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Q556J6

- Y4007_DICDI

UniProt

Q556J6 - Y4007_DICDI

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Protein

Putative cyclin-dependent serine/threonine-protein kinase DDB_G0272797/DDB_G0274007

Gene

DDB_G0272797

more
Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei33 – 331ATPPROSITE-ProRule annotation
Active sitei125 – 1251Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi10 – 189ATPPROSITE-ProRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. cyclin-dependent protein serine/threonine kinase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Putative cyclin-dependent serine/threonine-protein kinase DDB_G0272797/DDB_G0274007 (EC:2.7.11.22)
Gene namesi
ORF Names:DDB_G0272797
AND
ORF Names:DDB_G0274007
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
ProteomesiUP000002195: Chromosome 2, UP000002195: Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0272797.
DDB_G0274007.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 680680Putative cyclin-dependent serine/threonine-protein kinase DDB_G0272797/DDB_G0274007PRO_0000372696Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi44689.DDB_0230050.

Structurei

3D structure databases

ProteinModelPortaliQ556J6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini4 – 381378Protein kinasePROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi257 – 28630Poly-AsnAdd
BLAST
Compositional biasi410 – 4156Poly-Gln
Compositional biasi419 – 43315Poly-GlnAdd
BLAST
Compositional biasi441 – 45111Poly-GlnAdd
BLAST
Compositional biasi479 – 4824Poly-Gln
Compositional biasi499 – 53941Poly-GlnAdd
BLAST
Compositional biasi559 – 60446Poly-GlnAdd
BLAST
Compositional biasi611 – 64030His-richAdd
BLAST
Compositional biasi649 – 66214Poly-ThrAdd
BLAST

Sequence similaritiesi

Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0515.
InParanoidiQ556J6.
OMAiRYIASTR.
PhylomeDBiQ556J6.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 2 hits.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q556J6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEDYIILSKC GQGTYGSVFK GIHKITHSLV ALKRVTDIAQ EDGEPVEVKY
60 70 80 90 100
LNQLKNLSNI VNLRDHFYID KNSVLVLIME FIEGDLWKIM SNPQCTLSLG
110 120 130 140 150
QIKNFTKQLL EGVKQCHVNG IMHRDIKPAN LLITTNGVLK LTDFGLSTSY
160 170 180 190 200
SKRSEKFLSS NVVSLYYRPP ELLLGSCIYG PEIDMWSVGC ILMEMINNSY
210 220 230 240 250
LFAGADETAQ LDLIFKLFGC PTEKSWPGVS SLPGYNDLFN KQQQQQQNEN
260 270 280 290 300
NYSKQHNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNKYNN ISTSCLQSPS
310 320 330 340 350
SSPPIGGYAS SLSSDFNSNE YNGYNQTFSN EDCLAISQKK LIDKFPHLVL
360 370 380 390 400
LPSVLDLASK MLTLDPKKRI NSLEALEHPW FKSSNDMDQI VPFSKDFTDL
410 420 430 440 450
ANRYIASTRQ LQQQQHHHQQ QQQQQQQQQQ QQQPHQQQLI QRQHQEQQQQ
460 470 480 490 500
QLIQRQQEQS KQQLIQHHQQ SVNQQQLAQQ QQLAQHQQYN SQQHQQHHQQ
510 520 530 540 550
QHQQHQQHQQ QQQQQQQQQQ QQQQQQQQQQ QQQQQQQQQY HQHQQQYHQY
560 570 580 590 600
QQQYHQPSQQ QQQQQQQQQQ QQQQQQQQQQ QQQQQQQQQQ QQQQQQQQQQ
610 620 630 640 650
HQYQPPQQYN HQPPQHQHQH QHQHQHQHQH QHQPQPQHQH QPQPQPQPTP
660 670 680
TPTPTSTPTT TTIPPTITTT IQPTISKSNG
Length:680
Mass (Da):79,758
Last modified:May 2, 2006 - v1
Checksum:i6DB9FE3034BAC068
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000011 Genomic DNA. Translation: EAL70437.1.
AAFI02000009 Genomic DNA. Translation: EAL71036.1.
RefSeqiXP_644362.1. XM_639270.1.
XP_645052.1. XM_639960.1.

Genome annotation databases

EnsemblProtistsiDDB0230050; DDB0230050; DDB_G0272797.
DDB0267010; DDB0267010; DDB_G0274007.
GeneIDi8618728.
8619248.
KEGGiddi:DDB_G0272797.
ddi:DDB_G0274007.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000011 Genomic DNA. Translation: EAL70437.1 .
AAFI02000009 Genomic DNA. Translation: EAL71036.1 .
RefSeqi XP_644362.1. XM_639270.1.
XP_645052.1. XM_639960.1.

3D structure databases

ProteinModelPortali Q556J6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 44689.DDB_0230050.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblProtistsi DDB0230050 ; DDB0230050 ; DDB_G0272797 .
DDB0267010 ; DDB0267010 ; DDB_G0274007 .
GeneIDi 8618728.
8619248.
KEGGi ddi:DDB_G0272797.
ddi:DDB_G0274007.

Organism-specific databases

dictyBasei DDB_G0272797.
DDB_G0274007.

Phylogenomic databases

eggNOGi COG0515.
InParanoidi Q556J6.
OMAi RYIASTR.
PhylomeDBi Q556J6.

Miscellaneous databases

PROi Q556J6.

Family and domain databases

InterProi IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view ]
Pfami PF00069. Pkinase. 1 hit.
[Graphical view ]
SMARTi SM00220. S_TKc. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 2 hits.
PROSITEi PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AX4.
  2. "The genome of the social amoeba Dictyostelium discoideum."
    Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N.
    , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
    Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AX4.

Entry informationi

Entry nameiY4007_DICDI
AccessioniPrimary (citable) accession number: Q556J6
Secondary accession number(s): Q86AM9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 5, 2009
Last sequence update: May 2, 2006
Last modified: November 26, 2014
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Caution

The gene for this protein is duplicated in strains AX3 and AX4. These strains contain a duplication of a segment of 750 kb of chromosome 2 compared to the corresponding sequence in strain AX2.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3