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Q556Q0

- PSB4_DICDI

UniProt

Q556Q0 - PSB4_DICDI

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Protein

Proteasome subunit beta type-4

Gene
psmB4-1, DDB_G0273163
psmB4-2, DDB_G0273909
Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity By similarity.

Catalytic activityi

Cleavage of peptide bonds with very broad specificity.

GO - Molecular functioni

  1. peptidase activity Source: dictyBase
  2. threonine-type endopeptidase activity Source: UniProtKB-KW

GO - Biological processi

  1. proteolysis Source: dictyBase
  2. proteolysis involved in cellular protein catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Threonine protease

Enzyme and pathway databases

ReactomeiREACT_204617. Antigen processing: Ubiquitination & Proteasome degradation.
REACT_210566. AUF1 (hnRNP D0) destabilizes mRNA.
REACT_212010. Regulation of activated PAK-2p34 by proteasome mediated degradation.
REACT_214682. Cross-presentation of soluble exogenous antigens (endosomes).
REACT_217211. ER-Phagosome pathway.
REACT_217636. Autodegradation of the E3 ubiquitin ligase COP1.
REACT_221036. Separation of Sister Chromatids.
REACT_225025. APC/C:Cdc20 mediated degradation of Securin.
REACT_226311. APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1.
REACT_226712. Autodegradation of Cdh1 by Cdh1:APC/C.
REACT_95813. Ubiquitin Mediated Degradation of Phosphorylated Cdc25A.

Protein family/group databases

MEROPSiT01.A13.

Names & Taxonomyi

Organism-specific databases

Protein namesi
Recommended name:
Proteasome subunit beta type-4 (EC:3.4.25.1)
Gene namesi
Name:psmB4-1
ORF Names:DDB_G0273163
AND
Name:psmB4-2
ORF Names:DDB_G0273909
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
ProteomesiUP000002195: Chromosome 2, UP000002195: Unassembled WGS sequence
dictyBaseiDDB_G0273163. psmB4-1.
DDB_G0273909. psmB4-2.

Subcellular locationi

Cytoplasm By similarity. Nucleus By similarity

GO - Cellular componenti

  1. cytoplasm Source: dictyBase
  2. cytosol Source: dictyBase
  3. nucleus Source: dictyBase
  4. proteasome core complex Source: InterPro

Keywords - Cellular componenti

Cytoplasm, Nucleus, Proteasome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 259259Proteasome subunit beta type-4PRO_0000328482Add
BLAST

Proteomic databases

PRIDEiQ556Q0.

Interactioni

Subunit structurei

The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel By similarity.

Protein-protein interaction databases

STRINGi44689.DDB_0232934.

Structurei

3D structure databases

ProteinModelPortaliQ556Q0.

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase T1B family.

Phylogenomic databases

eggNOGiCOG0638.
KOiK02736.
OMAiRIMRVND.
PhylomeDBiQ556Q0.

Family and domain databases

Gene3Di3.60.20.10. 1 hit.
InterProiIPR029055. Ntn_hydrolases_N.
IPR016050. Proteasome_bsu_CS.
IPR016295. Proteasome_endopept_cplx_B.
IPR001353. Proteasome_sua/b.
IPR023333. Proteasome_suB-type.
[Graphical view]
PfamiPF00227. Proteasome. 1 hit.
[Graphical view]
PIRSFiPIRSF001213. Psome_endopept_beta. 1 hit.
SUPFAMiSSF56235. SSF56235. 1 hit.
PROSITEiPS00854. PROTEASOME_BETA_1. 1 hit.
PS51476. PROTEASOME_BETA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q556Q0-1 [UniParc]FASTAAdd to Basket

