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Q553B6

- NMT_DICDI

UniProt

Q553B6 - NMT_DICDI

Protein

Glycylpeptide N-tetradecanoyltransferase

Gene

nmt

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 60 (01 Oct 2014)
      Sequence version 2 (19 Jan 2010)
      Previous versions | rss
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    Functioni

    Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins.By similarity

    Catalytic activityi

    Tetradecanoyl-CoA + glycylpeptide = CoA + N-tetradecanoylglycylpeptide.

    GO - Molecular functioni

    1. glycylpeptide N-tetradecanoyltransferase activity Source: dictyBase

    GO - Biological processi

    1. N-terminal protein myristoylation Source: dictyBase

    Keywords - Molecular functioni

    Acyltransferase, Transferase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glycylpeptide N-tetradecanoyltransferase (EC:2.3.1.97)
    Alternative name(s):
    Myristoyl-CoA:protein N-myristoyltransferase
    Short name:
    NMT
    Peptide N-myristoyltransferase
    Gene namesi
    Name:nmt
    ORF Names:DDB_G0275863
    OrganismiDictyostelium discoideum (Slime mold)
    Taxonomic identifieri44689 [NCBI]
    Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
    ProteomesiUP000002195: Chromosome 2, UP000002195: Unassembled WGS sequence

    Organism-specific databases

    dictyBaseiDDB_G0275863. nmt.

    Subcellular locationi

    Cytoplasm Curated

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 413413Glycylpeptide N-tetradecanoyltransferasePRO_0000331294Add
    BLAST

    Proteomic databases

    PRIDEiQ553B6.

    Interactioni

    Protein-protein interaction databases

    STRINGi44689.DDBDRAFT_0217694.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the NMT family.Curated

    Phylogenomic databases

    eggNOGiCOG5092.
    KOiK00671.
    OMAiQRTIKLY.
    PhylomeDBiQ553B6.

    Family and domain databases

    Gene3Di3.40.630.30. 2 hits.
    InterProiIPR016181. Acyl_CoA_acyltransferase.
    IPR000903. MyristoylCoA_TrFase.
    IPR022677. MyristoylCoA_TrFase_C.
    IPR022678. MyristoylCoA_TrFase_CS.
    IPR022676. MyristoylCoA_TrFase_N.
    [Graphical view]
    PANTHERiPTHR11377. PTHR11377. 1 hit.
    PfamiPF01233. NMT. 1 hit.
    PF02799. NMT_C. 1 hit.
    [Graphical view]
    PIRSFiPIRSF015892. N-myristl_transf. 1 hit.
    SUPFAMiSSF55729. SSF55729. 2 hits.
    PROSITEiPS00975. NMT_1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q553B6-1 [UniParc]FASTAAdd to Basket

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    MADDKKKQLE ESKRLVELFK ASSLASKKPK GHEFWDTQPV PKIDDKIIES    50
    GPIENKTLDD VRKDPLTLPP AFEWIELDCN KPEELKEIYT LLYENYVEDD 100
    DNMFRFDYSP EFLKWALQPP GFLKEWHIGV RVVESKKLVG FISGIPATIR 150
    VEGKPITMVE INFLCVHKKL REKRLAPVLI KEVTRRVNLR NIWQAAYTAG 200
    VVLPKPVAIC KYWHRSIKQQ KLVEVGFSAI PPKMTMASMV KLYRINDEMK 250
    HPLRPLTKED VPSFKVLLDD YLSKYKIAPE FTTDEDVWHW FETRKDVITC 300
    YVKVDESTKK VTDAFSFYNL PSTIIGNAKH NTLKAAFSFY NVATTMSITD 350
    LVGDALVTAK KMDYDVFNCL DVFENSTFFK DLKFAVGDGD LQYYLYNYST 400
    PTKKSSEIGL VLL 413
    Length:413
    Mass (Da):47,700
    Last modified:January 19, 2010 - v2
    Checksum:iB25A64368D84FEA9
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AAFI02000013 Genomic DNA. Translation: EAL69682.2.
    RefSeqiXP_643504.2. XM_638412.2.

    Genome annotation databases

    EnsemblProtistsiDDB0302502; DDB0302502; DDB_G0275863.
    GeneIDi8620085.
    KEGGiddi:DDB_G0275863.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AAFI02000013 Genomic DNA. Translation: EAL69682.2 .
    RefSeqi XP_643504.2. XM_638412.2.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 44689.DDBDRAFT_0217694.

    Proteomic databases

    PRIDEi Q553B6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblProtistsi DDB0302502 ; DDB0302502 ; DDB_G0275863 .
    GeneIDi 8620085.
    KEGGi ddi:DDB_G0275863.

    Organism-specific databases

    dictyBasei DDB_G0275863. nmt.

    Phylogenomic databases

    eggNOGi COG5092.
    KOi K00671.
    OMAi QRTIKLY.
    PhylomeDBi Q553B6.

    Family and domain databases

    Gene3Di 3.40.630.30. 2 hits.
    InterProi IPR016181. Acyl_CoA_acyltransferase.
    IPR000903. MyristoylCoA_TrFase.
    IPR022677. MyristoylCoA_TrFase_C.
    IPR022678. MyristoylCoA_TrFase_CS.
    IPR022676. MyristoylCoA_TrFase_N.
    [Graphical view ]
    PANTHERi PTHR11377. PTHR11377. 1 hit.
    Pfami PF01233. NMT. 1 hit.
    PF02799. NMT_C. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF015892. N-myristl_transf. 1 hit.
    SUPFAMi SSF55729. SSF55729. 2 hits.
    PROSITEi PS00975. NMT_1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: AX4.
    2. "The genome of the social amoeba Dictyostelium discoideum."
      Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N.
      , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
      Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: AX4.

    Entry informationi

    Entry nameiNMT_DICDI
    AccessioniPrimary (citable) accession number: Q553B6
    Secondary accession number(s): Q869M9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 29, 2008
    Last sequence update: January 19, 2010
    Last modified: October 1, 2014
    This is version 60 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Dictyostelium discoideum
      Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3