Q55593 (KTHY_SYNY3) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Thymidylate kinase
EC=2.7.4.9

Alternative name(s):
dTMP kinase

Gene names

Name:	tmk
Ordered Locus Names:	slr0379

Organism

Synechocystis sp. (strain PCC 6803 / Kazusa) [Reference proteome] [HAMAP]

Taxonomic identifier

1111708 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Cyanobacteria › Oscillatoriophycideae › Chroococcales › Synechocystis › Synechocystis sp. PCC 6803

Protein attributes

Sequence length	212 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis By similarity. HAMAP-Rule MF_00165
Catalytic activity	ATP + dTMP = ADP + dTDP. HAMAP-Rule MF_00165
Sequence similarities	Belongs to the thymidylate kinase family.
Sequence caution	The sequence BAA10099.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Nucleotide biosynthesis
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	dTDP biosynthetic process Inferred from electronic annotation. Source: InterPro dTTP biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular_function	ATP binding Inferred from electronic annotation. Source: HAMAP thymidylate kinase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 212	212	Thymidylate kinase HAMAP-Rule MF_00165		PRO_0000155358
Regions
	Nucleotide binding	10 – 17	8	ATP Potential

Sequences

	Sequence		Length	Mass (Da)
	Q55593 [UniParc]. Last modified May 30, 2000. Version 2. Checksum: B2EB13A29EDC0F8C	FASTA	212	24,350
	10 20 30 40 50 60 MAALFIVLEG IDGSGKTTQG DLLLAHFQRQ GLAAVLSPEP TNGPVGRLIR QALQGDLFTY 70 80 90 100 110 120 NDARQFEAQM GYLFAADRHY HLYHPGDGVE AKLAQQCHVI TTRYYFSSLA YNCHTEADWE 130 140 150 160 170 180 FVQRLNQSFP QPDWVIYLDL PVDLALQRLG DRQQLEDQAP RECYEQREKL ISVHRNYDRI 190 200 210 FAHYQGQLCR LDASLPVEQL HQAIITKVEE ML

References

[1]

"Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. I. Sequence features in the 1 Mb region from map positions 64% to 92% of the genome." Kaneko T., Tanaka A., Sato S., Kotani H., Sazuka T., Miyajima N., Sugiura M., Tabata S. DNA Res. 2:153-166(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 27184 / PCC 6803 / N-1.

[2]

"Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions." Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y., Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T., Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S. , Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S. DNA Res. 3:109-136(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: PCC 6803 / Kazusa.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BA000022 Genomic DNA. Translation: BAA10099.1. Different initiation.
PIR	S76121.
RefSeq	NP_442029.1. NC_000911.1. YP_005652088.1. NC_017277.1. YP_007451908.1. NC_020286.1.
3D structure databases
ProteinModelPortal	Q55593.
ModBase	Search...
Protein-protein interaction databases
STRING	1148.slr0379.
Proteomic databases
PaxDb	Q55593.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	BAA10099; BAA10099; BAA10099.
GeneID	12253300. 14617577. 952738.
KEGG	syn:slr0379. syy:SYNGTS_2135.
PATRIC	23841636. VBISynSp132158_2366.
Phylogenomic databases
eggNOG	COG0125.
KO	K00943.
OMA	RIQENRI.
ProtClustDB	CLSK893392.
Family and domain databases
HAMAP	MF_00165. Thymidylate_kinase.
InterPro	IPR027417. P-loop_NTPase. IPR018095. Thymidylate_kin_CS. IPR018094. Thymidylate_kinase. [Graphical view]
PANTHER	PTHR10344. PTHR10344. 1 hit.
SUPFAM	SSF52540. SSF52540. 1 hit.
TIGRFAMs	TIGR00041. DTMP_kinase. 1 hit.
PROSITE	PS01331. THYMIDYLATE_KINASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

KTHY_SYNY3

Accession

Primary (citable) accession number: Q55593

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1999
Last sequence update:	May 30, 2000
Last modified:	May 29, 2013
This is version 81 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program