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Q55684

- UPPP_SYNY3

UniProt

Q55684 - UPPP_SYNY3

Protein

Undecaprenyl-diphosphatase

Gene

uppP

Organism
Synechocystis sp. (strain PCC 6803 / Kazusa)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 98 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.UniRule annotation

    Catalytic activityi

    Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate.UniRule annotation

    GO - Molecular functioni

    1. undecaprenyl-diphosphatase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. dephosphorylation Source: InterPro
    2. peptidoglycan biosynthetic process Source: UniProtKB-KW
    3. regulation of cell shape Source: UniProtKB-KW
    4. response to antibiotic Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Antibiotic resistance, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Undecaprenyl-diphosphataseUniRule annotation (EC:3.6.1.27UniRule annotation)
    Alternative name(s):
    Bacitracin resistance proteinUniRule annotation
    Undecaprenyl pyrophosphate phosphataseUniRule annotation
    Gene namesi
    Name:uppPUniRule annotation
    Synonyms:bacA, upk
    Ordered Locus Names:sll0210
    OrganismiSynechocystis sp. (strain PCC 6803 / Kazusa)
    Taxonomic identifieri1111708 [NCBI]
    Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechocystis
    ProteomesiUP000001425: Chromosome

    Subcellular locationi

    Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell inner membrane, Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 326326Undecaprenyl-diphosphatasePRO_0000151226Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    IntActiQ55684. 2 interactions.
    STRINGi1148.sll0210.

    Structurei

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei11 – 3121HelicalUniRule annotationAdd
    BLAST
    Transmembranei42 – 6221HelicalUniRule annotationAdd
    BLAST
    Transmembranei90 – 11021HelicalUniRule annotationAdd
    BLAST
    Transmembranei138 – 15821HelicalUniRule annotationAdd
    BLAST
    Transmembranei165 – 18521HelicalUniRule annotationAdd
    BLAST
    Transmembranei212 – 23221HelicalUniRule annotationAdd
    BLAST
    Transmembranei242 – 26221HelicalUniRule annotationAdd
    BLAST
    Transmembranei272 – 29221HelicalUniRule annotationAdd
    BLAST
    Transmembranei304 – 32421HelicalUniRule annotationAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the UppP family.UniRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1968.
    KOiK06153.
    OMAiFNDAHAK.
    OrthoDBiEOG6QP13M.
    PhylomeDBiQ55684.

    Family and domain databases

    HAMAPiMF_01006. Undec_diphosphatase.
    InterProiIPR003824. UppP.
    [Graphical view]
    PfamiPF02673. BacA. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00753. undec_PP_bacA. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q55684-1 [UniParc]FASTAAdd to Basket

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    MSPRQLNFLS AFSLSVAIAV VYHQAWGIAV AQPILPSEAV ETGVISNGIS    50
    INLFQAFVLG FIQGATEFLP ISSTAHLKAV PMALGWGDPG VAFTAVIQLG 100
    SIGAVFWYFW EDLTGIAKGI IKAVQTRQYD SLEFKLGLGI GLGTIPIVFF 150
    GLLMKLLVQD LDNSFFRSLS TIAIASIVMA LLLALAEKLG THRRPFEKLR 200
    WQDGLIMGTA QALALIPGVS RSGSTLTAGL FINLERAAAA RFSFLLGIPA 250
    ITIAGLVELK GLLDKNLSND AILPLIVGTI SSAVFSYLAI AWLIKFLQKR 300
    STWIFVWYRL IFGVVILTAL GMGFGT 326
    Length:326
    Mass (Da):35,077
    Last modified:November 1, 1996 - v1
    Checksum:iD11C934FB8F23FFA
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000022 Genomic DNA. Translation: BAA10212.1.
    PIRiS76360.
    RefSeqiNP_442142.1. NC_000911.1.
    YP_005652200.1. NC_017277.1.
    YP_007452019.1. NC_020286.1.

    Genome annotation databases

    EnsemblBacteriaiBAA10212; BAA10212; BAA10212.
    GeneIDi952643.
    KEGGisyn:sll0210.
    syy:SYNGTS_2247.
    syz:MYO_122730.
    PATRICi23841896. VBISynSp132158_2490.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000022 Genomic DNA. Translation: BAA10212.1 .
    PIRi S76360.
    RefSeqi NP_442142.1. NC_000911.1.
    YP_005652200.1. NC_017277.1.
    YP_007452019.1. NC_020286.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q55684. 2 interactions.
    STRINGi 1148.sll0210.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAA10212 ; BAA10212 ; BAA10212 .
    GeneIDi 952643.
    KEGGi syn:sll0210.
    syy:SYNGTS_2247.
    syz:MYO_122730.
    PATRICi 23841896. VBISynSp132158_2490.

    Phylogenomic databases

    eggNOGi COG1968.
    KOi K06153.
    OMAi FNDAHAK.
    OrthoDBi EOG6QP13M.
    PhylomeDBi Q55684.

    Family and domain databases

    HAMAPi MF_01006. Undec_diphosphatase.
    InterProi IPR003824. UppP.
    [Graphical view ]
    Pfami PF02673. BacA. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00753. undec_PP_bacA. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. I. Sequence features in the 1 Mb region from map positions 64% to 92% of the genome."
      Kaneko T., Tanaka A., Sato S., Kotani H., Sazuka T., Miyajima N., Sugiura M., Tabata S.
      DNA Res. 2:153-166(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 27184 / PCC 6803 / N-1.
    2. "Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions."
      Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y., Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T., Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S.
      , Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.
      DNA Res. 3:109-136(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: PCC 6803 / Kazusa.

    Entry informationi

    Entry nameiUPPP_SYNY3
    AccessioniPrimary (citable) accession number: Q55684
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 5, 2002
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 98 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Synechocystis PCC 6803
      Synechocystis (strain PCC 6803): entries and gene names

    External Data

    Dasty 3