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Protein

DNA repair and recombination protein RadA

Gene

radA

Organism
Sulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi114 – 121ATPSequence analysis8

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

DNA damage, DNA recombination

Keywords - Ligandi

ATP-binding, DNA-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi3.6.4.B7. 6163.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA repair and recombination protein RadA
Gene namesi
Name:radA
Ordered Locus Names:SSO0250
OrganismiSulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
Taxonomic identifieri273057 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeSulfolobus
Proteomesi
  • UP000001974 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001501071 – 324DNA repair and recombination protein RadAAdd BLAST324

Interactioni

Protein-protein interaction databases

STRINGi273057.SSO0250.

Structurei

Secondary structure

1324
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi14 – 16Combined sources3
Beta strandi17 – 19Combined sources3
Helixi22 – 29Combined sources8
Turni30 – 32Combined sources3
Helixi36 – 40Combined sources5
Helixi44 – 51Combined sources8
Helixi55 – 68Combined sources14
Helixi76 – 83Combined sources8
Helixi94 – 99Combined sources6
Turni100 – 102Combined sources3
Beta strandi103 – 105Combined sources3
Beta strandi108 – 115Combined sources8
Helixi120 – 130Combined sources11
Beta strandi131 – 133Combined sources3
Helixi135 – 137Combined sources3
Beta strandi143 – 151Combined sources9
Helixi155 – 164Combined sources10
Helixi169 – 174Combined sources6
Beta strandi176 – 180Combined sources5
Helixi184 – 200Combined sources17
Beta strandi204 – 209Combined sources6
Turni210 – 213Combined sources4
Helixi214 – 219Combined sources6
Turni222 – 224Combined sources3
Helixi226 – 247Combined sources22
Beta strandi250 – 256Combined sources7
Beta strandi283 – 289Combined sources7
Beta strandi294 – 301Combined sources8
Beta strandi303 – 305Combined sources3
Beta strandi308 – 315Combined sources8
Beta strandi318 – 320Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2BKEX-ray3.20A1-324[»]
2DFLX-ray2.90A1-324[»]
2Z43X-ray1.93A/B/C1-324[»]
2ZUBX-ray2.90A/B1-324[»]
2ZUCX-ray3.30A/B1-324[»]
2ZUDX-ray3.20A/B1-324[»]
ProteinModelPortaliQ55075.
SMRiQ55075.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ55075.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiarCOG00415. Archaea.
COG0468. LUCA.
HOGENOMiHOG000227426.
InParanoidiQ55075.
KOiK04483.
OMAiCQLPIDQ.

Family and domain databases

CDDicd01123. Rad51_DMC1_radA. 1 hit.
Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00348. RadA_arch. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR013632. DNA_recomb/repair_Rad51_C.
IPR011938. DNA_recomb/repair_RadA.
IPR016467. DNA_recomb/repair_RecA-like.
IPR010995. DNA_repair_Rad51/TF_NusA_a-hlx.
IPR027417. P-loop_NTPase.
IPR033925. Rad51_DMC1_RadA.
IPR020588. RecA_ATP-bd.
IPR020587. RecA_monomer-monomer_interface.
[Graphical view]
PfamiPF08423. Rad51. 1 hit.
[Graphical view]
PIRSFiPIRSF005856. Rad51. 1 hit.
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF47794. SSF47794. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR02236. recomb_radA. 1 hit.
PROSITEiPS50162. RECA_2. 1 hit.
PS50163. RECA_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q55075-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSNEVEQKKN IKTINDLPGI SQTVINKLIE AGYSSLETLA VASPQDLSVA
60 70 80 90 100
AGIPLSTAQK IIKEARDALD IRFKTALEVK KERMNVKKIS TGSQALDGLL
110 120 130 140 150
AGGIETRTMT EFFGEFGSGK TQLCHQLSVN VQLPPEKGGL SGKAVYIDTE
160 170 180 190 200
GTFRWERIEN MAKALGLDID NVMNNIYYIR AINTDHQIAI VDDLQELVSK
210 220 230 240 250
DPSIKLIVVD SVTSHFRAEY PGRENLAVRQ QKLNKHLHQL TRLAEVYDIA
260 270 280 290 300
VIITNQVMAR PDMFYGDPTV AVGGHTLYHV PGIRIQLKKS RGNRRIARVV
310 320
DAPHLPEGEV VFALTEEGIR DAEE
Length:324
Mass (Da):35,867
Last modified:June 1, 2001 - v2
Checksum:iAD3CCD9DFF541BCD
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti225N → I in AAC44123 (PubMed:8668545).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U45310 Genomic DNA. Translation: AAC44123.1.
AE006641 Genomic DNA. Translation: AAK40589.1.
PIRiF90166.
S71093.
RefSeqiWP_009990512.1. NC_002754.1.

Genome annotation databases

EnsemblBacteriaiAAK40589; AAK40589; SSO0250.
GeneIDi27426543.
KEGGisso:SSO0250.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U45310 Genomic DNA. Translation: AAC44123.1.
AE006641 Genomic DNA. Translation: AAK40589.1.
PIRiF90166.
S71093.
RefSeqiWP_009990512.1. NC_002754.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2BKEX-ray3.20A1-324[»]
2DFLX-ray2.90A1-324[»]
2Z43X-ray1.93A/B/C1-324[»]
2ZUBX-ray2.90A/B1-324[»]
2ZUCX-ray3.30A/B1-324[»]
2ZUDX-ray3.20A/B1-324[»]
ProteinModelPortaliQ55075.
SMRiQ55075.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi273057.SSO0250.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAK40589; AAK40589; SSO0250.
GeneIDi27426543.
KEGGisso:SSO0250.

Phylogenomic databases

eggNOGiarCOG00415. Archaea.
COG0468. LUCA.
HOGENOMiHOG000227426.
InParanoidiQ55075.
KOiK04483.
OMAiCQLPIDQ.

Enzyme and pathway databases

BRENDAi3.6.4.B7. 6163.

Miscellaneous databases

EvolutionaryTraceiQ55075.

Family and domain databases

CDDicd01123. Rad51_DMC1_radA. 1 hit.
Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00348. RadA_arch. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR013632. DNA_recomb/repair_Rad51_C.
IPR011938. DNA_recomb/repair_RadA.
IPR016467. DNA_recomb/repair_RecA-like.
IPR010995. DNA_repair_Rad51/TF_NusA_a-hlx.
IPR027417. P-loop_NTPase.
IPR033925. Rad51_DMC1_RadA.
IPR020588. RecA_ATP-bd.
IPR020587. RecA_monomer-monomer_interface.
[Graphical view]
PfamiPF08423. Rad51. 1 hit.
[Graphical view]
PIRSFiPIRSF005856. Rad51. 1 hit.
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF47794. SSF47794. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR02236. recomb_radA. 1 hit.
PROSITEiPS50162. RECA_2. 1 hit.
PS50163. RECA_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRADA_SULSO
AccessioniPrimary (citable) accession number: Q55075
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: June 1, 2001
Last modified: November 30, 2016
This is version 117 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.