Q55074 (PANCY_SYNY3) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Bifunctional pantoate ligase/cytidylate kinase

Including the following 2 domains:

1. Pantoate--beta-alanine ligase
   EC=6.3.2.1
   Alternative name(s):
   Pantoate-activating enzyme
   Pantothenate synthetase
2. Cytidylate kinase
   Short name=CK
   EC=2.7.4.14
   Alternative name(s):
   Cytidine monophosphate kinase
   Short name=CMP kinase

Gene names

Name:	panC/cmk
Synonyms:	panC/kcy
Ordered Locus Names:	sll1249

Organism

Synechocystis sp. (strain PCC 6803 / Kazusa) [Reference proteome] [HAMAP]

Taxonomic identifier

1111708 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Cyanobacteria › Oscillatoriophycideae › Chroococcales › Synechocystis › Synechocystis sp. PCC 6803

Protein attributes

Sequence length	513 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + (R)-pantoate + beta-alanine = AMP + diphosphate + (R)-pantothenate. HAMAP-Rule MF_01349 ATP + (d)CMP = ADP + (d)CDP. HAMAP-Rule MF_01349
Pathway	Cofactor biosynthesis; (R)-pantothenate biosynthesis; (R)-pantothenate from (R)-pantoate and beta-alanine: step 1/1. HAMAP-Rule MF_01349
Subcellular location	Cytoplasm By similarity.
Sequence similarities	In the N-terminal section; belongs to the pantothenate synthetase family. In the C-terminal section; belongs to the cytidylate kinase family. Type 1 subfamily.
Sequence caution	The sequence AAA86660.1 differs from that shown. Reason: Frameshift at positions 213, 240, 254 and 258.

Ontologies

Keywords
Biological process	Pantothenate biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Ligase Transferase
Technical term	Complete proteome Multifunctional enzyme Reference proteome
Gene Ontology (GO)
Biological_process	pantothenate biosynthetic process Inferred from electronic annotation. Source: UniProtKB-UniPathway
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW cytidylate kinase activity Inferred from electronic annotation. Source: EC pantoate-beta-alanine ligase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 513	513	Bifunctional pantoate ligase/cytidylate kinase HAMAP-Rule MF_01349		PRO_0000131992
Regions
	Nucleotide binding	296 – 304	9	ATP By similarity
	Region	1 – 283	283	Pantoate--beta-alanine ligase HAMAP-Rule MF_01349
	Region	284 – 513	230	Cytidylate kinase HAMAP-Rule MF_01349

Sequences

	Sequence		Length	Mass (Da)
	Q55074 [UniParc]. Last modified June 13, 2006. Version 2. Checksum: 5A216A6E718A677B	FASTA	513	55,452
	10 20 30 40 50 60 MVQVFRTIAG LQTYLRQAGR GKTVGLVPTM GSLHAGHGSL LKRAVAEMDL VVLSIFVNPL 70 80 90 100 110 120 QFGPGEDLEK YPRDFDGDRQ WAESLGVAVI FAPTVTDLGI DAKGDQTTVL PPPAMTEVLC 130 140 150 160 170 180 GAHRPGHFQG VATIVTKLFT IVCPDVAYFG AKDAQQLAII RRLVQDLNLT VTIRSCATVR 190 200 210 220 230 240 EESGLAMSSR NQYLSPIEKE QATVLYRSLQ AAQQRYRQGD RQVSALLTAT QDVLDAEPSV 250 260 270 280 290 300 QVQYLQLVEA DTLQPITGTL PDQNPVLMAI AAYVGSTRLI DNLVLNHRLP IIAIDGPAGA 310 320 330 340 350 360 GKSTVTRQVA DGLGLTYLDT GAMYRALAWL ILDQGIAPED EPAVAELTSG AEIELMPRPA 370 380 390 400 410 420 PQLTGVKVNG QDVSDAIRTP AVTQLVSTIA AQGAVRAKLL KLQRKYGDQG GIVAEGRDIG 430 440 450 460 470 480 TQVFPNAELK IFLTASVQER ARRRLKDFEA QGNQAVDLAQ LEADIAHRDH LDSTRAIAPL 490 500 510 QKAVDAVEII TDNLTIAEVV ETIIELYKKY NKG

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning, characterization and expression of carbonic anhydrase from the cyanobacterium Synechocystis PCC6803." So A.K.C., Espie G.S. Plant Mol. Biol. 37:205-215(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions." Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y., Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T., Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S. , Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S. DNA Res. 3:109-136(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: PCC 6803 / Kazusa.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U44896 Genomic DNA. Translation: AAA86660.1. Frameshift. U44896 Genomic DNA. Translation: AAA86661.1. BA000022 Genomic DNA. Translation: BAA18165.1.
PIR	S75604.
RefSeq	NP_441485.1. NC_000911.1. YP_005651543.1. NC_017277.1. YP_007451367.1. NC_020286.1.
3D structure databases
ProteinModelPortal	Q55074.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q55074. 1 interaction.
STRING	1148.sll1249.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	BAA18165; BAA18165; BAA18165.
GeneID	12254195. 14617027. 954865.
KEGG	syn:sll1249. syy:SYNGTS_1590.
PATRIC	23840383. VBISynSp132158_1749.
Phylogenomic databases
eggNOG	COG0283.
HOGENOM	HOG000233355.
KO	K13799.
OMA	LGEKDWQ.
ProtClustDB	PRK13477.
Enzyme and pathway databases
UniPathway	UPA00028; UER00005.
Family and domain databases
Gene3D	3.40.50.620. 1 hit.
HAMAP	MF_01349. PanCY.
InterPro	IPR003136. Cytidylate_kin. IPR011994. Cytidylate_kinase_dom. IPR003721. Pantoate_ligase. IPR024894. Pantoate_ligase/cytidylate_kin. IPR014729. Rossmann-like_a/b/a_fold. [Graphical view]
PANTHER	PTHR21299:SF1. PTHR21299:SF1. 1 hit.
Pfam	PF02224. Cytidylate_kin. 1 hit. PF02569. Pantoate_ligase. 1 hit. [Graphical view]
TIGRFAMs	TIGR00017. cmk. 1 hit. TIGR00018. panC. 1 hit.
ProtoNet	Search...

Entry information

Entry name

PANCY_SYNY3

Accession

Primary (citable) accession number: Q55074
Secondary accession number(s): P74087, Q55073

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
Last sequence update:	June 13, 2006
Last modified:	May 1, 2013
This is version 88 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program