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Q556U6

- BIP1_DICDI

UniProt

Q556U6 - BIP1_DICDI

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Protein
Luminal-binding protein 1
Gene
bip1-1, DDB_G0273093
bip1-2, DDB_G0273813
Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Probably plays a role in facilitating the assembly of multimeric protein complexes inside the ER By similarity.

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_218739. XBP1(S) activates chaperone genes.

Names & Taxonomyi

Organism-specific databases

Protein namesi
Recommended name:
Luminal-binding protein 1
Short name:
BiP 1
Alternative name(s):
78 kDa glucose-regulated protein homolog
Short name:
GRP-78
Gene namesi
Name:bip1-1
ORF Names:DDB_G0273093
AND
Name:bip1-2
ORF Names:DDB_G0273813
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
ProteomesiUP000002195: Chromosome 2, UP000002195: Unassembled WGS sequence
dictyBaseiDDB_G0273093.
DDB_G0273813.

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum lumen Source: UniProtKB-SubCell

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2626 Reviewed prediction
Add
BLAST
Chaini27 – 926900Luminal-binding protein 1
PRO_0000327977Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi120 – 1201N-linked (GlcNAc...) Reviewed prediction
Glycosylationi136 – 1361N-linked (GlcNAc...) Reviewed prediction
Glycosylationi216 – 2161N-linked (GlcNAc...) Reviewed prediction
Glycosylationi249 – 2491N-linked (GlcNAc...) Reviewed prediction
Glycosylationi311 – 3111N-linked (GlcNAc...) Reviewed prediction
Glycosylationi468 – 4681N-linked (GlcNAc...) Reviewed prediction
Glycosylationi544 – 5441N-linked (GlcNAc...) Reviewed prediction
Glycosylationi584 – 5841N-linked (GlcNAc...) Reviewed prediction
Glycosylationi596 – 5961N-linked (GlcNAc...) Reviewed prediction
Glycosylationi649 – 6491N-linked (GlcNAc...) Reviewed prediction
Glycosylationi797 – 7971N-linked (GlcNAc...) Reviewed prediction
Glycosylationi881 – 8811N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiQ556U6.

Interactioni

Protein-protein interaction databases

STRINGi44689.DDBDRAFT_0217320.

Structurei

3D structure databases

ProteinModelPortaliQ556U6.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi923 – 9264Prevents secretion from ER Reviewed prediction

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi474 – 4796Poly-Gln
Compositional biasi618 – 6225Poly-Gln
Compositional biasi623 – 6297Poly-Glu
Compositional biasi856 – 8605Poly-Lys
Compositional biasi896 – 9005Poly-Gln

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG0443.
KOiK09486.
OMAiNDNTETE.
PhylomeDBiQ556U6.

Family and domain databases

Gene3Di1.20.1270.10. 1 hit.
InterProiIPR029048. HSP70_C.
IPR013126. Hsp_70_fam.
[Graphical view]
PfamiPF00012. HSP70. 1 hit.
[Graphical view]
PRINTSiPR00301. HEATSHOCK70.
SUPFAMiSSF100934. SSF100934. 1 hit.
PROSITEiPS00014. ER_TARGET. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q556U6-1 [UniParc]FASTAAdd to Basket

