ID   AOFB_DICDI              Reviewed;         471 AA.
AC   Q556K3; Q86AM6;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   02-MAY-2006, sequence version 1.
DT   27-MAR-2024, entry version 97.
DE   RecName: Full=Probable flavin-containing monoamine oxidase B;
DE            EC=1.4.3.4;
GN   Name=maoB-1; ORFNames=DDB_G0272582;
GN   and
GN   Name=maoB-2; ORFNames=DDB_G0273993;
OS   Dictyostelium discoideum (Social amoeba).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=12097910; DOI=10.1038/nature00847;
RA   Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T.,
RA   Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R.,
RA   Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A.,
RA   Noegel A.A.;
RT   "Sequence and analysis of chromosome 2 of Dictyostelium discoideum.";
RL   Nature 418:79-85(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a secondary aliphatic amine + H2O + O2 = a primary amine + an
CC         aldehyde + H2O2; Xref=Rhea:RHEA:26414, ChEBI:CHEBI:15377,
CC         ChEBI:CHEBI:15379, ChEBI:CHEBI:16240, ChEBI:CHEBI:17478,
CC         ChEBI:CHEBI:58855, ChEBI:CHEBI:65296; EC=1.4.3.4;
CC   -!- COFACTOR:
CC       Name=FAD; Xref=ChEBI:CHEBI:57692;
CC   -!- SIMILARITY: Belongs to the flavin monoamine oxidase family.
CC       {ECO:0000305}.
CC   -!- CAUTION: The gene for this protein is duplicated in strains AX3 and
CC       AX4. These strains contain a duplication of a segment of 750 kb of
CC       chromosome 2 compared to the corresponding sequence in strain AX2.
CC       {ECO:0000305}.
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DR   EMBL; AAFI02000011; EAL70430.1; -; Genomic_DNA.
DR   EMBL; AAFI02000009; EAL70928.1; -; Genomic_DNA.
DR   RefSeq; XP_644355.1; XM_639263.1.
DR   RefSeq; XP_645059.1; XM_639967.1.
DR   AlphaFoldDB; Q556K3; -.
DR   SMR; Q556K3; -.
DR   STRING; 44689.Q556K3; -.
DR   PaxDb; 44689-DDB0231711; -.
DR   EnsemblProtists; EAL70430; EAL70430; DDB_G0273993.
DR   EnsemblProtists; EAL70928; EAL70928; DDB_G0272582.
DR   GeneID; 8618734; -.
DR   GeneID; 8619242; -.
DR   KEGG; ddi:DDB_G0272582; -.
DR   KEGG; ddi:DDB_G0273993; -.
DR   dictyBase; DDB_G0272582; maoB-1.
DR   dictyBase; DDB_G0273993; maoB-2.
DR   eggNOG; KOG0029; Eukaryota.
DR   HOGENOM; CLU_004498_0_4_1; -.
DR   InParanoid; Q556K3; -.
DR   OMA; GETAYEW; -.
DR   PhylomeDB; Q556K3; -.
DR   Reactome; R-DDI-141333; Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB.
DR   Reactome; R-DDI-181430; Norepinephrine Neurotransmitter Release Cycle.
DR   Reactome; R-DDI-379397; Enzymatic degradation of dopamine by COMT.
DR   Reactome; R-DDI-379398; Enzymatic degradation of Dopamine by monoamine oxidase.
DR   Reactome; R-DDI-379401; Dopamine clearance from the synaptic cleft.
DR   Reactome; R-DDI-380612; Metabolism of serotonin.
DR   PRO; PR:Q556K3; -.
DR   Proteomes; UP000002195; Chromosome 2.
DR   GO; GO:0097621; F:monoamine oxidase activity; IEA:UniProtKB-EC.
DR   Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 1.
DR   InterPro; IPR002937; Amino_oxidase.
DR   InterPro; IPR036188; FAD/NAD-bd_sf.
DR   InterPro; IPR001613; Flavin_amine_oxidase.
DR   PANTHER; PTHR43563; AMINE OXIDASE; 1.
DR   PANTHER; PTHR43563:SF1; FLAVIN-CONTAINING MONOAMINE OXIDASE B-RELATED; 1.
DR   Pfam; PF01593; Amino_oxidase; 1.
DR   PRINTS; PR00757; AMINEOXDASEF.
DR   SUPFAM; SSF54373; FAD-linked reductases, C-terminal domain; 1.
DR   SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
PE   3: Inferred from homology;
KW   FAD; Flavoprotein; Oxidoreductase; Reference proteome.
FT   CHAIN           1..471
FT                   /note="Probable flavin-containing monoamine oxidase B"
FT                   /id="PRO_0000328629"
FT   MOD_RES         406
FT                   /note="S-8alpha-FAD cysteine"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   471 AA;  53612 MW;  76D9EF17F67950F0 CRC64;
     MEMEILYNYD TIIIGGGLSG LNTAYDLKKS NFKILVLEAR NRFGGRTDSV KVGDGWVDAG
     GQWLGTNNPN LKQLCKELKL ETYKQFYQGK TVFDIYDDGL IKSFDESSPN FDLCEIGLGN
     INPIIRAIKE VMKNIDFSKC SKESPIMLSL EKLTVSEWLR VCGYGESVKF FNWFCKMSVA
     SSSDDISILF LLKYVNSING FESLFISDDD CTESDRIIGG SSMVSERIVS YLKDDCKLNC
     EVTLIDQISH KNSRLIKITT SNNENYYCRN VVSTIPPMLL KNVIFKPDLP IEKQRLKNEM
     EMGNTIKVIV IYDSVFWRDQ GYNGKSQSFV GPIYQSFDNC TNDLSVKSII GFINGKEEIK
     YWYSKSLEER RSAVLNQYSK YWGPKALNPI HYIERNWSLD KYSAGCFMGV CKSGDIISQC
     NNYYTQPHGN IHWAGTETST QWYGHMEGAI TSSKRVVNEI LKNSLNSKSK L
//