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Q55369

- MOAA_SYNY3

UniProt

Q55369 - MOAA_SYNY3

Protein

Cyclic pyranopterin monophosphate synthase

Gene

moaA

Organism
Synechocystis sp. (strain PCC 6803 / Kazusa)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 101 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z).By similarity

    Catalytic activityi

    GTP = cyclic pyranopterin phosphate + diphosphate.

    Cofactori

    Binds 2 4Fe-4S clusters. Binds 1 4Fe-4S cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine and 1 4Fe-4S cluster coordinated with 3 cysteines and the GTP-derived substrate By similarity.By similarity
    Binds 1 S-adenosyl-L-methionine per subunit.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei30 – 301GTPBy similarity
    Metal bindingi37 – 371Iron-sulfur 1 (4Fe-4S-S-AdoMet)By similarity
    Metal bindingi41 – 411Iron-sulfur 1 (4Fe-4S-S-AdoMet)By similarity
    Binding sitei43 – 431S-adenosyl-L-methionineBy similarity
    Metal bindingi44 – 441Iron-sulfur 1 (4Fe-4S-S-AdoMet)By similarity
    Binding sitei79 – 791GTPBy similarity
    Binding sitei83 – 831S-adenosyl-L-methionine; via carbonyl oxygenBy similarity
    Binding sitei109 – 1091GTPBy similarity
    Binding sitei133 – 1331S-adenosyl-L-methionineBy similarity
    Binding sitei169 – 1691GTPBy similarity
    Binding sitei203 – 2031S-adenosyl-L-methionine; via amide nitrogen and carbonyl oxygenBy similarity
    Metal bindingi265 – 2651Iron-sulfur 2 (4Fe-4S-substrate)By similarity
    Metal bindingi268 – 2681Iron-sulfur 2 (4Fe-4S-substrate)By similarity
    Metal bindingi282 – 2821Iron-sulfur 2 (4Fe-4S-substrate)By similarity

    GO - Molecular functioni

    1. 4 iron, 4 sulfur cluster binding Source: UniProtKB-KW
    2. cyclic pyranopterin monophosphate synthase activity Source: UniProtKB-EC
    3. GTP binding Source: UniProtKB-KW
    4. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. Mo-molybdopterin cofactor biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Lyase

    Keywords - Biological processi

    Molybdenum cofactor biosynthesis

    Keywords - Ligandi

    4Fe-4S, GTP-binding, Iron, Iron-sulfur, Metal-binding, Nucleotide-binding, S-adenosyl-L-methionine

    Enzyme and pathway databases

    UniPathwayiUPA00344.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cyclic pyranopterin monophosphate synthase (EC:4.1.99.18)
    Alternative name(s):
    Molybdenum cofactor biosynthesis protein A
    Gene namesi
    Name:moaA
    Ordered Locus Names:slr0901
    OrganismiSynechocystis sp. (strain PCC 6803 / Kazusa)
    Taxonomic identifieri1111708 [NCBI]
    Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechocystis
    ProteomesiUP000001425: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. molybdopterin synthase complex Source: InterPro

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 327327Cyclic pyranopterin monophosphate synthasePRO_0000153005Add
    BLAST

    Proteomic databases

    PRIDEiQ55369.

    Interactioni

    Subunit structurei

    Monomer and homodimer.By similarity

    Protein-protein interaction databases

    STRINGi1148.slr0901.

    Structurei

    3D structure databases

    ProteinModelPortaliQ55369.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni270 – 2723GTP bindingBy similarity

    Sequence similaritiesi

    Belongs to the radical SAM superfamily. MoaA family.Curated

    Phylogenomic databases

    eggNOGiCOG2896.
    HOGENOMiHOG000228680.
    KOiK03639.
    OMAiMFHQITG.
    OrthoDBiEOG64XXNN.
    PhylomeDBiQ55369.

