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Q55664

- ALF2_SYNY3

UniProt

Q55664 - ALF2_SYNY3

Protein

Fructose-bisphosphate aldolase class 2

Gene

fbaA

Organism
Synechocystis sp. (strain PCC 6803 / Kazusa)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 100 (01 Oct 2014)
      Sequence version 3 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis.By similarity

    Catalytic activityi

    D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate.

    Cofactori

    Binds 2 zinc ions per subunit. One is catalytic and the other provides a structural contribution By similarity.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei50 – 501Glyceraldehyde 3-phosphateBy similarity
    Active sitei83 – 831Proton donorBy similarity
    Metal bindingi84 – 841Zinc 1; catalyticBy similarity
    Metal bindingi105 – 1051Zinc 2By similarity
    Metal bindingi142 – 1421Zinc 2By similarity
    Metal bindingi198 – 1981Zinc 1; catalyticBy similarity
    Binding sitei199 – 1991Dihydroxyacetone phosphate; via amide nitrogenBy similarity
    Metal bindingi232 – 2321Zinc 1; catalyticBy similarity

    GO - Molecular functioni

    1. fructose-bisphosphate aldolase activity Source: UniProtKB-EC
    2. zinc ion binding Source: InterPro

    GO - Biological processi

    1. glycolytic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Lyase

    Keywords - Biological processi

    Glycolysis

    Keywords - Ligandi

    Metal-binding, Zinc

    Enzyme and pathway databases

    SABIO-RKQ55664.
    UniPathwayiUPA00109; UER00183.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Fructose-bisphosphate aldolase class 2 (EC:4.1.2.13)
    Short name:
    FBP aldolase
    Short name:
    FBPA
    Alternative name(s):
    Fructose-1,6-bisphosphate aldolase
    Fructose-bisphosphate aldolase class II
    Gene namesi
    Name:fbaA
    Synonyms:fda
    Ordered Locus Names:sll0018
    OrganismiSynechocystis sp. (strain PCC 6803 / Kazusa)
    Taxonomic identifieri1111708 [NCBI]
    Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechocystis
    ProteomesiUP000001425: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed1 Publication
    Chaini2 – 359358Fructose-bisphosphate aldolase class 2PRO_0000178751Add
    BLAST

    Proteomic databases

    PaxDbiQ55664.

    Interactioni

    Protein-protein interaction databases

    IntActiQ55664. 1 interaction.
    STRINGi1148.sll0018.

    Structurei

    3D structure databases

    ProteinModelPortaliQ55664.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni233 – 2353Dihydroxyacetone phosphate bindingBy similarity
    Regioni275 – 2784Dihydroxyacetone phosphate bindingBy similarity

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0191.
    HOGENOMiHOG000227792.
    KOiK01624.
    OMAiGMYARAP.
    OrthoDBiEOG6HXJ7B.
    PhylomeDBiQ55664.

    Family and domain databases

    Gene3Di3.20.20.70. 1 hit.
    InterProiIPR013785. Aldolase_TIM.
    IPR006412. Fruct_bisP_Calv.
    IPR000771. Ketose_bisP_aldolase_II.
    [Graphical view]
    PfamiPF01116. F_bP_aldolase. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001359. F_bP_aldolase_II. 1 hit.
    TIGRFAMsiTIGR00167. cbbA. 1 hit.
    TIGR01521. FruBisAldo_II_B. 1 hit.
    PROSITEiPS00602. ALDOLASE_CLASS_II_1. 1 hit.
    PS00806. ALDOLASE_CLASS_II_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q55664-1 [UniParc]FASTAAdd to Basket

