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Q54YZ0

- UGPA2_DICDI

UniProt

Q54YZ0 - UGPA2_DICDI

Protein

UTP--glucose-1-phosphate uridylyltransferase 2

Gene

ugpB

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 62 (01 Oct 2014)
      Sequence version 1 (24 May 2005)
      Previous versions | rss
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    Functioni

    Plays a central role as a glucosyl donor in cellular metabolic pathways.1 Publication

    Catalytic activityi

    UTP + alpha-D-glucose 1-phosphate = diphosphate + UDP-glucose.

    GO - Molecular functioni

    1. UTP:glucose-1-phosphate uridylyltransferase activity Source: UniProtKB-EC

    GO - Biological processi

    1. autophagic vacuole assembly Source: dictyBase
    2. cellulose biosynthetic process Source: dictyBase

    Keywords - Molecular functioni

    Nucleotidyltransferase, Transferase

    Enzyme and pathway databases

    ReactomeiREACT_176277. Glycogen synthesis.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    UTP--glucose-1-phosphate uridylyltransferase 2 (EC:2.7.7.9)
    Alternative name(s):
    UDP-glucose pyrophosphorylase 2
    Short name:
    UDPGP 2
    Short name:
    UGPase 2
    Gene namesi
    Name:ugpB
    ORF Names:DDB_G0277879
    OrganismiDictyostelium discoideum (Slime mold)
    Taxonomic identifieri44689 [NCBI]
    Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
    ProteomesiUP000002195: Chromosome 3, UP000002195: Unassembled WGS sequence

    Organism-specific databases

    dictyBaseiDDB_G0277879. ugpB.

    Pathology & Biotechi

    Disruption phenotypei

    Cells undergo aberrant differentiation and development ending with small, gnarled fruiting bodies. They also have decreased spore viability and decreased levels of glycogen.1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 502502UTP--glucose-1-phosphate uridylyltransferase 2PRO_0000327942Add
    BLAST

    Proteomic databases

    PRIDEiQ54YZ0.

    Expressioni

    Developmental stagei

    Expressed in both prestalk and prespore cells. Expression becomes strong after 12 hours of development and peaks at 16 hours.1 Publication

    Interactioni

    Protein-protein interaction databases

    STRINGi44689.DDB_0214911.

    Structurei

    3D structure databases

    ProteinModelPortaliQ54YZ0.
    SMRiQ54YZ0. Positions 55-496.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the UDPGP type 1 family.Curated

    Phylogenomic databases

    eggNOGiCOG4284.
    KOiK00963.
    OMAiPPNGKRC.
    PhylomeDBiQ54YZ0.

    Family and domain databases

    Gene3Di3.90.550.10. 1 hit.
    InterProiIPR029044. Nucleotide-diphossugar_trans.
    IPR016267. UDPGP_trans.
    IPR002618. UDPGP_trans_fam.
    [Graphical view]
    PANTHERiPTHR11952. PTHR11952. 1 hit.
    PTHR11952:SF1. PTHR11952:SF1. 1 hit.
    PfamiPF01704. UDPGP. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000806. UDPGP. 1 hit.
    SUPFAMiSSF53448. SSF53448. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q54YZ0-1 [UniParc]FASTAAdd to Basket

