Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Ornithine carbamoyltransferase

Gene

argF

Organism
Synechocystis sp. (strain PCC 6803 / Kazusa)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline.By similarity

Catalytic activityi

Carbamoyl phosphate + L-ornithine = phosphate + L-citrulline.

Pathwayi: L-arginine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes L-arginine from L-ornithine and carbamoyl phosphate.
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Ornithine carbamoyltransferase (argF)
  2. Argininosuccinate synthase (argG)
  3. Argininosuccinate lyase (argH)
This subpathway is part of the pathway L-arginine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-arginine from L-ornithine and carbamoyl phosphate, the pathway L-arginine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei80Carbamoyl phosphateUniRule annotation1
Binding sitei104Carbamoyl phosphateUniRule annotation1
Binding sitei162OrnithineUniRule annotation1
Binding sitei225OrnithineUniRule annotation1
Binding sitei293Carbamoyl phosphateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processAmino-acid biosynthesis, Arginine biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00068; UER00112.

Names & Taxonomyi

Protein namesi
Recommended name:
Ornithine carbamoyltransferase (EC:2.1.3.3)
Short name:
OTCase
Gene namesi
Name:argF
Ordered Locus Names:sll0902
OrganismiSynechocystis sp. (strain PCC 6803 / Kazusa)
Taxonomic identifieri1111708 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaSynechococcalesMerismopediaceaeSynechocystis
Proteomesi
  • UP000001425 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001130481 – 308Ornithine carbamoyltransferaseAdd BLAST308

Proteomic databases

PRIDEiQ55497.

Interactioni

Protein-protein interaction databases

IntActiQ55497. 2 interactors.
STRINGi1148.SYNGTS_2884.

Structurei

3D structure databases

ProteinModelPortaliQ55497.
SMRiQ55497.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni53 – 56Carbamoyl phosphate bindingUniRule annotation4
Regioni131 – 134Carbamoyl phosphate bindingUniRule annotation4
Regioni229 – 230Ornithine bindingUniRule annotation2
Regioni265 – 266Carbamoyl phosphate bindingUniRule annotation2

Sequence similaritiesi

Belongs to the ATCase/OTCase family.Curated

Phylogenomic databases

HOGENOMiHOG000022686.
InParanoidiQ55497.
KOiK00611.
OMAiHPMFLGK.
PhylomeDBiQ55497.

Family and domain databases

Gene3Di3.40.50.1370. 2 hits.
HAMAPiMF_01109. OTCase. 1 hit.
InterProiView protein in InterPro
IPR006132. Asp/Orn_carbamoyltranf_P-bd.
IPR006130. Asp/Orn_carbamoylTrfase.
IPR006131. Asp_carbamoyltransf_Asp/Orn-bd.
IPR002292. Orn/put_carbamltrans.
IPR024904. OTCase_ArgI.
PfamiView protein in Pfam
PF00185. OTCace. 1 hit.
PF02729. OTCace_N. 1 hit.
PRINTSiPR00100. AOTCASE.
PR00102. OTCASE.
SUPFAMiSSF53671. SSF53671. 1 hit.
TIGRFAMsiTIGR00658. orni_carb_tr. 1 hit.
PROSITEiView protein in PROSITE
PS00097. CARBAMOYLTRANSFERASE. 1 hit.

Sequencei

Sequence statusi: Complete.

Q55497-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGIKALAGRD LLAIADLTIE EMKSLLQLAA DLKSGVLKPH CRKILGLLFY
60 70 80 90 100
KASTRTRVSF TAAMYQLGGQ VLDLNPSVTQ VGRGEPIQDT ARVLDRYIDI
110 120 130 140 150
LAVRTFKQTD LQTFADHAKM PIINALSDLE HPCQILADLQ TIKECFGKLE
160 170 180 190 200
GLTVTYLGDG NNVAHSLILG GVMMGMTVRV ATPKNYEPLA EIVQQAQQIA
210 220 230 240 250
APGGKVELTD DPKAAAQGSH ILYTDVWASM GQEDLADSRI PIFQPYQINQ
260 270 280 290 300
ELLALADPEA IVLHCLPAHR GEEITDAVME GPQSRLWDQA ENRMHAQKAL

MVALLGLV
Length:308
Mass (Da):33,616
Last modified:November 1, 1996 - v1
Checksum:iC6CD2E4998592CFA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000022 Genomic DNA. Translation: BAA10847.1.
PIRiS76000.

Genome annotation databases

EnsemblBacteriaiBAA10847; BAA10847; BAA10847.
KEGGisyn:sll0902.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiOTC_SYNY3
AccessioniPrimary (citable) accession number: Q55497
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: July 5, 2017
This is version 124 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
  3. Synechocystis PCC 6803
    Synechocystis (strain PCC 6803): entries and gene names