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Protein

DNA repair and recombination protein RadA

Gene

radA

Organism
Sulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi114 – 1218ATPSequence analysis

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

DNA damage, DNA recombination

Keywords - Ligandi

ATP-binding, DNA-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSSOL273057:GCH2-237-MONOMER.
BRENDAi3.6.4.B7. 6163.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA repair and recombination protein RadA
Gene namesi
Name:radA
Ordered Locus Names:SSO0250
OrganismiSulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
Taxonomic identifieri273057 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeSulfolobus
Proteomesi
  • UP000001974 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 324324DNA repair and recombination protein RadAPRO_0000150107Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi273057.SSO0250.

Structurei

Secondary structure

1
324
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi14 – 163Combined sources
Beta strandi17 – 193Combined sources
Helixi22 – 298Combined sources
Turni30 – 323Combined sources
Helixi36 – 405Combined sources
Helixi44 – 518Combined sources
Helixi55 – 6814Combined sources
Helixi76 – 838Combined sources
Helixi94 – 996Combined sources
Turni100 – 1023Combined sources
Beta strandi103 – 1053Combined sources
Beta strandi108 – 1158Combined sources
Helixi120 – 13011Combined sources
Beta strandi131 – 1333Combined sources
Helixi135 – 1373Combined sources
Beta strandi143 – 1519Combined sources
Helixi155 – 16410Combined sources
Helixi169 – 1746Combined sources
Beta strandi176 – 1805Combined sources
Helixi184 – 20017Combined sources
Beta strandi204 – 2096Combined sources
Turni210 – 2134Combined sources
Helixi214 – 2196Combined sources
Turni222 – 2243Combined sources
Helixi226 – 24722Combined sources
Beta strandi250 – 2567Combined sources
Beta strandi283 – 2897Combined sources
Beta strandi294 – 3018Combined sources
Beta strandi303 – 3053Combined sources
Beta strandi308 – 3158Combined sources
Beta strandi318 – 3203Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2BKEX-ray3.20A1-324[»]
2DFLX-ray2.90A1-324[»]
2Z43X-ray1.93A/B/C1-324[»]
2ZUBX-ray2.90A/B1-324[»]
2ZUCX-ray3.30A/B1-324[»]
2ZUDX-ray3.20A/B1-324[»]
ProteinModelPortaliQ55075.
SMRiQ55075. Positions 13-322.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ55075.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiarCOG00415. Archaea.
COG0468. LUCA.
HOGENOMiHOG000227426.
InParanoidiQ55075.
KOiK04483.
OMAiCQLPIDQ.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00348. RadA_arch. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR013632. DNA_recomb/repair_Rad51_C.
IPR011938. DNA_recomb/repair_RadA.
IPR016467. DNA_recomb/repair_RecA-like.
IPR010995. DNA_repair_Rad51/TF_NusA_a-hlx.
IPR027417. P-loop_NTPase.
IPR020588. RecA_ATP-bd.
IPR020587. RecA_monomer-monomer_interface.
[Graphical view]
PfamiPF08423. Rad51. 1 hit.
[Graphical view]
PIRSFiPIRSF005856. Rad51. 1 hit.
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF47794. SSF47794. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR02236. recomb_radA. 1 hit.
PROSITEiPS50162. RECA_2. 1 hit.
PS50163. RECA_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q55075-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSNEVEQKKN IKTINDLPGI SQTVINKLIE AGYSSLETLA VASPQDLSVA
60 70 80 90 100
AGIPLSTAQK IIKEARDALD IRFKTALEVK KERMNVKKIS TGSQALDGLL
110 120 130 140 150
AGGIETRTMT EFFGEFGSGK TQLCHQLSVN VQLPPEKGGL SGKAVYIDTE
160 170 180 190 200
GTFRWERIEN MAKALGLDID NVMNNIYYIR AINTDHQIAI VDDLQELVSK
210 220 230 240 250
DPSIKLIVVD SVTSHFRAEY PGRENLAVRQ QKLNKHLHQL TRLAEVYDIA
260 270 280 290 300
VIITNQVMAR PDMFYGDPTV AVGGHTLYHV PGIRIQLKKS RGNRRIARVV
310 320
DAPHLPEGEV VFALTEEGIR DAEE
Length:324
Mass (Da):35,867
Last modified:June 1, 2001 - v2
Checksum:iAD3CCD9DFF541BCD
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti225 – 2251N → I in AAC44123 (PubMed:8668545).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U45310 Genomic DNA. Translation: AAC44123.1.
AE006641 Genomic DNA. Translation: AAK40589.1.
PIRiF90166.
S71093.
RefSeqiWP_009990512.1. NC_002754.1.

Genome annotation databases

EnsemblBacteriaiAAK40589; AAK40589; SSO0250.
GeneIDi27426543.
KEGGisso:SSO0250.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U45310 Genomic DNA. Translation: AAC44123.1.
AE006641 Genomic DNA. Translation: AAK40589.1.
PIRiF90166.
S71093.
RefSeqiWP_009990512.1. NC_002754.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2BKEX-ray3.20A1-324[»]
2DFLX-ray2.90A1-324[»]
2Z43X-ray1.93A/B/C1-324[»]
2ZUBX-ray2.90A/B1-324[»]
2ZUCX-ray3.30A/B1-324[»]
2ZUDX-ray3.20A/B1-324[»]
ProteinModelPortaliQ55075.
SMRiQ55075. Positions 13-322.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi273057.SSO0250.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAK40589; AAK40589; SSO0250.
GeneIDi27426543.
KEGGisso:SSO0250.

Phylogenomic databases

eggNOGiarCOG00415. Archaea.
COG0468. LUCA.
HOGENOMiHOG000227426.
InParanoidiQ55075.
KOiK04483.
OMAiCQLPIDQ.

Enzyme and pathway databases

BioCyciSSOL273057:GCH2-237-MONOMER.
BRENDAi3.6.4.B7. 6163.

Miscellaneous databases

EvolutionaryTraceiQ55075.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00348. RadA_arch. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR013632. DNA_recomb/repair_Rad51_C.
IPR011938. DNA_recomb/repair_RadA.
IPR016467. DNA_recomb/repair_RecA-like.
IPR010995. DNA_repair_Rad51/TF_NusA_a-hlx.
IPR027417. P-loop_NTPase.
IPR020588. RecA_ATP-bd.
IPR020587. RecA_monomer-monomer_interface.
[Graphical view]
PfamiPF08423. Rad51. 1 hit.
[Graphical view]
PIRSFiPIRSF005856. Rad51. 1 hit.
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF47794. SSF47794. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR02236. recomb_radA. 1 hit.
PROSITEiPS50162. RECA_2. 1 hit.
PS50163. RECA_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRADA_SULSO
AccessioniPrimary (citable) accession number: Q55075
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: June 1, 2001
Last modified: September 7, 2016
This is version 114 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.