Reviewed, UniProtKB/Swiss-Prot Q55585 (GABD_SYNY3)

Names and origin

Protein names

Recommended name:
    Probable succinate-semialdehyde dehydrogenase [NADP+]
      Short name=SSDH
    EC=1.2.1.16

Gene names

Name:	gabD
Ordered Locus Names:	slr0370

Organism

Synechocystis sp. (strain PCC 6803) [Complete proteome] [HAMAP]

Taxonomic identifier

1148 [NCBI]

Taxonomic lineage

Bacteria › Cyanobacteria › Chroococcales › Synechocystis

Protein attributes

Sequence length	454 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Succinate semialdehyde + NAD(P)+ + H2O = succinate + NAD(P)H.
Pathway	Amino-acid degradation; 4-aminobutanoate degradation.
Sequence similarities	Belongs to the aldehyde dehydrogenase family.

Ontologies

Keywords
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	succinate-semialdehyde dehydrogenase [NAD(P)+] activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 454	454	Probable succinate-semialdehyde dehydrogenase [NADP+]		PRO_0000056574
Regions
	Nucleotide binding	206 – 211	6	NAD or NADP By similarity
Sites
	Active site	228	1	By similarity
	Active site	262	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q55585-1 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: 8785B19AEF376317	FASTA	454	48,749
	10 20 30 40 50 60 MAIATINPAT GQTVQTFIAH SQVEVNAKLD LAQETFQSFR HLPFAQRGQW LRKAADILEQ 70 80 90 100 110 120 RRDEWAALMT LEMGKSIPQA IAEVNKCALV CRFYADKAEE YLADEVVTTD ASQSFIAYQP 130 140 150 160 170 180 LGVILAVMPW NFPFWQVFRF AAPALMAGNV GLLKHASNVP QCALAIAEIF QTAGFPEGAF 190 200 210 220 230 240 QTLLIGGKVA SELMADDRIQ AGTLTGSEPA GASFASAAAG QIKKTVLELG GSDPFIVLED 250 260 270 280 290 300 ADLDQALKVA VPARMQNNGQ SCIAAKRFIV QASVAEEFFQ RLTKAFQALK VGDPSLSTTD 310 320 330 340 350 360 IGPLATPDIL ADIVAQVEQT IAAGAHCRCG GQALDQPGNY YPPTLLTDVP PNAPTYRQEF 370 380 390 400 410 420 FGPVALGFTV DNLEEAIALA NDIPFGLGAS AWTTNPENQQ KLIRGIEAGA VFINGMTKSD 430 440 450 PRIPFGGIKR SGFGRELGRM GILEFVNAKT VWIA

References

[1]

"Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. I. Sequence features in the 1 Mb region from map positions 64% to 92% of the genome." Kaneko T., Tanaka A., Sato S., Kotani H., Sazuka T., Miyajima N., Sugiura M., Tabata S. DNA Res. 2:153-166(1995) [PubMed: 8590279] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

[2]

"Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions." Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y., Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T., Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S. , Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S. DNA Res. 3:109-136(1996) [PubMed: 8905231] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	BA000022 Genomic DNA. Translation: BAA10090.1.
PIR	S76112.
RefSeq	NP_442020.1.
3D structure databases
HSSP	HSSP built from PDB template 1KY8 based on UniProtKB O57693.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q55585. 2 interactions.
Genome annotation databases
GeneID	952057.
GenomeReviews	Gene locus slr0370 in contig BA000022_GR.
KEGG	syn:slr0370.
NMPDR	fig|1148.1.peg.2121.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q55585.
Enzyme and pathway databases
BioCyc	SSP1148:SLR0370-MON.
Family and domain databases
InterPro	IPR016160. Ald_DH_CS. IPR016162. Ald_DH_N. IPR015590. Aldehyde_DH. [Graphical view]
Gene3D	G3DSA:3.40.605.10. Aldehyde_dehydrogenase_N. 1 hit.
PANTHER	PTHR11699. Aldehyde_dehyd. 1 hit.
Pfam	PF00171. Aldedh. 1 hit. [Graphical view]
PROSITE	PS00070. ALDEHYDE_DEHYDR_CYS. False negative. PS00687. ALDEHYDE_DEHYDR_GLU. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GABD_SYNY3

Accession

Primary (citable) accession number: Q55585

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	November 1, 1996
Last modified:	June 16, 2009
This is version 54 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)