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Protein

Putative glutathione S-transferase alpha-2

Gene

gsta2-1

more
Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.By similarity

Caution

The gene for this protein is duplicated in strains AX3 and AX4. These strains contain a duplication of a segment of 750 kb of chromosome 2 compared to the corresponding sequence in strain AX2.Curated

Catalytic activityi

RX + glutathione = HX + R-S-glutathione.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei11GlutathioneBy similarity1
Binding sitei45GlutathioneBy similarity1

GO - Molecular functioni

GO - Biological processi

  • response to curcumin Source: dictyBase

Keywordsi

Molecular functionTransferase

Names & Taxonomyi

Protein namesi
Recommended name:
Putative glutathione S-transferase alpha-2 (EC:2.5.1.18)
Alternative name(s):
GST class-alpha 2
Gene namesi
Name:gsta2-1
ORF Names:DDB_G0272632
AND
Name:gsta2-2
ORF Names:DDB_G0274081
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyostelidsDictyostelialesDictyosteliaceaeDictyostelium
Proteomesi
  • UP000002195 Componentsi: Chromosome 2, Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0272632
DDB_G0274081

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00003507392 – 198Putative glutathione S-transferase alpha-2Add BLAST197

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserine1 Publication1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ556G3
PRIDEiQ556G3

Interactioni

Protein-protein interaction databases

STRINGi44689.DDB0238181

Structurei

3D structure databases

ProteinModelPortaliQ556G3
SMRiQ556G3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini5 – 81GST N-terminalAdd BLAST77
Domaini83 – 198GST C-terminalAdd BLAST116

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni52 – 53Glutathione bindingBy similarity2
Regioni65 – 66Glutathione bindingBy similarity2

Sequence similaritiesi

Belongs to the GST superfamily. Alpha family.Curated

Phylogenomic databases

eggNOGiKOG1695 Eukaryota
ENOG4111VAU LUCA
InParanoidiQ556G3
KOiK04097
OMAiHGEDFLV
PhylomeDBiQ556G3

Family and domain databases

InterProiView protein in InterPro
IPR010987 Glutathione-S-Trfase_C-like
IPR036282 Glutathione-S-Trfase_C_sf
IPR004045 Glutathione_S-Trfase_N
IPR004046 GST_C
IPR036249 Thioredoxin-like_sf
PfamiView protein in Pfam
PF14497 GST_C_3, 1 hit
PF02798 GST_N, 1 hit
SUPFAMiSSF47616 SSF47616, 1 hit
SSF52833 SSF52833, 1 hit
PROSITEiView protein in PROSITE
PS50405 GST_CTER, 1 hit
PS50404 GST_NTER, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q556G3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTSSVPSLT YFQGRGLGQF SRVLLSYLGI PYENITVTEI SDALRATLPY
60 70 80 90 100
GQLPIYRDGD FVLTQSSTIA RYIAKKHNFM GKNLEEEFLV DQIVTAIHAD
110 120 130 140 150
IFPAFNNPVP EKLQKLYEKY FGSFEKKLQE TGFLVGSSVT LADLYVYVGF
160 170 180 190
DYIRFRGEAA LSSELSDEKY PKIAELKKFF ESNEGVAKYI KERPETKF
Length:198
Mass (Da):22,538
Last modified:May 2, 2006 - v1
Checksum:i36104DBFD83CA2D1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000011 Genomic DNA Translation: EAL70474.1
AAFI02000009 Genomic DNA Translation: EAL70953.1
RefSeqiXP_644399.1, XM_639307.1
XP_645014.1, XM_639922.1

Genome annotation databases

EnsemblProtistsiEAL70474; EAL70474; DDB_G0274081
EAL70953; EAL70953; DDB_G0272632
GeneIDi8618691
8619285
KEGGiddi:DDB_G0272632
ddi:DDB_G0274081

Similar proteinsi

Entry informationi

Entry nameiGSTA2_DICDI
AccessioniPrimary (citable) accession number: Q556G3
Secondary accession number(s): Q86AN9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 23, 2008
Last sequence update: May 2, 2006
Last modified: May 23, 2018
This is version 83 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. SIMILARITY comments
    Index of protein domains and families

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