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Q55630

- SASA_SYNY3

UniProt

Q55630 - SASA_SYNY3

Protein

Adaptive-response sensory-kinase SasA

Gene

sasA

Organism
Synechocystis sp. (strain PCC 6803 / Kazusa)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 97 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    May be involved in signal transduction. Participates in the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria, via its interaction with KaiC. Required for robustness of the circadian rhythm of gene expression and is involved in clock outputs.UniRule annotation

    Catalytic activityi

    ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. phosphorelay sensor kinase activity Source: InterPro

    GO - Biological processi

    1. circadian rhythm Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Biological processi

    Biological rhythms, Two-component regulatory system

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Adaptive-response sensory-kinase SasAUniRule annotation (EC:2.7.13.3)
    Gene namesi
    Name:sasAUniRule annotation
    Synonyms:sarA
    Ordered Locus Names:sll0750
    OrganismiSynechocystis sp. (strain PCC 6803 / Kazusa)
    Taxonomic identifieri1111708 [NCBI]
    Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechocystis
    ProteomesiUP000001425: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. membrane Source: InterPro

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 383383Adaptive-response sensory-kinase SasAPRO_0000074874Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei164 – 1641Phosphohistidine; by autocatalysisUniRule annotation

    Keywords - PTMi

    Phosphoprotein

    Interactioni

    Subunit structurei

    Interacts with KaiC. Participates in the KaiABC complex, whose core is composed of a KaiC homohexamer, a KaiB dimer and two KaiA dimers.UniRule annotation

    Protein-protein interaction databases

    IntActiQ55630. 9 interactions.
    STRINGi1148.sll0750.

    Structurei

    3D structure databases

    ProteinModelPortaliQ55630.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini161 – 383223Histidine kinaseUniRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 histidine kinase domain.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0642.
    HOGENOMiHOG000233315.
    KOiK08479.
    OMAiHFTLPVY.
    OrthoDBiEOG6G4VQG.
    PhylomeDBiQ55630.

    Family and domain databases

    Gene3Di1.10.287.130. 1 hit.
    3.30.565.10. 1 hit.
    3.40.30.10. 1 hit.
    HAMAPiMF_01837. Kinase_SasA.
    InterProiIPR003661. EnvZ-like_dim/P.
    IPR003594. HATPase_ATP-bd.
    IPR011649. KaiB_domain.
    IPR023527. Kinase_SasA.
    IPR004358. Sig_transdc_His_kin-like_C.
    IPR005467. Sig_transdc_His_kinase_core.
    IPR009082. Sig_transdc_His_kinase_dimeric.
    IPR012336. Thioredoxin-like_fold.
    [Graphical view]
    PfamiPF02518. HATPase_c. 1 hit.
    PF00512. HisKA. 1 hit.
    PF07689. KaiB. 1 hit.
    [Graphical view]
    PRINTSiPR00344. BCTRLSENSOR.
    SMARTiSM00387. HATPase_c. 1 hit.
    SM00388. HisKA. 1 hit.
    [Graphical view]
    SUPFAMiSSF47384. SSF47384. 1 hit.
    SSF52833. SSF52833. 1 hit.
    SSF55874. SSF55874. 1 hit.
    PROSITEiPS50109. HIS_KIN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q55630-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSSSSELGNA SSVPLQFLLF IDDRPNSQDS VQEIGQCLTN LLDGHSHDLQ    50
    ILQISKHPHL VEHFRLVATP SLIKLQPEPR QVLAGSNIIQ QLQKWWPRWQ 100
    QELAMDPNPE DTGQSPSCPR EISSVGYSGE LMKMSDELFL LKKDKEELLQ 150
    QIQFKDQILA MLAHDLRSPL TAASIAVDTL ELLQHKPIEE QKPALRSQLL 200
    YQARKQFKIM DRLIEDILQA SKNLNSQFQV HGRPLAIADL CQEVLELYQA 250
    KFSKKNLTIT YDIPKDLPNV FADEELIRQV IANLLDNAIK YTPAHGSITV 300
    GALHRTTQKV QVSITDNGPG IPNSKQETIF EGHFRLQRDE QTDGYGLGLS 350
    LCRKIIQAHY GQIWVDSRPK QGSSFHFTLP VYR 383
    Length:383
    Mass (Da):43,436
    Last modified:November 1, 1996 - v1
    Checksum:i395621F5C4BF42F1
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000022 Genomic DNA. Translation: BAA10143.1.
    PIRiS76291.
    RefSeqiNP_442073.1. NC_000911.1.
    YP_005652131.1. NC_017277.1.
    YP_007451950.1. NC_020286.1.

