Reviewed,
UniProtKB/Swiss-Prot Q55665 (GSA_SYNY3)
Last modified
December 15, 2009.
Version 71.
History...
Clusters with 100%,
90%,
50% identity |
Documents (3) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Glutamate-1-semialdehyde 2,1-aminomutase Short name=GSA EC=5.4.3.8 Alternative name(s): Glutamate-1-semialdehyde aminotransferase Short name=GSA-AT | ||||||
| Gene names |
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| Organism | Synechocystis sp. (strain PCC 6803) [Complete proteome] [HAMAP] | ||||||
| Taxonomic identifier | 1148 [NCBI] | ||||||
| Taxonomic lineage | Bacteria › Cyanobacteria › Chroococcales › Synechocystis |
Protein attributes
| Sequence length | 433 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Catalytic activity | (S)-4-amino-5-oxopentanoate = 5-aminolevulinate. HAMAP MF_00375 |
| Cofactor | Pyridoxal phosphate. HAMAP MF_00375 |
| Pathway | Porphyrin metabolism; protoporphyrin-IX biosynthesis; 5-aminolevulinate from L-glutamyl-tRNA(Glu): step 2/2. HAMAP MF_00375 Porphyrin biosynthesis; chlorophyll biosynthesis. HAMAP MF_00375 |
| Subunit structure | Homodimer. HAMAP MF_00375 |
| Subcellular location | Cytoplasm Potential. |
| Sequence similarities | Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Chlorophyll biosynthesis Porphyrin biosynthesis |
| Cellular component | Cytoplasm |
| Ligand | Pyridoxal phosphate |
| Molecular function | Isomerase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | chlorophyll biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | glutamate-1-semialdehyde 2,1-aminomutase activity Inferred from electronic annotation. Source: HAMAP pyridoxal phosphate bindingInferred from electronic annotation. Source: InterPro transaminase activityInferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 433 | 433 | Glutamate-1-semialdehyde 2,1-aminomutase HAMAP MF_00375 | PRO_0000120462 | |||||
Amino acid modifications | |||||||||
| Modified residue | 273 | 1 | N6-(pyridoxal phosphate)lysine By similarity | ||||||
Sequences
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References
| [1] | "Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. I. Sequence features in the 1 Mb region from map positions 64% to 92% of the genome." Kaneko T., Tanaka A., Sato S., Kotani H., Sazuka T., Miyajima N., Sugiura M., Tabata S. DNA Res. 2:153-166(1995) [PubMed: 8590279] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [2] | "Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions." Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y., Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T., Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S. Tabata S.DNA Res. 3:109-136(1996) [PubMed: 8905231] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
Cross-references
Sequence databases | |
|---|---|
| BA000022 Genomic DNA. Translation: BAA10185.1. Different initiation. | |
| PIR | S76333. |
| RefSeq | NP_442115.2. |
3D structure databases | |
| SMR | Q55665. Positions 7-433. |
| ModBase | Search... |
Protein-protein interaction databases | |
| IntAct | Q55665. 1 interaction. |
| STRING | Q55665. |
Genome annotation databases | |
| GeneID | 952666. |
| GenomeReviews | Gene locus sll0017 in contig BA000022_GR. |
| KEGG | syn:sll0017. |
| NMPDR | fig|1148.1.peg.2216. |
Organism-specific databases | |
| CMR | Search... |
Phylogenomic databases | |
| HOGENOM | HBG725944. |
| OMA | VGCFGGK. |
Enzyme and pathway databases | |
| BioCyc | SSP1148:SLL0017-MON. |
Family and domain databases | |
| HAMAP | MF_00375. [Tree] |
| InterPro | IPR004639. 4pyrrol_synth_GluAld_NH2Trfase. IPR005814. Aminotrans_3. IPR015424. PyrdxlP-dep_Trfase_major. IPR015421. PyrdxlP-dep_Trfase_major_sub1. [Graphical view] |
| Gene3D | G3DSA:3.40.640.10. PyrdxlP-dep_Trfase_major_sub1. 1 hit. |
| PANTHER | PTHR11986. Aminotrans_3. 1 hit. |
| Pfam | PF00202. Aminotran_3. 1 hit. [Graphical view] |
| PROSITE | PS00600. AA_TRANSFER_CLASS_3. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | GSA_SYNY3 | ||||||||
| Accession | Primary (citable) accession number: Q55665 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |
| Synechocystis PCC 6803 Synechocystis (strain PCC 6803): entries and gene names |

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