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Protein

Ornithine carbamoyltransferase

Gene

argF

Organism
Synechocystis sp. (strain PCC 6803 / Kazusa)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline.By similarity

Catalytic activityi

Carbamoyl phosphate + L-ornithine = phosphate + L-citrulline.

Pathwayi: L-arginine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes L-arginine from L-ornithine and carbamoyl phosphate.
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Ornithine carbamoyltransferase (argF)
  2. Argininosuccinate synthase (argG)
  3. Argininosuccinate lyase (argH)
This subpathway is part of the pathway L-arginine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-arginine from L-ornithine and carbamoyl phosphate, the pathway L-arginine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei80Carbamoyl phosphateUniRule annotation1
Binding sitei104Carbamoyl phosphateUniRule annotation1
Binding sitei162OrnithineUniRule annotation1
Binding sitei225OrnithineUniRule annotation1
Binding sitei293Carbamoyl phosphateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processAmino-acid biosynthesis, Arginine biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00068; UER00112

Names & Taxonomyi

Protein namesi
Recommended name:
Ornithine carbamoyltransferase (EC:2.1.3.3)
Short name:
OTCase
Gene namesi
Name:argF
Ordered Locus Names:sll0902
OrganismiSynechocystis sp. (strain PCC 6803 / Kazusa)
Taxonomic identifieri1111708 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaSynechococcalesMerismopediaceaeSynechocystis
Proteomesi
  • UP000001425 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001130481 – 308Ornithine carbamoyltransferaseAdd BLAST308

Proteomic databases

PaxDbiQ55497
PRIDEiQ55497

Interactioni

Protein-protein interaction databases

IntActiQ55497, 2 interactors
STRINGi1148.SYNGTS_2884

Structurei

3D structure databases

ProteinModelPortaliQ55497
SMRiQ55497
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni53 – 56Carbamoyl phosphate bindingUniRule annotation4
Regioni131 – 134Carbamoyl phosphate bindingUniRule annotation4
Regioni229 – 230Ornithine bindingUniRule annotation2
Regioni265 – 266Carbamoyl phosphate bindingUniRule annotation2

Sequence similaritiesi

Belongs to the ATCase/OTCase family.Curated

Phylogenomic databases

HOGENOMiHOG000022686
InParanoidiQ55497
KOiK00611
OMAiDGNNVCN
PhylomeDBiQ55497

Family and domain databases

Gene3Di3.40.50.1370, 3 hits
HAMAPiMF_01109 OTCase, 1 hit
InterProiView protein in InterPro
IPR006132 Asp/Orn_carbamoyltranf_P-bd
IPR006130 Asp/Orn_carbamoylTrfase
IPR036901 Asp/Orn_carbamoylTrfase_sf
IPR006131 Asp_carbamoyltransf_Asp/Orn-bd
IPR002292 Orn/put_carbamltrans
IPR024904 OTCase_ArgI
PfamiView protein in Pfam
PF00185 OTCace, 1 hit
PF02729 OTCace_N, 1 hit
PRINTSiPR00100 AOTCASE
PR00102 OTCASE
SUPFAMiSSF53671 SSF53671, 1 hit
TIGRFAMsiTIGR00658 orni_carb_tr, 1 hit
PROSITEiView protein in PROSITE
PS00097 CARBAMOYLTRANSFERASE, 1 hit

Sequencei

Sequence statusi: Complete.

Q55497-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGIKALAGRD LLAIADLTIE EMKSLLQLAA DLKSGVLKPH CRKILGLLFY
60 70 80 90 100
KASTRTRVSF TAAMYQLGGQ VLDLNPSVTQ VGRGEPIQDT ARVLDRYIDI
110 120 130 140 150
LAVRTFKQTD LQTFADHAKM PIINALSDLE HPCQILADLQ TIKECFGKLE
160 170 180 190 200
GLTVTYLGDG NNVAHSLILG GVMMGMTVRV ATPKNYEPLA EIVQQAQQIA
210 220 230 240 250
APGGKVELTD DPKAAAQGSH ILYTDVWASM GQEDLADSRI PIFQPYQINQ
260 270 280 290 300
ELLALADPEA IVLHCLPAHR GEEITDAVME GPQSRLWDQA ENRMHAQKAL

MVALLGLV
Length:308
Mass (Da):33,616
Last modified:November 1, 1996 - v1
Checksum:iC6CD2E4998592CFA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000022 Genomic DNA Translation: BAA10847.1
PIRiS76000

Genome annotation databases

EnsemblBacteriaiBAA10847; BAA10847; BAA10847
KEGGisyn:sll0902

Similar proteinsi

Entry informationi

Entry nameiOTC_SYNY3
AccessioniPrimary (citable) accession number: Q55497
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: March 28, 2018
This is version 128 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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