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Protein

Acetyl-coenzyme A synthetase

Gene

acsA

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + acetate + CoA = AMP + diphosphate + acetyl-CoA.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei320Coenzyme ABy similarity1
Binding sitei518ATPBy similarity1
Binding sitei533ATPBy similarity1
Binding sitei541Coenzyme A; via carbonyl oxygenBy similarity1
Binding sitei544ATPBy similarity1
Binding sitei603Coenzyme ABy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi396 – 398ATPBy similarity3
Nucleotide bindingi420 – 425ATPBy similarity6

GO - Molecular functioni

  • acetate-CoA ligase activity Source: dictyBase
  • AMP binding Source: dictyBase
  • ATP binding Source: UniProtKB-KW

GO - Biological processi

  • acetyl-CoA biosynthetic process Source: dictyBase
  • acetyl-CoA biosynthetic process from acetate Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-DDI-71384. Ethanol oxidation.

Names & Taxonomyi

Protein namesi
Recommended name:
Acetyl-coenzyme A synthetase (EC:6.2.1.1)
Alternative name(s):
Acetate--CoA ligase
Acyl-activating enzyme
Gene namesi
Name:acsA
ORF Names:DDB_G0277815
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
Proteomesi
  • UP000002195 Componentsi: Chromosome 2, Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0277815. acsA.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003283541 – 674Acetyl-coenzyme A synthetaseAdd BLAST674

Proteomic databases

PaxDbiQ54Z60.

Interactioni

Protein-protein interaction databases

STRINGi44689.DDB0231684.

Structurei

3D structure databases

ProteinModelPortaliQ54Z60.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni201 – 204Coenzyme A bindingBy similarity4

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1175. Eukaryota.
COG0365. LUCA.
InParanoidiQ54Z60.
KOiK01895.
OMAiTANEGPR.
PhylomeDBiQ54Z60.

Family and domain databases

CDDicd05966. ACS. 1 hit.
InterProiIPR011904. Ac_CoA_lig.
IPR032387. ACAS_N.
IPR025110. AMP-bd_C.
IPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
[Graphical view]
PfamiPF16177. ACAS_N. 1 hit.
PF00501. AMP-binding. 1 hit.
PF13193. AMP-binding_C. 1 hit.
[Graphical view]
TIGRFAMsiTIGR02188. Ac_CoA_lig_AcsA. 1 hit.
PROSITEiPS00455. AMP_BINDING. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q54Z60-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQITEKETVQ EEQQKLLYPP PSFSTKCHIS SVEQYNEMYK ESIESPNQFW
60 70 80 90 100
DKKAKEFLTW FSDYTTVQHG SFEKGDISWF LNGKINVSYN CIDRHLKENA
110 120 130 140 150
DKVAILFEGD EETMVKKVTY REMFEEVCRL SNLLISLGVG KGDTVAIYLP
160 170 180 190 200
NTPTAIYSML ACARIGAIHS VIFAGFGYES IVSRVHDAKC RVIITADEGL
210 220 230 240 250
RGGRYIPLKE KIDQVVQHCK LVQHVLVFKN TGRPTITFNP SIDIWADEAM
260 270 280 290 300
LDHRPYCPPV WLDSEDPLFI LYTSGSTGTP KGLVHTQAGY LLYAAMTHRY
310 320 330 340 350
VFDYHDSDVY ACMADVGWIT GHSYIVYGPL ANGATTFIFE GTPLYPTPAR
360 370 380 390 400
YWEMVQRHKI TQFYTAPTAI RSLMKFPISF TQQSDKSSLR VLGSVGEPIN
410 420 430 440 450
PEAWRWFNTN VGEGRCAIVD TYWQTESGGH LITPLPGVTS TKPGSATKPF
460 470 480 490 500
FGIELQVLDS KTGERLYINP DINGCKEISG VLAISKPWPG IARSVYRSHG
510 520 530 540 550
RYLQTYMTQY KGHYFTGDGV KLDSDGYYWI EGRVDDVINV SGHRLGTAEL
560 570 580 590 600
ESALVGCSIC AEAAVVGYPH DIKGQGILAF CTLKEGYQED ESNVIMMLKK
610 620 630 640 650
EVRNVIGPFA TPDVIVITPS LPKTRSGKIM RRILRKIGCH ESSAEQLGDI
660 670
STLAEPEVVK LLIEKVSKVI PKTH
Length:674
Mass (Da):75,586
Last modified:May 24, 2005 - v1
Checksum:i4DF825F016ECAB8F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000022 Genomic DNA. Translation: EAL68581.1.
RefSeqiXP_642493.1. XM_637401.1.

Genome annotation databases

EnsemblProtistsiEAL68581; EAL68581; DDB_G0277815.
GeneIDi8621204.
KEGGiddi:DDB_G0277815.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000022 Genomic DNA. Translation: EAL68581.1.
RefSeqiXP_642493.1. XM_637401.1.

3D structure databases

ProteinModelPortaliQ54Z60.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi44689.DDB0231684.

Proteomic databases

PaxDbiQ54Z60.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsiEAL68581; EAL68581; DDB_G0277815.
GeneIDi8621204.
KEGGiddi:DDB_G0277815.

Organism-specific databases

dictyBaseiDDB_G0277815. acsA.

Phylogenomic databases

eggNOGiKOG1175. Eukaryota.
COG0365. LUCA.
InParanoidiQ54Z60.
KOiK01895.
OMAiTANEGPR.
PhylomeDBiQ54Z60.

Enzyme and pathway databases

ReactomeiR-DDI-71384. Ethanol oxidation.

Miscellaneous databases

PROiQ54Z60.

Family and domain databases

CDDicd05966. ACS. 1 hit.
InterProiIPR011904. Ac_CoA_lig.
IPR032387. ACAS_N.
IPR025110. AMP-bd_C.
IPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
[Graphical view]
PfamiPF16177. ACAS_N. 1 hit.
PF00501. AMP-binding. 1 hit.
PF13193. AMP-binding_C. 1 hit.
[Graphical view]
TIGRFAMsiTIGR02188. Ac_CoA_lig_AcsA. 1 hit.
PROSITEiPS00455. AMP_BINDING. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiACSA_DICDI
AccessioniPrimary (citable) accession number: Q54Z60
Secondary accession number(s): Q86AW6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: May 24, 2005
Last modified: November 2, 2016
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.