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Protein

26S proteasome non-ATPase regulatory subunit 4

Gene

psmD4

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Binds and presumably selects ubiquitin-conjugates for destruction.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-DDI-1236978. Cross-presentation of soluble exogenous antigens (endosomes).
R-DDI-174084. Autodegradation of Cdh1 by Cdh1:APC/C.
R-DDI-174113. SCF-beta-TrCP mediated degradation of Emi1.
R-DDI-174178. APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1.
R-DDI-174184. Cdc20:Phospho-APC/C mediated degradation of Cyclin A.
R-DDI-349425. Autodegradation of the E3 ubiquitin ligase COP1.
R-DDI-450408. AUF1 (hnRNP D0) binds and destabilizes mRNA.
R-DDI-5632684. Hedgehog 'on' state.
R-DDI-5658442. Regulation of RAS by GAPs.
R-DDI-68949. Orc1 removal from chromatin.
R-DDI-69017. CDK-mediated phosphorylation and removal of Cdc6.
R-DDI-69601. Ubiquitin Mediated Degradation of Phosphorylated Cdc25A.
R-DDI-983168. Antigen processing: Ubiquitination & Proteasome degradation.

Names & Taxonomyi

Protein namesi
Recommended name:
26S proteasome non-ATPase regulatory subunit 4
Alternative name(s):
26S proteasome regulatory subunit RPN10
26S proteasome regulatory subunit S5A
Gene namesi
Name:psmD4
ORF Names:DDB_G0275775
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
Proteomesi
  • UP000002195 Componentsi: Chromosome 2, Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0275775. psmD4.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Proteasome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 34934926S proteasome non-ATPase regulatory subunit 4PRO_0000327456Add
BLAST

Proteomic databases

PaxDbiQ553E0.

Interactioni

Subunit structurei

The 26S proteasome is composed of a core protease, known as the 20S proteasome, capped at one or both ends by the 19S regulatory complex (RC). The RC is composed of at least 18 different subunits in two subcomplexes, the base and the lid, which form the portions proximal and distal to the 20S proteolytic core, respectively (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi44689.DDB0232981.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini5 – 188184VWFAPROSITE-ProRule annotationAdd
BLAST
Domaini204 – 22320UIM 1PROSITE-ProRule annotationAdd
BLAST
Domaini259 – 27820UIM 2PROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi243 – 2475Poly-Thr
Compositional biasi292 – 2965Poly-Gln

Sequence similaritiesi

Belongs to the proteasome subunit S5A family.Curated
Contains 2 UIM (ubiquitin-interacting motif) domains.PROSITE-ProRule annotation
Contains 1 VWFA domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG2884. Eukaryota.
COG5148. LUCA.
InParanoidiQ553E0.
KOiK03029.
OMAiIDSSEYM.
PhylomeDBiQ553E0.

Family and domain databases

Gene3Di3.40.50.410. 1 hit.
InterProiIPR027040. Proteasome_su_Rpn10.
IPR003903. UIM_dom.
IPR002035. VWF_A.
[Graphical view]
PANTHERiPTHR10223. PTHR10223. 1 hit.
PfamiPF13519. VWA_2. 1 hit.
[Graphical view]
SMARTiSM00726. UIM. 2 hits.
SM00327. VWA. 1 hit.
[Graphical view]
SUPFAMiSSF53300. SSF53300. 1 hit.
PROSITEiPS50330. UIM. 2 hits.
PS50234. VWFA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q553E0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTLEATIVCL DNSEWMRNGD FTPSRSEAQK DAVNLICASK TQSNPESAVS
60 70 80 90 100
IMSMAGKKPE VLVTLTQELS KILSGAQELK INGKIDFSTT MQIAQLALRH
110 120 130 140 150
RQNNHQHPRI IAFVGSPLKE TKEELIQLAK RLKKNGVAVD IINFGEVTEN
160 170 180 190 200
SDKLEAFIND VNNNDESHLL TVPPGPHILS DIILQSPIVE SGSGQFGSEF
210 220 230 240 250
INADTDPDLA MALKLSLEEE KQRQERERKA REEANGGSTN SGTTTTTAPT
260 270 280 290 300
ESNMDVNFED DPELAEALAL SMATDKMEVQ SSTTNTDSQP PQQQQQPPTD
310 320 330 340
DTSSEAFKDQ DFLNSTLNSL PGVDPNRIKN ALENLSKKDE DKDKDNEKK
Length:349
Mass (Da):38,394
Last modified:May 24, 2005 - v1
Checksum:i7D7FF6BDF225FE46
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000013 Genomic DNA. Translation: EAL69638.1.
RefSeqiXP_643477.1. XM_638385.1.

Genome annotation databases

EnsemblProtistsiDDB0232981; DDB0232981; DDB_G0275775.
GeneIDi8620058.
KEGGiddi:DDB_G0275775.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000013 Genomic DNA. Translation: EAL69638.1.
RefSeqiXP_643477.1. XM_638385.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi44689.DDB0232981.

Proteomic databases

PaxDbiQ553E0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsiDDB0232981; DDB0232981; DDB_G0275775.
GeneIDi8620058.
KEGGiddi:DDB_G0275775.

Organism-specific databases

dictyBaseiDDB_G0275775. psmD4.

Phylogenomic databases

eggNOGiKOG2884. Eukaryota.
COG5148. LUCA.
InParanoidiQ553E0.
KOiK03029.
OMAiIDSSEYM.
PhylomeDBiQ553E0.

Enzyme and pathway databases

ReactomeiR-DDI-1236978. Cross-presentation of soluble exogenous antigens (endosomes).
R-DDI-174084. Autodegradation of Cdh1 by Cdh1:APC/C.
R-DDI-174113. SCF-beta-TrCP mediated degradation of Emi1.
R-DDI-174178. APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1.
R-DDI-174184. Cdc20:Phospho-APC/C mediated degradation of Cyclin A.
R-DDI-349425. Autodegradation of the E3 ubiquitin ligase COP1.
R-DDI-450408. AUF1 (hnRNP D0) binds and destabilizes mRNA.
R-DDI-5632684. Hedgehog 'on' state.
R-DDI-5658442. Regulation of RAS by GAPs.
R-DDI-68949. Orc1 removal from chromatin.
R-DDI-69017. CDK-mediated phosphorylation and removal of Cdc6.
R-DDI-69601. Ubiquitin Mediated Degradation of Phosphorylated Cdc25A.
R-DDI-983168. Antigen processing: Ubiquitination & Proteasome degradation.

Miscellaneous databases

PROiQ553E0.

Family and domain databases

Gene3Di3.40.50.410. 1 hit.
InterProiIPR027040. Proteasome_su_Rpn10.
IPR003903. UIM_dom.
IPR002035. VWF_A.
[Graphical view]
PANTHERiPTHR10223. PTHR10223. 1 hit.
PfamiPF13519. VWA_2. 1 hit.
[Graphical view]
SMARTiSM00726. UIM. 2 hits.
SM00327. VWA. 1 hit.
[Graphical view]
SUPFAMiSSF53300. SSF53300. 1 hit.
PROSITEiPS50330. UIM. 2 hits.
PS50234. VWFA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPSMD4_DICDI
AccessioniPrimary (citable) accession number: Q553E0
Secondary accession number(s): Q86HC8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: May 24, 2005
Last modified: September 7, 2016
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.