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Q55074 (PANCY_SYNY3) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 94. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Bifunctional pantoate ligase/cytidylate kinase

Including the following 2 domains:

  1. Pantoate--beta-alanine ligase
    EC=6.3.2.1
    Alternative name(s):
    Pantoate-activating enzyme
    Pantothenate synthetase
  2. Cytidylate kinase
    Short name=CK
    EC=2.7.4.14
    Alternative name(s):
    Cytidine monophosphate kinase
    Short name=CMP kinase
Gene names
Name:panC/cmk
Synonyms:panC/kcy
Ordered Locus Names:sll1249
OrganismSynechocystis sp. (strain PCC 6803 / Kazusa) [Reference proteome] [HAMAP]
Taxonomic identifier1111708 [NCBI]
Taxonomic lineageBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechocystis

Protein attributes

Sequence length513 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + (R)-pantoate + beta-alanine = AMP + diphosphate + (R)-pantothenate. HAMAP-Rule MF_00158

ATP + (d)CMP = ADP + (d)CDP. HAMAP-Rule MF_00158

Pathway

Cofactor biosynthesis; (R)-pantothenate biosynthesis; (R)-pantothenate from (R)-pantoate and beta-alanine: step 1/1. HAMAP-Rule MF_00158

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00158.

Sequence similarities

In the N-terminal section; belongs to the pantothenate synthetase family.

In the C-terminal section; belongs to the cytidylate kinase family. Type 1 subfamily.

Sequence caution

The sequence AAA86660.1 differs from that shown. Reason: Frameshift at positions 213, 240, 254 and 258.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 513513Bifunctional pantoate ligase/cytidylate kinase HAMAP-Rule MF_00158
PRO_0000131992

Regions

Nucleotide binding296 – 3049ATP By similarity
Region1 – 283283Pantoate--beta-alanine ligase HAMAP-Rule MF_00158
Region284 – 513230Cytidylate kinase HAMAP-Rule MF_00158

Sequences

Sequence LengthMass (Da)Tools
Q55074 [UniParc].

Last modified June 13, 2006. Version 2.
Checksum: 5A216A6E718A677B

FASTA51355,452
        10         20         30         40         50         60 
MVQVFRTIAG LQTYLRQAGR GKTVGLVPTM GSLHAGHGSL LKRAVAEMDL VVLSIFVNPL 

        70         80         90        100        110        120 
QFGPGEDLEK YPRDFDGDRQ WAESLGVAVI FAPTVTDLGI DAKGDQTTVL PPPAMTEVLC 

       130        140        150        160        170        180 
GAHRPGHFQG VATIVTKLFT IVCPDVAYFG AKDAQQLAII RRLVQDLNLT VTIRSCATVR 

       190        200        210        220        230        240 
EESGLAMSSR NQYLSPIEKE QATVLYRSLQ AAQQRYRQGD RQVSALLTAT QDVLDAEPSV 

       250        260        270        280        290        300 
QVQYLQLVEA DTLQPITGTL PDQNPVLMAI AAYVGSTRLI DNLVLNHRLP IIAIDGPAGA 

       310        320        330        340        350        360 
GKSTVTRQVA DGLGLTYLDT GAMYRALAWL ILDQGIAPED EPAVAELTSG AEIELMPRPA 

       370        380        390        400        410        420 
PQLTGVKVNG QDVSDAIRTP AVTQLVSTIA AQGAVRAKLL KLQRKYGDQG GIVAEGRDIG 

       430        440        450        460        470        480 
TQVFPNAELK IFLTASVQER ARRRLKDFEA QGNQAVDLAQ LEADIAHRDH LDSTRAIAPL 

       490        500        510 
QKAVDAVEII TDNLTIAEVV ETIIELYKKY NKG 

« Hide

References

« Hide 'large scale' references
[1]"Cloning, characterization and expression of carbonic anhydrase from the cyanobacterium Synechocystis PCC6803."
So A.K.C., Espie G.S.
Plant Mol. Biol. 37:205-215(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions."
Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y., Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T., Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S. expand/collapse author list , Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.
DNA Res. 3:109-136(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: PCC 6803 / Kazusa.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U44896 Genomic DNA. Translation: AAA86660.1. Frameshift.
U44896 Genomic DNA. Translation: AAA86661.1.
BA000022 Genomic DNA. Translation: BAA18165.1.
PIRS75604.
RefSeqNP_441485.1. NC_000911.1.
YP_005651543.1. NC_017277.1.
YP_007451367.1. NC_020286.1.

3D structure databases

ProteinModelPortalQ55074.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ55074. 1 interaction.
STRING1148.sll1249.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAA18165; BAA18165; BAA18165.
GeneID12254195.
14617027.
954865.
KEGGsyn:sll1249.
syy:SYNGTS_1590.
syz:MYO_116050.
PATRIC23840383. VBISynSp132158_1749.

Phylogenomic databases

eggNOGCOG0283.
HOGENOMHOG000233355.
KOK13799.
OMALGEKDWQ.
OrthoDBEOG6Z6FZ4.
PhylomeDBQ55074.
ProtClustDBPRK13477.

Enzyme and pathway databases

UniPathwayUPA00028; UER00005.

Family and domain databases

Gene3D3.40.50.300. 1 hit.
3.40.50.620. 1 hit.
HAMAPMF_00158. PanC.
MF_00238. Cytidyl_kinase_type1.
MF_01349. PanCY.
InterProIPR003136. Cytidylate_kin.
IPR011994. Cytidylate_kinase_dom.
IPR027417. P-loop_NTPase.
IPR003721. Pantoate_ligase.
IPR024894. Pantoate_ligase/cytidylate_kin.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PANTHERPTHR21299:SF2. PTHR21299:SF2. 1 hit.
PfamPF02224. Cytidylate_kin. 1 hit.
PF02569. Pantoate_ligase. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
TIGRFAMsTIGR00017. cmk. 1 hit.
TIGR00018. panC. 1 hit.
ProtoNetSearch...

Entry information

Entry namePANCY_SYNY3
AccessionPrimary (citable) accession number: Q55074
Secondary accession number(s): P74087, Q55073
Entry history
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: June 13, 2006
Last modified: April 16, 2014
This is version 94 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Synechocystis PCC 6803

Synechocystis (strain PCC 6803): entries and gene names

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways