Q55034 (STPA_SYNY3) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Glucosylglycerol-phosphate phosphatase
Short name=GGP-P
EC=3.1.3.69

Alternative name(s):
Glucosylglycerol 3-phosphatase
Salt tolerance protein A

Gene names

Name:	stpA
Ordered Locus Names:	slr0746

Organism

Synechocystis sp. (strain PCC 6803 / Kazusa)

Taxonomic identifier

1111708 [NCBI]

Taxonomic lineage

Bacteria › Cyanobacteria › Chroococcales › Synechocystis

Protein attributes

Sequence length	422 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Phosphorylates glucosylglycerol-phosphate the precursor of the osmoprotectant glucosylglycerol necessary for salt adaptation of Synechocystis.
Catalytic activity	2-(beta-D-glucosyl)-sn-glycerol-3-phosphate + H2O = 2-(beta-D-glucosyl)-sn-glycerol + phosphate.
Subunit structure	Monomer Probable. Interacts with GGPS Probable. Ref.5
Sequence similarities	Belongs to the histidine acid phosphatase family.

Ontologies

Keywords
Molecular function	Hydrolase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	signal transduction Inferred from electronic annotation. Source: InterPro
Cellular component	intracellular Inferred from electronic annotation. Source: InterPro
Molecular function	acid phosphatase activity Inferred from electronic annotation. Source: InterPro glucosylglycerol 3-phosphatase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 422	422	Glucosylglycerol-phosphate phosphatase		PRO_0000114472
Sites
	Active site	403	1	Proton donor By similarity
Experimental info
	Sequence conflict	384	1	D → E in CAA53245. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q55034 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: E9C58CBC91A938F2	FASTA	422	46,542
	10 20 30 40 50 60 MVLHQQRFSL DHGAFCQTLA QTENLLIVQD LDGVCMELVQ DPLSRRLDAD YVRATTLFAE 70 80 90 100 110 120 HFYVLTNGEH VGKRGVQGIV EQSFGDASFV QQEGLYLPGL AAGGVQWQDR HGKVSHPGVG 130 140 150 160 170 180 QTELEFLAAV PEKITNCLKT FFGDRPHSLS PEQLQTGIEA SVLDNVASPT ANLNTLANLL 190 200 210 220 230 240 QDFPQIYRDL QETMAQLLDQ LMAEAVAQGL GNSFFVHYAP NLGRDERGKE IIRWAKAGDS 250 260 270 280 290 300 GTTDFQFMLR GGVKEAGVLA LLNRYYHNRT GQYPLGESFS ARQAPPSHQD LLHLVKAQFD 310 320 330 340 350 360 PALMPLIIGV GDTVTSQVDE ATGEIRRGGS DRQFLQLIQD LGDWGNHGNL VVYVDSSQGE 370 380 390 400 410 420 VKNRQPLQLE TVAGQTQVVA GPGDMRDREE PLKINVAFPG GHDQYVAAFK QAAQRRRVHF SQ

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A gene stpA involved in the establishment of salt tolerance in the cyanobacterium Synechocystis PCC6803." Onana B., Jeanjean R., Joset F. Russ. J. Plant Physiol. 41:176-183(1994) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Characterization of a glucosylglycerol-phosphate-accumulating, salt-sensitive mutant of the cyanobacterium Synechocystis sp. strain PCC 6803." Hagemann M., Richter S., Zuther E., Schoor A. Arch. Microbiol. 166:83-91(1996) [PubMed: 8772170] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	"Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions." Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y., Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T., Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S. , Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S. DNA Res. 3:109-136(1996) [PubMed: 8905231] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 27184 / PCC 6803 / N-1.
[4]	"The stpA gene form synechocystis sp. strain PCC 6803 encodes the glucosylglycerol-phosphate phosphatase involved in cyanobacterial osmotic response to salt shock." Hagemann M., Schoor A., Jeanjean R., Zuther E., Joset F. J. Bacteriol. 179:1727-1733(1997) [PubMed: 9045835] [Abstract] Cited for: CHARACTERIZATION.
[5]	"A membrane-bound FtsH protease is involved in osmoregulation in Synechocystis sp. PCC 6803: the compatible solute synthesizing enzyme GgpS is one of the targets for proteolysis." Stirnberg M., Fulda S., Huckauf J., Hagemann M., Kramer R., Marin K. Mol. Microbiol. 63:86-102(2007) [PubMed: 17116240] [Abstract] Cited for: POSSIBLE INTERACTION WITH GGPS.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U32936 Genomic DNA. Translation: AAB41279.1. X75566 Genomic DNA. Translation: CAA53245.1. BA000022 Genomic DNA. Translation: BAA18740.1.
PIR	S76828.
RefSeq	NP_442928.1. NC_000911.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
IntAct	Q55034. 1 interaction.
STRING	Q55034.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	953064.
GenomeReviews	Gene locus slr0746 in contig BA000022_GR.
KEGG	syn:slr0746.
NMPDR	fig|1148.1.peg.3029.
PATRIC	23843662. VBISynSp132158_3361.
Phylogenomic databases
eggNOG	NOG45088.
HOGENOM	HBG284536.
OMA	QDLDGVC.
PhylomeDB	Q55034.
ProtClustDB	CLSK893778.
Enzyme and pathway databases
BioCyc	SSP1148:SLR0746-MONOMER.
Family and domain databases
InterPro	IPR012765. GGPPase. IPR000560. His_Pase_superF_clade-2. IPR000198. RhoGAP_dom. [Graphical view]
Gene3D	G3DSA:1.10.555.10. RhoGAP. 1 hit.
KO	K05978.
Pfam	PF09506. Salt_tol_Pase. 1 hit. [Graphical view]
PIRSF	PIRSF020945. GGPPase. 1 hit.
TIGRFAMs	TIGR02399. Salt_tol_Pase. 1 hit.
PROSITE	PS00778. HIS_ACID_PHOSPHAT_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

STPA_SYNY3

Accession

Primary (citable) accession number: Q55034
Secondary accession number(s): Q54787

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 14, 2001
Last sequence update:	November 1, 1996
Last modified:	January 25, 2012
This is version 67 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program