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Q55585

- GABD_SYNY3

UniProt

Q55585 - GABD_SYNY3

Protein

Probable succinate-semialdehyde dehydrogenase [NADP(+)]

Gene

gabD

Organism
Synechocystis sp. (strain PCC 6803 / Kazusa)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 91 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Catalyzes the NADP+ dependent oxidation of succinate semialdehyde to succinate.By similarity

    Catalytic activityi

    Succinate semialdehyde + NADP+ + H2O = succinate + NADPH.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei228 – 2281Proton acceptorBy similarity
    Binding sitei229 – 2291NADP; via carbonyl oxygenBy similarity
    Active sitei262 – 2621NucleophileBy similarity
    Binding sitei359 – 3591NADPBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi130 – 1312NADPBy similarity
    Nucleotide bindingi154 – 1574NADPBy similarity
    Nucleotide bindingi206 – 2072NADPBy similarity

    GO - Molecular functioni

    1. oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor Source: InterPro

    GO - Biological processi

    1. gamma-aminobutyric acid catabolic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    NADP

    Enzyme and pathway databases

    UniPathwayiUPA00733.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable succinate-semialdehyde dehydrogenase [NADP(+)] (EC:1.2.1.79)
    Short name:
    SSDH
    Gene namesi
    Name:gabD
    Ordered Locus Names:slr0370
    OrganismiSynechocystis sp. (strain PCC 6803 / Kazusa)
    Taxonomic identifieri1111708 [NCBI]
    Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechocystis
    ProteomesiUP000001425: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 454454Probable succinate-semialdehyde dehydrogenase [NADP(+)]PRO_0000056574Add
    BLAST

    Proteomic databases

    PaxDbiQ55585.

    Interactioni

    Protein-protein interaction databases

    IntActiQ55585. 2 interactions.
    STRINGi1148.slr0370.

    Structurei

    3D structure databases

    ProteinModelPortaliQ55585.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the aldehyde dehydrogenase family.Curated

    Phylogenomic databases

    eggNOGiCOG1012.
    HOGENOMiHOG000271513.
    KOiK00135.
    OMAiSHIIENQ.
    OrthoDBiEOG6BS8QW.
    PhylomeDBiQ55585.

    Family and domain databases

    Gene3Di3.40.309.10. 1 hit.
    3.40.605.10. 1 hit.
    InterProiIPR016161. Ald_DH/histidinol_DH.
    IPR016163. Ald_DH_C.
    IPR016162. Ald_DH_N.
    IPR015590. Aldehyde_DH_dom.
    [Graphical view]
    PfamiPF00171. Aldedh. 1 hit.
    [Graphical view]
    SUPFAMiSSF53720. SSF53720. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q55585-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAIATINPAT GQTVQTFIAH SQVEVNAKLD LAQETFQSFR HLPFAQRGQW    50
    LRKAADILEQ RRDEWAALMT LEMGKSIPQA IAEVNKCALV CRFYADKAEE 100
    YLADEVVTTD ASQSFIAYQP LGVILAVMPW NFPFWQVFRF AAPALMAGNV 150
    GLLKHASNVP QCALAIAEIF QTAGFPEGAF QTLLIGGKVA SELMADDRIQ 200
    AGTLTGSEPA GASFASAAAG QIKKTVLELG GSDPFIVLED ADLDQALKVA 250
    VPARMQNNGQ SCIAAKRFIV QASVAEEFFQ RLTKAFQALK VGDPSLSTTD 300
    IGPLATPDIL ADIVAQVEQT IAAGAHCRCG GQALDQPGNY YPPTLLTDVP 350
    PNAPTYRQEF FGPVALGFTV DNLEEAIALA NDIPFGLGAS AWTTNPENQQ 400
    KLIRGIEAGA VFINGMTKSD PRIPFGGIKR SGFGRELGRM GILEFVNAKT 450
    VWIA 454
    Length:454
    Mass (Da):48,749
    Last modified:November 1, 1996 - v1
    Checksum:i8785B19AEF376317
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000022 Genomic DNA. Translation: BAA10090.1.
    PIRiS76112.
    RefSeqiNP_442020.1. NC_000911.1.
    YP_005652079.1. NC_017277.1.
    YP_007451899.1. NC_020286.1.

    Genome annotation databases

    EnsemblBacteriaiBAA10090; BAA10090; BAA10090.
    GeneIDi952057.
    KEGGisyn:slr0370.
    syy:SYNGTS_2126.
    syz:MYO_121460.
    PATRICi23841616. VBISynSp132158_2356.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000022 Genomic DNA. Translation: BAA10090.1 .
    PIRi S76112.
    RefSeqi NP_442020.1. NC_000911.1.
    YP_005652079.1. NC_017277.1.
    YP_007451899.1. NC_020286.1.

    3D structure databases

    ProteinModelPortali Q55585.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q55585. 2 interactions.
    STRINGi 1148.slr0370.

    Proteomic databases

    PaxDbi Q55585.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAA10090 ; BAA10090 ; BAA10090 .
    GeneIDi 952057.
    KEGGi syn:slr0370.
    syy:SYNGTS_2126.
    syz:MYO_121460.
    PATRICi 23841616. VBISynSp132158_2356.

    Phylogenomic databases

    eggNOGi COG1012.
    HOGENOMi HOG000271513.
    KOi K00135.
    OMAi SHIIENQ.
    OrthoDBi EOG6BS8QW.
    PhylomeDBi Q55585.

    Enzyme and pathway databases

    UniPathwayi UPA00733 .

    Family and domain databases

    Gene3Di 3.40.309.10. 1 hit.
    3.40.605.10. 1 hit.
    InterProi IPR016161. Ald_DH/histidinol_DH.
    IPR016163. Ald_DH_C.
    IPR016162. Ald_DH_N.
    IPR015590. Aldehyde_DH_dom.
    [Graphical view ]
    Pfami PF00171. Aldedh. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53720. SSF53720. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. I. Sequence features in the 1 Mb region from map positions 64% to 92% of the genome."
      Kaneko T., Tanaka A., Sato S., Kotani H., Sazuka T., Miyajima N., Sugiura M., Tabata S.
      DNA Res. 2:153-166(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 27184 / PCC 6803 / N-1.
    2. "Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions."
      Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y., Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T., Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S.
      , Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.
      DNA Res. 3:109-136(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: PCC 6803 / Kazusa.

    Entry informationi

    Entry nameiGABD_SYNY3
    AccessioniPrimary (citable) accession number: Q55585
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 91 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families
    3. Synechocystis PCC 6803
      Synechocystis (strain PCC 6803): entries and gene names

    External Data

    Dasty 3