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Protein

Protein DrgA

Gene

drgA

Organism
Synechocystis sp. (strain PCC 6803 / Kazusa)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Controls resistance to the herbicide Dinoseb and metronidazole. Involved in detoxification of Dinoseb via the reduction of the nitro group(s) and this process is accompanied by the formation of toxic superoxide anions.

Cofactori

FMNCurated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Herbicide resistance

Keywords - Ligandi

Flavoprotein, FMN, NAD, NADP

Names & Taxonomyi

Protein namesi
Recommended name:
Protein DrgA
Gene namesi
Name:drgA
Ordered Locus Names:slr1719
OrganismiSynechocystis sp. (strain PCC 6803 / Kazusa)
Taxonomic identifieri1111708 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechocystis
ProteomesiUP000001425 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 210210Protein DrgAPRO_0000072722Add
BLAST

Proteomic databases

PaxDbiQ55233.

Interactioni

Protein-protein interaction databases

IntActiQ55233. 1 interaction.
STRINGi1148.SYNGTS_1333.

Structurei

3D structure databases

ProteinModelPortaliQ55233.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the nitroreductase family.Curated

Phylogenomic databases

eggNOGiCOG0778.
HOGENOMiHOG000146739.
InParanoidiQ55233.
OrthoDBiEOG6N947Z.
PhylomeDBiQ55233.

Family and domain databases

Gene3Di3.40.109.10. 1 hit.
InterProiIPR029479. Nitroreductase.
IPR000415. Nitroreductase-like.
[Graphical view]
PfamiPF00881. Nitroreductase. 1 hit.
[Graphical view]
SUPFAMiSSF55469. SSF55469. 1 hit.

Sequencei

Sequence statusi: Complete.

Q55233-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDTFDAIYQR RSVKHFDPDH RLTAEEERKL HEAAIQAPTS FNIQLWRFLI
60 70 80 90 100
IRDPQLRQTI REKYGNQAQM TDASLLILVA ADVNAWDKDP ARYWRNAPRE
110 120 130 140 150
VANYLVGAIA SFYGGKPQLQ RDEAQRSIGM AMQNLMLAAK AMGYDSCPMI
160 170 180 190 200
GFDLQKVAEL VKLPADYAIG PMVAIGKRTE DAPGKRRSNS PGRIPLGKLL
210
CLTKVWCLAI
Length:210
Mass (Da):23,703
Last modified:November 1, 1996 - v1
Checksum:iC29A1293996EBB95
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti31 – 311H → L in BAA17909 (PubMed:8905231).Curated
Sequence conflicti45 – 451L → H in BAA17909 (PubMed:8905231).Curated
Sequence conflicti183 – 21028PGKRR…WCLAI → RAKGGQTPLEELVWENSF (PubMed:8905231).CuratedAdd
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L29426 Genomic DNA. Translation: AAA91952.1.
BA000022 Genomic DNA. Translation: BAA17909.1.
PIRiS75047.
RefSeqiYP_005651286.1. NC_017277.1.
YP_007451111.1. NC_020286.1.

Genome annotation databases

EnsemblBacteriaiBAA17909; BAA17909; BAA17909.
KEGGisyn:slr1719.
PATRICi23839798. VBISynSp132158_1460.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L29426 Genomic DNA. Translation: AAA91952.1.
BA000022 Genomic DNA. Translation: BAA17909.1.
PIRiS75047.
RefSeqiYP_005651286.1. NC_017277.1.
YP_007451111.1. NC_020286.1.

3D structure databases

ProteinModelPortaliQ55233.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ55233. 1 interaction.
STRINGi1148.SYNGTS_1333.

Proteomic databases

PaxDbiQ55233.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAA17909; BAA17909; BAA17909.
KEGGisyn:slr1719.
PATRICi23839798. VBISynSp132158_1460.

Phylogenomic databases

eggNOGiCOG0778.
HOGENOMiHOG000146739.
InParanoidiQ55233.
OrthoDBiEOG6N947Z.
PhylomeDBiQ55233.

Family and domain databases

Gene3Di3.40.109.10. 1 hit.
InterProiIPR029479. Nitroreductase.
IPR000415. Nitroreductase-like.
[Graphical view]
PfamiPF00881. Nitroreductase. 1 hit.
[Graphical view]
SUPFAMiSSF55469. SSF55469. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Resistance to nitrophenolic herbicides and metronidazole in the cyanobacterium Synechocystis sp. PCC 6803 as a result of the inactivation of a nitroreductase-like protein encoded by drgA gene."
    Elanskaya I.V., Chesnavichene E.A., Vernotte C., Astier C.
    FEBS Lett. 428:188-192(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions."
    Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y., Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T., Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S.
    , Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.
    DNA Res. 3:109-136(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PCC 6803 / Kazusa.
  3. "Towards a proteome project of cyanobacterium Synechocystis sp. strain PCC6803: linking 130 protein spots with their respective genes."
    Sazuka T., Ohara O.
    Electrophoresis 18:1252-1258(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 1-17.

Entry informationi

Entry nameiDRGA_SYNY3
AccessioniPrimary (citable) accession number: Q55233
Secondary accession number(s): P73850
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: June 24, 2015
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Synechocystis PCC 6803
    Synechocystis (strain PCC 6803): entries and gene names

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.