Q556I2 (AEDO_DICDI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable 2-aminoethanethiol dioxygenase
EC=1.13.11.19

Alternative name(s):
Cysteamine dioxygenase

Gene names

Name:	ado-1
ORF Names:	DDB_G0273031
AND
Name:	ado-2
ORF Names:	DDB_G0274043

Organism

Dictyostelium discoideum (Slime mold)

Taxonomic identifier

44689 [NCBI]

Taxonomic lineage

Eukaryota › Amoebozoa › Mycetozoa › Dictyosteliida › Dictyostelium

Protein attributes

Sequence length	218 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	2-aminoethanethiol + O2 = hypotaurine.
Cofactor	Iron By similarity.
Caution	The gene for this protein is duplicated in strains AX3 and AX4. These strains contain a duplication of a segment of 750 kb of chromosome 2 compared to the corresponding sequence in strain AX2.
Sequence caution	The sequence EAL70455.1 differs from that shown. Reason: Erroneous gene model prediction. The sequence EAL71153.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
Ligand	Iron Metal-binding
Molecular function	Dioxygenase Oxidoreductase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Molecular function	cysteamine dioxygenase activity Inferred from electronic annotation. Source: EC metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 218	218	Probable 2-aminoethanethiol dioxygenase		PRO_0000353848

Sequences

	Sequence		Length	Mass (Da)
	Q556I2 [UniParc]. Last modified September 21, 2011. Version 2. Checksum: 934BCB0A614BA865	FASTA	218	24,708
	10 20 30 40 50 60 MTILKQLITK ANLILPSVDK KVATLDSLVS VFKEIKCKDL KIDKPLTLTK PIGNGKKVFY 70 80 90 100 110 120 YPLVENEKFT LAIFAFPPNT CIPTHDHPQM TVLSKVLYGS ISCDSFDWID NTSNVKKQGK 130 140 150 160 170 180 AIYTGTNILN SNDEKVKITL PNENNIHRFQ SGDEHCAVLD LLYPPYDSNF YRSCTYYRPT 190 200 210 SVNGSIVDLM PYYPDFDCEG DSSNKELNDL HIELSKLK

References

[1]

"Sequence and analysis of chromosome 2 of Dictyostelium discoideum." Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T., Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R., Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A., Noegel A.A. Nature 418:79-85(2002) [PubMed: 12097910] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AX4.

[2]

"The genome of the social amoeba Dictyostelium discoideum." Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N. , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A. Nature 435:43-57(2005) [PubMed: 15875012] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AX4.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AAFI02000011 Genomic DNA. Translation: EAL70455.1. Sequence problems. AAFI02000009 Genomic DNA. Translation: EAL71153.1. Sequence problems.
RefSeq	XP_644380.1. XM_639288.1. XP_645033.1. XM_639941.1.
3D structure databases
ModBase	Search...
Proteomic databases
PRIDE	Q556I2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblProtists	DDB0217097; DDB0217097; DDB_G0273031. DDB0217434; DDB0217434; DDB_G0274043.
GeneID	8618710. 8619266.
GenomeReviews	Gene locus ado-2 in contig CM000151_GR.
KEGG	ddi:DDB_G0273031. ddi:DDB_G0274043.
Organism-specific databases
dictyBase	DDB_G0273031. DDB_G0274043.
Phylogenomic databases
eggNOG	KOG4281.
GeneTree	EPrGT00050000003190.
OMA	NENNIHR.
PhylomeDB	Q556I2.
ProtClustDB	CLSZ2431087.
Family and domain databases
InterPro	IPR011051. Cupin_RmlC_type. IPR012864. Cysteamine_dioxygenase. IPR014710. RmlC-like_jellyroll. [Graphical view]
Gene3D	G3DSA:2.60.120.10. RmlC-like_jellyroll. 1 hit.
Pfam	PF07847. DUF1637. 1 hit. [Graphical view]
SUPFAM	SSF51182. RmlC_like_cupin. 1 hit.
ProtoNet	Search...

Entry information

Entry name

AEDO_DICDI

Accession

Primary (citable) accession number: Q556I2
Secondary accession number(s): Q86K19

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 25, 2008
Last sequence update:	September 21, 2011
Last modified:	January 25, 2012
This is version 31 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)