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Q55593

- KTHY_SYNY3

UniProt

Q55593 - KTHY_SYNY3

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Protein
Thymidylate kinase
Gene
tmk, slr0379
Organism
Synechocystis sp. (strain PCC 6803 / Kazusa)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis By similarity.UniRule annotation

Catalytic activityi

ATP + dTMP = ADP + dTDP.UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi10 – 178ATP Reviewed prediction

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. thymidylate kinase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. dTDP biosynthetic process Source: InterPro
  2. dTTP biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Nucleotide biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidylate kinase (EC:2.7.4.9)
Alternative name(s):
dTMP kinase
Gene namesi
Name:tmk
Ordered Locus Names:slr0379
OrganismiSynechocystis sp. (strain PCC 6803 / Kazusa)
Taxonomic identifieri1111708 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechocystis
ProteomesiUP000001425: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 212212Thymidylate kinaseUniRule annotation
PRO_0000155358Add
BLAST

Proteomic databases

PaxDbiQ55593.

Interactioni

Protein-protein interaction databases

STRINGi1148.slr0379.

Structurei

3D structure databases

ProteinModelPortaliQ55593.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0125.
KOiK00943.
OMAiVADRYEH.
OrthoDBiEOG64JFSH.
PhylomeDBiQ55593.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00165. Thymidylate_kinase.
InterProiIPR027417. P-loop_NTPase.
IPR018095. Thymidylate_kin_CS.
IPR018094. Thymidylate_kinase.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00041. DTMP_kinase. 1 hit.
PROSITEiPS01331. THYMIDYLATE_KINASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q55593-1 [UniParc]FASTAAdd to Basket

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MAALFIVLEG IDGSGKTTQG DLLLAHFQRQ GLAAVLSPEP TNGPVGRLIR    50
QALQGDLFTY NDARQFEAQM GYLFAADRHY HLYHPGDGVE AKLAQQCHVI 100
TTRYYFSSLA YNCHTEADWE FVQRLNQSFP QPDWVIYLDL PVDLALQRLG 150
DRQQLEDQAP RECYEQREKL ISVHRNYDRI FAHYQGQLCR LDASLPVEQL 200
HQAIITKVEE ML 212
Length:212
Mass (Da):24,350
Last modified:May 30, 2000 - v2
Checksum:iB2EB13A29EDC0F8C
GO

Sequence cautioni

The sequence BAA10099.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000022 Genomic DNA. Translation: BAA10099.1. Different initiation.
PIRiS76121.
RefSeqiNP_442029.1. NC_000911.1.
YP_005652088.1. NC_017277.1.
YP_007451908.1. NC_020286.1.

Genome annotation databases

EnsemblBacteriaiBAA10099; BAA10099; BAA10099.
GeneIDi952738.
KEGGisyn:slr0379.
syy:SYNGTS_2135.
syz:MYO_121550.
PATRICi23841636. VBISynSp132158_2366.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000022 Genomic DNA. Translation: BAA10099.1 . Different initiation.
PIRi S76121.
RefSeqi NP_442029.1. NC_000911.1.
YP_005652088.1. NC_017277.1.
YP_007451908.1. NC_020286.1.

3D structure databases

ProteinModelPortali Q55593.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 1148.slr0379.

Proteomic databases

PaxDbi Q55593.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAA10099 ; BAA10099 ; BAA10099 .
GeneIDi 952738.
KEGGi syn:slr0379.
syy:SYNGTS_2135.
syz:MYO_121550.
PATRICi 23841636. VBISynSp132158_2366.

Phylogenomic databases

eggNOGi COG0125.
KOi K00943.
OMAi VADRYEH.
OrthoDBi EOG64JFSH.
PhylomeDBi Q55593.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
HAMAPi MF_00165. Thymidylate_kinase.
InterProi IPR027417. P-loop_NTPase.
IPR018095. Thymidylate_kin_CS.
IPR018094. Thymidylate_kinase.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
TIGRFAMsi TIGR00041. DTMP_kinase. 1 hit.
PROSITEi PS01331. THYMIDYLATE_KINASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. I. Sequence features in the 1 Mb region from map positions 64% to 92% of the genome."
    Kaneko T., Tanaka A., Sato S., Kotani H., Sazuka T., Miyajima N., Sugiura M., Tabata S.
    DNA Res. 2:153-166(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 27184 / PCC 6803 / N-1.
  2. "Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions."
    Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y., Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T., Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S.
    , Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.
    DNA Res. 3:109-136(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PCC 6803 / Kazusa.

Entry informationi

Entry nameiKTHY_SYNY3
AccessioniPrimary (citable) accession number: Q55593
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: May 30, 2000
Last modified: July 9, 2014
This is version 88 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Synechocystis PCC 6803
    Synechocystis (strain PCC 6803): entries and gene names

External Data

Dasty 3

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