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Protein

SH3 and F-BAR domain-containing protein DDB_G0274695

Gene

DDB_G0274695

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

GO - Molecular functioni

  • microtubule binding Source: dictyBase

GO - Biological processi

  • actin filament polymerization Source: dictyBase
  • chemotaxis to cAMP Source: dictyBase
  • vesicle organization Source: dictyBase
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_325996. Rho GTPase cycle.

Names & Taxonomyi

Protein namesi
Recommended name:
SH3 and F-BAR domain-containing protein DDB_G0274695
Gene namesi
ORF Names:DDB_G0274695
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
ProteomesiUP000002195 Componentsi: Chromosome 2, Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0274695. slp.

Subcellular locationi

GO - Cellular componenti

  • perinuclear region of cytoplasm Source: dictyBase
  • vesicle Source: dictyBase
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 389389SH3 and F-BAR domain-containing protein DDB_G0274695PRO_0000384437Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi44689.DDB0266841.

Structurei

3D structure databases

ProteinModelPortaliQ555L8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini3 – 258256F-BARPROSITE-ProRule annotationAdd
BLAST
Domaini332 – 38958SH3PROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili119 – 19274Sequence AnalysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi273 – 2764Poly-Pro

Sequence similaritiesi

Contains 1 F-BAR domain.PROSITE-ProRule annotation
Contains 1 SH3 domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, SH3 domain

Phylogenomic databases

eggNOGiNOG303711.
InParanoidiQ555L8.
OMAiMETAKNT.
PhylomeDBiQ555L8.

Family and domain databases

InterProiIPR031160. F_BAR.
IPR001060. FCH_dom.
IPR001452. SH3_domain.
[Graphical view]
PfamiPF00611. FCH. 1 hit.
PF14604. SH3_9. 1 hit.
[Graphical view]
PRINTSiPR00452. SH3DOMAIN.
SMARTiSM00055. FCH. 1 hit.
SM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 1 hit.
PROSITEiPS51741. F_BAR. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q555L8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSEQFKDNFW GPNGFETIEK RMNQGTESTR LFLLFLKERA AIEENYSKSL
60 70 80 90 100
QKLLKSTSQL IEYGTLRDAW YGVRGEAESL VRVHHELGQK IEKDIVAPFS
110 120 130 140 150
KFKSEQKKVK KNFLYDAYKL NKERKDMESS ITKTRAKYDD YSKQAETIAI
160 170 180 190 200
TMETAKNTKT AAEVGKIQSK LQKIQRDASS AEQDYRDSVN KLSMYQPTWE
210 220 230 240 250
DKVSSNYHTL QLTEEERIDY IKVQLEKYVG AIKSTVPDTE TTNRNLVNVI
260 270 280 290 300
TQIDKLEDIH CFVRESRTGT EKPPPPQFIS FGGKSSSDYI QNKASYSAPL
310 320 330 340 350
TSSVSSNSLT SSYNSATTTP TPAPRSTPIN LSKKKQAKAL YDYVGSDATE
360 370 380
LDFFAGDIIT ILDEDESGWF RGELGDRIGL YPSNYCEPI
Length:389
Mass (Da):44,221
Last modified:May 24, 2005 - v1
Checksum:i8E01112F246EDA86
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti204 – 2041S → F in AAM44380 (PubMed:12097910).Curated
Sequence conflicti235 – 2351T → P in AAM44380 (PubMed:12097910).Curated
Sequence conflicti242 – 2421T → P in AAM44380 (PubMed:12097910).Curated
Sequence conflicti335 – 3351K → N in AAM44380 (PubMed:12097910).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC123513 Genomic DNA. Translation: AAM44380.1.
AAFI02000012 Genomic DNA. Translation: EAL70240.1.
RefSeqiXP_644048.1. XM_638956.1.

Genome annotation databases

EnsemblProtistsiDDB0266841; DDB0266841; DDB_G0274695.
GeneIDi8619478.
KEGGiddi:DDB_G0274695.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC123513 Genomic DNA. Translation: AAM44380.1.
AAFI02000012 Genomic DNA. Translation: EAL70240.1.
RefSeqiXP_644048.1. XM_638956.1.

3D structure databases

ProteinModelPortaliQ555L8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi44689.DDB0266841.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsiDDB0266841; DDB0266841; DDB_G0274695.
GeneIDi8619478.
KEGGiddi:DDB_G0274695.

Organism-specific databases

dictyBaseiDDB_G0274695. slp.

Phylogenomic databases

eggNOGiNOG303711.
InParanoidiQ555L8.
OMAiMETAKNT.
PhylomeDBiQ555L8.

Enzyme and pathway databases

ReactomeiREACT_325996. Rho GTPase cycle.

Miscellaneous databases

PROiQ555L8.

Family and domain databases

InterProiIPR031160. F_BAR.
IPR001060. FCH_dom.
IPR001452. SH3_domain.
[Graphical view]
PfamiPF00611. FCH. 1 hit.
PF14604. SH3_9. 1 hit.
[Graphical view]
PRINTSiPR00452. SH3DOMAIN.
SMARTiSM00055. FCH. 1 hit.
SM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 1 hit.
PROSITEiPS51741. F_BAR. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AX4.
  2. "The genome of the social amoeba Dictyostelium discoideum."
    Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N.
    , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
    Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AX4.

Entry informationi

Entry nameiY4695_DICDI
AccessioniPrimary (citable) accession number: Q555L8
Secondary accession number(s): Q8MML2, Q8T177
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: May 24, 2005
Last modified: July 22, 2015
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.