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Protein

Bifunctional pantoate ligase/cytidylate kinase

Gene

panC/cmk

Organism
Synechocystis sp. (strain PCC 6803 / Kazusa)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + (R)-pantoate + beta-alanine = AMP + diphosphate + (R)-pantothenate.
ATP + (d)CMP = ADP + (d)CDP.

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi296 – 3049ATPBy similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. cytidylate kinase activity Source: UniProtKB-HAMAP
  3. pantoate-beta-alanine ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. pantothenate biosynthetic process Source: UniProtKB-HAMAP
  2. pyrimidine nucleotide metabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Ligase, Transferase

Keywords - Biological processi

Pantothenate biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00028; UER00005.

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional pantoate ligase/cytidylate kinase
Including the following 2 domains:
Pantoate--beta-alanine ligase (EC:6.3.2.1)
Alternative name(s):
Pantoate-activating enzyme
Pantothenate synthetase
Cytidylate kinase (EC:2.7.4.14)
Short name:
CK
Alternative name(s):
Cytidine monophosphate kinase
Short name:
CMP kinase
Gene namesi
Name:panC/cmk
Synonyms:panC/kcy
Ordered Locus Names:sll1249
OrganismiSynechocystis sp. (strain PCC 6803 / Kazusa)
Taxonomic identifieri1111708 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechocystis
ProteomesiUP000001425 Componenti: Chromosome

Subcellular locationi

  1. Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 513513Bifunctional pantoate ligase/cytidylate kinasePRO_0000131992Add
BLAST

Interactioni

Protein-protein interaction databases

IntActiQ55074. 1 interaction.
STRINGi1148.sll1249.

Structurei

3D structure databases

ProteinModelPortaliQ55074.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 283283Pantoate--beta-alanine ligaseAdd
BLAST
Regioni284 – 513230Cytidylate kinaseAdd
BLAST

Sequence similaritiesi

In the N-terminal section; belongs to the pantothenate synthetase family.Curated
In the C-terminal section; belongs to the cytidylate kinase family. Type 1 subfamily.Curated

Phylogenomic databases

eggNOGiCOG0283.
HOGENOMiHOG000233355.
InParanoidiQ55074.
KOiK13799.
OMAiLGEKDWQ.
OrthoDBiEOG6Z6FZ4.
PhylomeDBiQ55074.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
3.40.50.620. 1 hit.
HAMAPiMF_00158. PanC.
MF_00238. Cytidyl_kinase_type1.
MF_01349. PanCY.
InterProiIPR003136. Cytidylate_kin.
IPR011994. Cytidylate_kinase_dom.
IPR027417. P-loop_NTPase.
IPR003721. Pantoate_ligase.
IPR024894. Pantoate_ligase/cytidylate_kin.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PANTHERiPTHR21299:SF2. PTHR21299:SF2. 1 hit.
PfamiPF02224. Cytidylate_kin. 1 hit.
PF02569. Pantoate_ligase. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00017. cmk. 1 hit.
TIGR00018. panC. 1 hit.

Sequencei

Sequence statusi: Complete.

