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Q55038

- PUR1_SYNE7

UniProt

Q55038 - PUR1_SYNE7

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Protein

Amidophosphoribosyltransferase

Gene

purF

Organism
Synechococcus elongatus (strain PCC 7942) (Anacystis nidulans R2)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.UniRule annotation

Catalytic activityi

5-phospho-beta-D-ribosylamine + diphosphate + L-glutamate = L-glutamine + 5-phospho-alpha-D-ribose 1-diphosphate + H2O.UniRule annotation

Cofactori

Binds 1 magnesium ion per subunit.UniRule annotation
Binds 1 4Fe-4S cluster per subunit.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei27 – 271NucleophileUniRule annotation
Metal bindingi268 – 2681Iron-sulfur (4Fe-4S)UniRule annotation
Metal bindingi315 – 3151MagnesiumUniRule annotation
Metal bindingi377 – 3771MagnesiumUniRule annotation
Metal bindingi378 – 3781MagnesiumUniRule annotation
Metal bindingi414 – 4141Iron-sulfur (4Fe-4S)UniRule annotation
Metal bindingi465 – 4651Iron-sulfur (4Fe-4S)UniRule annotation
Metal bindingi468 – 4681Iron-sulfur (4Fe-4S)UniRule annotation

GO - Molecular functioni

  1. 4 iron, 4 sulfur cluster binding Source: UniProtKB-KW
  2. amidophosphoribosyltransferase activity Source: UniProtKB-EC
  3. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway
  2. glutamine metabolic process Source: UniProtKB-KW
  3. nucleoside metabolic process Source: InterPro
  4. purine nucleobase biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Purine biosynthesis

Keywords - Ligandi

4Fe-4S, Iron, Iron-sulfur, Magnesium, Metal-binding

Enzyme and pathway databases

BioCyciSYNEL:SYNPCC7942_0004-MONOMER.
UniPathwayiUPA00074; UER00124.

Protein family/group databases

MEROPSiC44.001.

Names & Taxonomyi

Protein namesi
Recommended name:
AmidophosphoribosyltransferaseUniRule annotation (EC:2.4.2.14UniRule annotation)
Short name:
ATaseUniRule annotation
Alternative name(s):
Glutamine phosphoribosylpyrophosphate amidotransferaseUniRule annotation
Short name:
GPATaseUniRule annotation
Gene namesi
Name:purFUniRule annotation
Ordered Locus Names:Synpcc7942_0004
OrganismiSynechococcus elongatus (strain PCC 7942) (Anacystis nidulans R2)
Taxonomic identifieri1140 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechococcus
ProteomesiUP000002717: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Propeptidei1 – 2626By similarityPRO_0000029271Add
BLAST
Chaini27 – 493467AmidophosphoribosyltransferasePRO_0000029272Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi1140.Synpcc7942_0004.

Structurei

3D structure databases

ProteinModelPortaliQ55038.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini27 – 252226Glutamine amidotransferase type-2UniRule annotationAdd
BLAST

Sequence similaritiesi

In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.UniRule annotation
Contains 1 glutamine amidotransferase type-2 domain.UniRule annotation

Keywords - Domaini

Glutamine amidotransferase

Phylogenomic databases

eggNOGiCOG0034.
HOGENOMiHOG000033688.
KOiK00764.
OrthoDBiEOG6KT2Q1.

