Q55630 (SASA_SYNY3) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Adaptive-response sensory-kinase SasA
EC=2.7.13.3

Gene names

Name:	sasA
Synonyms:	sarA
Ordered Locus Names:	sll0750

Organism

Synechocystis sp. (strain PCC 6803 / Kazusa) [Reference proteome] [HAMAP]

Taxonomic identifier

1111708 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Cyanobacteria › Oscillatoriophycideae › Chroococcales › Synechocystis › Synechocystis sp. PCC 6803

Protein attributes

Sequence length	383 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	May be involved in signal transduction. Participates in the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria, via its interaction with KaiC. Required for robustness of the circadian rhythm of gene expression and is involved in clock outputs By similarity. HAMAP-Rule MF_01837
Catalytic activity	ATP + protein L-histidine = ADP + protein N-phospho-L-histidine. HAMAP-Rule MF_01837
Subunit structure	Interacts with KaiC. Participates in the KaiABC complex, whose core is composed of a KaiC homohexamer, a KaiB dimer and two KaiA dimers By similarity.
Sequence similarities	Contains 1 histidine kinase domain.

Ontologies

Keywords
Biological process	Biological rhythms Two-component regulatory system
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	circadian rhythm Inferred from electronic annotation. Source: HAMAP signal transduction by phosphorylation Inferred from electronic annotation. Source: GOC
Cellular_component	membrane Inferred from electronic annotation. Source: InterPro
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW phosphorelay sensor kinase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 383	383	Adaptive-response sensory-kinase SasA HAMAP-Rule MF_01837		PRO_0000074874
Regions
	Domain	161 – 383	223	Histidine kinase
Amino acid modifications
	Modified residue	164	1	Phosphohistidine; by autocatalysis By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q55630 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: 395621F5C4BF42F1	FASTA	383	43,436
	10 20 30 40 50 60 MSSSSELGNA SSVPLQFLLF IDDRPNSQDS VQEIGQCLTN LLDGHSHDLQ ILQISKHPHL 70 80 90 100 110 120 VEHFRLVATP SLIKLQPEPR QVLAGSNIIQ QLQKWWPRWQ QELAMDPNPE DTGQSPSCPR 130 140 150 160 170 180 EISSVGYSGE LMKMSDELFL LKKDKEELLQ QIQFKDQILA MLAHDLRSPL TAASIAVDTL 190 200 210 220 230 240 ELLQHKPIEE QKPALRSQLL YQARKQFKIM DRLIEDILQA SKNLNSQFQV HGRPLAIADL 250 260 270 280 290 300 CQEVLELYQA KFSKKNLTIT YDIPKDLPNV FADEELIRQV IANLLDNAIK YTPAHGSITV 310 320 330 340 350 360 GALHRTTQKV QVSITDNGPG IPNSKQETIF EGHFRLQRDE QTDGYGLGLS LCRKIIQAHY 370 380 GQIWVDSRPK QGSSFHFTLP VYR

References

[1]

"Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. I. Sequence features in the 1 Mb region from map positions 64% to 92% of the genome." Kaneko T., Tanaka A., Sato S., Kotani H., Sazuka T., Miyajima N., Sugiura M., Tabata S. DNA Res. 2:153-166(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 27184 / PCC 6803 / N-1.

[2]

"Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions." Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y., Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T., Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S. , Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S. DNA Res. 3:109-136(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: PCC 6803 / Kazusa.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BA000022 Genomic DNA. Translation: BAA10143.1.
PIR	S76291.
RefSeq	NP_442073.1. NC_000911.1. YP_005652131.1. NC_017277.1. YP_007451950.1. NC_020286.1.
3D structure databases
ProteinModelPortal	Q55630.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q55630. 9 interactions.
STRING	1148.sll0750.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	BAA10143; BAA10143; BAA10143.
GeneID	12253344. 14617620. 952700.
KEGG	syn:sll0750. syy:SYNGTS_2178.
PATRIC	23841738. VBISynSp132158_2416.
Phylogenomic databases
eggNOG	COG0642.
HOGENOM	HOG000233315.
KO	K08479.
OMA	AHYGQIW.
ProtClustDB	PRK09303.
Family and domain databases
Gene3D	1.10.287.130. 1 hit. 3.30.565.10. 1 hit. 3.40.30.10. 1 hit.
HAMAP	MF_01837. Kinase_SasA.
InterPro	IPR003594. HATPase_ATP-bd. IPR011649. KaiB_domain. IPR023527. Kinase_SasA. IPR004358. Sig_transdc_His_kin-like_C. IPR003661. Sig_transdc_His_kin_sub1_dim/P. IPR005467. Sig_transdc_His_kinase_core. IPR009082. Sig_transdc_His_kinase_dimeric. IPR012336. Thioredoxin-like_fold. [Graphical view]
Pfam	PF02518. HATPase_c. 1 hit. PF00512. HisKA. 1 hit. PF07689. KaiB. 1 hit. [Graphical view]
PRINTS	PR00344. BCTRLSENSOR.
SMART	SM00387. HATPase_c. 1 hit. SM00388. HisKA. 1 hit. [Graphical view]
SUPFAM	SSF55874. ATP_bd_ATPase. 1 hit. SSF47384. His_kin_homodim. 1 hit. SSF52833. Thiordxn-like_fd. 1 hit.
PROSITE	PS50109. HIS_KIN. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

SASA_SYNY3

Accession

Primary (citable) accession number: Q55630

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 11, 2004
Last sequence update:	November 1, 1996
Last modified:	May 1, 2013
This is version 88 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program