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Protein

Magnesium-protoporphyrin O-methyltransferase

Gene

chlM

Organism
Synechocystis sp. (strain PCC 6803 / Kazusa)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Converts Mg-protoporphyrin IX to Mg-protoporphyrin IX methylester using S-adenosyl-L-methionine as a cofactor.

Catalytic activityi

S-adenosyl-L-methionine + magnesium protoporphyrin IX = S-adenosyl-L-homocysteine + magnesium protoporphyrin IX 13-methyl ester.PROSITE-ProRule annotation

Pathwayi: chlorophyll biosynthesis (light-independent)

This protein is involved in the pathway chlorophyll biosynthesis (light-independent), which is part of Porphyrin-containing compound metabolism.
View all proteins of this organism that are known to be involved in the pathway chlorophyll biosynthesis (light-independent) and in Porphyrin-containing compound metabolism.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

Chlorophyll biosynthesis, Photosynthesis

Keywords - Ligandi

S-adenosyl-L-methionine

Enzyme and pathway databases

SABIO-RKQ55467.
UniPathwayiUPA00670.

Names & Taxonomyi

Protein namesi
Recommended name:
Magnesium-protoporphyrin O-methyltransferase (EC:2.1.1.11)
Alternative name(s):
Magnesium-protoporphyrin IX methyltransferase
Gene namesi
Name:chlM
Ordered Locus Names:slr0525
OrganismiSynechocystis sp. (strain PCC 6803 / Kazusa)
Taxonomic identifieri1111708 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaSynechococcalesMerismopediaceaeSynechocystis
Proteomesi
  • UP000001425 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002044211 – 230Magnesium-protoporphyrin O-methyltransferaseAdd BLAST230

Proteomic databases

PRIDEiQ55467.

Interactioni

Protein-protein interaction databases

IntActiQ55467. 4 interactors.

Structurei

Secondary structure

1230
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi8 – 16Combined sources9
Helixi19 – 27Combined sources9
Beta strandi29 – 31Combined sources3
Helixi35 – 58Combined sources24
Beta strandi65 – 69Combined sources5
Turni72 – 76Combined sources5
Helixi77 – 82Combined sources6
Beta strandi86 – 92Combined sources7
Helixi94 – 108Combined sources15
Beta strandi115 – 118Combined sources4
Helixi121 – 123Combined sources3
Beta strandi128 – 133Combined sources6
Helixi137 – 139Combined sources3
Helixi142 – 155Combined sources14
Beta strandi156 – 164Combined sources9
Helixi169 – 178Combined sources10
Helixi195 – 204Combined sources10
Beta strandi207 – 216Combined sources10
Beta strandi221 – 229Combined sources9

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4QDJX-ray1.60A1-230[»]
4QDKX-ray1.70A/B1-230[»]
ProteinModelPortaliQ55467.
SMRiQ55467.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. Magnesium protoporphyrin O-methyltransferase family.PROSITE-ProRule annotation

Phylogenomic databases

HOGENOMiHOG000154343.
InParanoidiQ55467.
KOiK03428.
OMAiLDVFIHY.
PhylomeDBiQ55467.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
InterProiIPR010251. Mg_prot_MeTrfase.
IPR010940. Mg_prot_MeTrfase_C.
IPR029063. SAM-dependent_MTases.
[Graphical view]
PfamiPF07109. Mg-por_mtran_C. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
TIGRFAMsiTIGR02021. BchM-ChlM. 1 hit.
PROSITEiPS51556. SAM_MT_MG_PIX. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q55467-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTNAALDDKT IVRDYFNSTG FDRWRRIYGD GQVNFVQKDI RVGHQQTVDS
60 70 80 90 100
VVAWLVADGN LPGLLVCDAG CGVGSLSIPL AQAGALVYGS DISEKMVGEA
110 120 130 140 150
QQKAQEVLAY GNQPTFMTQD LAQLGGKYDT VICLDVLIHY PTEEASAMIS
160 170 180 190 200
HLASLADRRL ILSFAPKTLG LTVLKKIGGL FPGPSKTTRA YQHKEADIRK
210 220 230
ILGDNGFSIA RTGMTSTRFY YSRILEAVRS
Length:230
Mass (Da):25,081
Last modified:November 1, 1996 - v1
Checksum:i166D72CF3DD178A0
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti190A → V in AAA85380 (PubMed:8704138).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L47126 Genomic DNA. Translation: AAA85380.1.
BA000022 Genomic DNA. Translation: BAA10812.1.
PIRiS71781.

Genome annotation databases

EnsemblBacteriaiBAA10812; BAA10812; BAA10812.
KEGGisyn:slr0525.
PATRICi23843234. VBISynSp132158_3155.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L47126 Genomic DNA. Translation: AAA85380.1.
BA000022 Genomic DNA. Translation: BAA10812.1.
PIRiS71781.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4QDJX-ray1.60A1-230[»]
4QDKX-ray1.70A/B1-230[»]
ProteinModelPortaliQ55467.
SMRiQ55467.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ55467. 4 interactors.

Proteomic databases

PRIDEiQ55467.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAA10812; BAA10812; BAA10812.
KEGGisyn:slr0525.
PATRICi23843234. VBISynSp132158_3155.

Phylogenomic databases

HOGENOMiHOG000154343.
InParanoidiQ55467.
KOiK03428.
OMAiLDVFIHY.
PhylomeDBiQ55467.

Enzyme and pathway databases

UniPathwayiUPA00670.
SABIO-RKQ55467.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
InterProiIPR010251. Mg_prot_MeTrfase.
IPR010940. Mg_prot_MeTrfase_C.
IPR029063. SAM-dependent_MTases.
[Graphical view]
PfamiPF07109. Mg-por_mtran_C. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
TIGRFAMsiTIGR02021. BchM-ChlM. 1 hit.
PROSITEiPS51556. SAM_MT_MG_PIX. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCHLM_SYNY3
AccessioniPrimary (citable) accession number: Q55467
Secondary accession number(s): Q55344
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 14, 2001
Last sequence update: November 1, 1996
Last modified: November 2, 2016
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
  4. Synechocystis PCC 6803
    Synechocystis (strain PCC 6803): entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.