    Genome annotation databases

    EnsemblBacteriaiBAA10143; BAA10143; BAA10143.
    GeneIDi952700.
    KEGGisyn:sll0750.
    syy:SYNGTS_2178.
    syz:MYO_121980.
    PATRICi23841738. VBISynSp132158_2416.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000022 Genomic DNA. Translation: BAA10143.1 .
    PIRi S76291.
    RefSeqi NP_442073.1. NC_000911.1.
    YP_005652131.1. NC_017277.1.
    YP_007451950.1. NC_020286.1.

    3D structure databases

    ProteinModelPortali Q55630.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q55630. 9 interactions.
    STRINGi 1148.sll0750.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAA10143 ; BAA10143 ; BAA10143 .
    GeneIDi 952700.
    KEGGi syn:sll0750.
    syy:SYNGTS_2178.
    syz:MYO_121980.
    PATRICi 23841738. VBISynSp132158_2416.

    Phylogenomic databases

    eggNOGi COG0642.
    HOGENOMi HOG000233315.
    KOi K08479.
    OMAi HFTLPVY.
    OrthoDBi EOG6G4VQG.
    PhylomeDBi Q55630.

    Family and domain databases

    Gene3Di 1.10.287.130. 1 hit.
    3.30.565.10. 1 hit.
    3.40.30.10. 1 hit.
    HAMAPi MF_01837. Kinase_SasA.
    InterProi IPR003661. EnvZ-like_dim/P.
    IPR003594. HATPase_ATP-bd.
    IPR011649. KaiB_domain.
    IPR023527. Kinase_SasA.
    IPR004358. Sig_transdc_His_kin-like_C.
    IPR005467. Sig_transdc_His_kinase_core.
    IPR009082. Sig_transdc_His_kinase_dimeric.
    IPR012336. Thioredoxin-like_fold.
    [Graphical view ]
    Pfami PF02518. HATPase_c. 1 hit.
    PF00512. HisKA. 1 hit.
    PF07689. KaiB. 1 hit.
    [Graphical view ]
    PRINTSi PR00344. BCTRLSENSOR.
    SMARTi SM00387. HATPase_c. 1 hit.
    SM00388. HisKA. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47384. SSF47384. 1 hit.
    SSF52833. SSF52833. 1 hit.
    SSF55874. SSF55874. 1 hit.
    PROSITEi PS50109. HIS_KIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. I. Sequence features in the 1 Mb region from map positions 64% to 92% of the genome."
      Kaneko T., Tanaka A., Sato S., Kotani H., Sazuka T., Miyajima N., Sugiura M., Tabata S.
      DNA Res. 2:153-166(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 27184 / PCC 6803 / N-1.
    2. "Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions."
      Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y., Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T., Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S.
      , Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.
      DNA Res. 3:109-136(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: PCC 6803 / Kazusa.

    Entry informationi

    Entry nameiSASA_SYNY3
    AccessioniPrimary (citable) accession number: Q55630
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 11, 2004
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 97 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Synechocystis PCC 6803
      Synechocystis (strain PCC 6803): entries and gene names

    External Data

    Dasty 3