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Q556J6 (Y4007_DICDI) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 54. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Putative cyclin-dependent serine/threonine-protein kinase DDB_G0272797/DDB_G0274007

EC=2.7.11.22
Gene names
ORF Names:DDB_G0272797
AND
ORF Names:DDB_G0274007
OrganismDictyostelium discoideum (Slime mold) [Reference proteome]
Taxonomic identifier44689 [NCBI]
Taxonomic lineageEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium

Protein attributes

Sequence length680 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + a protein = ADP + a phosphoprotein.

Sequence similarities

Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.

Contains 1 protein kinase domain.

Caution

The gene for this protein is duplicated in strains AX3 and AX4. These strains contain a duplication of a segment of 750 kb of chromosome 2 compared to the corresponding sequence in strain AX2.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 680680Putative cyclin-dependent serine/threonine-protein kinase DDB_G0272797/DDB_G0274007
PRO_0000372696

Regions

Domain4 – 381378Protein kinase
Nucleotide binding10 – 189ATP By similarity
Compositional bias257 – 28630Poly-Asn
Compositional bias410 – 4156Poly-Gln
Compositional bias419 – 43315Poly-Gln
Compositional bias441 – 45111Poly-Gln
Compositional bias479 – 4824Poly-Gln
Compositional bias499 – 53941Poly-Gln
Compositional bias559 – 60446Poly-Gln
Compositional bias611 – 64030His-rich
Compositional bias649 – 66214Poly-Thr

Sites

Active site1251Proton acceptor By similarity
Binding site331ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q556J6 [UniParc].

Last modified May 2, 2006. Version 1.
Checksum: 6DB9FE3034BAC068

FASTA68079,758
        10         20         30         40         50         60 
MEDYIILSKC GQGTYGSVFK GIHKITHSLV ALKRVTDIAQ EDGEPVEVKY LNQLKNLSNI 

        70         80         90        100        110        120 
VNLRDHFYID KNSVLVLIME FIEGDLWKIM SNPQCTLSLG QIKNFTKQLL EGVKQCHVNG 

       130        140        150        160        170        180 
IMHRDIKPAN LLITTNGVLK LTDFGLSTSY SKRSEKFLSS NVVSLYYRPP ELLLGSCIYG 

       190        200        210        220        230        240 
PEIDMWSVGC ILMEMINNSY LFAGADETAQ LDLIFKLFGC PTEKSWPGVS SLPGYNDLFN 

       250        260        270        280        290        300 
KQQQQQQNEN NYSKQHNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNKYNN ISTSCLQSPS 

       310        320        330        340        350        360 
SSPPIGGYAS SLSSDFNSNE YNGYNQTFSN EDCLAISQKK LIDKFPHLVL LPSVLDLASK 

       370        380        390        400        410        420 
MLTLDPKKRI NSLEALEHPW FKSSNDMDQI VPFSKDFTDL ANRYIASTRQ LQQQQHHHQQ 

       430        440        450        460        470        480 
QQQQQQQQQQ QQQPHQQQLI QRQHQEQQQQ QLIQRQQEQS KQQLIQHHQQ SVNQQQLAQQ 

       490        500        510        520        530        540 
QQLAQHQQYN SQQHQQHHQQ QHQQHQQHQQ QQQQQQQQQQ QQQQQQQQQQ QQQQQQQQQY 

       550        560        570        580        590        600 
HQHQQQYHQY QQQYHQPSQQ QQQQQQQQQQ QQQQQQQQQQ QQQQQQQQQQ QQQQQQQQQQ 

       610        620        630        640        650        660 
HQYQPPQQYN HQPPQHQHQH QHQHQHQHQH QHQPQPQHQH QPQPQPQPTP TPTPTSTPTT 

       670        680 
TTIPPTITTT IQPTISKSNG 

« Hide

References

[1]"Sequence and analysis of chromosome 2 of Dictyostelium discoideum."
Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T., Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R., Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A., Noegel A.A.
Nature 418:79-85(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: AX4.
[2]"The genome of the social amoeba Dictyostelium discoideum."
Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N. expand/collapse author list , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: AX4.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AAFI02000011 Genomic DNA. Translation: EAL70437.1.
AAFI02000009 Genomic DNA. Translation: EAL71036.1.

3D structure databases

ProteinModelPortalQ556J6.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING44689.DDB_0230050.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsDDB0230050; DDB0230050; DDB_G0272797.
DDB0267010; DDB0267010; DDB_G0274007.
KEGGddi:DDB_G0272797.
ddi:DDB_G0274007.

Organism-specific databases

dictyBaseDDB_G0272797.
DDB_G0274007.

Phylogenomic databases

eggNOGCOG0515.
OMASHANLIN.
PhylomeDBQ556J6.
ProtClustDBCLSZ2431075.

Family and domain databases

InterProIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMSSF56112. SSF56112. 2 hits.
PROSITEPS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

PROQ556J6.

Entry information

Entry nameY4007_DICDI
AccessionPrimary (citable) accession number: Q556J6
Secondary accession number(s): Q86AM9
Entry history
Integrated into UniProtKB/Swiss-Prot: May 5, 2009
Last sequence update: May 2, 2006
Last modified: April 16, 2014
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families

Dictyostelium discoideum

Dictyostelium discoideum: entries, gene names and cross-references to dictyBase