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Q553V1

- CISYM_DICDI

UniProt

Q553V1 - CISYM_DICDI

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Protein
Citrate synthase, mitochondrial
Gene
cs, DDB_G0275311
Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

Acetyl-CoA + H2O + oxaloacetate = citrate + CoA.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei292 – 2921 By similarity
Active sitei339 – 3391 By similarity
Active sitei394 – 3941 By similarity

GO - Molecular functioni

  1. citrate (Si)-synthase activity Source: dictyBase

GO - Biological processi

  1. cellular carbohydrate metabolic process Source: InterPro
  2. response to reactive oxygen species Source: dictyBase
  3. tricarboxylic acid cycle Source: dictyBase
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Tricarboxylic acid cycle

Enzyme and pathway databases

UniPathwayiUPA00223; UER00717.

Names & Taxonomyi

Protein namesi
Recommended name:
Citrate synthase, mitochondrial (EC:2.3.3.16)
Gene namesi
Name:cs
ORF Names:DDB_G0275311
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
ProteomesiUP000002195: Chromosome 2, UP000002195: Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0275311.

Subcellular locationi

Mitochondrion matrix By similarity

GO - Cellular componenti

  1. mitochondrial matrix Source: UniProtKB-SubCell
  2. phagocytic vesicle Source: dictyBase
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 2525Mitochondrion Reviewed prediction
Add
BLAST
Chaini26 – 460435Citrate synthase, mitochondrial
PRO_0000327624Add
BLAST

Proteomic databases

PRIDEiQ553V1.

Interactioni

Protein-protein interaction databases

STRINGi44689.DDB_0220638.

Structurei

3D structure databases

ProteinModelPortaliQ553V1.
SMRiQ553V1. Positions 19-455.

Family & Domainsi

Sequence similaritiesi

Belongs to the citrate synthase family.

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG0372.
KOiK01647.
OMAiELIYEDC.
PhylomeDBiQ553V1.

Family and domain databases

Gene3Di1.10.580.10. 1 hit.
InterProiIPR016142. Citrate_synth-like_lrg_a-sub.
IPR002020. Citrate_synthase-like.
IPR016141. Citrate_synthase-like_core.
IPR019810. Citrate_synthase_AS.
IPR010109. Citrate_synthase_euk.
[Graphical view]
PANTHERiPTHR11739. PTHR11739. 1 hit.
PfamiPF00285. Citrate_synt. 1 hit.
[Graphical view]
PRINTSiPR00143. CITRTSNTHASE.
SUPFAMiSSF48256. SSF48256. 1 hit.
TIGRFAMsiTIGR01793. cit_synth_euk. 1 hit.
PROSITEiPS00480. CITRATE_SYNTHASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q553V1-1 [UniParc]FASTAAdd to Basket

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MFARLARANY LKNSGRYFST EPTLKERLVQ IIPGKIEQVK QLKTEHGDKI    50
IGTCTVAQAY GGMRSVKSLV TETSSLDPEE GIRFRGLTIP ECQEKLPKAP 100
GGAEPLPEGI LWLLLTGEVP TESQVKTLSK DLAKRAGLPK HVTSMIKAFP 150
EQMHPMSQLA AAILALQGES KFVKAYNDGV KKDKYWESTL EDSLDVIAKL 200
PEVAALIYQN TYKKSDITHK IDENLDWSAN FNRMLGYTSK DFDELMRLYL 250
TIHTDHEGGN VSAHTTHLVG SALSDSYLSL SAGMCGLAGP LHGLANQEVL 300
SWTMKLQEKL GNKEVSNEVL SEAIWEGLNA GRVVPGFGHA VLRKTDPRYT 350
CQREFALKHL PQDPLFKLVS QIYEVVPDIL TKHGKTKNPY PNVDAHSGCL 400
LQYYGLKEHN FYTVLFGVSR AIGVLSSLVW DRILGHPIER PKSVTTEWIS 450
SYVNSDQSKK 460
Length:460
Mass (Da):51,209
Last modified:May 24, 2005 - v1
Checksum:iD18EFF2775762E52
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAFI02000013 Genomic DNA. Translation: EAL69936.1.
RefSeqiXP_643860.1. XM_638768.1.

Genome annotation databases

EnsemblProtistsiDDB0220638; DDB0220638; DDB_G0275311.
GeneIDi8619911.
KEGGiddi:DDB_G0275311.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAFI02000013 Genomic DNA. Translation: EAL69936.1 .
RefSeqi XP_643860.1. XM_638768.1.

3D structure databases

ProteinModelPortali Q553V1.
SMRi Q553V1. Positions 19-455.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 44689.DDB_0220638.

Proteomic databases

PRIDEi Q553V1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblProtistsi DDB0220638 ; DDB0220638 ; DDB_G0275311 .
GeneIDi 8619911.
KEGGi ddi:DDB_G0275311.

Organism-specific databases

dictyBasei DDB_G0275311.

Phylogenomic databases

eggNOGi COG0372.
KOi K01647.
OMAi ELIYEDC.
PhylomeDBi Q553V1.

Enzyme and pathway databases

UniPathwayi UPA00223 ; UER00717 .

Miscellaneous databases

PROi Q553V1.

Family and domain databases

Gene3Di 1.10.580.10. 1 hit.
InterProi IPR016142. Citrate_synth-like_lrg_a-sub.
IPR002020. Citrate_synthase-like.
IPR016141. Citrate_synthase-like_core.
IPR019810. Citrate_synthase_AS.
IPR010109. Citrate_synthase_euk.
[Graphical view ]
PANTHERi PTHR11739. PTHR11739. 1 hit.
Pfami PF00285. Citrate_synt. 1 hit.
[Graphical view ]
PRINTSi PR00143. CITRTSNTHASE.
SUPFAMi SSF48256. SSF48256. 1 hit.
TIGRFAMsi TIGR01793. cit_synth_euk. 1 hit.
PROSITEi PS00480. CITRATE_SYNTHASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AX4.
  2. "The genome of the social amoeba Dictyostelium discoideum."
    Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N.
    , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
    Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AX4.

Entry informationi

Entry nameiCISYM_DICDI
AccessioniPrimary (citable) accession number: Q553V1
Secondary accession number(s): Q86I73
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: May 24, 2005
Last modified: September 3, 2014
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Miscellaneous

Citrate synthase is found in nearly all cells capable of oxidative metabolism.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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