Reviewed, UniProtKB/Swiss-Prot Q54ZD0 (PTH2_DICDI)

Names and origin

Protein names

Recommended name:
    Probable peptidyl-tRNA hydrolase 2
      Short name=PTH 2
    EC=3.1.1.29

Gene names

Name:	pth2
ORF Names:	DDB_G0277631

Organism

Dictyostelium discoideum (Slime mold) [Complete proteome]

Taxonomic identifier

44689 [NCBI]

Taxonomic lineage

Eukaryota › Amoebozoa › Mycetozoa › Dictyosteliida › Dictyostelium

Protein attributes

Sequence length	210 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis By similarity.
Catalytic activity	N-substituted aminoacyl-tRNA + H2O = N-substituted amino acid + tRNA.
Sequence similarities	Belongs to the PTH2 family.
Sequence caution	The sequence AAO50941.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	translation Inferred from electronic annotation. Source: InterPro
Molecular function	aminoacyl-tRNA hydrolase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 210	210	Probable peptidyl-tRNA hydrolase 2		PRO_0000355629
Regions
	Compositional bias	63 – 70	8	Poly-Asp

Sequences

	Sequence		Length	Mass (Da)
	Q54ZD0-1 [UniParc]. Last modified May 24, 2005. Version 1. Checksum: 6306C8B601C717B3	FASTA	210	23,517
	10 20 30 40 50 60 MQLNKDILLV SIISLFSGVL LGYFQAKCFK RSTITKNKEE VEQIKEIENN NQKEKEKEEK 70 80 90 100 110 120 EGDDDDDDDD ESESIDGDYD ENDDYEIEYD EEIGDCKQVL VIRTDLGMTK GKIIAQCCHA 130 140 150 160 170 180 SLGARQKALK DSKKVLRQWE NFGCAKITLK ANSKEELVDL RNKAKELGVV SYLVLDSGHT 190 200 210 QIPSGSATVL AVGPAPKEAV DAVTKHLKLY

References

[1]

"Sequence and analysis of chromosome 2 of Dictyostelium discoideum." Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T., Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R., Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A., Noegel A.A. Nature 418:79-85(2002) [PubMed: 12097910] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AX4.

[2]

"The genome of the social amoeba Dictyostelium discoideum." Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N. , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A. Nature 435:43-57(2005) [PubMed: 15875012] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AX4.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AC116100 Genomic DNA. Translation: AAO50941.1. Sequence problems. AAFI02000020 Genomic DNA. Translation: EAL68633.1.
RefSeq	XP_642567.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q54ZD0.
Genome annotation databases
GeneID	3393702.
GenomeReviews	Gene locus pth2 in contig CM000151_GR.
KEGG	ddi:DDBDRAFT_0203421.
Organism-specific databases
dictyBase	DDB_G0277631. pth2.
Phylogenomic databases
OMA	RMALVIR.
Family and domain databases
InterPro	IPR002833. Pep_tRNA_hydro_PTH2. [Graphical view]
Pfam	PF01981. PTH2. 1 hit. [Graphical view]
ProDom	PD010667. UPF0099. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR00283. Pep_tRNA_hydro_PTH2. 1 hit.
ProtoNet	Search...

Entry information

Entry name

PTH2_DICDI

Accession

Primary (citable) accession number: Q54ZD0
Secondary accession number(s): Q86AW1

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 16, 2008
Last sequence update:	May 24, 2005
Last modified:	November 3, 2009
This is version 24 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)