Reviewed, UniProtKB/Swiss-Prot Q55665 (GSA_SYNY3)

Names and origin

Protein names

Recommended name:
    Glutamate-1-semialdehyde 2,1-aminomutase
      Short name=GSA
    EC=5.4.3.8
Alternative name(s):
    Glutamate-1-semialdehyde aminotransferase
      Short name=GSA-AT

Gene names

Name:	hemL
Synonyms:	gsa
Ordered Locus Names:	sll0017

Organism

Synechocystis sp. (strain PCC 6803) [Complete proteome] [HAMAP]

Taxonomic identifier

1148 [NCBI]

Taxonomic lineage

Bacteria › Cyanobacteria › Chroococcales › Synechocystis

Protein attributes

Sequence length	433 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	(S)-4-amino-5-oxopentanoate = 5-aminolevulinate. HAMAP MF_00375
Cofactor	Pyridoxal phosphate. HAMAP MF_00375
Pathway	Porphyrin metabolism; protoporphyrin-IX biosynthesis; 5-aminolevulinate from L-glutamyl-tRNA(Glu): step 2/2. HAMAP MF_00375 Porphyrin biosynthesis; chlorophyll biosynthesis. HAMAP MF_00375
Subunit structure	Homodimer. HAMAP MF_00375
Subcellular location	Cytoplasm Potential.
Sequence similarities	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.

Ontologies

Keywords
Biological process	Chlorophyll biosynthesis Porphyrin biosynthesis
Cellular component	Cytoplasm
Ligand	Pyridoxal phosphate
Molecular function	Isomerase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	chlorophyll biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	glutamate-1-semialdehyde 2,1-aminomutase activity Inferred from electronic annotation. Source: HAMAP pyridoxal phosphate binding Inferred from electronic annotation. Source: InterPro transaminase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 433	433	Glutamate-1-semialdehyde 2,1-aminomutase HAMAP MF_00375		PRO_0000120462
Amino acid modifications
	Modified residue	273	1	N6-(pyridoxal phosphate)lysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q55665-1 [UniParc]. Last modified June 1, 2001. Version 2. Checksum: 467064245487F923	FASTA	433	45,892
	10 20 30 40 50 60 MVNATPFITT KSEEIFAAAQ HLMPGGVSSP VRAFKSVGGQ PIVFDRVEGA QIWDVDGNQY 70 80 90 100 110 120 IDYVGTWGPA ICGHAHPDVI SALKQALDKG TSFGAPCAQE NVLAEMVIDA VPSIEMVRFV 130 140 150 160 170 180 NSGTEACMSV LRLMRAFTGR EKIIKFEGCY HGHADMFLVK AGSGVATLGL PDSPGVPSNT 190 200 210 220 230 240 TKATLTAPYN DLEAVKALFV ENPDSIAGVI LEPVVGNAGF ILPDAGFLEG LRELTKEYGA 250 260 270 280 290 300 LLVFDEVMTG FRVSYGGAQA RFGITPDLTT LGKVIGGGLP VGAYGGREEI MAMVAPAGPM 310 320 330 340 350 360 YQAGTLSGNP LAMTAGIKTL EILQKPGSYE YLDKITKRLV DGLLAAAQDA GHEVCGGSIS 370 380 390 400 410 420 AMFGIFFAPG PVRNYEDAKL ADTNKFARFH RGMLERGIYL APSQYEAGFP SLAHTQEQID 430 QTIAVAKEVF ATL

References

[1]

"Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. I. Sequence features in the 1 Mb region from map positions 64% to 92% of the genome." Kaneko T., Tanaka A., Sato S., Kotani H., Sazuka T., Miyajima N., Sugiura M., Tabata S. DNA Res. 2:153-166(1995) [PubMed: 8590279] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

[2]

"Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions." Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y., Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T., Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S. , Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S. DNA Res. 3:109-136(1996) [PubMed: 8905231] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	BA000022 Genomic DNA. Translation: BAA10185.1. Different initiation.
PIR	S76333.
RefSeq	NP_442115.2.
3D structure databases
SMR	Q55665. Positions 7-433.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q55665. 1 interaction.
STRING	Q55665.
Genome annotation databases
GeneID	952666.
GenomeReviews	Gene locus sll0017 in contig BA000022_GR.
KEGG	syn:sll0017.
NMPDR	fig|1148.1.peg.2216.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG725944.
OMA	VGCFGGK.
Enzyme and pathway databases
BioCyc	SSP1148:SLL0017-MON.
Family and domain databases
HAMAP	MF_00375. [Tree]
InterPro	IPR004639. 4pyrrol_synth_GluAld_NH2Trfase. IPR005814. Aminotrans_3. IPR015424. PyrdxlP-dep_Trfase_major. IPR015421. PyrdxlP-dep_Trfase_major_sub1. [Graphical view]
Gene3D	G3DSA:3.40.640.10. PyrdxlP-dep_Trfase_major_sub1. 1 hit.
PANTHER	PTHR11986. Aminotrans_3. 1 hit.
Pfam	PF00202. Aminotran_3. 1 hit. [Graphical view]
PROSITE	PS00600. AA_TRANSFER_CLASS_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GSA_SYNY3

Accession

Primary (citable) accession number: Q55665

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	June 1, 2001
Last modified:	December 15, 2009
This is version 71 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)