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Protein

Luminal-binding protein 1

Gene

bip1-1

more
Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Probably plays a role in facilitating the assembly of multimeric protein complexes inside the ER.By similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Luminal-binding protein 1
Short name:
BiP 1
Alternative name(s):
78 kDa glucose-regulated protein homolog
Short name:
GRP-78
Gene namesi
Name:bip1-1
ORF Names:DDB_G0273093
AND
Name:bip1-2
ORF Names:DDB_G0273813
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
Proteomesi
  • UP000002195 Componentsi: Chromosome 2, Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0273093.
DDB_G0273813.

Subcellular locationi

  • Endoplasmic reticulum lumen PROSITE-ProRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26Sequence analysisAdd BLAST26
ChainiPRO_000032797727 – 926Luminal-binding protein 1Add BLAST900

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi120N-linked (GlcNAc...)Sequence analysis1
Glycosylationi136N-linked (GlcNAc...)Sequence analysis1
Glycosylationi216N-linked (GlcNAc...)Sequence analysis1
Glycosylationi249N-linked (GlcNAc...)Sequence analysis1
Glycosylationi311N-linked (GlcNAc...)Sequence analysis1
Glycosylationi468N-linked (GlcNAc...)Sequence analysis1
Glycosylationi544N-linked (GlcNAc...)Sequence analysis1
Glycosylationi584N-linked (GlcNAc...)Sequence analysis1
Glycosylationi596N-linked (GlcNAc...)Sequence analysis1
Glycosylationi649N-linked (GlcNAc...)Sequence analysis1
Glycosylationi797N-linked (GlcNAc...)Sequence analysis1
Glycosylationi881N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ556U6.
PRIDEiQ556U6.

Interactioni

Protein-protein interaction databases

STRINGi44689.DDB0266530.

Structurei

3D structure databases

ProteinModelPortaliQ556U6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi923 – 926Prevents secretion from ERPROSITE-ProRule annotation4

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi474 – 479Poly-Gln6
Compositional biasi618 – 622Poly-Gln5
Compositional biasi623 – 629Poly-Glu7
Compositional biasi856 – 860Poly-Lys5
Compositional biasi896 – 900Poly-Gln5

Sequence similaritiesi

Belongs to the heat shock protein 70 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG0103. Eukaryota.
KOG0104. Eukaryota.
ENOG41102PY. LUCA.
InParanoidiQ556U6.
KOiK09486.
OMAiNDNTETE.
PhylomeDBiQ556U6.

