Q556K3 (AOFB_DICDI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable flavin-containing monoamine oxidase B
EC=1.4.3.4

Gene names

Name:	maoB-1
ORF Names:	DDB_G0272582
AND
Name:	maoB-2
ORF Names:	DDB_G0273993

Organism

Dictyostelium discoideum (Slime mold) [Reference proteome]

Taxonomic identifier

44689 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Amoebozoa › Mycetozoa › Dictyosteliida › Dictyostelium

Protein attributes

Sequence length	471 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	RCH2NHR' + H2O + O2 = RCHO + R'NH2 + H2O2.
Cofactor	FAD.
Sequence similarities	Belongs to the flavin monoamine oxidase family.
Caution	The gene for this protein is duplicated in strains AX3 and AX4. These strains contain a duplication of a segment of 750 kb of chromosome 2 compared to the corresponding sequence in strain AX2.

Ontologies

Keywords
Ligand	FAD Flavoprotein
Molecular function	Oxidoreductase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Molecular_function	oxidoreductase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 471	471	Probable flavin-containing monoamine oxidase B		PRO_0000328629
Amino acid modifications
	Modified residue	406	1	S-8alpha-FAD cysteine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q556K3 [UniParc]. Last modified May 2, 2006. Version 1. Checksum: 76D9EF17F67950F0	FASTA	471	53,612
	10 20 30 40 50 60 MEMEILYNYD TIIIGGGLSG LNTAYDLKKS NFKILVLEAR NRFGGRTDSV KVGDGWVDAG 70 80 90 100 110 120 GQWLGTNNPN LKQLCKELKL ETYKQFYQGK TVFDIYDDGL IKSFDESSPN FDLCEIGLGN 130 140 150 160 170 180 INPIIRAIKE VMKNIDFSKC SKESPIMLSL EKLTVSEWLR VCGYGESVKF FNWFCKMSVA 190 200 210 220 230 240 SSSDDISILF LLKYVNSING FESLFISDDD CTESDRIIGG SSMVSERIVS YLKDDCKLNC 250 260 270 280 290 300 EVTLIDQISH KNSRLIKITT SNNENYYCRN VVSTIPPMLL KNVIFKPDLP IEKQRLKNEM 310 320 330 340 350 360 EMGNTIKVIV IYDSVFWRDQ GYNGKSQSFV GPIYQSFDNC TNDLSVKSII GFINGKEEIK 370 380 390 400 410 420 YWYSKSLEER RSAVLNQYSK YWGPKALNPI HYIERNWSLD KYSAGCFMGV CKSGDIISQC 430 440 450 460 470 NNYYTQPHGN IHWAGTETST QWYGHMEGAI TSSKRVVNEI LKNSLNSKSK L

References

[1]

"Sequence and analysis of chromosome 2 of Dictyostelium discoideum." Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T., Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R., Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A., Noegel A.A. Nature 418:79-85(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AX4.

[2]

"The genome of the social amoeba Dictyostelium discoideum." Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N. , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A. Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AX4.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AAFI02000011 Genomic DNA. Translation: EAL70430.1. AAFI02000009 Genomic DNA. Translation: EAL70928.1.
RefSeq	XP_644355.1. XM_639263.1. XP_645059.1. XM_639967.1.
3D structure databases
ProteinModelPortal	Q556K3.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblProtists	DDB0231711; DDB0231711; DDB_G0272582. DDB0266407; DDB0266407; DDB_G0273993.
GeneID	8618734. 8619242.
KEGG	ddi:DDB_G0272582. ddi:DDB_G0273993.
Organism-specific databases
dictyBase	DDB_G0272582. maoB-1. DDB_G0273993. maoB-2.
Phylogenomic databases
eggNOG	COG1231.
OMA	ISHKLAS.
ProtClustDB	CLSZ2429871.
Family and domain databases
InterPro	IPR002937. Amino_oxidase. IPR001613. Flavin_amine_oxidase. [Graphical view]
Pfam	PF01593. Amino_oxidase. 1 hit. [Graphical view]
PRINTS	PR00757. AMINEOXDASEF.
ProtoNet	Search...

Entry information

Entry name

AOFB_DICDI

Accession

Primary (citable) accession number: Q556K3
Secondary accession number(s): Q86AM6

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 8, 2008
Last sequence update:	May 2, 2006
Last modified:	May 1, 2013
This is version 50 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)