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Protein

Eukaryotic translation initiation factor 6

Gene

eif6

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May also be involved in ribosome biogenesis.UniRule annotation

GO - Molecular functioni

  • ribosomal large subunit binding Source: dictyBase
  • ribosome binding Source: InterPro
  • translation initiation factor activity Source: UniProtKB-KW

GO - Biological processi

Keywordsi

Molecular functionInitiation factor
Biological processProtein biosynthesis, Ribosome biogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Eukaryotic translation initiation factor 6UniRule annotation
Short name:
eIF-6UniRule annotation
Gene namesi
Name:eif6
ORF Names:DDB_G0276493
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
Proteomesi
  • UP000002195 Componentsi: Chromosome 2, Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0276493. eIF6.

Subcellular locationi

  • Cytoplasm UniRule annotation
  • Nucleusnucleolus UniRule annotation

  • Note: Shuttles between cytoplasm and nucleus/nucleolus.UniRule annotation

GO - Cellular componenti

  • cytoplasm Source: dictyBase
  • cytosol Source: GO_Central
  • nucleolus Source: dictyBase
  • nucleus Source: dictyBase
  • preribosome, large subunit precursor Source: GO_Central

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003200581 – 244Eukaryotic translation initiation factor 6Add BLAST244

Proteomic databases

PaxDbiQ551M2.

Interactioni

Subunit structurei

Monomer. Associates with the 60S ribosomal subunit.UniRule annotation

Protein-protein interaction databases

STRINGi44689.DDB0234038.

Structurei

Secondary structure

1244
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi2 – 4Combined sources3
Beta strandi14 – 19Combined sources6
Beta strandi24 – 26Combined sources3
Helixi32 – 40Combined sources9
Beta strandi44 – 46Combined sources3
Turni60 – 62Combined sources3
Beta strandi67 – 72Combined sources6
Helixi78 – 87Combined sources10
Beta strandi90 – 96Combined sources7
Beta strandi104 – 107Combined sources4
Beta strandi112 – 116Combined sources5
Helixi123 – 133Combined sources11
Beta strandi135 – 137Combined sources3
Turni149 – 151Combined sources3
Beta strandi152 – 154Combined sources3
Beta strandi159 – 161Combined sources3
Helixi167 – 177Combined sources11
Beta strandi186 – 189Combined sources4
Helixi193 – 196Combined sources4
Beta strandi197 – 199Combined sources3
Beta strandi204 – 206Combined sources3
Helixi212 – 222Combined sources11

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5AN9electron microscopy3.30I1-224[»]
5ANBelectron microscopy4.10I1-224[»]
ProteinModelPortaliQ551M2.
SMRiQ551M2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the eIF-6 family.UniRule annotation

Phylogenomic databases

eggNOGiKOG3185. Eukaryota.
COG1976. LUCA.
InParanoidiQ551M2.
KOiK03264.
OMAiTAGNRHG.
PhylomeDBiQ551M2.

Family and domain databases

CDDicd00527. IF6. 1 hit.
HAMAPiMF_00032. eIF_6. 1 hit.
InterProiView protein in InterPro
IPR002769. eIF6.
PANTHERiPTHR10784. PTHR10784. 1 hit.
PfamiView protein in Pfam
PF01912. eIF-6. 1 hit.
PIRSFiPIRSF006413. IF-6. 1 hit.
SMARTiView protein in SMART
SM00654. eIF6. 1 hit.
TIGRFAMsiTIGR00323. eIF-6. 1 hit.

Sequencei

Sequence statusi: Complete.

Q551M2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATRLQYENS CDVGVFLKLT NKYCLVGQCG SKQFLHTVEN RLADHIPVVE
60 70 80 90 100
TSIAGTRIVG RLSAGNKNGL LLPNTCTDQE LQQIRNSLPD DVVVQRIEEK
110 120 130 140 150
FSALGNCIAT NDYVALVHPD IDRETEEIIA DVLGVEVFRQ TVSGNVLVGT
160 170 180 190 200
YCALTNQGAL VHPMTSIADQ DELSSLLQVP LVAGTVNRGN ECVAAGCVVN
210 220 230 240
DWTAIVGADT TATEISVIES IFALQGSKPS NIINNIRNSI VDNV
Length:244
Mass (Da):26,254
Last modified:May 24, 2005 - v1
Checksum:i7C72A4210AE1EB2C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000015 Genomic DNA. Translation: EAL69200.1.
RefSeqiXP_643108.1. XM_638016.1.

Genome annotation databases

EnsemblProtistsiEAL69200; EAL69200; DDB_G0276493.
GeneIDi8620512.
KEGGiddi:DDB_G0276493.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000015 Genomic DNA. Translation: EAL69200.1.
RefSeqiXP_643108.1. XM_638016.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5AN9electron microscopy3.30I1-224[»]
5ANBelectron microscopy4.10I1-224[»]
ProteinModelPortaliQ551M2.
SMRiQ551M2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi44689.DDB0234038.

Proteomic databases

PaxDbiQ551M2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsiEAL69200; EAL69200; DDB_G0276493.
GeneIDi8620512.
KEGGiddi:DDB_G0276493.

Organism-specific databases

dictyBaseiDDB_G0276493. eIF6.

Phylogenomic databases

eggNOGiKOG3185. Eukaryota.
COG1976. LUCA.
InParanoidiQ551M2.
KOiK03264.
OMAiTAGNRHG.
PhylomeDBiQ551M2.

Miscellaneous databases

PROiPR:Q551M2.

Family and domain databases

CDDicd00527. IF6. 1 hit.
HAMAPiMF_00032. eIF_6. 1 hit.
InterProiView protein in InterPro
IPR002769. eIF6.
PANTHERiPTHR10784. PTHR10784. 1 hit.
PfamiView protein in Pfam
PF01912. eIF-6. 1 hit.
PIRSFiPIRSF006413. IF-6. 1 hit.
SMARTiView protein in SMART
SM00654. eIF6. 1 hit.
TIGRFAMsiTIGR00323. eIF-6. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiIF6_DICDI
AccessioniPrimary (citable) accession number: Q551M2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: May 24, 2005
Last modified: June 7, 2017
This is version 72 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. Translation initiation factors
    List of translation initiation factor entries
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.