Family and domain databases

Gene3Di3.40.50.2020. 1 hit.
3.60.20.10. 1 hit.
HAMAPiMF_01931. PurF.
InterProiIPR005854. Amd_phspho_trans.
IPR017932. GATase_2_dom.
IPR029055. Ntn_hydrolases_N.
IPR000836. PRibTrfase_dom.
IPR029057. PRTase-like.
[Graphical view]
PfamiPF00156. Pribosyltran. 1 hit.
[Graphical view]
PIRSFiPIRSF000485. Amd_phspho_trans. 1 hit.
SUPFAMiSSF53271. SSF53271. 1 hit.
SSF56235. SSF56235. 1 hit.
TIGRFAMsiTIGR01134. purF. 1 hit.
PROSITEiPS51278. GATASE_TYPE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q55038-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MIPTQPLTAD LDCDLGLERP DRPEEACGVF ALYAPGEEVA RMAYFGLYAL
60 70 80 90 100
QHRGQESAGI AVFEGDRVML HKDMGLVSQV FDPEILQQLQ GSLAVGHTRY
110 120 130 140 150
STTGSSRIAN AQPALLETRL GPVALAHNGN LVNTVELRQE LLAKNHELTT
160 170 180 190 200
TTDSELIAFA IMEAVAEGQD WRGAIESACR RSQGAFSLTI GTPEALYGTR
210 220 230 240 250
DPNGIRPLVL GTLESNGQTR YVLSSETCGL DIIGADYVRD IAPGEMVRIT
260 270 280 290 300
DAGLESWTWA EAPQPKLCVF EMIYFARPDS LFHGESLYSY RRRIGQRLAK
310 320 330 340 350
EAPADVDLVL GVPDSGIPAA IGFSEALGIP YAEGLIKNRY VGRTFIQPTQ
360 370 380 390 400
SMRETGIRMK LNPLKDVLAG KRIAIIDDSI VRGTTSRKLV KALRDAGATE
410 420 430 440 450
VHMRISSPPV THPCFYGIDT DTQDQLIAAT RSVSEITEQI GVDSLAYLTE
460 470 480 490
QGMLEATRES IGNFCTACFN GRYPIAIPEE IKRSKLMLET VTA
Length:493
Mass (Da):53,809
Last modified:November 1, 1996 - v1
Checksum:iE03508F8A922910C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U33211 Genomic DNA. Translation: AAA75107.1.
CP000100 Genomic DNA. Translation: ABB56036.1.
PIRiS77612.
RefSeqiYP_399023.1. NC_007604.1.

Genome annotation databases

EnsemblBacteriaiABB56036; ABB56036; Synpcc7942_0004.
GeneIDi3774224.
KEGGisyf:Synpcc7942_0004.
PATRICi23785029. VBISynElo51371_0065.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U33211 Genomic DNA. Translation: AAA75107.1 .
CP000100 Genomic DNA. Translation: ABB56036.1 .
PIRi S77612.
RefSeqi YP_399023.1. NC_007604.1.

3D structure databases

ProteinModelPortali Q55038.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 1140.Synpcc7942_0004.

Protein family/group databases

MEROPSi C44.001.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABB56036 ; ABB56036 ; Synpcc7942_0004 .
GeneIDi 3774224.
KEGGi syf:Synpcc7942_0004.
PATRICi 23785029. VBISynElo51371_0065.

Phylogenomic databases

eggNOGi COG0034.
HOGENOMi HOG000033688.
KOi K00764.
OrthoDBi EOG6KT2Q1.

Enzyme and pathway databases

UniPathwayi UPA00074 ; UER00124 .
BioCyci SYNEL:SYNPCC7942_0004-MONOMER.

Family and domain databases

Gene3Di 3.40.50.2020. 1 hit.
3.60.20.10. 1 hit.
HAMAPi MF_01931. PurF.
InterProi IPR005854. Amd_phspho_trans.
IPR017932. GATase_2_dom.
IPR029055. Ntn_hydrolases_N.
IPR000836. PRibTrfase_dom.
IPR029057. PRTase-like.
[Graphical view ]
Pfami PF00156. Pribosyltran. 1 hit.
[Graphical view ]
PIRSFi PIRSF000485. Amd_phspho_trans. 1 hit.
SUPFAMi SSF53271. SSF53271. 1 hit.
SSF56235. SSF56235. 1 hit.
TIGRFAMsi TIGR01134. purF. 1 hit.
PROSITEi PS51278. GATASE_TYPE_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Circadian expression of genes involved in the purine biosynthetic pathway of the cyanobacterium Synechococcus sp. strain PCC 7942."
    Liu Y., Tsinoremas N.F., Golden S.S., Kondo T., Johnson C.H.
    Mol. Microbiol. 20:1071-1081(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Complete sequence of chromosome 1 of Synechococcus elongatus PCC 7942."
    US DOE Joint Genome Institute
    Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Schmutz J., Larimer F., Land M., Kyrpides N., Lykidis A., Richardson P.
    Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PCC 7942.

Entry informationi

Entry nameiPUR1_SYNE7
AccessioniPrimary (citable) accession number: Q55038
Secondary accession number(s): Q31SD3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: October 29, 2014
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3