Family and domain databases

Gene3Di1.20.1270.10. 1 hit.
InterProiIPR029048. HSP70_C.
IPR013126. Hsp_70_fam.
[Graphical view]
PfamiPF00012. HSP70. 1 hit.
[Graphical view]
PRINTSiPR00301. HEATSHOCK70.
SUPFAMiSSF100934. SSF100934. 1 hit.
PROSITEiPS00014. ER_TARGET. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q556U6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVKNIKIFLS LFFVVVLGLL ATTANSMVIG IDLGSQTFKV SLIKPGAFET
60 70 80 90 100
VLNEQSGRKT ISSVGWFKDE RLFSSDSFSV WARNPKQNYN LIQAFLGIKY
110 120 130 140 150
KEGLVEEISN GLPLGFKVKN DTVRNTVSIV YDDDTNYSAE ELTGMLLRRV
160 170 180 190 200
KDMASSYAGS SIKDCAITIP PYFTQQQRQA LLDAAQLAGL NVLSLIHDVN
210 220 230 240 250
AAALSFAMDR TFLEKNESVI FYDMGARHTS VSLVEFESHN EQIKGVKKNK
260 270 280 290 300
TVSSASVKGI EWDEKLGGFD FDMVIVNHLK TLLKKQIPSA NVDDIKITIK
310 320 330 340 350
LLKEVGKMKE NLSVNQQAQI FIGSLVDDHD FQATISKQQF EELSQSLIER
360 370 380 390 400
SLLPLKKLIL STGIKLKDIE YFEVIGGGVR IPFIQQALKD YLKRDTLDKH
410 420 430 440 450
LNGDEAMSNG AAFYAASLTH YFKVKEIKLK DILLNSVDVE INNNIINSGG
460 470 480 490 500
AGETLLEETE DNEDNELNNS GNEQQQQQQP TINQGGLKDK KIQLFKVNSK
510 520 530 540 550
LGIKKTVSFS SENGFSLFLN NPTINNPLAT YTVSNVPTPG EKYNFTGKPK
560 570 580 590 600
IHCSFRLTTS GIVVLEKAEA EITVSLIKPQ PQQNKTSSST STTKKNTTTI
610 620 630 640 650
ETTDGGSEET TDETTTKQQQ QQEKEEEEEV VVVEKVIEYI QKTIRVPLNF
660 670 680 690 700
TIKYNGCVEP LSKELSQESN DRINKLDQVD RILRELRQER NNLESFIYET
710 720 730 740 750
KDKLESNEEY LKCSTQQERD QLVEELDKTS AWLSDALDND NTETEEYRKQ
760 770 780 790 800
LKDIKKKADK IVNRVSQYQL VPVALEELED TVDKVKPMFE IASKDLNVTA
810 820 830 840 850
EELKETTDKI QSVSDWVQEK KSEFKLADYS KDLQTSSFDI KFKLYDLERT
860 870 880 890 900
IKEILKKKKK PVKPSSSKKD KSSKSSKGKS NSTDEKDQKQ KEQKEQQQQQ
910 920
KEESQFQNDG AEEQQFEDDH KVHDEL
Length:926
Mass (Da):104,792
Last modified:May 2, 2006 - v1
Checksum:iEEA198A7B6B5E111
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000011 Genomic DNA. Translation: EAL70597.1.
AAFI02000009 Genomic DNA. Translation: EAL70764.1.
RefSeqiXP_644523.1. XM_639431.1.
XP_644727.1. XM_639635.1.

Genome annotation databases

EnsemblProtistsiEAL70597; EAL70597; DDB_G0273813.
EAL70764; EAL70764; DDB_G0273093.
GeneIDi8618827.
8619149.
KEGGiddi:DDB_G0273093.
ddi:DDB_G0273813.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000011 Genomic DNA. Translation: EAL70597.1.
AAFI02000009 Genomic DNA. Translation: EAL70764.1.
RefSeqiXP_644523.1. XM_639431.1.
XP_644727.1. XM_639635.1.

3D structure databases

ProteinModelPortaliQ556U6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi44689.DDB0266530.

Proteomic databases

PaxDbiQ556U6.
PRIDEiQ556U6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsiEAL70597; EAL70597; DDB_G0273813.
EAL70764; EAL70764; DDB_G0273093.
GeneIDi8618827.
8619149.
KEGGiddi:DDB_G0273093.
ddi:DDB_G0273813.

Organism-specific databases

dictyBaseiDDB_G0273093.
DDB_G0273813.

Phylogenomic databases

eggNOGiKOG0103. Eukaryota.
KOG0104. Eukaryota.
ENOG41102PY. LUCA.
InParanoidiQ556U6.
KOiK09486.
OMAiNDNTETE.
PhylomeDBiQ556U6.

Miscellaneous databases

PROiQ556U6.

Family and domain databases

Gene3Di1.20.1270.10. 1 hit.
InterProiIPR029048. HSP70_C.
IPR013126. Hsp_70_fam.
[Graphical view]
PfamiPF00012. HSP70. 1 hit.
[Graphical view]
PRINTSiPR00301. HEATSHOCK70.
SUPFAMiSSF100934. SSF100934. 1 hit.
PROSITEiPS00014. ER_TARGET. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiBIP1_DICDI
AccessioniPrimary (citable) accession number: Q556U6
Secondary accession number(s): Q86JV8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: May 2, 2006
Last modified: November 2, 2016
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Caution

The gene for this protein is duplicated in strains AX3 and AX4. These strains contain a duplication of a segment of 750 kb of chromosome 2 compared to the corresponding sequence in strain AX2.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.