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Protein

tRNA (guanine-N(7)-)-methyltransferase

Gene

mettl1

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the formation of N7-methylguanine at position 46 (m7G46) in tRNA.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + guanine(46) in tRNA = S-adenosyl-L-homocysteine + N7-methylguanine(46) in tRNA.UniRule annotation

Pathwayi: N(7)-methylguanine-tRNA biosynthesis

This protein is involved in the pathway N(7)-methylguanine-tRNA biosynthesis, which is part of tRNA modification.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway N(7)-methylguanine-tRNA biosynthesis and in tRNA modification.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei63S-adenosyl-L-methionine; via carbonyl oxygenUniRule annotation1
Binding sitei139S-adenosyl-L-methionine; via carbonyl oxygenUniRule annotation1
Active sitei142UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMethyltransferase, RNA-binding, Transferase, tRNA-binding
Biological processtRNA processing
LigandS-adenosyl-L-methionine

Enzyme and pathway databases

UniPathwayiUPA00989

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA (guanine-N(7)-)-methyltransferaseUniRule annotation (EC:2.1.1.33UniRule annotation)
Alternative name(s):
Methyltransferase-like protein 1 homologUniRule annotation
tRNA (guanine(46)-N(7))-methyltransferaseUniRule annotation
tRNA(m7G46)-methyltransferaseUniRule annotation
Gene namesi
Name:mettl1
ORF Names:DDB_G0276491
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyostelidsDictyostelialesDictyosteliaceaeDictyostelium
Proteomesi
  • UP000002195 Componentsi: Chromosome 2, Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0276491 mettl1

Subcellular locationi

  • Nucleus UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003705791 – 278tRNA (guanine-N(7)-)-methyltransferaseAdd BLAST278

Proteomic databases

PaxDbiQ551M3
PRIDEiQ551M3

Interactioni

Protein-protein interaction databases

STRINGi44689.DDB0238339

Structurei

3D structure databases

ProteinModelPortaliQ551M3
SMRiQ551M3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni86 – 87S-adenosyl-L-methionine bindingUniRule annotation2
Regioni119 – 120S-adenosyl-L-methionine bindingUniRule annotation2
Regioni217 – 219S-adenosyl-L-methionine bindingUniRule annotation3

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.UniRule annotation

Phylogenomic databases

eggNOGiKOG3115 Eukaryota
COG0220 LUCA
InParanoidiQ551M3
KOiK03439
OMAiIGMEIRV
PhylomeDBiQ551M3

Family and domain databases

HAMAPiMF_03055 tRNA_methyltr_TrmB_euk, 1 hit
InterProiView protein in InterPro
IPR029063 SAM-dependent_MTases
IPR025763 Trm8_euk
IPR003358 tRNA_(Gua-N-7)_MeTrfase_Trmb
PANTHERiPTHR23417 PTHR23417, 1 hit
PTHR23417:SF16 PTHR23417:SF16, 1 hit
SUPFAMiSSF53335 SSF53335, 1 hit
TIGRFAMsiTIGR00091 TIGR00091, 1 hit
PROSITEiView protein in PROSITE
PS51625 SAM_MT_TRMB, 1 hit

Sequencei

Sequence statusi: Complete.

Q551M3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVYQKQEPKK KKAIKPYHRI KAHANPASDY NFYYPTGPES YDWTKNYPQQ
60 70 80 90 100
AMNEKKVEIA DVGCGYGGLL ISLSSLFPER LSVGMELRDK VVQYVEERID
110 120 130 140 150
KLREKHVGQF QNISVIRTNA MKYLPNYFEK GQLQKIFFLF PDPHFKKATH
160 170 180 190 200
KRRIISPTLL SEYAYILAPG AYAYFISDVE ELYLWMFEHF KNHPLFEQVE
210 220 230 240 250
RDIAENDSCI PLIVNSTEEG RKVNRIDGKK WFAVFRRITD PSKKDLTFKN
260 270
YTLTSPKEID STTTTTTSTA TITEVESK
Length:278
Mass (Da):32,423
Last modified:May 24, 2005 - v1
Checksum:i95CFC26258A8DF2A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000015 Genomic DNA Translation: EAL69199.1
RefSeqiXP_643107.1, XM_638015.1

Genome annotation databases

EnsemblProtistsiEAL69199; EAL69199; DDB_G0276491
GeneIDi8620511
KEGGiddi:DDB_G0276491

Similar proteinsi

Entry informationi

Entry nameiTRMB_DICDI
AccessioniPrimary (citable) accession number: Q551M3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 5, 2009
Last sequence update: May 24, 2005
Last modified: May 23, 2018
This is version 98 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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