Q55087 (CHLP_SYNY3) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Geranylgeranyl diphosphate reductase
EC=1.3.1.83

Alternative name(s):
Geranylgeranyl reductase

Gene names

Name:	chlP
Ordered Locus Names:	sll1091

Organism

Synechocystis sp. (strain PCC 6803 / Kazusa) [Reference proteome] [HAMAP]

Taxonomic identifier

1111708 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Cyanobacteria › Oscillatoriophycideae › Chroococcales › Synechocystis › Synechocystis sp. PCC 6803

Protein attributes

Sequence length	407 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the stepwise hydrogenation of geranylgeraniol to phytol during chlorophyll A (ChlA) biosynthesis.
Catalytic activity	Phytyl diphosphate + 3 NADP+ = geranylgeranyl diphosphate + 3 NADPH.
Pathway	Porphyrin biosynthesis; chlorophyll biosynthesis.
Sequence similarities	Belongs to the geranylgeranyl reductase family. ChlP subfamily.
Sequence caution	The sequence BAA18339.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Chlorophyll biosynthesis Photosynthesis
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	chlorophyll biosynthetic process Inferred from electronic annotation. Source: UniProtKB-UniPathway photosynthesis Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	geranylgeranyl reductase activity Inferred from electronic annotation. Source: InterPro nucleotide binding Inferred from electronic annotation. Source: InterPro oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 407	407	Geranylgeranyl diphosphate reductase		PRO_0000219664

Sequences

	Sequence		Length	Mass (Da)
	Q55087 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: 1D46FA7AE1C43CC5	FASTA	407	44,883
	10 20 30 40 50 60 MVLRVAVVGG GPAGSSAAEI LVKAGIETYL FERKLDNAKP CGGAIPLCMV DEFDLPPEII 70 80 90 100 110 120 DRRVRKMKMI SPSNIEVNIG QTLKDDEYIG MCRREVLDGF LRERAEKLGT KVINGTVYKL 130 140 150 160 170 180 DIPSKDSDPY TLHYADHSVG GTTGEMKILK VDVVIGADGA NSRIAKAIDA GDYNYAIAFQ 190 200 210 220 230 240 ERIRLPEDKM AYYDELAEMY VGDDVSPDFY AWVFPKYDHV AVGTGTMKVN KARIKDLQAG 250 260 270 280 290 300 IRTRAAKKLE GGEIIKVEAH PIPEHPRPRR VVGRVALVGD AAGTVTKSSG EGIYFAAKSA 310 320 330 340 350 360 RMCAETIVAT SNNGQRVPTE ADLKQYIKQW DKRYGATYLV LDILQRVFYR TDATREAFVE 370 380 390 400 MCSDIDVQKL TFDSYLYKTV VPANPLVQMK ITAKTIGSLL RGNALAP

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning, sequencing and functional assignment of the chlorophyll biosynthesis gene, chlP, of Synechocystis sp. PCC 6803." Addlesee H.A., Gibson L.C.D., Jensen P.E., Hunter C.N. FEBS Lett. 389:126-130(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions." Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y., Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T., Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S. , Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S. DNA Res. 3:109-136(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: PCC 6803 / Kazusa.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X97972 Genomic DNA. Translation: CAA66615.1. BA000022 Genomic DNA. Translation: BAA18339.1. Different initiation.
PIR	S69286.
RefSeq	NP_441659.2. NC_000911.1. YP_005651717.1. NC_017277.1. YP_007451541.1. NC_020286.1.
3D structure databases
ProteinModelPortal	Q55087.
ModBase	Search...
Protein-protein interaction databases
STRING	1148.sll1091.
Proteomic databases
PaxDb	Q55087.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	BAA18339; BAA18339; BAA18339.
GeneID	12254372. 14617204. 954978.
KEGG	syn:sll1091. syy:SYNGTS_1764.
PATRIC	23840777. VBISynSp132158_1943.
Phylogenomic databases
eggNOG	COG0644.
HOGENOM	HOG000147662.
KO	K10960.
OMA	YIGMCRR.
ProtClustDB	CLSK893221.
Enzyme and pathway databases
UniPathway	UPA00668.
Family and domain databases
Gene3D	3.40.50.720. 2 hits.
InterPro	IPR010253. BchP_ChlP_pln/prok. IPR011777. Geranylgeranyl_Rdtase_fam. IPR011774. Geranylgeranyl_Rdtase_pln/cyn. IPR016040. NAD(P)-bd_dom. IPR023753. Pyr_nucl-diS_OxRdtase_FAD/NAD. IPR003042. Rng_hydrolase-like. [Graphical view]
Pfam	PF07992. Pyr_redox_2. 1 hit. [Graphical view]
PRINTS	PR00420. RNGMNOXGNASE.
TIGRFAMs	TIGR02023. BchP-ChlP. 1 hit. TIGR02028. ChlP. 1 hit. TIGR02032. GG-red-SF. 1 hit.
ProtoNet	Search...

Entry information

Entry name

CHLP_SYNY3

Accession

Primary (citable) accession number: Q55087
Secondary accession number(s): P74245

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1996
Last modified:	May 1, 2013
This is version 95 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program