Q55673 (MURA_SYNY3) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
UDP-N-acetylglucosamine 1-carboxyvinyltransferase
EC=2.5.1.7

Alternative name(s):
Enoylpyruvate transferase
UDP-N-acetylglucosamine enolpyruvyl transferase
Short name=EPT

Gene names

Name:	murA
Synonyms:	murZ
Ordered Locus Names:	slr0017

Organism

Synechocystis sp. (strain PCC 6803 / Kazusa) [Reference proteome] [HAMAP]

Taxonomic identifier

1111708 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Cyanobacteria › Oscillatoriophycideae › Chroococcales › Synechocystis › Synechocystis sp. PCC 6803

Protein attributes

Sequence length	438 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine By similarity. HAMAP-Rule MF_00111
Catalytic activity	Phosphoenolpyruvate + UDP-N-acetyl-alpha-D-glucosamine = phosphate + UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine. HAMAP-Rule MF_00111
Pathway	Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP-Rule MF_00111
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the EPSP synthase family. MurA subfamily.

Ontologies

Keywords
Biological process	Cell cycle Cell division Cell shape Cell wall biogenesis/degradation Peptidoglycan synthesis
Cellular component	Cytoplasm
Molecular function	Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	UDP-N-acetylgalactosamine biosynthetic process Inferred from electronic annotation. Source: InterPro cell cycle Inferred from electronic annotation. Source: UniProtKB-KW cell division Inferred from electronic annotation. Source: UniProtKB-KW peptidoglycan biosynthetic process Inferred from electronic annotation. Source: HAMAP regulation of cell shape Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	UDP-N-acetylglucosamine 1-carboxyvinyltransferase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 438	438	UDP-N-acetylglucosamine 1-carboxyvinyltransferase HAMAP-Rule MF_00111		PRO_0000178942
Sites
	Active site	129	1	Proton donor By similarity
Amino acid modifications
	Modified residue	129	1	2-(S-cysteinyl)pyruvic acid O-phosphothioketal By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q55673 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: C310AB287F2F0F55	FASTA	438	46,605
	10 20 30 40 50 60 MLQVATPTAT EETQTVIEIE GRASLKGEVR ISGAKNSALA IMAGTILCSD DCRLSNLPAL 70 80 90 100 110 120 ADIDKMCQIL AAIGVNLERD GDRLVVDSSN VGHGPAPYEL VSQLRASFFV IGPLLSRLGM 130 140 150 160 170 180 TKVPLPGGCA IGTRPVDLHV RGLQAMGADV HIEHGVVNAS IKGHSRRLTG AKIYLDYPSV 190 200 210 220 230 240 GATETILMAA TLAEGETVID NAAREPEIVD LANFCRSMGA QIRGDGSSRI IINGVEKLHS 250 260 270 280 290 300 TDFPIIPDRI EAATFLCAGA ITHSEISLFP VVPDHLASAI AKLREIGPEV AIDAPDRVRL 310 320 330 340 350 360 IPRDLRGTDI ETLPYPGFPT DMQAQFMALL AVSEGNSVVT ETVFENRLQH VAELQRMGAN 370 380 390 400 410 420 IKLKGNAAFI QGVPFLSGAP VMSTDLRASA ALVIAGLAAE GKTIVQGLRH LDRGYEDIEG 430 KLRKLGAKLT RIEQPVTL

References

[1]

"Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. I. Sequence features in the 1 Mb region from map positions 64% to 92% of the genome." Kaneko T., Tanaka A., Sato S., Kotani H., Sazuka T., Miyajima N., Sugiura M., Tabata S. DNA Res. 2:153-166(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 27184 / PCC 6803 / N-1.

[2]

"Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions." Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y., Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T., Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S. , Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S. DNA Res. 3:109-136(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: PCC 6803 / Kazusa.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BA000022 Genomic DNA. Translation: BAA10199.1.
PIR	S76347.
RefSeq	NP_442129.1. NC_000911.1. YP_005652187.1. NC_017277.1. YP_007452006.1. NC_020286.1.
3D structure databases
ProteinModelPortal	Q55673.
ModBase	Search...
Protein-protein interaction databases
STRING	1148.slr0017.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	BAA10199; BAA10199; BAA10199.
GeneID	12253404. 14617680. 952795.
KEGG	syn:slr0017. syy:SYNGTS_2234.
PATRIC	23841864. VBISynSp132158_2476.
Phylogenomic databases
eggNOG	COG0766.
HOGENOM	HOG000075602.
KO	K00790.
OMA	LSDVFMM.
ProtClustDB	PRK09369.
Enzyme and pathway databases
UniPathway	UPA00219.
Family and domain databases
Gene3D	3.65.10.10. 2 hits.
HAMAP	MF_00111. MurA.
InterPro	IPR001986. Enolpyruvate_Tfrase_dom. IPR013792. RNA3'P_cycl/enolpyr_Trfase_a/b. IPR005750. UDP_GlcNAc_COvinyl_MurA. [Graphical view]
PANTHER	PTHR21090:SF4. PTHR21090:SF4. 1 hit.
Pfam	PF00275. EPSP_synthase. 1 hit. [Graphical view]
SUPFAM	SSF55205. RNA3'_cycl/enolpyr_transf_A/B. 1 hit.
TIGRFAMs	TIGR01072. murA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

MURA_SYNY3

Accession

Primary (citable) accession number: Q55673

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1996
Last modified:	May 1, 2013
This is version 97 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program