 55. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Luminal-binding protein 1

Short name=BiP 1
Alternative name(s):
78 kDa glucose-regulated protein homolog
Short name=GRP-78
Gene names
Name:bip1-1
ORF Names:DDB_G0273093
AND
Name:bip1-2
ORF Names:DDB_G0273813
OrganismDictyostelium discoideum (Slime mold) [Reference proteome]
Taxonomic identifier44689 [NCBI]
Taxonomic lineageEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium

Protein attributes

Sequence length926 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Probably plays a role in facilitating the assembly of multimeric protein complexes inside the ER By similarity.

Subcellular location

Endoplasmic reticulum lumen By similarity.

Sequence similarities

Belongs to the heat shock protein 70 family.

Caution

The gene for this protein is duplicated in strains AX3 and AX4. These strains contain a duplication of a segment of 750 kb of chromosome 2 compared to the corresponding sequence in strain AX2.

Ontologies

Keywords
   Cellular componentEndoplasmic reticulum
   DomainSignal
   LigandATP-binding
Nucleotide-binding
   Molecular functionChaperone
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentendoplasmic reticulum lumen

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2626 Potential
Chain27 – 926900Luminal-binding protein 1
PRO_0000327977

Regions

Motif923 – 9264Prevents secretion from ER Potential
Compositional bias474 – 4796Poly-Gln
Compositional bias618 – 6225Poly-Gln
Compositional bias623 – 6297Poly-Glu
Compositional bias856 – 8605Poly-Lys
Compositional bias896 – 9005Poly-Gln

Amino acid modifications

Glycosylation1201N-linked (GlcNAc...) Potential
Glycosylation1361N-linked (GlcNAc...) Potential
Glycosylation2161N-linked (GlcNAc...) Potential
Glycosylation2491N-linked (GlcNAc...) Potential
Glycosylation3111N-linked (GlcNAc...) Potential
Glycosylation4681N-linked (GlcNAc...) Potential
Glycosylation5441N-linked (GlcNAc...) Potential
Glycosylation5841N-linked (GlcNAc...) Potential
Glycosylation5961N-linked (GlcNAc...) Potential
Glycosylation6491N-linked (GlcNAc...) Potential
Glycosylation7971N-linked (GlcNAc...) Potential
Glycosylation8811N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
Q556U6 [UniParc].

Last modified May 2, 2006. Version 1.
Checksum: EEA198A7B6B5E111

FASTA926104,792
        10         20         30         40         50         60 
MVKNIKIFLS LFFVVVLGLL ATTANSMVIG IDLGSQTFKV SLIKPGAFET VLNEQSGRKT 

        70         80         90        100        110        120 
ISSVGWFKDE RLFSSDSFSV WARNPKQNYN LIQAFLGIKY KEGLVEEISN GLPLGFKVKN 

       130        140        150        160        170        180 
DTVRNTVSIV YDDDTNYSAE ELTGMLLRRV KDMASSYAGS SIKDCAITIP PYFTQQQRQA 

       190        200        210        220        230        240 
LLDAAQLAGL NVLSLIHDVN AAALSFAMDR TFLEKNESVI FYDMGARHTS VSLVEFESHN 

       250        260        270        280        290        300 
EQIKGVKKNK TVSSASVKGI EWDEKLGGFD FDMVIVNHLK TLLKKQIPSA NVDDIKITIK 

       310        320        330        340        350        360 
LLKEVGKMKE NLSVNQQAQI FIGSLVDDHD FQATISKQQF EELSQSLIER SLLPLKKLIL 

       370        380        390        400        410        420 
STGIKLKDIE YFEVIGGGVR IPFIQQALKD YLKRDTLDKH LNGDEAMSNG AAFYAASLTH 

       430        440        450        460        470        480 
YFKVKEIKLK DILLNSVDVE INNNIINSGG AGETLLEETE DNEDNELNNS GNEQQQQQQP 

       490        500        510        520        530        540 
TINQGGLKDK KIQLFKVNSK LGIKKTVSFS SENGFSLFLN NPTINNPLAT YTVSNVPTPG 

       550        560        570        580        590        600 
EKYNFTGKPK IHCSFRLTTS GIVVLEKAEA EITVSLIKPQ PQQNKTSSST STTKKNTTTI 

       610        620        630        640        650        660 
ETTDGGSEET TDETTTKQQQ QQEKEEEEEV VVVEKVIEYI QKTIRVPLNF TIKYNGCVEP 

       670        680        690        700        710        720 
LSKELSQESN DRINKLDQVD RILRELRQER NNLESFIYET KDKLESNEEY LKCSTQQERD 

       730        740        750        760        770        780 
QLVEELDKTS AWLSDALDND NTETEEYRKQ LKDIKKKADK IVNRVSQYQL VPVALEELED 

       790        800        810        820        830        840 
TVDKVKPMFE IASKDLNVTA EELKETTDKI QSVSDWVQEK KSEFKLADYS KDLQTSSFDI 

       850        860        870        880        890        900 
KFKLYDLERT IKEILKKKKK PVKPSSSKKD KSSKSSKGKS NSTDEKDQKQ KEQKEQQQQQ 

       910        920 
KEESQFQNDG AEEQQFEDDH KVHDEL 

« Hide

References

[1]"Sequence and analysis of chromosome 2 of Dictyostelium discoideum."
Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T., Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R., Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A., Noegel A.A.
Nature 418:79-85(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: AX4.
[2]"The genome of the social amoeba Dictyostelium discoideum."
Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N. expand/collapse author list , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: AX4.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AAFI02000011 Genomic DNA. Translation: EAL70597.1.
AAFI02000009 Genomic DNA. Translation: EAL70764.1.

3D structure databases

ProteinModelPortalQ556U6.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING44689.DDBDRAFT_0217320.

Proteomic databases

PRIDEQ556U6.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsDDB0266529; DDB0266529; DDB_G0273093.
DDB0266530; DDB0266530; DDB_G0273813.
KEGGddi:DDB_G0273093.
ddi:DDB_G0273813.

Organism-specific databases

dictyBaseDDB_G0273093.
DDB_G0273813.

Phylogenomic databases

eggNOGCOG0443.
OMASVPPYFG.
PhylomeDBQ556U6.
ProtClustDBCLSZ2431182.

Family and domain databases

InterProIPR013126. Hsp_70_fam.
[Graphical view]
PfamPF00012. HSP70. 1 hit.
[Graphical view]
PRINTSPR00301. HEATSHOCK70.
PROSITEPS00014. ER_TARGET. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameBIP1_DICDI
AccessionPrimary (citable) accession number: Q556U6
Secondary accession number(s): Q86JV8
Entry history
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: May 2, 2006
Last modified: April 16, 2014
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families

Dictyostelium discoideum

Dictyostelium discoideum: entries, gene names and cross-references to dictyBase