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Q55233 (DRGA_SYNY3) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 75. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein DrgA
Gene names
Name:drgA
Ordered Locus Names:slr1719
OrganismSynechocystis sp. (strain PCC 6803 / Kazusa) [Reference proteome] [HAMAP]
Taxonomic identifier1111708 [NCBI]
Taxonomic lineageBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechocystis

Protein attributes

Sequence length210 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Controls resistance to the herbicide Dinoseb and metronidazole. Involved in detoxification of Dinoseb via the reduction of the nitro group(s) and this process is accompanied by the formation of toxic superoxide anions.

Cofactor

FMN Potential.

Sequence similarities

Belongs to the nitroreductase family.

Ontologies

Keywords
   Biological processHerbicide resistance
   LigandFlavoprotein
FMN
NAD
NADP
   Molecular functionOxidoreductase
   Technical termComplete proteome
Direct protein sequencing
Reference proteome
Gene Ontology (GO)
   Biological_processresponse to herbicide

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionoxidoreductase activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 210210Protein DrgA
PRO_0000072722

Experimental info

Sequence conflict311H → L in BAA17909. Ref.2
Sequence conflict451L → H in BAA17909. Ref.2
Sequence conflict183 – 21028PGKRR…WCLAI → RAKGGQTPLEELVWENSF Ref.2

Sequences

Sequence LengthMass (Da)Tools
Q55233 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: C29A1293996EBB95

FASTA21023,703
        10         20         30         40         50         60 
MDTFDAIYQR RSVKHFDPDH RLTAEEERKL HEAAIQAPTS FNIQLWRFLI IRDPQLRQTI 

        70         80         90        100        110        120 
REKYGNQAQM TDASLLILVA ADVNAWDKDP ARYWRNAPRE VANYLVGAIA SFYGGKPQLQ 

       130        140        150        160        170        180 
RDEAQRSIGM AMQNLMLAAK AMGYDSCPMI GFDLQKVAEL VKLPADYAIG PMVAIGKRTE 

       190        200        210 
DAPGKRRSNS PGRIPLGKLL CLTKVWCLAI 

« Hide

References

« Hide 'large scale' references
[1]"Resistance to nitrophenolic herbicides and metronidazole in the cyanobacterium Synechocystis sp. PCC 6803 as a result of the inactivation of a nitroreductase-like protein encoded by drgA gene."
Elanskaya I.V., Chesnavichene E.A., Vernotte C., Astier C.
FEBS Lett. 428:188-192(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions."
Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y., Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T., Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S. expand/collapse author list , Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.
DNA Res. 3:109-136(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: PCC 6803 / Kazusa.
[3]"Towards a proteome project of cyanobacterium Synechocystis sp. strain PCC6803: linking 130 protein spots with their respective genes."
Sazuka T., Ohara O.
Electrophoresis 18:1252-1258(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 1-17.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L29426 Genomic DNA. Translation: AAA91952.1.
BA000022 Genomic DNA. Translation: BAA17909.1.
PIRS75047.
RefSeqNP_441229.1. NC_000911.1.
YP_005651286.1. NC_017277.1.
YP_007451111.1. NC_020286.1.

3D structure databases

ProteinModelPortalQ55233.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ55233. 1 interaction.
STRING1148.slr1719.

Proteomic databases

PaxDbQ55233.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAA17909; BAA17909; BAA17909.
GeneID954571.
KEGGsyn:slr1719.
syy:SYNGTS_1333.
syz:MYO_113450.
PATRIC23839798. VBISynSp132158_1460.

Phylogenomic databases

eggNOGCOG0778.
HOGENOMHOG000146739.
OrthoDBEOG6N947Z.
PhylomeDBQ55233.

Family and domain databases

Gene3D3.40.109.10. 1 hit.
InterProIPR029479. Nitroreductase.
IPR000415. Nitroreductase-like.
[Graphical view]
PfamPF00881. Nitroreductase. 1 hit.
[Graphical view]
SUPFAMSSF55469. SSF55469. 1 hit.
ProtoNetSearch...

Entry information

Entry nameDRGA_SYNY3
AccessionPrimary (citable) accession number: Q55233
Secondary accession number(s): P73850
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: July 9, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Synechocystis PCC 6803

Synechocystis (strain PCC 6803): entries and gene names

SIMILARITY comments

Index of protein domains and families