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Q556J6

- Y4007_DICDI

UniProt

Q556J6 - Y4007_DICDI

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Protein

Putative cyclin-dependent serine/threonine-protein kinase DDB_G0272797/DDB_G0274007

Gene
DDB_G0272797
DDB_G0274007
Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei33 – 331ATP By similarity
Active sitei125 – 1251Proton acceptor By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi10 – 189ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. cyclin-dependent protein serine/threonine kinase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_223567. RNA Polymerase II Pre-transcription Events.
REACT_224777. RNA Polymerase II Transcription Elongation.

Names & Taxonomyi

Organism-specific databases

Protein namesi
Recommended name:
Putative cyclin-dependent serine/threonine-protein kinase DDB_G0272797/DDB_G0274007 (EC:2.7.11.22)
Gene namesi
ORF Names:DDB_G0272797
AND
ORF Names:DDB_G0274007
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
ProteomesiUP000002195: Chromosome 2, UP000002195: Unassembled WGS sequence
dictyBaseiDDB_G0272797.
DDB_G0274007.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 680680Putative cyclin-dependent serine/threonine-protein kinase DDB_G0272797/DDB_G0274007PRO_0000372696Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi44689.DDB_0230050.

Structurei

3D structure databases

ProteinModelPortaliQ556J6.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini4 – 381378Protein kinaseAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi257 – 28630Poly-AsnAdd
BLAST
Compositional biasi410 – 4156Poly-Gln
Compositional biasi419 – 43315Poly-GlnAdd
BLAST
Compositional biasi441 – 45111Poly-GlnAdd
BLAST
Compositional biasi479 – 4824Poly-Gln
Compositional biasi499 – 53941Poly-GlnAdd
BLAST
Compositional biasi559 – 60446Poly-GlnAdd
BLAST
Compositional biasi611 – 64030His-richAdd
BLAST
Compositional biasi649 – 66214Poly-ThrAdd
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0515.
OMAiRYIASTR.
PhylomeDBiQ556J6.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 2 hits.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q556J6-1 [UniParc]FASTAAdd to Basket

« Hide

MEDYIILSKC GQGTYGSVFK GIHKITHSLV ALKRVTDIAQ EDGEPVEVKY    50
LNQLKNLSNI VNLRDHFYID KNSVLVLIME FIEGDLWKIM SNPQCTLSLG 100
QIKNFTKQLL EGVKQCHVNG IMHRDIKPAN LLITTNGVLK LTDFGLSTSY 150
SKRSEKFLSS NVVSLYYRPP ELLLGSCIYG PEIDMWSVGC ILMEMINNSY 200
LFAGADETAQ LDLIFKLFGC PTEKSWPGVS SLPGYNDLFN KQQQQQQNEN 250
NYSKQHNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNKYNN ISTSCLQSPS 300
SSPPIGGYAS SLSSDFNSNE YNGYNQTFSN EDCLAISQKK LIDKFPHLVL 350
LPSVLDLASK MLTLDPKKRI NSLEALEHPW FKSSNDMDQI VPFSKDFTDL 400
ANRYIASTRQ LQQQQHHHQQ QQQQQQQQQQ QQQPHQQQLI QRQHQEQQQQ 450
QLIQRQQEQS KQQLIQHHQQ SVNQQQLAQQ QQLAQHQQYN SQQHQQHHQQ 500
QHQQHQQHQQ QQQQQQQQQQ QQQQQQQQQQ QQQQQQQQQY HQHQQQYHQY 550
QQQYHQPSQQ QQQQQQQQQQ QQQQQQQQQQ QQQQQQQQQQ QQQQQQQQQQ 600
HQYQPPQQYN HQPPQHQHQH QHQHQHQHQH QHQPQPQHQH QPQPQPQPTP 650
TPTPTSTPTT TTIPPTITTT IQPTISKSNG 680
Length:680
Mass (Da):79,758
Last modified:May 2, 2006 - v1
Checksum:i6DB9FE3034BAC068
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAFI02000011 Genomic DNA. Translation: EAL70437.1.
AAFI02000009 Genomic DNA. Translation: EAL71036.1.
RefSeqiXP_644362.1. XM_639270.1.
XP_645052.1. XM_639960.1.

Genome annotation databases

EnsemblProtistsiDDB0230050; DDB0230050; DDB_G0272797.
DDB0267010; DDB0267010; DDB_G0274007.
GeneIDi8618728.
8619248.
KEGGiddi:DDB_G0272797.
ddi:DDB_G0274007.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAFI02000011 Genomic DNA. Translation: EAL70437.1 .
AAFI02000009 Genomic DNA. Translation: EAL71036.1 .
RefSeqi XP_644362.1. XM_639270.1.
XP_645052.1. XM_639960.1.

3D structure databases

ProteinModelPortali Q556J6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 44689.DDB_0230050.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblProtistsi DDB0230050 ; DDB0230050 ; DDB_G0272797 .
DDB0267010 ; DDB0267010 ; DDB_G0274007 .
GeneIDi 8618728.
8619248.
KEGGi ddi:DDB_G0272797.
ddi:DDB_G0274007.

Organism-specific databases

dictyBasei DDB_G0272797.
DDB_G0274007.

Phylogenomic databases

eggNOGi COG0515.
OMAi RYIASTR.
PhylomeDBi Q556J6.

Enzyme and pathway databases

Reactomei REACT_223567. RNA Polymerase II Pre-transcription Events.
REACT_224777. RNA Polymerase II Transcription Elongation.

Miscellaneous databases

PROi Q556J6.

Family and domain databases

InterProi IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view ]
Pfami PF00069. Pkinase. 1 hit.
[Graphical view ]
SMARTi SM00220. S_TKc. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 2 hits.
PROSITEi PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AX4.
  2. "The genome of the social amoeba Dictyostelium discoideum."
    Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N.
    , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
    Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AX4.

Entry informationi

Entry nameiY4007_DICDI
AccessioniPrimary (citable) accession number: Q556J6
Secondary accession number(s): Q86AM9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 5, 2009
Last sequence update: May 2, 2006
Last modified: September 3, 2014
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Caution

The gene for this protein is duplicated in strains AX3 and AX4. These strains contain a duplication of a segment of 750 kb of chromosome 2 compared to the corresponding sequence in strain AX2.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3