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Protein

Geranylgeranyl diphosphate reductase

Gene

chlP

Organism
Synechocystis sp. (strain PCC 6803 / Kazusa)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the stepwise hydrogenation of geranylgeraniol to phytol during chlorophyll A (ChlA) biosynthesis.

Catalytic activityi

Phytyl diphosphate + 3 NADP+ = geranylgeranyl diphosphate + 3 NADPH.

Pathwayi

GO - Molecular functioni

  1. geranylgeranyl reductase activity Source: InterPro
  2. oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor Source: InterPro

GO - Biological processi

  1. chlorophyll biosynthetic process Source: UniProtKB-UniPathway
  2. photosynthesis Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Chlorophyll biosynthesis, Photosynthesis

Keywords - Ligandi

NADP

Enzyme and pathway databases

UniPathwayiUPA00668.

Names & Taxonomyi

Protein namesi
Recommended name:
Geranylgeranyl diphosphate reductase (EC:1.3.1.83)
Alternative name(s):
Geranylgeranyl reductase
Gene namesi
Name:chlP
Ordered Locus Names:sll1091
OrganismiSynechocystis sp. (strain PCC 6803 / Kazusa)
Taxonomic identifieri1111708 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechocystis
ProteomesiUP000001425: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 407407Geranylgeranyl diphosphate reductasePRO_0000219664Add
BLAST

Proteomic databases

PaxDbiQ55087.

Interactioni

Protein-protein interaction databases

STRINGi1148.sll1091.

Structurei

3D structure databases

ProteinModelPortaliQ55087.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0644.
HOGENOMiHOG000147662.
InParanoidiQ55087.
KOiK10960.
OMAiRTLAPHE.
PhylomeDBiQ55087.

Family and domain databases

Gene3Di3.40.50.720. 2 hits.
InterProiIPR010253. BchP_ChlP_pln/prok.
IPR011777. Geranylgeranyl_Rdtase_fam.
IPR011774. Geranylgeranyl_Rdtase_pln/cyn.
IPR016040. NAD(P)-bd_dom.
IPR023753. Pyr_nucl-diS_OxRdtase_FAD/NAD.
IPR003042. Rng_hydrolase-like.
[Graphical view]
PfamiPF07992. Pyr_redox_2. 1 hit.
[Graphical view]
PRINTSiPR00420. RNGMNOXGNASE.
TIGRFAMsiTIGR02023. BchP-ChlP. 1 hit.
TIGR02028. ChlP. 1 hit.
TIGR02032. GG-red-SF. 1 hit.

Sequencei

Sequence statusi: Complete.

Q55087-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVLRVAVVGG GPAGSSAAEI LVKAGIETYL FERKLDNAKP CGGAIPLCMV
60 70 80 90 100
DEFDLPPEII DRRVRKMKMI SPSNIEVNIG QTLKDDEYIG MCRREVLDGF
110 120 130 140 150
LRERAEKLGT KVINGTVYKL DIPSKDSDPY TLHYADHSVG GTTGEMKILK
160 170 180 190 200
VDVVIGADGA NSRIAKAIDA GDYNYAIAFQ ERIRLPEDKM AYYDELAEMY
210 220 230 240 250
VGDDVSPDFY AWVFPKYDHV AVGTGTMKVN KARIKDLQAG IRTRAAKKLE
260 270 280 290 300
GGEIIKVEAH PIPEHPRPRR VVGRVALVGD AAGTVTKSSG EGIYFAAKSA
310 320 330 340 350
RMCAETIVAT SNNGQRVPTE ADLKQYIKQW DKRYGATYLV LDILQRVFYR
360 370 380 390 400
TDATREAFVE MCSDIDVQKL TFDSYLYKTV VPANPLVQMK ITAKTIGSLL

RGNALAP
Length:407
Mass (Da):44,883
Last modified:November 1, 1996 - v1
Checksum:i1D46FA7AE1C43CC5
GO

Sequence cautioni

The sequence BAA18339.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X97972 Genomic DNA. Translation: CAA66615.1.
BA000022 Genomic DNA. Translation: BAA18339.1. Different initiation.
PIRiS69286.
RefSeqiNP_441659.2. NC_000911.1.
YP_005651717.1. NC_017277.1.
YP_007451541.1. NC_020286.1.

Genome annotation databases

EnsemblBacteriaiBAA18339; BAA18339; BAA18339.
GeneIDi954978.
KEGGisyn:sll1091.
PATRICi23840777. VBISynSp132158_1943.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X97972 Genomic DNA. Translation: CAA66615.1.
BA000022 Genomic DNA. Translation: BAA18339.1. Different initiation.
PIRiS69286.
RefSeqiNP_441659.2. NC_000911.1.
YP_005651717.1. NC_017277.1.
YP_007451541.1. NC_020286.1.

3D structure databases

ProteinModelPortaliQ55087.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi1148.sll1091.

Proteomic databases

PaxDbiQ55087.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAA18339; BAA18339; BAA18339.
GeneIDi954978.
KEGGisyn:sll1091.
PATRICi23840777. VBISynSp132158_1943.

Phylogenomic databases

eggNOGiCOG0644.
HOGENOMiHOG000147662.
InParanoidiQ55087.
KOiK10960.
OMAiRTLAPHE.
PhylomeDBiQ55087.

Enzyme and pathway databases

UniPathwayiUPA00668.

Family and domain databases

Gene3Di3.40.50.720. 2 hits.
InterProiIPR010253. BchP_ChlP_pln/prok.
IPR011777. Geranylgeranyl_Rdtase_fam.
IPR011774. Geranylgeranyl_Rdtase_pln/cyn.
IPR016040. NAD(P)-bd_dom.
IPR023753. Pyr_nucl-diS_OxRdtase_FAD/NAD.
IPR003042. Rng_hydrolase-like.
[Graphical view]
PfamiPF07992. Pyr_redox_2. 1 hit.
[Graphical view]
PRINTSiPR00420. RNGMNOXGNASE.
TIGRFAMsiTIGR02023. BchP-ChlP. 1 hit.
TIGR02028. ChlP. 1 hit.
TIGR02032. GG-red-SF. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning, sequencing and functional assignment of the chlorophyll biosynthesis gene, chlP, of Synechocystis sp. PCC 6803."
    Addlesee H.A., Gibson L.C.D., Jensen P.E., Hunter C.N.
    FEBS Lett. 389:126-130(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions."
    Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y., Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T., Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S.
    , Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.
    DNA Res. 3:109-136(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PCC 6803 / Kazusa.

Entry informationi

Entry nameiCHLP_SYNY3
AccessioniPrimary (citable) accession number: Q55087
Secondary accession number(s): P74245
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: January 7, 2015
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
  3. Synechocystis PCC 6803
    Synechocystis (strain PCC 6803): entries and gene names

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.