« Hide

MVKNIKIFLS LFFVVVLGLL ATTANSMVIG IDLGSQTFKV SLIKPGAFET    50
VLNEQSGRKT ISSVGWFKDE RLFSSDSFSV WARNPKQNYN LIQAFLGIKY 100
KEGLVEEISN GLPLGFKVKN DTVRNTVSIV YDDDTNYSAE ELTGMLLRRV 150
KDMASSYAGS SIKDCAITIP PYFTQQQRQA LLDAAQLAGL NVLSLIHDVN 200
AAALSFAMDR TFLEKNESVI FYDMGARHTS VSLVEFESHN EQIKGVKKNK 250
TVSSASVKGI EWDEKLGGFD FDMVIVNHLK TLLKKQIPSA NVDDIKITIK 300
LLKEVGKMKE NLSVNQQAQI FIGSLVDDHD FQATISKQQF EELSQSLIER 350
SLLPLKKLIL STGIKLKDIE YFEVIGGGVR IPFIQQALKD YLKRDTLDKH 400
LNGDEAMSNG AAFYAASLTH YFKVKEIKLK DILLNSVDVE INNNIINSGG 450
AGETLLEETE DNEDNELNNS GNEQQQQQQP TINQGGLKDK KIQLFKVNSK 500
LGIKKTVSFS SENGFSLFLN NPTINNPLAT YTVSNVPTPG EKYNFTGKPK 550
IHCSFRLTTS GIVVLEKAEA EITVSLIKPQ PQQNKTSSST STTKKNTTTI 600
ETTDGGSEET TDETTTKQQQ QQEKEEEEEV VVVEKVIEYI QKTIRVPLNF 650
TIKYNGCVEP LSKELSQESN DRINKLDQVD RILRELRQER NNLESFIYET 700
KDKLESNEEY LKCSTQQERD QLVEELDKTS AWLSDALDND NTETEEYRKQ 750
LKDIKKKADK IVNRVSQYQL VPVALEELED TVDKVKPMFE IASKDLNVTA 800
EELKETTDKI QSVSDWVQEK KSEFKLADYS KDLQTSSFDI KFKLYDLERT 850
IKEILKKKKK PVKPSSSKKD KSSKSSKGKS NSTDEKDQKQ KEQKEQQQQQ 900
KEESQFQNDG AEEQQFEDDH KVHDEL 926
Length:926
Mass (Da):104,792
Last modified:May 2, 2006 - v1
Checksum:iEEA198A7B6B5E111
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAFI02000011 Genomic DNA. Translation: EAL70597.1.
AAFI02000009 Genomic DNA. Translation: EAL70764.1.
RefSeqiXP_644523.1. XM_639431.1.
XP_644727.1. XM_639635.1.

Genome annotation databases

EnsemblProtistsiDDB0266529; DDB0266529; DDB_G0273093.
DDB0266530; DDB0266530; DDB_G0273813.
GeneIDi8618827.
8619149.
KEGGiddi:DDB_G0273093.
ddi:DDB_G0273813.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAFI02000011 Genomic DNA. Translation: EAL70597.1 .
AAFI02000009 Genomic DNA. Translation: EAL70764.1 .
RefSeqi XP_644523.1. XM_639431.1.
XP_644727.1. XM_639635.1.

3D structure databases

ProteinModelPortali Q556U6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 44689.DDBDRAFT_0217320.

Proteomic databases

PRIDEi Q556U6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblProtistsi DDB0266529 ; DDB0266529 ; DDB_G0273093 .
DDB0266530 ; DDB0266530 ; DDB_G0273813 .
GeneIDi 8618827.
8619149.
KEGGi ddi:DDB_G0273093.
ddi:DDB_G0273813.

Organism-specific databases

dictyBasei DDB_G0273093.
DDB_G0273813.

Phylogenomic databases

eggNOGi COG0443.
KOi K09486.
OMAi NDNTETE.
PhylomeDBi Q556U6.

Enzyme and pathway databases

Reactomei REACT_218739. XBP1(S) activates chaperone genes.

Family and domain databases

Gene3Di 1.20.1270.10. 1 hit.
InterProi IPR029048. HSP70_C.
IPR013126. Hsp_70_fam.
[Graphical view ]
Pfami PF00012. HSP70. 1 hit.
[Graphical view ]
PRINTSi PR00301. HEATSHOCK70.
SUPFAMi SSF100934. SSF100934. 1 hit.
PROSITEi PS00014. ER_TARGET. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AX4.
  2. "The genome of the social amoeba Dictyostelium discoideum."
    Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N.
    , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
    Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AX4.

Entry informationi

Entry nameiBIP1_DICDI
AccessioniPrimary (citable) accession number: Q556U6
Secondary accession number(s): Q86JV8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: May 2, 2006
Last modified: September 3, 2014
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Caution

The gene for this protein is duplicated in strains AX3 and AX4. These strains contain a duplication of a segment of 750 kb of chromosome 2 compared to the corresponding sequence in strain AX2.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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