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Q556J6

- Y4007_DICDI

UniProt

Q556J6 - Y4007_DICDI

Protein

Putative cyclin-dependent serine/threonine-protein kinase DDB_G0272797/DDB_G0274007

Gene

DDB_G0272797

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Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 57 (01 Oct 2014)
      Sequence version 1 (02 May 2006)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + a protein = ADP + a phosphoprotein.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei33 – 331ATPPROSITE-ProRule annotation
    Active sitei125 – 1251Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi10 – 189ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. cyclin-dependent protein serine/threonine kinase activity Source: UniProtKB-EC

    Keywords - Molecular functioni

    Kinase, Serine/threonine-protein kinase, Transferase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    ReactomeiREACT_223567. RNA Polymerase II Pre-transcription Events.
    REACT_224777. RNA Polymerase II Transcription Elongation.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Putative cyclin-dependent serine/threonine-protein kinase DDB_G0272797/DDB_G0274007 (EC:2.7.11.22)
    Gene namesi
    ORF Names:DDB_G0272797
    AND
    ORF Names:DDB_G0274007
    OrganismiDictyostelium discoideum (Slime mold)
    Taxonomic identifieri44689 [NCBI]
    Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
    ProteomesiUP000002195: Chromosome 2, UP000002195: Unassembled WGS sequence

    Organism-specific databases

    dictyBaseiDDB_G0272797.
    DDB_G0274007.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 680680Putative cyclin-dependent serine/threonine-protein kinase DDB_G0272797/DDB_G0274007PRO_0000372696Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi44689.DDB_0230050.

    Structurei

    3D structure databases

    ProteinModelPortaliQ556J6.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini4 – 381378Protein kinasePROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi257 – 28630Poly-AsnAdd
    BLAST
    Compositional biasi410 – 4156Poly-Gln
    Compositional biasi419 – 43315Poly-GlnAdd
    BLAST
    Compositional biasi441 – 45111Poly-GlnAdd
    BLAST
    Compositional biasi479 – 4824Poly-Gln
    Compositional biasi499 – 53941Poly-GlnAdd
    BLAST
    Compositional biasi559 – 60446Poly-GlnAdd
    BLAST
    Compositional biasi611 – 64030His-richAdd
    BLAST
    Compositional biasi649 – 66214Poly-ThrAdd
    BLAST

    Sequence similaritiesi

    Contains 1 protein kinase domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0515.
    OMAiRYIASTR.
    PhylomeDBiQ556J6.

    Family and domain databases

    InterProiIPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view]
    PfamiPF00069. Pkinase. 1 hit.
    [Graphical view]
    SMARTiSM00220. S_TKc. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 2 hits.
    PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q556J6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEDYIILSKC GQGTYGSVFK GIHKITHSLV ALKRVTDIAQ EDGEPVEVKY    50
    LNQLKNLSNI VNLRDHFYID KNSVLVLIME FIEGDLWKIM SNPQCTLSLG 100
    QIKNFTKQLL EGVKQCHVNG IMHRDIKPAN LLITTNGVLK LTDFGLSTSY 150
    SKRSEKFLSS NVVSLYYRPP ELLLGSCIYG PEIDMWSVGC ILMEMINNSY 200
    LFAGADETAQ LDLIFKLFGC PTEKSWPGVS SLPGYNDLFN KQQQQQQNEN 250
    NYSKQHNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNKYNN ISTSCLQSPS 300
    SSPPIGGYAS SLSSDFNSNE YNGYNQTFSN EDCLAISQKK LIDKFPHLVL 350
    LPSVLDLASK MLTLDPKKRI NSLEALEHPW FKSSNDMDQI VPFSKDFTDL 400
    ANRYIASTRQ LQQQQHHHQQ QQQQQQQQQQ QQQPHQQQLI QRQHQEQQQQ 450
    QLIQRQQEQS KQQLIQHHQQ SVNQQQLAQQ QQLAQHQQYN SQQHQQHHQQ 500
    QHQQHQQHQQ QQQQQQQQQQ QQQQQQQQQQ QQQQQQQQQY HQHQQQYHQY 550
    QQQYHQPSQQ QQQQQQQQQQ QQQQQQQQQQ QQQQQQQQQQ QQQQQQQQQQ 600
    HQYQPPQQYN HQPPQHQHQH QHQHQHQHQH QHQPQPQHQH QPQPQPQPTP 650
    TPTPTSTPTT TTIPPTITTT IQPTISKSNG 680
    Length:680
    Mass (Da):79,758
    Last modified:May 2, 2006 - v1
    Checksum:i6DB9FE3034BAC068
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AAFI02000011 Genomic DNA. Translation: EAL70437.1.
    AAFI02000009 Genomic DNA. Translation: EAL71036.1.
    RefSeqiXP_644362.1. XM_639270.1.
    XP_645052.1. XM_639960.1.

    Genome annotation databases

    EnsemblProtistsiDDB0230050; DDB0230050; DDB_G0272797.
    DDB0267010; DDB0267010; DDB_G0274007.
    GeneIDi8618728.
    8619248.
    KEGGiddi:DDB_G0272797.
    ddi:DDB_G0274007.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AAFI02000011 Genomic DNA. Translation: EAL70437.1 .
    AAFI02000009 Genomic DNA. Translation: EAL71036.1 .
    RefSeqi XP_644362.1. XM_639270.1.
    XP_645052.1. XM_639960.1.

    3D structure databases

    ProteinModelPortali Q556J6.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 44689.DDB_0230050.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblProtistsi DDB0230050 ; DDB0230050 ; DDB_G0272797 .
    DDB0267010 ; DDB0267010 ; DDB_G0274007 .
    GeneIDi 8618728.
    8619248.
    KEGGi ddi:DDB_G0272797.
    ddi:DDB_G0274007.

    Organism-specific databases

    dictyBasei DDB_G0272797.
    DDB_G0274007.

    Phylogenomic databases

    eggNOGi COG0515.
    OMAi RYIASTR.
    PhylomeDBi Q556J6.

    Enzyme and pathway databases

    Reactomei REACT_223567. RNA Polymerase II Pre-transcription Events.
    REACT_224777. RNA Polymerase II Transcription Elongation.

    Miscellaneous databases

    PROi Q556J6.

    Family and domain databases

    InterProi IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view ]
    Pfami PF00069. Pkinase. 1 hit.
    [Graphical view ]
    SMARTi SM00220. S_TKc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 2 hits.
    PROSITEi PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: AX4.
    2. "The genome of the social amoeba Dictyostelium discoideum."
      Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N.
      , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
      Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: AX4.

    Entry informationi

    Entry nameiY4007_DICDI
    AccessioniPrimary (citable) accession number: Q556J6
    Secondary accession number(s): Q86AM9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 5, 2009
    Last sequence update: May 2, 2006
    Last modified: October 1, 2014
    This is version 57 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Caution

    The gene for this protein is duplicated in strains AX3 and AX4. These strains contain a duplication of a segment of 750 kb of chromosome 2 compared to the corresponding sequence in strain AX2.Curated

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Dictyostelium discoideum
      Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3