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Q55593

- KTHY_SYNY3

UniProt

Q55593 - KTHY_SYNY3

Protein

Thymidylate kinase

Gene

tmk

Organism
Synechocystis sp. (strain PCC 6803 / Kazusa)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 89 (01 Oct 2014)
      Sequence version 2 (30 May 2000)
      Previous versions | rss
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    Functioni

    Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.By similarity

    Catalytic activityi

    ATP + dTMP = ADP + dTDP.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi10 – 178ATPSequence Analysis

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. thymidylate kinase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. dTDP biosynthetic process Source: InterPro
    2. dTTP biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Biological processi

    Nucleotide biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Thymidylate kinase (EC:2.7.4.9)
    Alternative name(s):
    dTMP kinase
    Gene namesi
    Name:tmk
    Ordered Locus Names:slr0379
    OrganismiSynechocystis sp. (strain PCC 6803 / Kazusa)
    Taxonomic identifieri1111708 [NCBI]
    Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechocystis
    ProteomesiUP000001425: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 212212Thymidylate kinasePRO_0000155358Add
    BLAST

    Proteomic databases

    PaxDbiQ55593.

    Interactioni

    Protein-protein interaction databases

    STRINGi1148.slr0379.

    Structurei

    3D structure databases

    ProteinModelPortaliQ55593.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the thymidylate kinase family.Curated

    Phylogenomic databases

    eggNOGiCOG0125.
    KOiK00943.
    OMAiVADRYEH.
    OrthoDBiEOG64JFSH.
    PhylomeDBiQ55593.

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    HAMAPiMF_00165. Thymidylate_kinase.
    InterProiIPR027417. P-loop_NTPase.
    IPR018095. Thymidylate_kin_CS.
    IPR018094. Thymidylate_kinase.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    TIGRFAMsiTIGR00041. DTMP_kinase. 1 hit.
    PROSITEiPS01331. THYMIDYLATE_KINASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q55593-1 [UniParc]FASTAAdd to Basket

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    MAALFIVLEG IDGSGKTTQG DLLLAHFQRQ GLAAVLSPEP TNGPVGRLIR    50
    QALQGDLFTY NDARQFEAQM GYLFAADRHY HLYHPGDGVE AKLAQQCHVI 100
    TTRYYFSSLA YNCHTEADWE FVQRLNQSFP QPDWVIYLDL PVDLALQRLG 150
    DRQQLEDQAP RECYEQREKL ISVHRNYDRI FAHYQGQLCR LDASLPVEQL 200
    HQAIITKVEE ML 212
    Length:212
    Mass (Da):24,350
    Last modified:May 30, 2000 - v2
    Checksum:iB2EB13A29EDC0F8C
    GO

    Sequence cautioni

    The sequence BAA10099.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000022 Genomic DNA. Translation: BAA10099.1. Different initiation.
    PIRiS76121.
    RefSeqiNP_442029.1. NC_000911.1.
    YP_005652088.1. NC_017277.1.
    YP_007451908.1. NC_020286.1.

    Genome annotation databases

    EnsemblBacteriaiBAA10099; BAA10099; BAA10099.
    GeneIDi952738.
    KEGGisyn:slr0379.
    syy:SYNGTS_2135.
    syz:MYO_121550.
    PATRICi23841636. VBISynSp132158_2366.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000022 Genomic DNA. Translation: BAA10099.1 . Different initiation.
    PIRi S76121.
    RefSeqi NP_442029.1. NC_000911.1.
    YP_005652088.1. NC_017277.1.
    YP_007451908.1. NC_020286.1.

    3D structure databases

    ProteinModelPortali Q55593.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 1148.slr0379.

    Proteomic databases

    PaxDbi Q55593.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAA10099 ; BAA10099 ; BAA10099 .
    GeneIDi 952738.
    KEGGi syn:slr0379.
    syy:SYNGTS_2135.
    syz:MYO_121550.
    PATRICi 23841636. VBISynSp132158_2366.

    Phylogenomic databases

    eggNOGi COG0125.
    KOi K00943.
    OMAi VADRYEH.
    OrthoDBi EOG64JFSH.
    PhylomeDBi Q55593.

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    HAMAPi MF_00165. Thymidylate_kinase.
    InterProi IPR027417. P-loop_NTPase.
    IPR018095. Thymidylate_kin_CS.
    IPR018094. Thymidylate_kinase.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    TIGRFAMsi TIGR00041. DTMP_kinase. 1 hit.
    PROSITEi PS01331. THYMIDYLATE_KINASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. I. Sequence features in the 1 Mb region from map positions 64% to 92% of the genome."
      Kaneko T., Tanaka A., Sato S., Kotani H., Sazuka T., Miyajima N., Sugiura M., Tabata S.
      DNA Res. 2:153-166(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 27184 / PCC 6803 / N-1.
    2. "Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions."
      Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y., Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T., Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S.
      , Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.
      DNA Res. 3:109-136(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: PCC 6803 / Kazusa.

    Entry informationi

    Entry nameiKTHY_SYNY3
    AccessioniPrimary (citable) accession number: Q55593
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1999
    Last sequence update: May 30, 2000
    Last modified: October 1, 2014
    This is version 89 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Synechocystis PCC 6803
      Synechocystis (strain PCC 6803): entries and gene names

    External Data

    Dasty 3