    Family and domain databases

    Gene3Di3.20.20.70. 1 hit.
    HAMAPiMF_01225_B. MoaA_B.
    InterProiIPR013785. Aldolase_TIM.
    IPR006638. Elp3/MiaB/NifB.
    IPR013483. MoaA.
    IPR000385. MoaA_NifB_PqqE_Fe-S-bd_CS.
    IPR010505. Mob_synth_C.
    IPR007197. rSAM.
    [Graphical view]
    PfamiPF06463. Mob_synth_C. 1 hit.
    PF04055. Radical_SAM. 1 hit.
    [Graphical view]
    SMARTiSM00729. Elp3. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR02666. moaA. 1 hit.
    PROSITEiPS01305. MOAA_NIFB_PQQE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q55369-1 [UniParc]FASTAAdd to Basket

    « Hide

    MFSFLCLVEL ALPMSKTLVD SYGRRIRKLR VSLTDQCNLR CHYCMPVDAI    50
    FLEQSSYLSC QEYGEIIGEL IALGLEEVRL TGGEPLLRRN FTEIVRAIGQ 100
    LKLKKIGLTT NGIVLDRHLD TLGENNVLDL NVSLDSLNAK TFSEITHRNC 150
    LNTILRNLEL ASRQGFKIKL NTVVMREIND REIFDLIEYA KRWEMEIRFL 200
    EIMRIGYACR HQEKTFISAQ ELLAKIQQKY SLKPIQSALD ATAFRYSTSC 250
    GGIIGFIASE SQPFCGHCSR WRLSVDGTLR ACLLKNEGIN IRNFSSLERQ 300
    HVYQQLLGMK PYLRPPEVSH AMHQIGG 327
    Length:327
    Mass (Da):37,365
    Last modified:November 1, 1996 - v1
    Checksum:i44D1854617A7C41E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000022 Genomic DNA. Translation: BAA10451.1.
    PIRiS75716.
    RefSeqiNP_442381.1. NC_000911.1.
    YP_005652441.1. NC_017277.1.
    YP_007452257.1. NC_020286.1.

    Genome annotation databases

    EnsemblBacteriaiBAA10451; BAA10451; BAA10451.
    GeneIDi953273.
    KEGGisyn:slr0901.
    syy:SYNGTS_2488.
    syz:MYO_125130.
    PATRICi23842448. VBISynSp132158_2764.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000022 Genomic DNA. Translation: BAA10451.1 .
    PIRi S75716.
    RefSeqi NP_442381.1. NC_000911.1.
    YP_005652441.1. NC_017277.1.
    YP_007452257.1. NC_020286.1.

    3D structure databases

    ProteinModelPortali Q55369.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 1148.slr0901.

    Proteomic databases

    PRIDEi Q55369.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAA10451 ; BAA10451 ; BAA10451 .
    GeneIDi 953273.
    KEGGi syn:slr0901.
    syy:SYNGTS_2488.
    syz:MYO_125130.
    PATRICi 23842448. VBISynSp132158_2764.

    Phylogenomic databases

    eggNOGi COG2896.
    HOGENOMi HOG000228680.
    KOi K03639.
    OMAi MFHQITG.
    OrthoDBi EOG64XXNN.
    PhylomeDBi Q55369.

    Enzyme and pathway databases

    UniPathwayi UPA00344 .

    Family and domain databases

    Gene3Di 3.20.20.70. 1 hit.
    HAMAPi MF_01225_B. MoaA_B.
    InterProi IPR013785. Aldolase_TIM.
    IPR006638. Elp3/MiaB/NifB.
    IPR013483. MoaA.
    IPR000385. MoaA_NifB_PqqE_Fe-S-bd_CS.
    IPR010505. Mob_synth_C.
    IPR007197. rSAM.
    [Graphical view ]
    Pfami PF06463. Mob_synth_C. 1 hit.
    PF04055. Radical_SAM. 1 hit.
    [Graphical view ]
    SMARTi SM00729. Elp3. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR02666. moaA. 1 hit.
    PROSITEi PS01305. MOAA_NIFB_PQQE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. I. Sequence features in the 1 Mb region from map positions 64% to 92% of the genome."
      Kaneko T., Tanaka A., Sato S., Kotani H., Sazuka T., Miyajima N., Sugiura M., Tabata S.
      DNA Res. 2:153-166(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 27184 / PCC 6803 / N-1.
    2. "Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions."
      Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y., Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T., Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S.
      , Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.
      DNA Res. 3:109-136(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: PCC 6803 / Kazusa.

    Entry informationi

    Entry nameiMOAA_SYNY3
    AccessioniPrimary (citable) accession number: Q55369
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1998
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 101 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families
    3. Synechocystis PCC 6803
      Synechocystis (strain PCC 6803): entries and gene names

    External Data

    Dasty 3