Q55233 (DRGA_SYNY3) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein DrgA

Gene names

Name:	drgA
Ordered Locus Names:	slr1719

Organism

Synechocystis sp. (strain PCC 6803 / Kazusa) [Reference proteome] [HAMAP]

Taxonomic identifier

1111708 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Cyanobacteria › Oscillatoriophycideae › Chroococcales › Synechocystis › Synechocystis sp. PCC 6803

Protein attributes

Sequence length	210 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Controls resistance to the herbicide Dinoseb and metronidazole. Involved in detoxification of Dinoseb via the reduction of the nitro group(s) and this process is accompanied by the formation of toxic superoxide anions.
Cofactor	FMN Potential.
Sequence similarities	Belongs to the nitroreductase family.

Ontologies

Keywords
Biological process	Herbicide resistance
Ligand	FMN Flavoprotein NAD NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	response to herbicide Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	oxidoreductase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 210	210	Protein DrgA		PRO_0000072722
Experimental info
	Sequence conflict	31	1	H → L in BAA17909. Ref.2
	Sequence conflict	45	1	L → H in BAA17909. Ref.2
	Sequence conflict	183 – 210	28	PGKRR…WCLAI → RAKGGQTPLEELVWENSF Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Q55233 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: C29A1293996EBB95	FASTA	210	23,703
	10 20 30 40 50 60 MDTFDAIYQR RSVKHFDPDH RLTAEEERKL HEAAIQAPTS FNIQLWRFLI IRDPQLRQTI 70 80 90 100 110 120 REKYGNQAQM TDASLLILVA ADVNAWDKDP ARYWRNAPRE VANYLVGAIA SFYGGKPQLQ 130 140 150 160 170 180 RDEAQRSIGM AMQNLMLAAK AMGYDSCPMI GFDLQKVAEL VKLPADYAIG PMVAIGKRTE 190 200 210 DAPGKRRSNS PGRIPLGKLL CLTKVWCLAI

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Resistance to nitrophenolic herbicides and metronidazole in the cyanobacterium Synechocystis sp. PCC 6803 as a result of the inactivation of a nitroreductase-like protein encoded by drgA gene." Elanskaya I.V., Chesnavichene E.A., Vernotte C., Astier C. FEBS Lett. 428:188-192(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions." Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y., Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T., Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S. , Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S. DNA Res. 3:109-136(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: PCC 6803 / Kazusa.
[3]	"Towards a proteome project of cyanobacterium Synechocystis sp. strain PCC6803: linking 130 protein spots with their respective genes." Sazuka T., Ohara O. Electrophoresis 18:1252-1258(1997) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE OF 1-17.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L29426 Genomic DNA. Translation: AAA91952.1. BA000022 Genomic DNA. Translation: BAA17909.1.
PIR	S75047.
RefSeq	NP_441229.1. NC_000911.1. YP_005651286.1. NC_017277.1. YP_007451111.1. NC_020286.1.
3D structure databases
ProteinModelPortal	Q55233.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q55233. 1 interaction.
STRING	1148.slr1719.
Proteomic databases
PaxDb	Q55233.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	BAA17909; BAA17909; BAA17909.
GeneID	12255694. 14616767. 954571.
KEGG	syn:slr1719. syy:SYNGTS_1333.
PATRIC	23839798. VBISynSp132158_1460.
Phylogenomic databases
eggNOG	COG0778.
HOGENOM	HOG000146739.
ProtClustDB	CLSK893048.
Family and domain databases
Gene3D	3.40.109.10. 1 hit.
InterPro	IPR000415. Nitroreductase-like. [Graphical view]
Pfam	PF00881. Nitroreductase. 1 hit. [Graphical view]
SUPFAM	SSF55469. Nitroreductase. 1 hit.
ProtoNet	Search...

Entry information

Entry name

DRGA_SYNY3

Accession

Primary (citable) accession number: Q55233
Secondary accession number(s): P73850

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1996
Last modified:	May 1, 2013
This is version 68 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program