ID   Y328_SYNY3              Reviewed;         157 AA.
AC   Q55535;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 1.
DT   27-MAR-2024, entry version 125.
DE   RecName: Full=Putative low molecular weight protein-tyrosine-phosphatase slr0328;
DE            EC=3.1.3.48;
GN   OrderedLocusNames=slr0328;
OS   Synechocystis sp. (strain PCC 6803 / Kazusa).
OC   Bacteria; Cyanobacteriota; Cyanophyceae; Synechococcales; Merismopediaceae;
OC   Synechocystis.
OX   NCBI_TaxID=1111708;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 27184 / PCC 6803 / N-1;
RX   PubMed=8590279; DOI=10.1093/dnares/2.4.153;
RA   Kaneko T., Tanaka A., Sato S., Kotani H., Sazuka T., Miyajima N.,
RA   Sugiura M., Tabata S.;
RT   "Sequence analysis of the genome of the unicellular cyanobacterium
RT   Synechocystis sp. strain PCC6803. I. Sequence features in the 1 Mb region
RT   from map positions 64% to 92% of the genome.";
RL   DNA Res. 2:153-166(1995).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PCC 6803 / Kazusa;
RX   PubMed=8905231; DOI=10.1093/dnares/3.3.109;
RA   Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y.,
RA   Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T.,
RA   Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S.,
RA   Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.;
RT   "Sequence analysis of the genome of the unicellular cyanobacterium
RT   Synechocystis sp. strain PCC6803. II. Sequence determination of the entire
RT   genome and assignment of potential protein-coding regions.";
RL   DNA Res. 3:109-136(1996).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] +
CC         phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC         COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858,
CC         ChEBI:CHEBI:82620; EC=3.1.3.48;
CC   -!- SIMILARITY: Belongs to the low molecular weight phosphotyrosine protein
CC       phosphatase family. {ECO:0000305}.
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DR   EMBL; BA000022; BAA10030.1; -; Genomic_DNA.
DR   PIR; S76052; S76052.
DR   PDB; 5O7B; X-ray; 2.28 A; A=2-157.
DR   PDBsum; 5O7B; -.
DR   AlphaFoldDB; Q55535; -.
DR   SMR; Q55535; -.
DR   STRING; 1148.gene:10499522; -.
DR   PaxDb; 1148-1001408; -.
DR   EnsemblBacteria; BAA10030; BAA10030; BAA10030.
DR   KEGG; syn:slr0328; -.
DR   eggNOG; COG0394; Bacteria.
DR   InParanoid; Q55535; -.
DR   PhylomeDB; Q55535; -.
DR   Proteomes; UP000001425; Chromosome.
DR   GO; GO:0004725; F:protein tyrosine phosphatase activity; IBA:GO_Central.
DR   CDD; cd16343; LMWPTP; 1.
DR   Gene3D; 3.40.50.2300; -; 1.
DR   InterPro; IPR023485; Ptyr_pPase.
DR   InterPro; IPR036196; Ptyr_pPase_sf.
DR   InterPro; IPR017867; Tyr_phospatase_low_mol_wt.
DR   PANTHER; PTHR47439:SF1; ACID PHOSPHATASE; 1.
DR   PANTHER; PTHR47439; LOW MOLECULAR WEIGHT PHOSPHOTYROSINE PROTEIN PHOSPHATASE-RELATED; 1.
DR   Pfam; PF01451; LMWPc; 1.
DR   PRINTS; PR00719; LMWPTPASE.
DR   SMART; SM00226; LMWPc; 1.
DR   SUPFAM; SSF52788; Phosphotyrosine protein phosphatases I; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Hydrolase; Protein phosphatase; Reference proteome.
FT   CHAIN           1..157
FT                   /note="Putative low molecular weight protein-tyrosine-
FT                   phosphatase slr0328"
FT                   /id="PRO_0000046581"
FT   ACT_SITE        7
FT                   /note="Nucleophile"
FT                   /evidence="ECO:0000250|UniProtKB:P11064"
FT   ACT_SITE        13
FT                   /evidence="ECO:0000250|UniProtKB:P11064"
FT   ACT_SITE        124
FT                   /note="Proton donor"
FT                   /evidence="ECO:0000250|UniProtKB:P11064"
FT   STRAND          4..12
FT                   /evidence="ECO:0007829|PDB:5O7B"
FT   HELIX           13..24
FT                   /evidence="ECO:0007829|PDB:5O7B"
FT   STRAND          37..41
FT                   /evidence="ECO:0007829|PDB:5O7B"
FT   TURN            44..47
FT                   /evidence="ECO:0007829|PDB:5O7B"
FT   HELIX           52..55
FT                   /evidence="ECO:0007829|PDB:5O7B"
FT   STRAND          85..87
FT                   /evidence="ECO:0007829|PDB:5O7B"
FT   HELIX           88..91
FT                   /evidence="ECO:0007829|PDB:5O7B"
FT   HELIX           130..143
FT                   /evidence="ECO:0007829|PDB:5O7B"
SQ   SEQUENCE   157 AA;  17470 MW;  D642D8E6D3A49751 CRC64;
     MKLLFVCLGN ICRSPAAENI MNAQIDQAGL GAKIVCDSAG TSSYHVGDSP DRRMTESLKK
     RGYRVQGRAR QFFPEDFAEF DLILAMDGDN YRNILAQDPA GQYHHKVKMI CDYTEKFGDR
     EVPDPYYGGQ AGFEHVIDLL EDACGNLLTS LGKELVN
//