Reviewed, UniProtKB/Swiss-Prot Q556I2 (AEDO_DICDI)

Names and origin

Protein names

Recommended name:
    Probable 2-aminoethanethiol dioxygenase
    EC=1.13.11.19
Alternative name(s):
    Cysteamine dioxygenase

Gene names

Name:	ado-1
ORF Names:	DDB_G0273031
AND
Name:	ado-2
ORF Names:	DDB_G0274043

Organism

Dictyostelium discoideum (Slime mold) [Complete proteome]

Taxonomic identifier

44689 [NCBI]

Taxonomic lineage

Eukaryota › Amoebozoa › Mycetozoa › Dictyosteliida › Dictyostelium

Protein attributes

Sequence length	231 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	2-aminoethanethiol + O2 = hypotaurine.
Cofactor	Iron By similarity.
Caution	The gene for this protein is duplicated in strains AX3 and AX4. These strains contain a duplication of a segment of 750 kb of chromosome 2 compared to the corresponding sequence in strain AX2.

Ontologies

Keywords
Ligand	Iron Metal-binding
Molecular function	Dioxygenase Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	cysteamine dioxygenase activity Inferred from electronic annotation. Source: EC iron ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 231	231	Probable 2-aminoethanethiol dioxygenase		PRO_0000353848
Regions
	Compositional bias	201 – 204	4	Poly-Ile
	Compositional bias	206 – 229	24	Asn-rich

Sequences

	Sequence		Length	Mass (Da)
	Q556I2-1 [UniParc]. Last modified May 2, 2006. Version 1. Checksum: C8B566974F8329C4	FASTA	231	26,309
	10 20 30 40 50 60 MTILKQLITK ANLILPSVDK KVATLDSLVS VFKEIKCKDL KIDKPLTLTK PIGNGKKVFY 70 80 90 100 110 120 YPLVENEKFT LAIFAFPPNT CIPTHDHPQM TVLSKVLYGS ISCDSFDWID NTSNVKKQGK 130 140 150 160 170 180 AIYTGTNILN SNDEKVKITL PNENNIHRFQ SGDEHCAVLD LLYPPYDSNF YRSCTYYRPT 190 200 210 220 230 SVNGSIVDLM PYYPDFDCEE IIIIPNYNNN NNNNNNNNNN NNNNNNNNNK K

References

[1]

"Sequence and analysis of chromosome 2 of Dictyostelium discoideum." Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T., Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R., Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A., Noegel A.A. Nature 418:79-85(2002) [PubMed: 12097910] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AX4.

[2]

"The genome of the social amoeba Dictyostelium discoideum." Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N. , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A. Nature 435:43-57(2005) [PubMed: 15875012] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AX4.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AC116984 Genomic DNA. Translation: AAO51306.1. AAFI02000011 Genomic DNA. Translation: EAL70455.1. AAFI02000009 Genomic DNA. Translation: EAL71153.1.
RefSeq	XP_644380.1. XP_645033.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3395517. 3396198.
GenomeReviews	Gene locus ado-2 in contig CM000151_GR.
KEGG	ddi:DDBDRAFT_0217097. ddi:DDBDRAFT_0217434.
Organism-specific databases
dictyBase	DDB_G0273031. ado-1. DDB_G0274043. ado-2.
Family and domain databases
InterPro	IPR012864. DUF1637. [Graphical view]
PANTHER	PTHR22966. DUF1637. 1 hit.
Pfam	PF07847. DUF1637. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AEDO_DICDI

Accession

Primary (citable) accession number: Q556I2
Secondary accession number(s): Q86K19

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 25, 2008
Last sequence update:	May 2, 2006
Last modified:	September 22, 2009
This is version 16 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)