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Protein

Proteasome subunit beta type-4

Gene

psmB4-1

more
Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity (By similarity).By similarity

Caution

The gene for this protein is duplicated in strains AX3 and AX4. These strains contain a duplication of a segment of 750 kb of chromosome 2 compared to the corresponding sequence in strain AX2.Curated

Catalytic activityi

Cleavage of peptide bonds with very broad specificity.

GO - Molecular functioni

  • peptidase activity Source: dictyBase
  • threonine-type endopeptidase activity Source: UniProtKB-KW

GO - Biological processi

  • proteolysis Source: dictyBase
  • proteolysis involved in cellular protein catabolic process Source: InterPro

Keywordsi

Molecular functionHydrolase, Protease, Threonine protease

Enzyme and pathway databases

ReactomeiR-DDI-1236978 Cross-presentation of soluble exogenous antigens (endosomes)
R-DDI-174084 Autodegradation of Cdh1 by Cdh1:APC/C
R-DDI-174178 APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
R-DDI-174184 Cdc20:Phospho-APC/C mediated degradation of Cyclin A
R-DDI-349425 Autodegradation of the E3 ubiquitin ligase COP1
R-DDI-5632684 Hedgehog 'on' state
R-DDI-5658442 Regulation of RAS by GAPs
R-DDI-5689603 UCH proteinases
R-DDI-5689880 Ub-specific processing proteases
R-DDI-68949 Orc1 removal from chromatin
R-DDI-69601 Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
R-DDI-8854050 FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
R-DDI-8948751 Regulation of PTEN stability and activity
R-DDI-983168 Antigen processing: Ubiquitination & Proteasome degradation

Protein family/group databases

MEROPSiT01.A13

Names & Taxonomyi

Protein namesi
Recommended name:
Proteasome subunit beta type-4 (EC:3.4.25.1)
Gene namesi
Name:psmB4-1
ORF Names:DDB_G0273163
AND
Name:psmB4-2
ORF Names:DDB_G0273909
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyostelidsDictyostelialesDictyosteliaceaeDictyostelium
Proteomesi
  • UP000002195 Componentsi: Chromosome 2, Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0273163 psmB4-1
DDB_G0273909 psmB4-2

Subcellular locationi

  • Cytoplasm PROSITE-ProRule annotation
  • Nucleus By similarity

GO - Cellular componenti

  • cytoplasm Source: dictyBase
  • cytosol Source: dictyBase
  • nucleus Source: dictyBase
  • proteasome core complex, beta-subunit complex Source: UniProtKB

Keywords - Cellular componenti

Cytoplasm, Nucleus, Proteasome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003284821 – 259Proteasome subunit beta type-4Add BLAST259

Proteomic databases

PaxDbiQ556Q0

Interactioni

Subunit structurei

The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel (By similarity).By similarity

Protein-protein interaction databases

STRINGi44689.DDB0266501

Structurei

3D structure databases

ProteinModelPortaliQ556Q0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase T1B family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0185 Eukaryota
ENOG410YAMA LUCA
InParanoidiQ556Q0
KOiK02736
OMAiKECMKVL
PhylomeDBiQ556Q0

Family and domain databases

CDDicd03760 proteasome_beta_type_4, 1 hit
Gene3Di3.60.20.10, 1 hit
InterProiView protein in InterPro
IPR029055 Ntn_hydrolases_N
IPR016050 Proteasome_bsu_CS
IPR016295 Proteasome_endopept_cplx_B
IPR001353 Proteasome_sua/b
IPR023333 Proteasome_suB-type
PANTHERiPTHR11599:SF5 PTHR11599:SF5, 1 hit
PfamiView protein in Pfam
PF00227 Proteasome, 1 hit
PIRSFiPIRSF001213 Psome_endopept_beta, 1 hit
SUPFAMiSSF56235 SSF56235, 1 hit
PROSITEiView protein in PROSITE
PS00854 PROTEASOME_BETA_1, 1 hit
PS51476 PROTEASOME_BETA_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q556Q0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSHEHVNFPV YGQVDYFKQQ QPQQPQYNPH LGGKQKTLDP IVTGTSVIAI
60 70 80 90 100
KYDKGVVMGS DMLLSYGSLA RFNSTERMKK FGGYTIVGAS GEYSDFQSIT
110 120 130 140 150
NTLNDLVTDD HCMDDGSKLS SEEIWNYLAR VLYNQRNRGN PLWNTLVVMG
160 170 180 190 200
YQGGKSFLGK VDLVGTCYKD DIITTGYGSH IALPLLRKAR DENPNMNLEQ
210 220 230 240 250
AKQLIQDCLR VLFYRDARSS KKIQISVAGE EGIEISGPIE LDTFHWNSGE

AAVKNFSQV
Length:259
Mass (Da):29,006
Last modified:May 2, 2006 - v1
Checksum:iB9224DA76DE99FF2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000011 Genomic DNA Translation: EAL70645.1
AAFI02000009 Genomic DNA Translation: EAL70799.1
RefSeqiXP_644571.1, XM_639479.1
XP_644680.1, XM_639588.1

Genome annotation databases

EnsemblProtistsiEAL70645; EAL70645; DDB_G0273909
EAL70799; EAL70799; DDB_G0273163
GeneIDi8618774
8619202
KEGGiddi:DDB_G0273163
ddi:DDB_G0273909

Similar proteinsi

Entry informationi

Entry nameiPSB4_DICDI
AccessioniPrimary (citable) accession number: Q556Q0
Secondary accession number(s): Q86JY1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: May 2, 2006
Last modified: May 23, 2018
This is version 91 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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