Q55074-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVQVFRTIAG LQTYLRQAGR GKTVGLVPTM GSLHAGHGSL LKRAVAEMDL
60 70 80 90 100
VVLSIFVNPL QFGPGEDLEK YPRDFDGDRQ WAESLGVAVI FAPTVTDLGI
110 120 130 140 150
DAKGDQTTVL PPPAMTEVLC GAHRPGHFQG VATIVTKLFT IVCPDVAYFG
160 170 180 190 200
AKDAQQLAII RRLVQDLNLT VTIRSCATVR EESGLAMSSR NQYLSPIEKE
210 220 230 240 250
QATVLYRSLQ AAQQRYRQGD RQVSALLTAT QDVLDAEPSV QVQYLQLVEA
260 270 280 290 300
DTLQPITGTL PDQNPVLMAI AAYVGSTRLI DNLVLNHRLP IIAIDGPAGA
310 320 330 340 350
GKSTVTRQVA DGLGLTYLDT GAMYRALAWL ILDQGIAPED EPAVAELTSG
360 370 380 390 400
AEIELMPRPA PQLTGVKVNG QDVSDAIRTP AVTQLVSTIA AQGAVRAKLL
410 420 430 440 450
KLQRKYGDQG GIVAEGRDIG TQVFPNAELK IFLTASVQER ARRRLKDFEA
460 470 480 490 500
QGNQAVDLAQ LEADIAHRDH LDSTRAIAPL QKAVDAVEII TDNLTIAEVV
510
ETIIELYKKY NKG
Length:513
Mass (Da):55,452
Last modified:June 13, 2006 - v2
Checksum:i5A216A6E718A677B
GO

Sequence cautioni

The sequence AAA86660.1 differs from that shown. Reason: Frameshift at positions 213, 240, 254 and 258. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U44896 Genomic DNA. Translation: AAA86660.1. Frameshift.
U44896 Genomic DNA. Translation: AAA86661.1.
BA000022 Genomic DNA. Translation: BAA18165.1.
PIRiS75604.
RefSeqiNP_441485.1. NC_000911.1.
YP_005651543.1. NC_017277.1.
YP_007451367.1. NC_020286.1.

Genome annotation databases

EnsemblBacteriaiBAA18165; BAA18165; BAA18165.
KEGGisyn:sll1249.
PATRICi23840383. VBISynSp132158_1749.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U44896 Genomic DNA. Translation: AAA86660.1. Frameshift.
U44896 Genomic DNA. Translation: AAA86661.1.
BA000022 Genomic DNA. Translation: BAA18165.1.
PIRiS75604.
RefSeqiNP_441485.1. NC_000911.1.
YP_005651543.1. NC_017277.1.
YP_007451367.1. NC_020286.1.

3D structure databases

ProteinModelPortaliQ55074.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ55074. 1 interaction.
STRINGi1148.sll1249.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAA18165; BAA18165; BAA18165.
KEGGisyn:sll1249.
PATRICi23840383. VBISynSp132158_1749.

Phylogenomic databases

eggNOGiCOG0283.
HOGENOMiHOG000233355.
InParanoidiQ55074.
KOiK13799.
OMAiLGEKDWQ.
OrthoDBiEOG6Z6FZ4.
PhylomeDBiQ55074.

Enzyme and pathway databases

UniPathwayiUPA00028; UER00005.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
3.40.50.620. 1 hit.
HAMAPiMF_00158. PanC.
MF_00238. Cytidyl_kinase_type1.
MF_01349. PanCY.
InterProiIPR003136. Cytidylate_kin.
IPR011994. Cytidylate_kinase_dom.
IPR027417. P-loop_NTPase.
IPR003721. Pantoate_ligase.
IPR024894. Pantoate_ligase/cytidylate_kin.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PANTHERiPTHR21299:SF2. PTHR21299:SF2. 1 hit.
PfamiPF02224. Cytidylate_kin. 1 hit.
PF02569. Pantoate_ligase. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00017. cmk. 1 hit.
TIGR00018. panC. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning, characterization and expression of carbonic anhydrase from the cyanobacterium Synechocystis PCC6803."
    So A.K.C., Espie G.S.
    Plant Mol. Biol. 37:205-215(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions."
    Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y., Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T., Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S.
    , Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.
    DNA Res. 3:109-136(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PCC 6803 / Kazusa.

Entry informationi

Entry nameiPANCY_SYNY3
AccessioniPrimary (citable) accession number: Q55074
Secondary accession number(s): P74087, Q55073
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: June 13, 2006
Last modified: April 1, 2015
This is version 101 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
  3. Synechocystis PCC 6803
    Synechocystis (strain PCC 6803): entries and gene names

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.