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Protein

Frizzled and smoothened-like protein H

Gene

fslH

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionReceptor

Names & Taxonomyi

Protein namesi
Recommended name:
Frizzled and smoothened-like protein H
Gene namesi
Name:fslH
ORF Names:DDB_G0274773
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
Proteomesi
  • UP000002195 Componentsi: Chromosome 2, Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0274773. fslH.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini22 – 246ExtracellularSequence analysisAdd BLAST225
Transmembranei247 – 267Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini268 – 277CytoplasmicSequence analysis10
Transmembranei278 – 298Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini299 – 318ExtracellularSequence analysisAdd BLAST20
Transmembranei319 – 339Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini340 – 359CytoplasmicSequence analysisAdd BLAST20
Transmembranei360 – 380Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini381 – 400ExtracellularSequence analysisAdd BLAST20
Transmembranei401 – 421Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini422 – 464CytoplasmicSequence analysisAdd BLAST43
Transmembranei465 – 485Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini486 – 520ExtracellularSequence analysisAdd BLAST35
Transmembranei521 – 541Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini542 – 621CytoplasmicSequence analysisAdd BLAST80

GO - Cellular componenti

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000037137022 – 621Frizzled and smoothened-like protein HAdd BLAST600

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi32 ↔ 103By similarity
Disulfide bondi46 ↔ 96By similarity
Glycosylationi60N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi107N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi163N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi176N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi206N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ556C6.

Expressioni

Inductioni

Up-regulated by P.aeruginosa, PAO1 strain and down-regulated by P.aeruginosa, PA14 strain infection.1 Publication

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini27 – 166FZAdd BLAST140

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi431 – 456Poly-SerAdd BLAST26
Compositional biasi617 – 620Poly-Asp4

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

InParanoidiQ556C6.
OMAiCEKYIGD.
PhylomeDBiQ556C6.

Family and domain databases

Gene3Di1.10.2000.10. 1 hit.
InterProiView protein in InterPro
IPR036790. Frizzled_dom_sf.
IPR017981. GPCR_2-like.
PROSITEiView protein in PROSITE
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q556C6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNLKFYNLIF FISFLICCIH GQRYLPVEGG KCEKYIGDGD SGKRICNGYL
60 70 80 90 100
ANPDSVYVHN KTQQETLKDL RSLINLLELN NPSKECINPS NYKIMCAMMF
110 120 130 140 150
PECIEINGTN IVKPITLPIY TCNSFCKEAL VTCSVPNTIA SCDGGTNLPI
160 170 180 190 200
QLPYTPIEWV KYNLTIYGGV DDYRVNCTDP TLISDSGSSS EIEVGCVEPL
210 220 230 240 250
IKRPTNDTKG DLEKGYFYVN SQCVINCPVT GMHPKSVWNQ IFKINDVLSS
260 270 280 290 300
ISLACTLILL FTFGILNPKL NRFDKKNLFF IAGVFGMSVS GVLIAANGSE
310 320 330 340 350
KTVCPTPERY AVNTDRVCVA SGFLVHFSAL FAILWWTIGL ADVYYGIKFV
360 370 380 390 400
GKKIKIKVRY YLLATLTISL AFTLVPLGTG QYQAGLSNVM CFLKDEIYQS
410 420 430 440 450
MTFFVPLGIC LTMGTILMIL VMREIYVIVK SNSTSSSFSS SSSKSKSKSK
460 470 480 490 500
SSDSISYLKL QVKPMLNIIL FYFTFLYLFL FVRVINSRYQ EYEDSAIPYM
510 520 530 540 550
LCLAKGGGDS CRLKGPSAGS LGYFAYCLRI YGIYLFIISF LSSRTIKIWK
560 570 580 590 600
ESIILNNAFV TPIIKFIDSS FSNRFSSSKN TSTTQNSTLN NTESDTSKRG
610 620
NSSAVSINLE SRNYNTDDDD L
Length:621
Mass (Da):69,274
Last modified:May 24, 2005 - v1
Checksum:i32C935055D1F1EE2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000012 Genomic DNA. Translation: EAL70279.1.
RefSeqiXP_643884.1. XM_638792.1.

Genome annotation databases

EnsemblProtistsiEAL70279; EAL70279; DDB_G0274773.
GeneIDi8619310.
KEGGiddi:DDB_G0274773.

Similar proteinsi

Entry informationi

Entry nameiFSLH_DICDI
AccessioniPrimary (citable) accession number: Q556C6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 5, 2009
Last sequence update: May 24, 2005
Last modified: October 25, 2017
This is version 58 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  3. SIMILARITY comments
    Index of protein domains and families