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Protein

Eukaryotic translation initiation factor 6

Gene

eif6

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May also be involved in ribosome biogenesis.UniRule annotation

GO - Molecular functioni

  • ribosomal large subunit binding Source: dictyBase
  • ribosome binding Source: InterPro
  • translation initiation factor activity Source: UniProtKB-KW

GO - Biological processi

Keywordsi

Molecular functionInitiation factor
Biological processProtein biosynthesis, Ribosome biogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Eukaryotic translation initiation factor 6UniRule annotation
Short name:
eIF-6UniRule annotation
Gene namesi
Name:eif6
ORF Names:DDB_G0276493
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyostelidsDictyostelialesDictyosteliaceaeDictyostelium
Proteomesi
  • UP000002195 Componentsi: Chromosome 2, Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0276493 eIF6

Subcellular locationi

  • Cytoplasm UniRule annotation
  • nucleolus UniRule annotation
  • Note: Shuttles between cytoplasm and nucleus/nucleolus.UniRule annotation

GO - Cellular componenti

  • cytoplasm Source: dictyBase
  • cytosol Source: GO_Central
  • nucleolus Source: dictyBase
  • nucleus Source: dictyBase
  • preribosome, large subunit precursor Source: GO_Central

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003200581 – 244Eukaryotic translation initiation factor 6Add BLAST244

Proteomic databases

PaxDbiQ551M2

Interactioni

Subunit structurei

Monomer. Associates with the 60S ribosomal subunit.UniRule annotation

Protein-protein interaction databases

STRINGi44689.DDB0234038

Structurei

Secondary structure

1244
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi2 – 4Combined sources3
Beta strandi14 – 19Combined sources6
Beta strandi24 – 26Combined sources3
Helixi32 – 40Combined sources9
Beta strandi44 – 46Combined sources3
Turni60 – 62Combined sources3
Beta strandi67 – 72Combined sources6
Helixi78 – 87Combined sources10
Beta strandi90 – 96Combined sources7
Beta strandi104 – 107Combined sources4
Beta strandi112 – 116Combined sources5
Helixi123 – 133Combined sources11
Beta strandi135 – 137Combined sources3
Turni149 – 151Combined sources3
Beta strandi152 – 154Combined sources3
Beta strandi159 – 161Combined sources3
Helixi167 – 177Combined sources11
Beta strandi186 – 189Combined sources4
Helixi193 – 196Combined sources4
Beta strandi197 – 199Combined sources3
Beta strandi204 – 206Combined sources3
Helixi212 – 222Combined sources11

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5AN9electron microscopy3.30I1-224[»]
5ANBelectron microscopy4.10I1-224[»]
ProteinModelPortaliQ551M2
SMRiQ551M2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the eIF-6 family.UniRule annotation

Phylogenomic databases

eggNOGiKOG3185 Eukaryota
COG1976 LUCA
InParanoidiQ551M2
KOiK03264
OMAiNDWCAFT
PhylomeDBiQ551M2

Family and domain databases

CDDicd00527 IF6, 1 hit
HAMAPiMF_00032 eIF_6, 1 hit
InterProiView protein in InterPro
IPR002769 eIF6
PANTHERiPTHR10784 PTHR10784, 1 hit
PfamiView protein in Pfam
PF01912 eIF-6, 1 hit
PIRSFiPIRSF006413 IF-6, 1 hit
SMARTiView protein in SMART
SM00654 eIF6, 1 hit
TIGRFAMsiTIGR00323 eIF-6, 1 hit

Sequencei

Sequence statusi: Complete.

Q551M2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATRLQYENS CDVGVFLKLT NKYCLVGQCG SKQFLHTVEN RLADHIPVVE
60 70 80 90 100
TSIAGTRIVG RLSAGNKNGL LLPNTCTDQE LQQIRNSLPD DVVVQRIEEK
110 120 130 140 150
FSALGNCIAT NDYVALVHPD IDRETEEIIA DVLGVEVFRQ TVSGNVLVGT
160 170 180 190 200
YCALTNQGAL VHPMTSIADQ DELSSLLQVP LVAGTVNRGN ECVAAGCVVN
210 220 230 240
DWTAIVGADT TATEISVIES IFALQGSKPS NIINNIRNSI VDNV
Length:244
Mass (Da):26,254
Last modified:May 24, 2005 - v1
Checksum:i7C72A4210AE1EB2C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000015 Genomic DNA Translation: EAL69200.1
RefSeqiXP_643108.1, XM_638016.1

Genome annotation databases

EnsemblProtistsiEAL69200; EAL69200; DDB_G0276493
GeneIDi8620512
KEGGiddi:DDB_G0276493

Similar proteinsi

Entry informationi

Entry nameiIF6_DICDI
AccessioniPrimary (citable) accession number: Q551M2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: May 24, 2005
Last modified: March 28, 2018
This is version 75 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

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