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Protein

Fructose-bisphosphate aldolase class 2

Gene

fbaA

Organism
Synechocystis sp. (strain PCC 6803 / Kazusa)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis.By similarity

Catalytic activityi

D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate.

Cofactori

Zn2+By similarityNote: Binds 2 Zn2+ ions per subunit. One is catalytic and the other provides a structural contribution.By similarity

Pathwayi: glycolysis

This protein is involved in step 4 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose.
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Glucose-6-phosphate isomerase (pgi)
  3. ATP-dependent 6-phosphofructokinase 2 (pfkA2), ATP-dependent 6-phosphofructokinase 1 (pfkA1)
  4. Fructose-bisphosphate aldolase class 1 (fda), Fructose-bisphosphate aldolase class 2 (fbaA)
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei50Glyceraldehyde 3-phosphateBy similarity1
Active sitei83Proton donorBy similarity1
Metal bindingi84Zinc 1; catalyticBy similarity1
Metal bindingi105Zinc 2By similarity1
Metal bindingi142Zinc 2By similarity1
Metal bindingi198Zinc 1; catalyticBy similarity1
Binding sitei199Dihydroxyacetone phosphate; via amide nitrogenBy similarity1
Metal bindingi232Zinc 1; catalyticBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BRENDAi4.1.2.13. 6192.
SABIO-RKQ55664.
UniPathwayiUPA00109; UER00183.

Names & Taxonomyi

Protein namesi
Recommended name:
Fructose-bisphosphate aldolase class 2 (EC:4.1.2.13)
Short name:
FBP aldolase
Short name:
FBPA
Alternative name(s):
Fructose-1,6-bisphosphate aldolase
Fructose-bisphosphate aldolase class II
Gene namesi
Name:fbaA
Synonyms:fda
Ordered Locus Names:sll0018
OrganismiSynechocystis sp. (strain PCC 6803 / Kazusa)
Taxonomic identifieri1111708 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaSynechococcalesMerismopediaceaeSynechocystis
Proteomesi
  • UP000001425 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00001787512 – 359Fructose-bisphosphate aldolase class 2Add BLAST358

Proteomic databases

PRIDEiQ55664.

Interactioni

Protein-protein interaction databases

IntActiQ55664. 1 interactor.

Structurei

3D structure databases

ProteinModelPortaliQ55664.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni233 – 235Dihydroxyacetone phosphate bindingBy similarity3
Regioni275 – 278Dihydroxyacetone phosphate bindingBy similarity4

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000227792.
InParanoidiQ55664.
KOiK01624.
OMAiVNTREMF.
PhylomeDBiQ55664.

Family and domain databases

CDDicd00947. TBP_aldolase_IIB. 1 hit.
Gene3Di3.20.20.70. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR000771. FBA_II.
IPR006412. Fruct_bisP_Calv.
[Graphical view]
PfamiPF01116. F_bP_aldolase. 1 hit.
[Graphical view]
PIRSFiPIRSF001359. F_bP_aldolase_II. 1 hit.
TIGRFAMsiTIGR00167. cbbA. 1 hit.
TIGR01521. FruBisAldo_II_B. 1 hit.
PROSITEiPS00602. ALDOLASE_CLASS_II_1. 1 hit.
PS00806. ALDOLASE_CLASS_II_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q55664-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALVPMRLLL DHAAENGYGI PAFNVNNMEQ IISIMQAADE TDSPVILQAS
60 70 80 90 100
RGARSYAGEN FLRHLVLGAV ETYPHIPIAM HQDHGNSPAT CYSAIRNGFT
110 120 130 140 150
SVMMDGSLEA DAKTPASFEY NVNVTAEVVK VAHSVGASVE GELGCLGSLE
160 170 180 190 200
TGQGEAEDGH GFEGKLDHSQ LLTDPEEAVE FVNKTQVDAL AVAIGTSHGA
210 220 230 240 250
YKFTRKPTGE VLAISRIEEI HRLLPNTHLV MHGSSSVPQE WIDMINEFGG
260 270 280 290 300
AIPETYGVPV EEIQKGIKSG VRKVNIDTDN RLAITAAFRE AAAKDPKNFD
310 320 330 340 350
PRHFLKPSIK YMKQVCADRY QQFWTAGNAS KIKQLTLDDY AAKYAKGELT

ATSRTSVAV
Length:359
Mass (Da):38,972
Last modified:January 23, 2007 - v3
Checksum:i2D005351B70931C3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000022 Genomic DNA. Translation: BAA10184.1.
PIRiS76332.

Genome annotation databases

EnsemblBacteriaiBAA10184; BAA10184; BAA10184.
KEGGisyn:sll0018.
PATRICi23841830. VBISynSp132158_2459.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000022 Genomic DNA. Translation: BAA10184.1.
PIRiS76332.

3D structure databases

ProteinModelPortaliQ55664.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ55664. 1 interactor.

Proteomic databases

PRIDEiQ55664.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAA10184; BAA10184; BAA10184.
KEGGisyn:sll0018.
PATRICi23841830. VBISynSp132158_2459.

Phylogenomic databases

HOGENOMiHOG000227792.
InParanoidiQ55664.
KOiK01624.
OMAiVNTREMF.
PhylomeDBiQ55664.

Enzyme and pathway databases

UniPathwayiUPA00109; UER00183.
BRENDAi4.1.2.13. 6192.
SABIO-RKQ55664.

Family and domain databases

CDDicd00947. TBP_aldolase_IIB. 1 hit.
Gene3Di3.20.20.70. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR000771. FBA_II.
IPR006412. Fruct_bisP_Calv.
[Graphical view]
PfamiPF01116. F_bP_aldolase. 1 hit.
[Graphical view]
PIRSFiPIRSF001359. F_bP_aldolase_II. 1 hit.
TIGRFAMsiTIGR00167. cbbA. 1 hit.
TIGR01521. FruBisAldo_II_B. 1 hit.
PROSITEiPS00602. ALDOLASE_CLASS_II_1. 1 hit.
PS00806. ALDOLASE_CLASS_II_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiALF2_SYNY3
AccessioniPrimary (citable) accession number: Q55664
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: January 23, 2007
Last modified: November 30, 2016
This is version 113 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
  3. Synechocystis PCC 6803
    Synechocystis (strain PCC 6803): entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.