Q55585 (GABD_SYNY3) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable succinate-semialdehyde dehydrogenase [NADP(+)]
Short name=SSDH
EC=1.2.1.79

Gene names

Name:	gabD
Ordered Locus Names:	slr0370

Organism

Synechocystis sp. (strain PCC 6803 / Kazusa) [Reference proteome] [HAMAP]

Taxonomic identifier

1111708 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Cyanobacteria › Oscillatoriophycideae › Chroococcales › Synechocystis › Synechocystis sp. PCC 6803

Protein attributes

Sequence length	454 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the NADP+ dependent oxidation of succinate semialdehyde to succinate By similarity.
Catalytic activity	Succinate semialdehyde + NADP+ + H2O = succinate + NADPH.
Pathway	Amino-acid degradation; 4-aminobutanoate degradation.
Sequence similarities	Belongs to the aldehyde dehydrogenase family.

Ontologies

Keywords
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	gamma-aminobutyric acid catabolic process Inferred from electronic annotation. Source: UniProtKB-UniPathway
Molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 454	454	Probable succinate-semialdehyde dehydrogenase [NADP(+)]		PRO_0000056574
Regions
	Nucleotide binding	130 – 131	2	NADP By similarity
	Nucleotide binding	154 – 157	4	NADP By similarity
	Nucleotide binding	206 – 207	2	NADP By similarity
Sites
	Active site	228	1	Proton acceptor By similarity
	Active site	262	1	Nucleophile By similarity
	Binding site	229	1	NADP; via carbonyl oxygen By similarity
	Binding site	359	1	NADP By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q55585 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: 8785B19AEF376317	FASTA	454	48,749
	10 20 30 40 50 60 MAIATINPAT GQTVQTFIAH SQVEVNAKLD LAQETFQSFR HLPFAQRGQW LRKAADILEQ 70 80 90 100 110 120 RRDEWAALMT LEMGKSIPQA IAEVNKCALV CRFYADKAEE YLADEVVTTD ASQSFIAYQP 130 140 150 160 170 180 LGVILAVMPW NFPFWQVFRF AAPALMAGNV GLLKHASNVP QCALAIAEIF QTAGFPEGAF 190 200 210 220 230 240 QTLLIGGKVA SELMADDRIQ AGTLTGSEPA GASFASAAAG QIKKTVLELG GSDPFIVLED 250 260 270 280 290 300 ADLDQALKVA VPARMQNNGQ SCIAAKRFIV QASVAEEFFQ RLTKAFQALK VGDPSLSTTD 310 320 330 340 350 360 IGPLATPDIL ADIVAQVEQT IAAGAHCRCG GQALDQPGNY YPPTLLTDVP PNAPTYRQEF 370 380 390 400 410 420 FGPVALGFTV DNLEEAIALA NDIPFGLGAS AWTTNPENQQ KLIRGIEAGA VFINGMTKSD 430 440 450 PRIPFGGIKR SGFGRELGRM GILEFVNAKT VWIA

References

[1]

"Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. I. Sequence features in the 1 Mb region from map positions 64% to 92% of the genome." Kaneko T., Tanaka A., Sato S., Kotani H., Sazuka T., Miyajima N., Sugiura M., Tabata S. DNA Res. 2:153-166(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 27184 / PCC 6803 / N-1.

[2]

"Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions." Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y., Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T., Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S. , Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S. DNA Res. 3:109-136(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: PCC 6803 / Kazusa.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BA000022 Genomic DNA. Translation: BAA10090.1.
PIR	S76112.
RefSeq	NP_442020.1. NC_000911.1. YP_005652079.1. NC_017277.1. YP_007451899.1. NC_020286.1.
3D structure databases
ProteinModelPortal	Q55585.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q55585. 2 interactions.
STRING	1148.slr0370.
Proteomic databases
PaxDb	Q55585.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	BAA10090; BAA10090; BAA10090.
GeneID	12253291. 14617568. 952057.
KEGG	syn:slr0370. syy:SYNGTS_2126.
PATRIC	23841616. VBISynSp132158_2356.
Phylogenomic databases
eggNOG	COG1012.
HOGENOM	HOG000271513.
KO	K00135.
Enzyme and pathway databases
UniPathway	UPA00733.
Family and domain databases
Gene3D	3.40.309.10. 1 hit. 3.40.605.10. 1 hit.
InterPro	IPR016161. Ald_DH/histidinol_DH. IPR016163. Ald_DH_C. IPR016162. Ald_DH_N. IPR015590. Aldehyde_DH_dom. [Graphical view]
Pfam	PF00171. Aldedh. 1 hit. [Graphical view]
SUPFAM	SSF53720. Aldehyde_DH/Histidinol_DH. 1 hit.
PROSITE	PS00070. ALDEHYDE_DEHYDR_CYS. False negative. PS00687. ALDEHYDE_DEHYDR_GLU. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GABD_SYNY3

Accession

Primary (citable) accession number: Q55585

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	November 1, 1996
Last modified:	May 1, 2013
This is version 83 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program