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Protein

Glycylpeptide N-tetradecanoyltransferase

Gene

nmt

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins.By similarity

Catalytic activityi

Tetradecanoyl-CoA + glycylpeptide = CoA + N-tetradecanoylglycylpeptide.

GO - Molecular functioni

  1. glycylpeptide N-tetradecanoyltransferase activity Source: dictyBase

GO - Biological processi

  1. N-terminal protein myristoylation Source: dictyBase
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Glycylpeptide N-tetradecanoyltransferase (EC:2.3.1.97)
Alternative name(s):
Myristoyl-CoA:protein N-myristoyltransferase
Short name:
NMT
Peptide N-myristoyltransferase
Gene namesi
Name:nmt
ORF Names:DDB_G0275863
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
ProteomesiUP000002195 Componentsi: Chromosome 2, Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0275863. nmt.

Subcellular locationi

Cytoplasm Curated

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 413413Glycylpeptide N-tetradecanoyltransferasePRO_0000331294Add
BLAST

Proteomic databases

PRIDEiQ553B6.

Interactioni

Protein-protein interaction databases

STRINGi44689.DDBDRAFT_0217694.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni33 – 353Myristoyl-CoA bindingBy similarity
Regioni164 – 1663Myristoyl-CoA bindingBy similarity
Regioni172 – 1765Myristoyl-CoA bindingBy similarity

Sequence similaritiesi

Belongs to the NMT family.Curated

Phylogenomic databases

eggNOGiCOG5092.
InParanoidiQ553B6.
KOiK00671.
OMAiIATCRYW.
PhylomeDBiQ553B6.

Family and domain databases

Gene3Di3.40.630.30. 2 hits.
InterProiIPR016181. Acyl_CoA_acyltransferase.
IPR000903. MyristoylCoA_TrFase.
IPR022677. MyristoylCoA_TrFase_C.
IPR022678. MyristoylCoA_TrFase_CS.
IPR022676. MyristoylCoA_TrFase_N.
[Graphical view]
PANTHERiPTHR11377. PTHR11377. 1 hit.
PfamiPF01233. NMT. 1 hit.
PF02799. NMT_C. 1 hit.
[Graphical view]
PIRSFiPIRSF015892. N-myristl_transf. 1 hit.
SUPFAMiSSF55729. SSF55729. 2 hits.
PROSITEiPS00975. NMT_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q553B6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADDKKKQLE ESKRLVELFK ASSLASKKPK GHEFWDTQPV PKIDDKIIES
60 70 80 90 100
GPIENKTLDD VRKDPLTLPP AFEWIELDCN KPEELKEIYT LLYENYVEDD
110 120 130 140 150
DNMFRFDYSP EFLKWALQPP GFLKEWHIGV RVVESKKLVG FISGIPATIR
160 170 180 190 200
VEGKPITMVE INFLCVHKKL REKRLAPVLI KEVTRRVNLR NIWQAAYTAG
210 220 230 240 250
VVLPKPVAIC KYWHRSIKQQ KLVEVGFSAI PPKMTMASMV KLYRINDEMK
260 270 280 290 300
HPLRPLTKED VPSFKVLLDD YLSKYKIAPE FTTDEDVWHW FETRKDVITC
310 320 330 340 350
YVKVDESTKK VTDAFSFYNL PSTIIGNAKH NTLKAAFSFY NVATTMSITD
360 370 380 390 400
LVGDALVTAK KMDYDVFNCL DVFENSTFFK DLKFAVGDGD LQYYLYNYST
410
PTKKSSEIGL VLL
Length:413
Mass (Da):47,700
Last modified:January 18, 2010 - v2
Checksum:iB25A64368D84FEA9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000013 Genomic DNA. Translation: EAL69682.2.
RefSeqiXP_643504.2. XM_638412.2.

Genome annotation databases

EnsemblProtistsiDDB0302502; DDB0302502; DDB_G0275863.
GeneIDi8620085.
KEGGiddi:DDB_G0275863.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000013 Genomic DNA. Translation: EAL69682.2.
RefSeqiXP_643504.2. XM_638412.2.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi44689.DDBDRAFT_0217694.

Proteomic databases

PRIDEiQ553B6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsiDDB0302502; DDB0302502; DDB_G0275863.
GeneIDi8620085.
KEGGiddi:DDB_G0275863.

Organism-specific databases

dictyBaseiDDB_G0275863. nmt.

Phylogenomic databases

eggNOGiCOG5092.
InParanoidiQ553B6.
KOiK00671.
OMAiIATCRYW.
PhylomeDBiQ553B6.

Family and domain databases

Gene3Di3.40.630.30. 2 hits.
InterProiIPR016181. Acyl_CoA_acyltransferase.
IPR000903. MyristoylCoA_TrFase.
IPR022677. MyristoylCoA_TrFase_C.
IPR022678. MyristoylCoA_TrFase_CS.
IPR022676. MyristoylCoA_TrFase_N.
[Graphical view]
PANTHERiPTHR11377. PTHR11377. 1 hit.
PfamiPF01233. NMT. 1 hit.
PF02799. NMT_C. 1 hit.
[Graphical view]
PIRSFiPIRSF015892. N-myristl_transf. 1 hit.
SUPFAMiSSF55729. SSF55729. 2 hits.
PROSITEiPS00975. NMT_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AX4.
  2. "The genome of the social amoeba Dictyostelium discoideum."
    Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N.
    , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
    Nature 435:43-57(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AX4.

Entry informationi

Entry nameiNMT_DICDI
AccessioniPrimary (citable) accession number: Q553B6
Secondary accession number(s): Q869M9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 28, 2008
Last sequence update: January 18, 2010
Last modified: January 6, 2015
This is version 62 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.