Q556J6 (Y4007_DICDI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Putative cyclin-dependent serine/threonine-protein kinase DDB_G0272797/DDB_G0274007
EC=2.7.11.22

Gene names

ORF Names:	DDB_G0272797
AND
ORF Names:	DDB_G0274007

Organism

Dictyostelium discoideum (Slime mold) [Reference proteome]

Taxonomic identifier

44689 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Amoebozoa › Mycetozoa › Dictyosteliida › Dictyostelium

Protein attributes

Sequence length	680 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + a protein = ADP + a phosphoprotein.
Sequence similarities	Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. Contains 1 protein kinase domain.
Caution	The gene for this protein is duplicated in strains AX3 and AX4. These strains contain a duplication of a segment of 750 kb of chromosome 2 compared to the corresponding sequence in strain AX2.

Ontologies

Keywords
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Serine/threonine-protein kinase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW cyclin-dependent protein serine/threonine kinase activity Inferred from electronic annotation. Source: UniProtKB-EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 680	680	Putative cyclin-dependent serine/threonine-protein kinase DDB_G0272797/DDB_G0274007		PRO_0000372696
Regions
	Domain	4 – 381	378	Protein kinase
	Nucleotide binding	10 – 18	9	ATP By similarity
	Compositional bias	257 – 286	30	Poly-Asn
	Compositional bias	410 – 415	6	Poly-Gln
	Compositional bias	419 – 433	15	Poly-Gln
	Compositional bias	441 – 451	11	Poly-Gln
	Compositional bias	479 – 482	4	Poly-Gln
	Compositional bias	499 – 539	41	Poly-Gln
	Compositional bias	559 – 604	46	Poly-Gln
	Compositional bias	611 – 640	30	His-rich
	Compositional bias	649 – 662	14	Poly-Thr
Sites
	Active site	125	1	Proton acceptor By similarity
	Binding site	33	1	ATP By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q556J6 [UniParc]. Last modified May 2, 2006. Version 1. Checksum: 6DB9FE3034BAC068	FASTA	680	79,758
	10 20 30 40 50 60 MEDYIILSKC GQGTYGSVFK GIHKITHSLV ALKRVTDIAQ EDGEPVEVKY LNQLKNLSNI 70 80 90 100 110 120 VNLRDHFYID KNSVLVLIME FIEGDLWKIM SNPQCTLSLG QIKNFTKQLL EGVKQCHVNG 130 140 150 160 170 180 IMHRDIKPAN LLITTNGVLK LTDFGLSTSY SKRSEKFLSS NVVSLYYRPP ELLLGSCIYG 190 200 210 220 230 240 PEIDMWSVGC ILMEMINNSY LFAGADETAQ LDLIFKLFGC PTEKSWPGVS SLPGYNDLFN 250 260 270 280 290 300 KQQQQQQNEN NYSKQHNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNKYNN ISTSCLQSPS 310 320 330 340 350 360 SSPPIGGYAS SLSSDFNSNE YNGYNQTFSN EDCLAISQKK LIDKFPHLVL LPSVLDLASK 370 380 390 400 410 420 MLTLDPKKRI NSLEALEHPW FKSSNDMDQI VPFSKDFTDL ANRYIASTRQ LQQQQHHHQQ 430 440 450 460 470 480 QQQQQQQQQQ QQQPHQQQLI QRQHQEQQQQ QLIQRQQEQS KQQLIQHHQQ SVNQQQLAQQ 490 500 510 520 530 540 QQLAQHQQYN SQQHQQHHQQ QHQQHQQHQQ QQQQQQQQQQ QQQQQQQQQQ QQQQQQQQQY 550 560 570 580 590 600 HQHQQQYHQY QQQYHQPSQQ QQQQQQQQQQ QQQQQQQQQQ QQQQQQQQQQ QQQQQQQQQQ 610 620 630 640 650 660 HQYQPPQQYN HQPPQHQHQH QHQHQHQHQH QHQPQPQHQH QPQPQPQPTP TPTPTSTPTT 670 680 TTIPPTITTT IQPTISKSNG

References

[1]	"Sequence and analysis of chromosome 2 of Dictyostelium discoideum." Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T., Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R., Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A., Noegel A.A. Nature 418:79-85(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AX4.
[2]	"The genome of the social amoeba Dictyostelium discoideum." Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N. , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A. Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AX4.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AAFI02000011 Genomic DNA. Translation: EAL70437.1. AAFI02000009 Genomic DNA. Translation: EAL71036.1.
3D structure databases
ProteinModelPortal	Q556J6.
ModBase	Search...
MobiDB	Search...
Protein-protein interaction databases
STRING	44689.DDB_0230050.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblProtists	DDB0230050; DDB0230050; DDB_G0272797. DDB0267010; DDB0267010; DDB_G0274007.
KEGG	ddi:DDB_G0272797. ddi:DDB_G0274007.
Organism-specific databases
dictyBase	DDB_G0272797. DDB_G0274007.
Phylogenomic databases
eggNOG	COG0515.
OMA	SHANLIN.
PhylomeDB	Q556J6.
ProtClustDB	CLSZ2431075.
Family and domain databases
InterPro	IPR011009. Kinase-like_dom. IPR000719. Prot_kinase_dom. IPR002290. Ser/Thr_dual-sp_kinase_dom. IPR008271. Ser/Thr_kinase_AS. [Graphical view]
Pfam	PF00069. Pkinase. 1 hit. [Graphical view]
SMART	SM00220. S_TKc. 1 hit. [Graphical view]
SUPFAM	SSF56112. SSF56112. 2 hits.
PROSITE	PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit. [Graphical view]
ProtoNet	Search...
Other
PRO	Q556J6.

Entry information

Entry name

Y4007_DICDI

Accession

Primary (citable) accession number: Q556J6
Secondary accession number(s): Q86AM9

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 5, 2009
Last sequence update:	May 2, 2006
Last modified:	April 16, 2014
This is version 54 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)