Reviewed,
UniProtKB/Swiss-Prot Q55664 (ALF2_SYNY3)
Last modified
February 9, 2010.
Version 64.
History...
Clusters with 100%,
90%,
50% identity |
Documents (3) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Fructose-bisphosphate aldolase class 2 Short name=FBP aldolase Short name=FBPA EC=4.1.2.13 Alternative name(s): Fructose-bisphosphate aldolase class II Fructose-1,6-bisphosphate aldolase | ||||||
| Gene names |
| ||||||
| Organism | Synechocystis sp. (strain PCC 6803) [Complete proteome] [HAMAP] | ||||||
| Taxonomic identifier | 1148 [NCBI] | ||||||
| Taxonomic lineage | Bacteria › Cyanobacteria › Chroococcales › Synechocystis |
Protein attributes
| Sequence length | 359 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis By similarity. |
| Catalytic activity | D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate. |
| Cofactor | Binds 2 zinc ions per subunit. One is catalytic and the other provides a structural contribution By similarity. |
| Pathway | |
| Sequence similarities | Belongs to the class II fructose-bisphosphate aldolase family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Glycolysis |
| Ligand | Metal-binding Zinc |
| Molecular function | Lyase |
| Technical term | Complete proteome Direct protein sequencing |
| Gene Ontology (GO) | |
| Biological process | glycolysis Inferred from electronic annotation. Source: UniProtKB-KW |
| Molecular function | fructose-bisphosphate aldolase activity Inferred from electronic annotation. Source: EC zinc ion bindingInferred from electronic annotation. Source: UniProtKB-KW |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Initiator methionine | 1 | 1 | Removed Ref.3 | ||||||
| Chain | 2 – 359 | 358 | Fructose-bisphosphate aldolase class 2 | PRO_0000178751 | |||||
Regions | |||||||||
| Region | 233 – 235 | 3 | Dihydroxyacetone phosphate binding By similarity | ||||||
| Region | 275 – 278 | 4 | Dihydroxyacetone phosphate binding By similarity | ||||||
Sites | |||||||||
| Active site | 83 | 1 | Proton donor By similarity | ||||||
| Metal binding | 84 | 1 | Zinc 1; catalytic By similarity | ||||||
| Metal binding | 105 | 1 | Zinc 2 By similarity | ||||||
| Metal binding | 142 | 1 | Zinc 2 By similarity | ||||||
| Metal binding | 198 | 1 | Zinc 1; catalytic By similarity | ||||||
| Metal binding | 232 | 1 | Zinc 1; catalytic By similarity | ||||||
| Binding site | 50 | 1 | Glyceraldehyde 3-phosphate By similarity | ||||||
| Binding site | 199 | 1 | Dihydroxyacetone phosphate; via amide nitrogen By similarity | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. I. Sequence features in the 1 Mb region from map positions 64% to 92% of the genome." Kaneko T., Tanaka A., Sato S., Kotani H., Sazuka T., Miyajima N., Sugiura M., Tabata S. DNA Res. 2:153-166(1995) [PubMed: 8590279] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [2] | "Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions." Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y., Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T., Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S. Tabata S.DNA Res. 3:109-136(1996) [PubMed: 8905231] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [3] | "Towards a proteome project of cyanobacterium Synechocystis sp. strain PCC6803: linking 130 protein spots with their respective genes." Sazuka T., Ohara O. Electrophoresis 18:1252-1258(1997) [PubMed: 9298645] [Abstract] Cited for: PROTEIN SEQUENCE OF 2-21. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | BA000022 Genomic DNA. Translation: BAA10184.1. |
| PIR | S76332. |
| RefSeq | NP_442114.1. |
3D structure databases | |
| SMR | Q55664. Positions 3-329. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | Q55664. |
Genome annotation databases | |
| GeneID | 952668. |
| GenomeReviews | Gene locus sll0018 in contig BA000022_GR. |
| KEGG | syn:sll0018. |
| NMPDR | fig|1148.1.peg.2215. |
Organism-specific databases | |
| CMR | Search... |
Phylogenomic databases | |
| eggNOG | COG0191. |
| HOGENOM | HBG327581. |
| OMA | EWLKIIN. |
| PhylomeDB | Q55664. |
Enzyme and pathway databases | |
| BioCyc | SSP1148:SLL0018-MONOMER. |
Family and domain databases | |
| InterPro | IPR013785. Aldolase_TIM. IPR006412. Fruct_bisP_Calv. IPR000771. Ketose_bisP_aldolase_II. [Graphical view] |
| Gene3D | G3DSA:3.20.20.70. Aldolase_TIM. 1 hit. |
| Pfam | PF01116. F_bP_aldolase. 1 hit. [Graphical view] |
| PIRSF | PIRSF001359. F_bP_aldolase_II. 1 hit. |
| TIGRFAMs | TIGR00167. cbbA. 1 hit. TIGR01521. FruBisAldo_II_B. 1 hit. |
| PROSITE | PS00602. ALDOLASE_CLASS_II_1. 1 hit. PS00806. ALDOLASE_CLASS_II_2. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | ALF2_SYNY3 | ||||||||
| Accession | Primary (citable) accession number: Q55664 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |
| Synechocystis PCC 6803 Synechocystis (strain PCC 6803): entries and gene names |

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