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Q55074

- PANCY_SYNY3

UniProt

Q55074 - PANCY_SYNY3

Protein

Bifunctional pantoate ligase/cytidylate kinase

Gene

panC/cmk

Organism
Synechocystis sp. (strain PCC 6803 / Kazusa)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 97 (01 Oct 2014)
      Sequence version 2 (13 Jun 2006)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + (R)-pantoate + beta-alanine = AMP + diphosphate + (R)-pantothenate.
    ATP + (d)CMP = ADP + (d)CDP.

    Pathwayi

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi296 – 3049ATPBy similarity

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. cytidylate kinase activity Source: UniProtKB-HAMAP
    3. pantoate-beta-alanine ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. pantothenate biosynthetic process Source: UniProtKB-HAMAP
    2. pyrimidine nucleotide metabolic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Kinase, Ligase, Transferase

    Keywords - Biological processi

    Pantothenate biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    UniPathwayiUPA00028; UER00005.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Bifunctional pantoate ligase/cytidylate kinase
    Including the following 2 domains:
    Pantoate--beta-alanine ligase (EC:6.3.2.1)
    Alternative name(s):
    Pantoate-activating enzyme
    Pantothenate synthetase
    Cytidylate kinase (EC:2.7.4.14)
    Short name:
    CK
    Alternative name(s):
    Cytidine monophosphate kinase
    Short name:
    CMP kinase
    Gene namesi
    Name:panC/cmk
    Synonyms:panC/kcy
    Ordered Locus Names:sll1249
    OrganismiSynechocystis sp. (strain PCC 6803 / Kazusa)
    Taxonomic identifieri1111708 [NCBI]
    Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechocystis
    ProteomesiUP000001425: Chromosome

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 513513Bifunctional pantoate ligase/cytidylate kinasePRO_0000131992Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    IntActiQ55074. 1 interaction.
    STRINGi1148.sll1249.

    Structurei

    3D structure databases

    ProteinModelPortaliQ55074.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 283283Pantoate--beta-alanine ligaseAdd
    BLAST
    Regioni284 – 513230Cytidylate kinaseAdd
    BLAST

    Sequence similaritiesi

    In the N-terminal section; belongs to the pantothenate synthetase family.Curated
    In the C-terminal section; belongs to the cytidylate kinase family. Type 1 subfamily.Curated

    Phylogenomic databases

    eggNOGiCOG0283.
    HOGENOMiHOG000233355.
    KOiK13799.
    OMAiLGEKDWQ.
    OrthoDBiEOG6Z6FZ4.
    PhylomeDBiQ55074.

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    3.40.50.620. 1 hit.
    HAMAPiMF_00158. PanC.
    MF_00238. Cytidyl_kinase_type1.
    MF_01349. PanCY.
    InterProiIPR003136. Cytidylate_kin.
    IPR011994. Cytidylate_kinase_dom.
    IPR027417. P-loop_NTPase.
    IPR003721. Pantoate_ligase.
    IPR024894. Pantoate_ligase/cytidylate_kin.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view]
    PANTHERiPTHR21299:SF2. PTHR21299:SF2. 1 hit.
    PfamiPF02224. Cytidylate_kin. 1 hit.
    PF02569. Pantoate_ligase. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    TIGRFAMsiTIGR00017. cmk. 1 hit.
    TIGR00018. panC. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q55074-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVQVFRTIAG LQTYLRQAGR GKTVGLVPTM GSLHAGHGSL LKRAVAEMDL    50
    VVLSIFVNPL QFGPGEDLEK YPRDFDGDRQ WAESLGVAVI FAPTVTDLGI 100
    DAKGDQTTVL PPPAMTEVLC GAHRPGHFQG VATIVTKLFT IVCPDVAYFG 150
    AKDAQQLAII RRLVQDLNLT VTIRSCATVR EESGLAMSSR NQYLSPIEKE 200
    QATVLYRSLQ AAQQRYRQGD RQVSALLTAT QDVLDAEPSV QVQYLQLVEA 250
    DTLQPITGTL PDQNPVLMAI AAYVGSTRLI DNLVLNHRLP IIAIDGPAGA 300
    GKSTVTRQVA DGLGLTYLDT GAMYRALAWL ILDQGIAPED EPAVAELTSG 350
    AEIELMPRPA PQLTGVKVNG QDVSDAIRTP AVTQLVSTIA AQGAVRAKLL 400
    KLQRKYGDQG GIVAEGRDIG TQVFPNAELK IFLTASVQER ARRRLKDFEA 450
    QGNQAVDLAQ LEADIAHRDH LDSTRAIAPL QKAVDAVEII TDNLTIAEVV 500
    ETIIELYKKY NKG 513
    Length:513
    Mass (Da):55,452
    Last modified:June 13, 2006 - v2
    Checksum:i5A216A6E718A677B
    GO

