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Q55247

- GLNB_SYNY3

UniProt

Q55247 - GLNB_SYNY3

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Protein

Nitrogen regulatory protein P-II

Gene

glnB

Organism
Synechocystis sp. (strain PCC 6803 / Kazusa)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

P-II indirectly controls the transcription of the GS gene (glnA). P-II prevents NR-II-catalyzed conversion of NR-I to NR-I-phosphate, the transcriptional activator of glnA. When P-II is phosphorylated, these events are reversed. In nitrogen-limiting conditions, when the ratio of Gln to 2-ketoglutarate decreases, P-II is phosphorylated which allows the deadenylation of glutamine synthetase (GS), thus activating the enzyme (By similarity).By similarity

GO - Molecular functioni

  1. enzyme regulator activity Source: InterPro
  2. nucleotide binding Source: UniProtKB-KW

GO - Biological processi

  1. regulation of nitrogen utilization Source: InterPro
  2. regulation of transcription, DNA-templated Source: UniProtKB-KW
  3. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Nitrogen regulatory protein P-II
Alternative name(s):
PII signal transducing protein
Gene namesi
Name:glnB
Ordered Locus Names:ssl0707
OrganismiSynechocystis sp. (strain PCC 6803 / Kazusa)
Taxonomic identifieri1111708 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechocystis
ProteomesiUP000001425: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 112112Nitrogen regulatory protein P-IIPRO_0000139795Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei49 – 491PhosphoserineCurated
Modified residuei51 – 511O-UMP-tyrosinePROSITE-ProRule annotation

Post-translational modificationi

Phosphorylation dependent on the nitrogen source and spectral light quality.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ55247.

PTM databases

PhosSiteiP0806321.

Interactioni

Subunit structurei

Homotrimer.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
sll0985P731485EBI-906365,EBI-906297

Protein-protein interaction databases

IntActiQ55247. 3 interactions.
STRINGi1148.ssl0707.

Structurei

Secondary structure

1
112
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi2 – 87
Helixi10 – 123
Helixi13 – 219
Turni22 – 243
Beta strandi28 – 358
Beta strandi56 – 6510
Helixi67 – 693
Helixi70 – 8112
Beta strandi90 – 956
Beta strandi98 – 1014
Turni102 – 1043
Beta strandi107 – 1093

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1UL3X-ray2.00A/B/C/D1-112[»]
ProteinModelPortaliQ55247.
SMRiQ55247. Positions 1-112.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ55247.

Family & Domainsi

Sequence similaritiesi

Belongs to the P(II) protein family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0347.
HOGENOMiHOG000017847.
InParanoidiQ55247.
KOiK04751.
OMAiVCEVERV.
PhylomeDBiQ55247.

Family and domain databases

Gene3Di3.30.70.120. 1 hit.
InterProiIPR002187. N-reg_PII.
IPR011322. N-reg_PII-like_a/b.
IPR015867. N-reg_PII/ATP_PRibTrfase_C.
IPR017918. N-reg_PII_CS.
IPR002332. N-reg_PII_urydylation_site.
[Graphical view]
PfamiPF00543. P-II. 1 hit.
[Graphical view]
PRINTSiPR00340. PIIGLNB.
SMARTiSM00938. P-II. 1 hit.
[Graphical view]
SUPFAMiSSF54913. SSF54913. 1 hit.
PROSITEiPS00638. PII_GLNB_CTER. 1 hit.
PS51343. PII_GLNB_DOM. 1 hit.
PS00496. PII_GLNB_UMP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q55247-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKKVEAIIRP FKLDEVKIAL VNAGIVGMTV SEVRGFGRQK GQTERYRGSE
60 70 80 90 100
YTVEFLQKLK IEIVVDEGQV DMVVDKLVSA ARTGEIGDGK IFISPVDSVV
110
RIRTGEKDTE AI
Length:112
Mass (Da):12,397
Last modified:November 1, 1997 - v1
Checksum:iF9ABD0F5C173B799
GO

Sequence cautioni

The sequence BAA18533.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X97496 Genomic DNA. Translation: CAA66127.1.
BA000022 Genomic DNA. Translation: BAA18533.1. Different initiation.
PIRiS76404.
RefSeqiNP_441855.2. NC_000911.1.
YP_005651915.1. NC_017277.1.
YP_007451736.1. NC_020286.1.

Genome annotation databases

EnsemblBacteriaiBAA18533; BAA18533; BAA18533.
GeneIDi952897.
KEGGisyn:ssl0707.
syy:SYNGTS_1962.
syz:MYO_119810.
PATRICi23841230. VBISynSp132158_2165.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X97496 Genomic DNA. Translation: CAA66127.1 .
BA000022 Genomic DNA. Translation: BAA18533.1 . Different initiation.
PIRi S76404.
RefSeqi NP_441855.2. NC_000911.1.
YP_005651915.1. NC_017277.1.
YP_007451736.1. NC_020286.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1UL3 X-ray 2.00 A/B/C/D 1-112 [» ]
ProteinModelPortali Q55247.
SMRi Q55247. Positions 1-112.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q55247. 3 interactions.
STRINGi 1148.ssl0707.

PTM databases

PhosSitei P0806321.

Proteomic databases

PaxDbi Q55247.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAA18533 ; BAA18533 ; BAA18533 .
GeneIDi 952897.
KEGGi syn:ssl0707.
syy:SYNGTS_1962.
syz:MYO_119810.
PATRICi 23841230. VBISynSp132158_2165.

Phylogenomic databases

eggNOGi COG0347.
HOGENOMi HOG000017847.
InParanoidi Q55247.
KOi K04751.
OMAi VCEVERV.
PhylomeDBi Q55247.

Miscellaneous databases

EvolutionaryTracei Q55247.

Family and domain databases

Gene3Di 3.30.70.120. 1 hit.
InterProi IPR002187. N-reg_PII.
IPR011322. N-reg_PII-like_a/b.
IPR015867. N-reg_PII/ATP_PRibTrfase_C.
IPR017918. N-reg_PII_CS.
IPR002332. N-reg_PII_urydylation_site.
[Graphical view ]
Pfami PF00543. P-II. 1 hit.
[Graphical view ]
PRINTSi PR00340. PIIGLNB.
SMARTi SM00938. P-II. 1 hit.
[Graphical view ]
SUPFAMi SSF54913. SSF54913. 1 hit.
PROSITEi PS00638. PII_GLNB_CTER. 1 hit.
PS51343. PII_GLNB_DOM. 1 hit.
PS00496. PII_GLNB_UMP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Nitrogen availability and electron transport control the expression of glnB gene (encoding PII protein) in the cyanobacterium Synechocystis sp. PCC 6803."
    Garcia-Dominguez M., Florencio F.J.
    Plant Mol. Biol. 35:723-734(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions."
    Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y., Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T., Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S.
    , Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.
    DNA Res. 3:109-136(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PCC 6803 / Kazusa.
  3. "The structures of the PII proteins from the cyanobacteria Synechococcus sp. PCC 7942 and Synechocystis sp. PCC 6803."
    Xu Y., Carr P.D., Clancy P., Garcia-Dominguez M., Forchhammer K., Florencio F., Vasudevan S.G., Tandeau de Marsac N., Ollis D.L.
    Acta Crystallogr. D 59:2183-2190(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS).

Entry informationi

Entry nameiGLNB_SYNY3
AccessioniPrimary (citable) accession number: Q55247
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: October 29, 2014
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Synechocystis PCC 6803
    Synechocystis (strain PCC 6803): entries and gene names

External Data

Dasty 3