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    MMKPDLNSPL PQSPQLQAFG SRSSDLATED LFLKKLEAIS QTAPNETVKN    50
    EFLNKEIPSI NKLFTRFLKN RKKVIDWDKI NPPPADMVLN YKDLPAITEQ 100
    RTSELASKLA VLKLNGGLGT TMGCTGPKSV IEVRSEKTFL DLSVQQIKEM 150
    NERYNIKVPL VLMNSFNTHQ ETGKIIQKYK YSDVKIHSFN QSRFPRILKD 200
    NLMPVPDKLF GSDSEWYPPG HGDVFFALQN SGLLETLINE GKEYLFISNV 250
    DNLGAVVDFN ILEAMDKNKV EYIMEVTNKT RADVKGGTLI QYEGKAKLLE 300
    IAQVPSSKVE EFKSIKKFKI FNTNNIWVNL KAMDRILKQN LLDDMDIIIN 350
    PKVADGKNII QLEIAAGAAI EFFNNARGVN VPRSRFLPVK STSDLFIVQS 400
    NLYSLEKGVL VMNKNRPFTT VPLVKLGDNF KKVSDYQARI KGIPDILELD 450
    QLTVSGDITF GPNMVLKGTV IIVANHGSRI DIPEGSEFEN KVVSGNLHCG 500
    AL 502
    Length:502
    Mass (Da):56,268
    Last modified:May 24, 2005 - v1
    Checksum:i3FC27BF59798F944
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti18 – 181A → S in AAD34028. (PubMed:12060658)Curated
    Sequence conflicti320 – 3201I → V in AAA91057. 1 PublicationCurated
    Sequence conflicti363 – 3642EI → RL in AAA91057. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF150929 mRNA. Translation: AAD34028.1.
    AAFI02000023 Genomic DNA. Translation: EAL68112.1.
    L28007 Genomic DNA. Translation: AAA91057.1.
    RefSeqiXP_642062.1. XM_636970.1.

    Genome annotation databases

    EnsemblProtistsiDDB0214911; DDB0214911; DDB_G0277879.
    GeneIDi8621274.
    KEGGiddi:DDB_G0277879.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF150929 mRNA. Translation: AAD34028.1 .
    AAFI02000023 Genomic DNA. Translation: EAL68112.1 .
    L28007 Genomic DNA. Translation: AAA91057.1 .
    RefSeqi XP_642062.1. XM_636970.1.

    3D structure databases

    ProteinModelPortali Q54YZ0.
    SMRi Q54YZ0. Positions 55-496.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 44689.DDB_0214911.

    Proteomic databases

    PRIDEi Q54YZ0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblProtistsi DDB0214911 ; DDB0214911 ; DDB_G0277879 .
    GeneIDi 8621274.
    KEGGi ddi:DDB_G0277879.

    Organism-specific databases

    dictyBasei DDB_G0277879. ugpB.

    Phylogenomic databases

    eggNOGi COG4284.
    KOi K00963.
    OMAi PPNGKRC.
    PhylomeDBi Q54YZ0.

    Enzyme and pathway databases

    Reactomei REACT_176277. Glycogen synthesis.

    Miscellaneous databases

    PROi Q54YZ0.

    Family and domain databases

    Gene3Di 3.90.550.10. 1 hit.
    InterProi IPR029044. Nucleotide-diphossugar_trans.
    IPR016267. UDPGP_trans.
    IPR002618. UDPGP_trans_fam.
    [Graphical view ]
    PANTHERi PTHR11952. PTHR11952. 1 hit.
    PTHR11952:SF1. PTHR11952:SF1. 1 hit.
    Pfami PF01704. UDPGP. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000806. UDPGP. 1 hit.
    SUPFAMi SSF53448. SSF53448. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "A second UDP-glucose pyrophosphorylase is required for differentiation and development in Dictyostelium discoideum."
      Bishop J.D., Moon B.C., Harrow F., Ratner D., Gomer R.H., Dottin R.P., Brazill D.T.
      J. Biol. Chem. 277:32430-32437(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, DEVELOPMENTAL STAGE, DISRUPTION PHENOTYPE.
      Strain: AX4.
    2. "The genome of the social amoeba Dictyostelium discoideum."
      Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N.
      , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
      Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: AX4.
    3. "Null mutation of a UDPGP-glucose pyrophosphorylase gene by homologous recombination provides evidence for a second gene in Dictyostelium discoideum."
      Moon B.C., Haribabu B., Dottin R.P.
      Submitted (MAR-1996) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 319-370.

    Entry informationi

    Entry nameiUGPA2_DICDI
    AccessioniPrimary (citable) accession number: Q54YZ0
    Secondary accession number(s): Q27566, Q9XZN2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 8, 2008
    Last sequence update: May 24, 2005
    Last modified: October 1, 2014
    This is version 62 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Dictyostelium discoideum
      Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3