Q552M6 (ZDHC7_DICDI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Putative ZDHHC-type palmitoyltransferase 7
EC=2.3.1.-

Alternative name(s):
Zinc finger DHHC domain-containing protein 7

Gene names

ORF Names:

DDB_G0276017

Organism

Dictyostelium discoideum (Slime mold) [Reference proteome]

Taxonomic identifier

44689 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Amoebozoa › Mycetozoa › Dictyosteliida › Dictyostelium

Protein attributes

Sequence length	438 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Catalytic activity	Palmitoyl-CoA + protein-cysteine = S-palmitoyl protein + CoA.
Subcellular location	Membrane; Multi-pass membrane protein Potential.
Domain	The DHHC domain is required for palmitoyltransferase activity By similarity.
Sequence similarities	Belongs to the DHHC palmitoyltransferase family. Contains 1 DHHC-type zinc finger.

Ontologies

Keywords
Cellular component	Membrane
Domain	Transmembrane Transmembrane helix Zinc-finger
Ligand	Metal-binding Zinc
Molecular function	Acyltransferase Transferase
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	transferase activity, transferring acyl groups Inferred from electronic annotation. Source: UniProtKB-KW zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 438	438	Putative ZDHHC-type palmitoyltransferase 7		PRO_0000262946
Regions
	Transmembrane	48 – 68	21	Helical; Potential
	Transmembrane	77 – 97	21	Helical; Potential
	Transmembrane	294 – 314	21	Helical; Potential
	Transmembrane	330 – 350	21	Helical; Potential
	Zinc finger	249 – 299	51	DHHC-type
	Compositional bias	4 – 25	22	Asn-rich
	Compositional bias	109 – 234	126	Asn-rich
	Compositional bias	190 – 205	16	Thr-rich
Amino acid modifications
	Glycosylation	12	1	N-linked (GlcNAc...) Potential
	Glycosylation	13	1	N-linked (GlcNAc...) Potential
	Glycosylation	119	1	N-linked (GlcNAc...) Potential
	Glycosylation	144	1	N-linked (GlcNAc...) Potential
	Glycosylation	157	1	N-linked (GlcNAc...) Potential
	Glycosylation	231	1	N-linked (GlcNAc...) Potential
	Glycosylation	360	1	N-linked (GlcNAc...) Potential
Experimental info
	Sequence conflict	352	1	F → Y in C91183. Ref.3
	Sequence conflict	434 – 438	5	Missing in C91183. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Q552M6 [UniParc]. Last modified May 24, 2005. Version 1. Checksum: 832C08B0D3ABBC0A	FASTA	438	50,297
	10 20 30 40 50 60 MKLNSNINNN INNSSNSNNN FDAKNIIVDT ITPPDPSVEF ERKLAKSIFC LVHFIVYCVI 70 80 90 100 110 120 IFRKGTILDQ AFKDKDYFYL IWTHCVFFFA IGTYFLISSK RPGFVSLSNQ NLNNNNNNNG 130 140 150 160 170 180 SSNKFILEDS MGCIPQLNIN PTPNYSKISN IKRKLKNSSG DITKNQENED LVPLMEISKN 190 200 210 220 230 240 IDEDSINDDT ITTTTTTTTT TSTSTIPEIS NDDDDNNNEN NNDNVNNRNN NNSNGEKEDN 250 260 270 280 290 300 DIDKLKNHYF CKKCLVDIPL RTKHCVKCNR CVLKYDHHCV FIGGCVGLNN HKNFLLFLLA 310 320 330 340 350 360 ESLLLLLGLR IIVTGFVREN SIKEWIFSNI AIIPPTLLIF GGLCMPFALF CFHSFLILTN 370 380 390 400 410 420 QSSWEFNKYQ RITYLKPFSK RGINPFNKGP WNNLKKFLKG DENPSDWILL SKYEVDQMKK 430 KEENTFNIWN NKYYSCCG

References

[1]	"Sequence and analysis of chromosome 2 of Dictyostelium discoideum." Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T., Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R., Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A., Noegel A.A. Nature 418:79-85(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AX4.
[2]	"The genome of the social amoeba Dictyostelium discoideum." Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N. , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A. Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AX4.
[3]	"Analyses of cDNAs from growth and slug stages of Dictyostelium discoideum." Urushihara H., Morio T., Saito T., Kohara Y., Koriki E., Ochiai H., Maeda M., Williams J.G., Takeuchi I., Tanaka Y. Nucleic Acids Res. 32:1647-1653(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-60 AND 298-438. Strain: AX4.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AAFI02000013 Genomic DNA. Translation: EAL69465.1. AU074197 mRNA. No translation available. C91183 mRNA. No translation available.
RefSeq	XP_643386.1. XM_638294.1.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblProtists	DDB0217752; DDB0217752; DDB_G0276017.
GeneID	8620271.
KEGG	ddi:DDB_G0276017.
Organism-specific databases
dictyBase	DDB_G0276017.
Phylogenomic databases
eggNOG	NOG305404.
Family and domain databases
InterPro	IPR001594. Znf_DHHC_palmitoyltrfase. [Graphical view]
Pfam	PF01529. zf-DHHC. 1 hit. [Graphical view]
PROSITE	PS50216. ZF_DHHC. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ZDHC7_DICDI

Accession

Primary (citable) accession number: Q552M6
Secondary accession number(s): Q86JC6

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 28, 2006
Last sequence update:	May 24, 2005
Last modified:	April 3, 2013
This is version 36 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)