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Protein

Putative cyclin-dependent serine/threonine-protein kinase DDB_G0272797/DDB_G0274007

Gene

DDB_G0272797

more
Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei33ATPPROSITE-ProRule annotation1
Active sitei125Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi10 – 18ATPPROSITE-ProRule annotation9

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Putative cyclin-dependent serine/threonine-protein kinase DDB_G0272797/DDB_G0274007 (EC:2.7.11.22)
Gene namesi
ORF Names:DDB_G0272797
AND
ORF Names:DDB_G0274007
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
Proteomesi
  • UP000002195 Componentsi: Chromosome 2, Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0272797.
DDB_G0274007.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003726961 – 680Putative cyclin-dependent serine/threonine-protein kinase DDB_G0272797/DDB_G0274007Add BLAST680

Proteomic databases

PaxDbiQ556J6.

Interactioni

Protein-protein interaction databases

STRINGi44689.DDB0267010.

Structurei

3D structure databases

ProteinModelPortaliQ556J6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 381Protein kinasePROSITE-ProRule annotationAdd BLAST378

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi257 – 286Poly-AsnAdd BLAST30
Compositional biasi410 – 415Poly-Gln6
Compositional biasi419 – 433Poly-GlnAdd BLAST15
Compositional biasi441 – 451Poly-GlnAdd BLAST11
Compositional biasi479 – 482Poly-Gln4
Compositional biasi499 – 539Poly-GlnAdd BLAST41
Compositional biasi559 – 604Poly-GlnAdd BLAST46
Compositional biasi611 – 640His-richAdd BLAST30
Compositional biasi649 – 662Poly-ThrAdd BLAST14

Sequence similaritiesi

Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0594. Eukaryota.
ENOG410XPP3. LUCA.
InParanoidiQ556J6.
OMAiINNIGSE.
PhylomeDBiQ556J6.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 2 hits.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q556J6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEDYIILSKC GQGTYGSVFK GIHKITHSLV ALKRVTDIAQ EDGEPVEVKY
60 70 80 90 100
LNQLKNLSNI VNLRDHFYID KNSVLVLIME FIEGDLWKIM SNPQCTLSLG
110 120 130 140 150
QIKNFTKQLL EGVKQCHVNG IMHRDIKPAN LLITTNGVLK LTDFGLSTSY
160 170 180 190 200
SKRSEKFLSS NVVSLYYRPP ELLLGSCIYG PEIDMWSVGC ILMEMINNSY
210 220 230 240 250
LFAGADETAQ LDLIFKLFGC PTEKSWPGVS SLPGYNDLFN KQQQQQQNEN
260 270 280 290 300
NYSKQHNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNKYNN ISTSCLQSPS
310 320 330 340 350
SSPPIGGYAS SLSSDFNSNE YNGYNQTFSN EDCLAISQKK LIDKFPHLVL
360 370 380 390 400
LPSVLDLASK MLTLDPKKRI NSLEALEHPW FKSSNDMDQI VPFSKDFTDL
410 420 430 440 450
ANRYIASTRQ LQQQQHHHQQ QQQQQQQQQQ QQQPHQQQLI QRQHQEQQQQ
460 470 480 490 500
QLIQRQQEQS KQQLIQHHQQ SVNQQQLAQQ QQLAQHQQYN SQQHQQHHQQ
510 520 530 540 550
QHQQHQQHQQ QQQQQQQQQQ QQQQQQQQQQ QQQQQQQQQY HQHQQQYHQY
560 570 580 590 600
QQQYHQPSQQ QQQQQQQQQQ QQQQQQQQQQ QQQQQQQQQQ QQQQQQQQQQ
610 620 630 640 650
HQYQPPQQYN HQPPQHQHQH QHQHQHQHQH QHQPQPQHQH QPQPQPQPTP
660 670 680
TPTPTSTPTT TTIPPTITTT IQPTISKSNG
Length:680
Mass (Da):79,758
Last modified:May 2, 2006 - v1
Checksum:i6DB9FE3034BAC068
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000011 Genomic DNA. Translation: EAL70437.1.
AAFI02000009 Genomic DNA. Translation: EAL71036.1.
RefSeqiXP_644362.1. XM_639270.1.
XP_645052.1. XM_639960.1.

Genome annotation databases

EnsemblProtistsiEAL70437; EAL70437; DDB_G0274007.
EAL71036; EAL71036; DDB_G0272797.
GeneIDi8618728.
8619248.
KEGGiddi:DDB_G0272797.
ddi:DDB_G0274007.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000011 Genomic DNA. Translation: EAL70437.1.
AAFI02000009 Genomic DNA. Translation: EAL71036.1.
RefSeqiXP_644362.1. XM_639270.1.
XP_645052.1. XM_639960.1.

3D structure databases

ProteinModelPortaliQ556J6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi44689.DDB0267010.

Proteomic databases

PaxDbiQ556J6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsiEAL70437; EAL70437; DDB_G0274007.
EAL71036; EAL71036; DDB_G0272797.
GeneIDi8618728.
8619248.
KEGGiddi:DDB_G0272797.
ddi:DDB_G0274007.

Organism-specific databases

dictyBaseiDDB_G0272797.
DDB_G0274007.

Phylogenomic databases

eggNOGiKOG0594. Eukaryota.
ENOG410XPP3. LUCA.
InParanoidiQ556J6.
OMAiINNIGSE.
PhylomeDBiQ556J6.

Miscellaneous databases

PROiQ556J6.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 2 hits.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiY4007_DICDI
AccessioniPrimary (citable) accession number: Q556J6
Secondary accession number(s): Q86AM9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 5, 2009
Last sequence update: May 2, 2006
Last modified: November 2, 2016
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Caution

The gene for this protein is duplicated in strains AX3 and AX4. These strains contain a duplication of a segment of 750 kb of chromosome 2 compared to the corresponding sequence in strain AX2.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.