Q555Z5 (ABCA4_DICDI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
ABC transporter A family member 4

Alternative name(s):
ABC transporter ABCA.4

Gene names

Name:	abcA4
ORF Names:	DDB_G0274121

Organism

Dictyostelium discoideum (Slime mold)

Taxonomic identifier

44689 [NCBI]

Taxonomic lineage

Eukaryota › Amoebozoa › Mycetozoa › Dictyosteliida › Dictyostelium

Protein attributes

Sequence length	1615 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Subcellular location	Membrane; Multi-pass membrane protein Potential.
Sequence similarities	Belongs to the ABC transporter superfamily. ABCA family. Contains 1 ABC transmembrane type-2 domain. Contains 2 ABC transporter domains.

Ontologies

Keywords
Biological process	Transport
Cellular component	Membrane
Domain	Repeat Transmembrane Transmembrane helix
Ligand	ATP-binding Nucleotide-binding
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW ATPase activity, coupled to transmembrane movement of substances Inferred from sequence or structural similarity Ref.1. Source: dictyBase
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1615	1615	ABC transporter A family member 4		PRO_0000363836
Regions
	Transmembrane	30 – 50	21	Helical; Potential
	Transmembrane	233 – 253	21	Helical; Potential
	Transmembrane	278 – 298	21	Helical; Potential
	Transmembrane	308 – 328	21	Helical; Potential
	Transmembrane	337 – 357	21	Helical; Potential
	Transmembrane	365 – 385	21	Helical; Potential
	Transmembrane	405 – 425	21	Helical; Potential
	Transmembrane	855 – 875	21	Helical; Potential
	Transmembrane	1022 – 1042	21	Helical; Potential
	Transmembrane	1075 – 1095	21	Helical; Potential
	Transmembrane	1106 – 1126	21	Helical; Potential
	Transmembrane	1135 – 1155	21	Helical; Potential
	Transmembrane	1174 – 1194	21	Helical; Potential
	Transmembrane	1218 – 1238	21	Helical; Potential
	Domain	182 – 383	202	ABC transmembrane type-2
	Domain	492 – 727	236	ABC transporter 1
	Domain	1293 – 1528	236	ABC transporter 2
	Nucleotide binding	528 – 535	8	ATP 1 Potential
	Nucleotide binding	1331 – 1338	8	ATP 2 Potential
Experimental info
	Sequence conflict	29	1	E → K in AAL85297. Ref.1
	Sequence conflict	38 – 45	8	GILFGILY → D in AAL85297. Ref.1
	Sequence conflict	66	1	I → N in AAL85297. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q555Z5 [UniParc]. Last modified May 24, 2005. Version 1. Checksum: 72AFF1ABFF583086	FASTA	1,615	182,397
	10 20 30 40 50 60 MESIKNQLIP LLKKNWTLKG KSKIKLLLEI LLPLISIGIL FGILYLSMII TRDFKERPAS 70 80 90 100 110 120 GFAFDIAHTK QLLIGSNGGL NSDQRNILDN LKLQVSIQHP EFSNDYINRC FVEFKDIESM 130 140 150 160 170 180 DEYFHDPFNY RGVMGGVWFP DDSFNGNTIK YSIRVDSDFT HDNTQQFQDR EDSQIYLRHY 190 200 210 220 230 240 FTQIQTGVDQ AILLTNQIAI PIFATGQRFP NPYISFWEKW TDGRKLILLN TGGVFITASL 250 260 270 280 290 300 FATLFTLITN IVIEKETKIL EGMKTMGLNS FAYYISNSII SLITLLSSTL LVSIILSASQ 310 320 330 340 350 360 LVHHVKWITL ILILIPYSIT LLLIAFILCK FFTKSKYAGL MAFLIVLLLS GIGIIIGRFN 370 380 390 400 410 420 ISPTLKLLSC LFSPIAISVA NYVWCYKDLI VFKEVDINVN MVNEYEIIGM LVFDIFLYIL 430 440 450 460 470 480 ILWYLDNVIT GEYGIPKKWY FFLTKNYWRK NKKSNINNNG VFDVEATSCN RNSSYNEKNF 490 500 510 520 530 540 EKIEHQLERP TISIRNLRKE FKTGDGNRIA VNDLSIDMYK NRIHSFLGPN GSGKSTTLSM 550 560 570 580 590 600 LTGMIEPTSG DALINGFDIR NNIDEIRKHL GVCPQSDIIW EQLTVMEHLE FYAALKGFTN 610 620 630 640 650 660 SNQRKVEATK IALEVGLGEK LNAPAGTLSG GQKRKLCLAI AFIGPNSDII LIDEPTSGLD 670 680 690 700 710 720 ASNRRLIWDF ILKYRENKTI ILVSHYLEEC DILSNTISII ANGELKCNGS SLFLKNRFGV 730 740 750 760 770 780 GYLLTISKEH NSINNSNLTK TISDIIFNHI PKGSLLSDAG TELCFRLPNE SIGNFSNLFK 790 800 810 820 830 840 ELDDRKKQLS IENYGISITT LEEVFLKIIS NSETNPNFNQ SVLNTALKTN SSGIKSYQQL 850 860 870 880 890 900 KGLLIKRVKT SRKDIKSFVL SILIPILILA GGLILYKNMR TIDIYNTVTQ PLILDFNVYG 910 920 930 940 950 960 KSVTPVSIDK VNETMTSLFD NSIGHSDRTT LVPYDELHDY LIHHYFGVPG ALYFDFRYFK 970 980 990 1000 1010 1020 NVKFLHYNVF FNKDYLHALP IYINFVDSEI LRSVTGKRIQ TTSLPFEHIQ SPLEVASLDV 1030 1040 1050 1060 1070 1080 NFVAIVFFII LTLASFSLIA ASHAGNISHE RSTRVKRLLY ISGLRKSIYW LSNLIWDYLQ 1090 1100 1110 1120 1130 1140 TFILVIFLTI VIIAVDDKFR THFDLYISGV VLFTFSIIPL SYLMSFKFSS HGKAVGAIFA 1150 1160 1170 1180 1190 1200 IHFGVGLIFT VISFILRVWA IKENSISFQF LTDIIEYCFY AISPFFCFSK ILAIVTKFPG 1210 1220 1230 1240 1250 1260 VSRVDQSFID YWSFHFGLLP NAILFLHCIV WITWILLIDY SSEIKGKFTI SKLFSNSPIP 1270 1280 1290 1300 1310 1320 DSNEDSDVSN ERIIVKQLLD NNTNGGSGNV YPIIFNNLYK KFNSVGNYKS KIAVYNSTLA 1330 1340 1350 1360 1370 1380 IPTGQTFGLL GLNGCGKSTT LGMISGEISP TGGKIKLNGY DLIKNRNDAL TSIGYCFQFD 1390 1400 1410 1420 1430 1440 ALIGLLSARE QLELYCRIKG VDESKIKDTV NAFIQMMDLE SISNSNTSGY SGGNKRKVSL 1450 1460 1470 1480 1490 1500 SIACIGSPSI LLLDEISCGV DACVKRFMWN VLMELKKNKA IILTTHSIAE CQAVCDKLTI 1510 1520 1530 1540 1550 1560 MKDGKLQALG SNQHIKDKFG SGYSIEVKFK KEYLENGVEL FLQSFPSASL IDNQHALSAS 1570 1580 1590 1600 1610 FELPNPPNNP IKLSSIFSNI EQSLKFILDD YSVSQTSIEQ IFIKLTKNSI TNIDN

