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Protein

Citrate synthase, mitochondrial

Gene

cs

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Miscellaneous

Citrate synthase is found in nearly all cells capable of oxidative metabolism.

Catalytic activityi

Acetyl-CoA + H2O + oxaloacetate = citrate + CoA.PROSITE-ProRule annotation

Pathwayi: tricarboxylic acid cycle

This protein is involved in step 1 of the subpathway that synthesizes isocitrate from oxaloacetate.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Citrate synthase, mitochondrial (cs), Citrate synthase (gltA), Citrate synthase, peroxisomal (cshA)
  2. Probable aconitate hydratase, mitochondrial (aco2)
This subpathway is part of the pathway tricarboxylic acid cycle, which is itself part of Carbohydrate metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes isocitrate from oxaloacetate, the pathway tricarboxylic acid cycle and in Carbohydrate metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei292PROSITE-ProRule annotation1
Active sitei339PROSITE-ProRule annotation1
Active sitei394PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processTricarboxylic acid cycle

Enzyme and pathway databases

ReactomeiR-DDI-71403 Citric acid cycle (TCA cycle)
UniPathwayiUPA00223; UER00717

Names & Taxonomyi

Protein namesi
Recommended name:
Citrate synthase, mitochondrial (EC:2.3.3.16)
Gene namesi
Name:cs
ORF Names:DDB_G0275311
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyostelidsDictyostelialesDictyosteliaceaeDictyostelium
Proteomesi
  • UP000002195 Componentsi: Chromosome 2, Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0275311

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 25MitochondrionSequence analysisAdd BLAST25
ChainiPRO_000032762426 – 460Citrate synthase, mitochondrialAdd BLAST435

Proteomic databases

PaxDbiQ553V1

Interactioni

Protein-protein interaction databases

STRINGi44689.DDB0220638

Structurei

3D structure databases

ProteinModelPortaliQ553V1
SMRiQ553V1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the citrate synthase family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG2617 Eukaryota
COG0372 LUCA
InParanoidiQ553V1
KOiK01647
OMAiTVGWCAQ
PhylomeDBiQ553V1

Family and domain databases

Gene3Di1.10.230.10, 1 hit
1.10.580.10, 2 hits
InterProiView protein in InterPro
IPR016142 Citrate_synth-like_lrg_a-sub
IPR016143 Citrate_synth-like_sm_a-sub
IPR002020 Citrate_synthase
IPR019810 Citrate_synthase_AS
IPR010109 Citrate_synthase_euk
IPR036969 Citrate_synthase_sf
PANTHERiPTHR11739 PTHR11739, 1 hit
PfamiView protein in Pfam
PF00285 Citrate_synt, 1 hit
PRINTSiPR00143 CITRTSNTHASE
SUPFAMiSSF48256 SSF48256, 1 hit
TIGRFAMsiTIGR01793 cit_synth_euk, 1 hit
PROSITEiView protein in PROSITE
PS00480 CITRATE_SYNTHASE, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q553V1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFARLARANY LKNSGRYFST EPTLKERLVQ IIPGKIEQVK QLKTEHGDKI
60 70 80 90 100
IGTCTVAQAY GGMRSVKSLV TETSSLDPEE GIRFRGLTIP ECQEKLPKAP
110 120 130 140 150
GGAEPLPEGI LWLLLTGEVP TESQVKTLSK DLAKRAGLPK HVTSMIKAFP
160 170 180 190 200
EQMHPMSQLA AAILALQGES KFVKAYNDGV KKDKYWESTL EDSLDVIAKL
210 220 230 240 250
PEVAALIYQN TYKKSDITHK IDENLDWSAN FNRMLGYTSK DFDELMRLYL
260 270 280 290 300
TIHTDHEGGN VSAHTTHLVG SALSDSYLSL SAGMCGLAGP LHGLANQEVL
310 320 330 340 350
SWTMKLQEKL GNKEVSNEVL SEAIWEGLNA GRVVPGFGHA VLRKTDPRYT
360 370 380 390 400
CQREFALKHL PQDPLFKLVS QIYEVVPDIL TKHGKTKNPY PNVDAHSGCL
410 420 430 440 450
LQYYGLKEHN FYTVLFGVSR AIGVLSSLVW DRILGHPIER PKSVTTEWIS
460
SYVNSDQSKK
Length:460
Mass (Da):51,209
Last modified:May 24, 2005 - v1
Checksum:iD18EFF2775762E52
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000013 Genomic DNA Translation: EAL69936.1
RefSeqiXP_643860.1, XM_638768.1

Genome annotation databases

EnsemblProtistsiEAL69936; EAL69936; DDB_G0275311
GeneIDi8619911
KEGGiddi:DDB_G0275311

Similar proteinsi

Entry informationi

Entry nameiCISYM_DICDI
AccessioniPrimary (citable) accession number: Q553V1
Secondary accession number(s): Q86I73
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: May 24, 2005
Last modified: April 25, 2018
This is version 83 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health