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Protein

26S proteasome non-ATPase regulatory subunit 4

Gene

psmD4

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Binds and presumably selects ubiquitin-conjugates for destruction.By similarity

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-DDI-1236978 Cross-presentation of soluble exogenous antigens (endosomes)
R-DDI-174084 Autodegradation of Cdh1 by Cdh1:APC/C
R-DDI-174113 SCF-beta-TrCP mediated degradation of Emi1
R-DDI-174178 APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
R-DDI-174184 Cdc20:Phospho-APC/C mediated degradation of Cyclin A
R-DDI-349425 Autodegradation of the E3 ubiquitin ligase COP1
R-DDI-382556 ABC-family proteins mediated transport
R-DDI-450408 AUF1 (hnRNP D0) binds and destabilizes mRNA
R-DDI-5632684 Hedgehog 'on' state
R-DDI-5658442 Regulation of RAS by GAPs
R-DDI-5689603 UCH proteinases
R-DDI-5689880 Ub-specific processing proteases
R-DDI-68949 Orc1 removal from chromatin
R-DDI-69017 CDK-mediated phosphorylation and removal of Cdc6
R-DDI-69601 Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
R-DDI-8854050 FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
R-DDI-8948751 Regulation of PTEN stability and activity
R-DDI-983168 Antigen processing: Ubiquitination & Proteasome degradation

Names & Taxonomyi

Protein namesi
Recommended name:
26S proteasome non-ATPase regulatory subunit 4
Alternative name(s):
26S proteasome regulatory subunit RPN10
26S proteasome regulatory subunit S5A
Gene namesi
Name:psmD4
ORF Names:DDB_G0275775
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyostelidsDictyostelialesDictyosteliaceaeDictyostelium
Proteomesi
  • UP000002195 Componentsi: Chromosome 2, Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0275775 psmD4

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Proteasome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003274561 – 34926S proteasome non-ATPase regulatory subunit 4Add BLAST349

Proteomic databases

PaxDbiQ553E0

Interactioni

Subunit structurei

The 26S proteasome is composed of a core protease, known as the 20S proteasome, capped at one or both ends by the 19S regulatory complex (RC). The RC is composed of at least 18 different subunits in two subcomplexes, the base and the lid, which form the portions proximal and distal to the 20S proteolytic core, respectively (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi44689.DDB0232981

Structurei

3D structure databases

SMRiQ553E0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini5 – 188VWFAPROSITE-ProRule annotationAdd BLAST184
Domaini204 – 223UIM 1PROSITE-ProRule annotationAdd BLAST20
Domaini259 – 278UIM 2PROSITE-ProRule annotationAdd BLAST20

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi243 – 247Poly-Thr5
Compositional biasi292 – 296Poly-Gln5

Sequence similaritiesi

Belongs to the proteasome subunit S5A family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG2884 Eukaryota
COG5148 LUCA
InParanoidiQ553E0
KOiK03029
OMAiMGGKGPE
PhylomeDBiQ553E0

Family and domain databases

Gene3Di3.40.50.410, 1 hit
InterProiView protein in InterPro
IPR027040 Proteasome_su_Rpn10
IPR003903 UIM_dom
IPR002035 VWF_A
IPR036465 vWFA_dom_sf
PANTHERiPTHR10223:SF0 PTHR10223:SF0, 1 hit
PfamiView protein in Pfam
PF13519 VWA_2, 1 hit
SMARTiView protein in SMART
SM00726 UIM, 2 hits
SM00327 VWA, 1 hit
SUPFAMiSSF53300 SSF53300, 1 hit
PROSITEiView protein in PROSITE
PS50330 UIM, 2 hits
PS50234 VWFA, 1 hit

Sequencei

Sequence statusi: Complete.

Q553E0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTLEATIVCL DNSEWMRNGD FTPSRSEAQK DAVNLICASK TQSNPESAVS
60 70 80 90 100
IMSMAGKKPE VLVTLTQELS KILSGAQELK INGKIDFSTT MQIAQLALRH
110 120 130 140 150
RQNNHQHPRI IAFVGSPLKE TKEELIQLAK RLKKNGVAVD IINFGEVTEN
160 170 180 190 200
SDKLEAFIND VNNNDESHLL TVPPGPHILS DIILQSPIVE SGSGQFGSEF
210 220 230 240 250
INADTDPDLA MALKLSLEEE KQRQERERKA REEANGGSTN SGTTTTTAPT
260 270 280 290 300
ESNMDVNFED DPELAEALAL SMATDKMEVQ SSTTNTDSQP PQQQQQPPTD
310 320 330 340
DTSSEAFKDQ DFLNSTLNSL PGVDPNRIKN ALENLSKKDE DKDKDNEKK
Length:349
Mass (Da):38,394
Last modified:May 24, 2005 - v1
Checksum:i7D7FF6BDF225FE46
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000013 Genomic DNA Translation: EAL69638.1
RefSeqiXP_643477.1, XM_638385.1

Genome annotation databases

EnsemblProtistsiEAL69638; EAL69638; DDB_G0275775
GeneIDi8620058
KEGGiddi:DDB_G0275775

Similar proteinsi

Entry informationi

Entry nameiPSMD4_DICDI
AccessioniPrimary (citable) accession number: Q553E0
Secondary accession number(s): Q86HC8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: May 24, 2005
Last modified: April 25, 2018
This is version 81 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health