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Evolutionary analyses of ABC transporters of Dictyostelium discoideum." Anjard C., Loomis W.F. Eukaryot. Cell 1:643-652(2002) [PubMed: 12456012] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], NOMENCLATURE. Strain: AX4.
[2]	"Sequence and analysis of chromosome 2 of Dictyostelium discoideum." Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T., Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R., Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A., Noegel A.A. Nature 418:79-85(2002) [PubMed: 12097910] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AX4.
[3]	"The genome of the social amoeba Dictyostelium discoideum." Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N. , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A. Nature 435:43-57(2005) [PubMed: 15875012] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AX4.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF465306 Genomic DNA. Translation: AAL85297.1. AAFI02000012 Genomic DNA. Translation: EAL69953.1.
RefSeq	XP_643915.1. XM_638823.1.
3D structure databases
ProteinModelPortal	Q555Z5.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblProtists	DDB0219982; DDB0219982; DDB_G0274121.
GeneID	8619342.
GenomeReviews	Gene locus abcA4 in contig CM000151_GR.
KEGG	ddi:DDB_G0274121.
Organism-specific databases
dictyBase	DDB_G0274121. abcA4.
Phylogenomic databases
eggNOG	KOG0059.
GeneTree	EPrGT00050000002981.
HOGENOM	HBG082294.
InParanoid	Q555Z5.
OMA	ISHERST.
PhylomeDB	Q555Z5.
ProtClustDB	CLSZ2429271.
Family and domain databases
InterPro	IPR003439. ABC_transporter-like. IPR017871. ABC_transporter_CS. IPR003593. ATPase_AAA+_core. [Graphical view]
Pfam	PF00005. ABC_tran. 2 hits. [Graphical view]
SMART	SM00382. AAA. 2 hits. [Graphical view]
PROSITE	PS51012. ABC_TM2. False negative. PS00211. ABC_TRANSPORTER_1. 1 hit. PS50893. ABC_TRANSPORTER_2. 2 hits. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ABCA4_DICDI

Accession

Primary (citable) accession number: Q555Z5
Secondary accession number(s): Q86IX7, Q8T6J3

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 10, 2009
Last sequence update:	May 24, 2005
Last modified:	September 21, 2011
This is version 64 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)