Q55497 (OTC_SYNY3) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ornithine carbamoyltransferase
Short name=OTCase
EC=2.1.3.3

Gene names

Name:	argF
Ordered Locus Names:	sll0902

Organism

Synechocystis sp. (strain PCC 6803 / Kazusa)

Taxonomic identifier

1111708 [NCBI]

Taxonomic lineage

Bacteria › Cyanobacteria › Chroococcales › Synechocystis

Protein attributes

Sequence length	308 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Carbamoyl phosphate + L-ornithine = phosphate + L-citrulline. HAMAP MF_01109
Pathway	Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 1/3. HAMAP MF_01109
Subcellular location	Cytoplasm Probable HAMAP MF_01109.
Sequence similarities	Belongs to the ATCase/OTCase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Arginine biosynthesis
Cellular component	Cytoplasm
Molecular function	Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	arginine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	ornithine carbamoyltransferase complex Inferred from electronic annotation. Source: InterPro
Molecular function	amino acid binding Inferred from electronic annotation. Source: InterPro ornithine carbamoyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 308	308	Ornithine carbamoyltransferase HAMAP MF_01109		PRO_0000113048
Regions
	Region	53 – 57	5	Carbamoyl phosphate binding By similarity
	Region	264 – 267	4	Ornithine binding By similarity
Sites
	Binding site	104	1	Carbamoyl phosphate By similarity
	Binding site	131	1	Carbamoyl phosphate By similarity
	Site	33	1	Important for structural integrity By similarity
	Site	144	1	Important for structural integrity By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q55497 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: C6CD2E4998592CFA	FASTA	308	33,616
	10 20 30 40 50 60 MGIKALAGRD LLAIADLTIE EMKSLLQLAA DLKSGVLKPH CRKILGLLFY KASTRTRVSF 70 80 90 100 110 120 TAAMYQLGGQ VLDLNPSVTQ VGRGEPIQDT ARVLDRYIDI LAVRTFKQTD LQTFADHAKM 130 140 150 160 170 180 PIINALSDLE HPCQILADLQ TIKECFGKLE GLTVTYLGDG NNVAHSLILG GVMMGMTVRV 190 200 210 220 230 240 ATPKNYEPLA EIVQQAQQIA APGGKVELTD DPKAAAQGSH ILYTDVWASM GQEDLADSRI 250 260 270 280 290 300 PIFQPYQINQ ELLALADPEA IVLHCLPAHR GEEITDAVME GPQSRLWDQA ENRMHAQKAL MVALLGLV

References

[1]	"Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. I. Sequence features in the 1 Mb region from map positions 64% to 92% of the genome." Kaneko T., Tanaka A., Sato S., Kotani H., Sazuka T., Miyajima N., Sugiura M., Tabata S. DNA Res. 2:153-166(1995) [PubMed: 8590279] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 27184 / PCC 6803 / N-1.
[2]	"Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions." Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y., Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T., Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S. , Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S. DNA Res. 3:109-136(1996) [PubMed: 8905231] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 27184 / PCC 6803 / N-1.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BA000022 Genomic DNA. Translation: BAA10847.1.
PIR	S76000.
RefSeq	NP_442776.1. NC_000911.1.
3D structure databases
ProteinModelPortal	Q55497.
SMR	Q55497. Positions 8-306.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q55497. 2 interactions.
STRING	Q55497.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	953251.
GenomeReviews	Gene locus sll0902 in contig BA000022_GR.
KEGG	syn:sll0902.
NMPDR	fig|1148.1.peg.2877.
PATRIC	23843314. VBISynSp132158_3193.
Phylogenomic databases
eggNOG	COG0078.
HOGENOM	HBG579429.
OMA	KHLLSIK.
PhylomeDB	Q55497.
ProtClustDB	PRK00779.
Enzyme and pathway databases
BioCyc	SSP1148:SLL0902-MONOMER.
Family and domain databases
HAMAP	MF_01109. OTCase. [Tree]
InterPro	IPR006132. Asp/Orn_carbamoyltranf_P-bd. IPR006130. Asp/Orn_carbamoylTrfase. IPR006131. Asp_carbamoyltransf_Asp/Orn-bd. IPR002292. Orn/put_carbamltrans. IPR024904. Orn_carbamltrans. [Graphical view]
KO	K00611.
Pfam	PF00185. OTCace. 1 hit. PF02729. OTCace_N. 1 hit. [Graphical view]
PRINTS	PR00100. AOTCASE. PR00102. OTCASE.
SUPFAM	SSF53671. Asp/Orn_carbamoyltranf. 1 hit.
TIGRFAMs	TIGR00658. Orni_carb_tr. 1 hit.
PROSITE	PS00097. CARBAMOYLTRANSFERASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

OTC_SYNY3

Accession

Primary (citable) accession number: Q55497

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
Last sequence update:	November 1, 1996
Last modified:	January 25, 2012
This is version 82 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program