    Sequence cautioni

    The sequence AAA86660.1 differs from that shown. Reason: Frameshift at positions 213, 240, 254 and 258.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U44896 Genomic DNA. Translation: AAA86660.1. Frameshift.
    U44896 Genomic DNA. Translation: AAA86661.1.
    BA000022 Genomic DNA. Translation: BAA18165.1.
    PIRiS75604.
    RefSeqiNP_441485.1. NC_000911.1.
    YP_005651543.1. NC_017277.1.
    YP_007451367.1. NC_020286.1.

    Genome annotation databases

    EnsemblBacteriaiBAA18165; BAA18165; BAA18165.
    GeneIDi954865.
    KEGGisyn:sll1249.
    syy:SYNGTS_1590.
    syz:MYO_116050.
    PATRICi23840383. VBISynSp132158_1749.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U44896 Genomic DNA. Translation: AAA86660.1 . Frameshift.
    U44896 Genomic DNA. Translation: AAA86661.1 .
    BA000022 Genomic DNA. Translation: BAA18165.1 .
    PIRi S75604.
    RefSeqi NP_441485.1. NC_000911.1.
    YP_005651543.1. NC_017277.1.
    YP_007451367.1. NC_020286.1.

    3D structure databases

    ProteinModelPortali Q55074.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q55074. 1 interaction.
    STRINGi 1148.sll1249.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAA18165 ; BAA18165 ; BAA18165 .
    GeneIDi 954865.
    KEGGi syn:sll1249.
    syy:SYNGTS_1590.
    syz:MYO_116050.
    PATRICi 23840383. VBISynSp132158_1749.

    Phylogenomic databases

    eggNOGi COG0283.
    HOGENOMi HOG000233355.
    KOi K13799.
    OMAi LGEKDWQ.
    OrthoDBi EOG6Z6FZ4.
    PhylomeDBi Q55074.

    Enzyme and pathway databases

    UniPathwayi UPA00028 ; UER00005 .

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    3.40.50.620. 1 hit.
    HAMAPi MF_00158. PanC.
    MF_00238. Cytidyl_kinase_type1.
    MF_01349. PanCY.
    InterProi IPR003136. Cytidylate_kin.
    IPR011994. Cytidylate_kinase_dom.
    IPR027417. P-loop_NTPase.
    IPR003721. Pantoate_ligase.
    IPR024894. Pantoate_ligase/cytidylate_kin.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view ]
    PANTHERi PTHR21299:SF2. PTHR21299:SF2. 1 hit.
    Pfami PF02224. Cytidylate_kin. 1 hit.
    PF02569. Pantoate_ligase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    TIGRFAMsi TIGR00017. cmk. 1 hit.
    TIGR00018. panC. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Cloning, characterization and expression of carbonic anhydrase from the cyanobacterium Synechocystis PCC6803."
      So A.K.C., Espie G.S.
      Plant Mol. Biol. 37:205-215(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions."
      Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y., Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T., Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S.
      , Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.
      DNA Res. 3:109-136(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: PCC 6803 / Kazusa.

    Entry informationi

    Entry nameiPANCY_SYNY3
    AccessioniPrimary (citable) accession number: Q55074
    Secondary accession number(s): P74087, Q55073
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 2000
    Last sequence update: June 13, 2006
    Last modified: October 1, 2014
    This is version 97 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Multifunctional enzyme, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families
    3. Synechocystis PCC 6803
      Synechocystis (strain PCC 6803): entries and gene names

    External Data

    Dasty 3