    « Hide

    MALVPMRLLL DHAAENGYGI PAFNVNNMEQ IISIMQAADE TDSPVILQAS    50
    RGARSYAGEN FLRHLVLGAV ETYPHIPIAM HQDHGNSPAT CYSAIRNGFT 100
    SVMMDGSLEA DAKTPASFEY NVNVTAEVVK VAHSVGASVE GELGCLGSLE 150
    TGQGEAEDGH GFEGKLDHSQ LLTDPEEAVE FVNKTQVDAL AVAIGTSHGA 200
    YKFTRKPTGE VLAISRIEEI HRLLPNTHLV MHGSSSVPQE WIDMINEFGG 250
    AIPETYGVPV EEIQKGIKSG VRKVNIDTDN RLAITAAFRE AAAKDPKNFD 300
    PRHFLKPSIK YMKQVCADRY QQFWTAGNAS KIKQLTLDDY AAKYAKGELT 350
    ATSRTSVAV 359
    Length:359
    Mass (Da):38,972
    Last modified:January 23, 2007 - v3
    Checksum:i2D005351B70931C3
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000022 Genomic DNA. Translation: BAA10184.1.
    PIRiS76332.
    RefSeqiNP_442114.1. NC_000911.1.
    YP_005652172.1. NC_017277.1.
    YP_007451991.1. NC_020286.1.

    Genome annotation databases

    EnsemblBacteriaiBAA10184; BAA10184; BAA10184.
    GeneIDi952668.
    KEGGisyn:sll0018.
    syy:SYNGTS_2219.
    syz:MYO_122430.
    PATRICi23841830. VBISynSp132158_2459.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000022 Genomic DNA. Translation: BAA10184.1 .
    PIRi S76332.
    RefSeqi NP_442114.1. NC_000911.1.
    YP_005652172.1. NC_017277.1.
    YP_007451991.1. NC_020286.1.

    3D structure databases

    ProteinModelPortali Q55664.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q55664. 1 interaction.
    STRINGi 1148.sll0018.

    Proteomic databases

    PaxDbi Q55664.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAA10184 ; BAA10184 ; BAA10184 .
    GeneIDi 952668.
    KEGGi syn:sll0018.
    syy:SYNGTS_2219.
    syz:MYO_122430.
    PATRICi 23841830. VBISynSp132158_2459.

    Phylogenomic databases

    eggNOGi COG0191.
    HOGENOMi HOG000227792.
    KOi K01624.
    OMAi GMYARAP.
    OrthoDBi EOG6HXJ7B.
    PhylomeDBi Q55664.

    Enzyme and pathway databases

    UniPathwayi UPA00109 ; UER00183 .
    SABIO-RK Q55664.

    Family and domain databases

    Gene3Di 3.20.20.70. 1 hit.
    InterProi IPR013785. Aldolase_TIM.
    IPR006412. Fruct_bisP_Calv.
    IPR000771. Ketose_bisP_aldolase_II.
    [Graphical view ]
    Pfami PF01116. F_bP_aldolase. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001359. F_bP_aldolase_II. 1 hit.
    TIGRFAMsi TIGR00167. cbbA. 1 hit.
    TIGR01521. FruBisAldo_II_B. 1 hit.
    PROSITEi PS00602. ALDOLASE_CLASS_II_1. 1 hit.
    PS00806. ALDOLASE_CLASS_II_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. I. Sequence features in the 1 Mb region from map positions 64% to 92% of the genome."
      Kaneko T., Tanaka A., Sato S., Kotani H., Sazuka T., Miyajima N., Sugiura M., Tabata S.
      DNA Res. 2:153-166(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 27184 / PCC 6803 / N-1.
    2. "Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions."
      Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y., Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T., Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S.
      , Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.
      DNA Res. 3:109-136(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: PCC 6803 / Kazusa.
    3. "Towards a proteome project of cyanobacterium Synechocystis sp. strain PCC6803: linking 130 protein spots with their respective genes."
      Sazuka T., Ohara O.
      Electrophoresis 18:1252-1258(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 2-21.

    Entry informationi

    Entry nameiALF2_SYNY3
    AccessioniPrimary (citable) accession number: Q55664
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 100 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families
    3. Synechocystis PCC 6803
      Synechocystis (strain PCC 6803): entries and gene names

    External Data

    Dasty 3