« Hide

MSHEHVNFPV YGQVDYFKQQ QPQQPQYNPH LGGKQKTLDP IVTGTSVIAI    50
KYDKGVVMGS DMLLSYGSLA RFNSTERMKK FGGYTIVGAS GEYSDFQSIT 100
NTLNDLVTDD HCMDDGSKLS SEEIWNYLAR VLYNQRNRGN PLWNTLVVMG 150
YQGGKSFLGK VDLVGTCYKD DIITTGYGSH IALPLLRKAR DENPNMNLEQ 200
AKQLIQDCLR VLFYRDARSS KKIQISVAGE EGIEISGPIE LDTFHWNSGE 250
AAVKNFSQV 259
Length:259
Mass (Da):29,006
Last modified:May 2, 2006 - v1
Checksum:iB9224DA76DE99FF2
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAFI02000011 Genomic DNA. Translation: EAL70645.1.
AAFI02000009 Genomic DNA. Translation: EAL70799.1.
RefSeqiXP_644571.1. XM_639479.1.
XP_644680.1. XM_639588.1.

Genome annotation databases

EnsemblProtistsiDDB0232934; DDB0232934; DDB_G0273163.
DDB0266501; DDB0266501; DDB_G0273909.
GeneIDi8618774.
8619202.
KEGGiddi:DDB_G0273163.
ddi:DDB_G0273909.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAFI02000011 Genomic DNA. Translation: EAL70645.1 .
AAFI02000009 Genomic DNA. Translation: EAL70799.1 .
RefSeqi XP_644571.1. XM_639479.1.
XP_644680.1. XM_639588.1.

3D structure databases

ProteinModelPortali Q556Q0.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 44689.DDB_0232934.

Protein family/group databases

MEROPSi T01.A13.

Proteomic databases

PRIDEi Q556Q0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblProtistsi DDB0232934 ; DDB0232934 ; DDB_G0273163 .
DDB0266501 ; DDB0266501 ; DDB_G0273909 .
GeneIDi 8618774.
8619202.
KEGGi ddi:DDB_G0273163.
ddi:DDB_G0273909.

Organism-specific databases

dictyBasei DDB_G0273163. psmB4-1.
DDB_G0273909. psmB4-2.

Phylogenomic databases

eggNOGi COG0638.
KOi K02736.
OMAi RIMRVND.
PhylomeDBi Q556Q0.

Enzyme and pathway databases

Reactomei REACT_204617. Antigen processing: Ubiquitination & Proteasome degradation.
REACT_210566. AUF1 (hnRNP D0) destabilizes mRNA.
REACT_212010. Regulation of activated PAK-2p34 by proteasome mediated degradation.
REACT_214682. Cross-presentation of soluble exogenous antigens (endosomes).
REACT_217211. ER-Phagosome pathway.
REACT_217636. Autodegradation of the E3 ubiquitin ligase COP1.
REACT_221036. Separation of Sister Chromatids.
REACT_225025. APC/C:Cdc20 mediated degradation of Securin.
REACT_226311. APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1.
REACT_226712. Autodegradation of Cdh1 by Cdh1:APC/C.
REACT_95813. Ubiquitin Mediated Degradation of Phosphorylated Cdc25A.

Miscellaneous databases

PROi Q556Q0.

Family and domain databases

Gene3Di 3.60.20.10. 1 hit.
InterProi IPR029055. Ntn_hydrolases_N.
IPR016050. Proteasome_bsu_CS.
IPR016295. Proteasome_endopept_cplx_B.
IPR001353. Proteasome_sua/b.
IPR023333. Proteasome_suB-type.
[Graphical view ]
Pfami PF00227. Proteasome. 1 hit.
[Graphical view ]
PIRSFi PIRSF001213. Psome_endopept_beta. 1 hit.
SUPFAMi SSF56235. SSF56235. 1 hit.
PROSITEi PS00854. PROTEASOME_BETA_1. 1 hit.
PS51476. PROTEASOME_BETA_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AX4.
  2. "The genome of the social amoeba Dictyostelium discoideum."
    Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N.
    , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
    Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AX4.

Entry informationi

Entry nameiPSB4_DICDI
AccessioniPrimary (citable) accession number: Q556Q0
Secondary accession number(s): Q86JY1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: May 2, 2006
Last modified: September 3, 2014
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Caution

The gene for this protein is duplicated in strains AX3 and AX4. These strains contain a duplication of a segment of 750 kb of chromosome 2 compared to the corresponding sequence in strain AX2.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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