Reviewed, UniProtKB/Swiss-Prot Q55684 (UPPP_SYNY3)

Names and origin

Protein names

Recommended name:
    Undecaprenyl-diphosphatase
    EC=3.6.1.27
Alternative name(s):
    Undecaprenyl pyrophosphate phosphatase
    Bacitracin resistance protein

Gene names

Name:	uppP
Synonyms:	bacA, upk
Ordered Locus Names:	sll0210

Organism

Synechocystis sp. (strain PCC 6803) [Complete proteome] [HAMAP]

Taxonomic identifier

1148 [NCBI]

Taxonomic lineage

Bacteria › Cyanobacteria › Chroococcales › Synechocystis

Protein attributes

Sequence length	326 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity.
Catalytic activity	Undecaprenyl diphosphate + H2O = undecaprenyl phosphate + phosphate. HAMAP MF_01006
Subcellular location	Cell inner membrane; Multi-pass membrane protein By similarity.
Miscellaneous	Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available. HAMAP MF_01006
Sequence similarities	Belongs to the uppP family.

Ontologies

Keywords
Biological process	Antibiotic resistance Cell shape Cell wall biogenesis/degradation Peptidoglycan synthesis
Cellular component	Cell inner membrane Cell membrane Membrane
Domain	Transmembrane
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	cell wall organization Inferred from electronic annotation. Source: UniProtKB-KW dephosphorylation Inferred from electronic annotation. Source: InterPro peptidoglycan biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW regulation of cell shape Inferred from electronic annotation. Source: UniProtKB-KW response to antibiotic Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell plasma membrane Inferred from electronic annotation. Source: HAMAP
Molecular function	undecaprenyl-diphosphatase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 326	326	Undecaprenyl-diphosphatase HAMAP MF_01006		PRO_0000151226
Regions
	Transmembrane	11 – 31	21	Potential
	Transmembrane	42 – 62	21	Potential
	Transmembrane	90 – 110	21	Potential
	Transmembrane	138 – 158	21	Potential
	Transmembrane	165 – 185	21	Potential
	Transmembrane	212 – 232	21	Potential
	Transmembrane	242 – 262	21	Potential
	Transmembrane	272 – 292	21	Potential
	Transmembrane	304 – 324	21	Potential

Sequences

	Sequence		Length	Mass (Da)
	Q55684-1 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: D11C934FB8F23FFA	FASTA	326	35,077
	10 20 30 40 50 60 MSPRQLNFLS AFSLSVAIAV VYHQAWGIAV AQPILPSEAV ETGVISNGIS INLFQAFVLG 70 80 90 100 110 120 FIQGATEFLP ISSTAHLKAV PMALGWGDPG VAFTAVIQLG SIGAVFWYFW EDLTGIAKGI 130 140 150 160 170 180 IKAVQTRQYD SLEFKLGLGI GLGTIPIVFF GLLMKLLVQD LDNSFFRSLS TIAIASIVMA 190 200 210 220 230 240 LLLALAEKLG THRRPFEKLR WQDGLIMGTA QALALIPGVS RSGSTLTAGL FINLERAAAA 250 260 270 280 290 300 RFSFLLGIPA ITIAGLVELK GLLDKNLSND AILPLIVGTI SSAVFSYLAI AWLIKFLQKR 310 320 STWIFVWYRL IFGVVILTAL GMGFGT

References

[1]

"Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. I. Sequence features in the 1 Mb region from map positions 64% to 92% of the genome." Kaneko T., Tanaka A., Sato S., Kotani H., Sazuka T., Miyajima N., Sugiura M., Tabata S. DNA Res. 2:153-166(1995) [PubMed: 8590279] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

[2]

"Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions." Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y., Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T., Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S. , Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S. DNA Res. 3:109-136(1996) [PubMed: 8905231] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	BA000022 Genomic DNA. Translation: BAA10212.1.
PIR	S76360.
RefSeq	NP_442142.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
IntAct	Q55684. 2 interactions.
STRING	Q55684.
Genome annotation databases
GeneID	952643.
GenomeReviews	Gene locus sll0210 in contig BA000022_GR.
KEGG	syn:sll0210.
NMPDR	fig|1148.1.peg.2243.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q55684.
OMA	YEASSIR
Enzyme and pathway databases
BioCyc	SSP1148:SLL0210-MON.
Family and domain databases
HAMAP	MF_01006. [Tree]
InterPro	IPR003824. Bacitracin-R_BacA. [Graphical view]
Pfam	PF02673. BacA. 1 hit. [Graphical view]
TIGRFAMs	TIGR00753. undec_PP_bacA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

UPPP_SYNY3

Accession

Primary (citable) accession number: Q55684

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 5, 2002
Last sequence update:	November 1, 1996
Last modified:	November 24, 2009
This is version 59 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)