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Q54YZ0

- UGPA2_DICDI

UniProt

Q54YZ0 - UGPA2_DICDI

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Protein
UTP--glucose-1-phosphate uridylyltransferase 2
Gene
ugpB, DDB_G0277879
Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Plays a central role as a glucosyl donor in cellular metabolic pathways.1 Publication

Catalytic activityi

UTP + alpha-D-glucose 1-phosphate = diphosphate + UDP-glucose.

GO - Molecular functioni

  1. UTP:glucose-1-phosphate uridylyltransferase activity Source: UniProtKB-EC

GO - Biological processi

  1. autophagic vacuole assembly Source: dictyBase
  2. cellulose biosynthetic process Source: dictyBase
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Enzyme and pathway databases

ReactomeiREACT_176277. Glycogen synthesis.

Names & Taxonomyi

Protein namesi
Recommended name:
UTP--glucose-1-phosphate uridylyltransferase 2 (EC:2.7.7.9)
Alternative name(s):
UDP-glucose pyrophosphorylase 2
Short name:
UDPGP 2
Short name:
UGPase 2
Gene namesi
Name:ugpB
ORF Names:DDB_G0277879
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
ProteomesiUP000002195: Chromosome 3, UP000002195: Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0277879. ugpB.

Pathology & Biotechi

Disruption phenotypei

Cells undergo aberrant differentiation and development ending with small, gnarled fruiting bodies. They also have decreased spore viability and decreased levels of glycogen.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 502502UTP--glucose-1-phosphate uridylyltransferase 2
PRO_0000327942Add
BLAST

Proteomic databases

PRIDEiQ54YZ0.

Expressioni

Developmental stagei

Expressed in both prestalk and prespore cells. Expression becomes strong after 12 hours of development and peaks at 16 hours.1 Publication

Interactioni

Protein-protein interaction databases

STRINGi44689.DDB_0214911.

Structurei

3D structure databases

ProteinModelPortaliQ54YZ0.
SMRiQ54YZ0. Positions 55-496.

Family & Domainsi

Sequence similaritiesi

Belongs to the UDPGP type 1 family.

Phylogenomic databases

eggNOGiCOG4284.
KOiK00963.
OMAiPPNGKRC.
PhylomeDBiQ54YZ0.

Family and domain databases

Gene3Di3.90.550.10. 1 hit.
InterProiIPR029044. Nucleotide-diphossugar_trans.
IPR016267. UDPGP_trans.
IPR002618. UDPGP_trans_fam.
[Graphical view]
PANTHERiPTHR11952. PTHR11952. 1 hit.
PTHR11952:SF1. PTHR11952:SF1. 1 hit.
PfamiPF01704. UDPGP. 1 hit.
[Graphical view]
PIRSFiPIRSF000806. UDPGP. 1 hit.
SUPFAMiSSF53448. SSF53448. 1 hit.

Sequencei

Sequence statusi: Complete.

Q54YZ0-1 [UniParc]FASTAAdd to Basket

« Hide

MMKPDLNSPL PQSPQLQAFG SRSSDLATED LFLKKLEAIS QTAPNETVKN    50
EFLNKEIPSI NKLFTRFLKN RKKVIDWDKI NPPPADMVLN YKDLPAITEQ 100
RTSELASKLA VLKLNGGLGT TMGCTGPKSV IEVRSEKTFL DLSVQQIKEM 150
NERYNIKVPL VLMNSFNTHQ ETGKIIQKYK YSDVKIHSFN QSRFPRILKD 200
NLMPVPDKLF GSDSEWYPPG HGDVFFALQN SGLLETLINE GKEYLFISNV 250
DNLGAVVDFN ILEAMDKNKV EYIMEVTNKT RADVKGGTLI QYEGKAKLLE 300
IAQVPSSKVE EFKSIKKFKI FNTNNIWVNL KAMDRILKQN LLDDMDIIIN 350
PKVADGKNII QLEIAAGAAI EFFNNARGVN VPRSRFLPVK STSDLFIVQS 400
NLYSLEKGVL VMNKNRPFTT VPLVKLGDNF KKVSDYQARI KGIPDILELD 450
QLTVSGDITF GPNMVLKGTV IIVANHGSRI DIPEGSEFEN KVVSGNLHCG 500
AL 502
Length:502
Mass (Da):56,268
Last modified:May 24, 2005 - v1
Checksum:i3FC27BF59798F944
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti18 – 181A → S in AAD34028. 1 Publication
Sequence conflicti320 – 3201I → V in AAA91057. 1 Publication
Sequence conflicti363 – 3642EI → RL in AAA91057. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF150929 mRNA. Translation: AAD34028.1.
AAFI02000023 Genomic DNA. Translation: EAL68112.1.
L28007 Genomic DNA. Translation: AAA91057.1.
RefSeqiXP_642062.1. XM_636970.1.

Genome annotation databases

EnsemblProtistsiDDB0214911; DDB0214911; DDB_G0277879.
GeneIDi8621274.
KEGGiddi:DDB_G0277879.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF150929 mRNA. Translation: AAD34028.1 .
AAFI02000023 Genomic DNA. Translation: EAL68112.1 .
L28007 Genomic DNA. Translation: AAA91057.1 .
RefSeqi XP_642062.1. XM_636970.1.

3D structure databases

ProteinModelPortali Q54YZ0.
SMRi Q54YZ0. Positions 55-496.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 44689.DDB_0214911.

Proteomic databases

PRIDEi Q54YZ0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblProtistsi DDB0214911 ; DDB0214911 ; DDB_G0277879 .
GeneIDi 8621274.
KEGGi ddi:DDB_G0277879.

Organism-specific databases

dictyBasei DDB_G0277879. ugpB.

Phylogenomic databases

eggNOGi COG4284.
KOi K00963.
OMAi PPNGKRC.
PhylomeDBi Q54YZ0.

Enzyme and pathway databases

Reactomei REACT_176277. Glycogen synthesis.

Miscellaneous databases

PROi Q54YZ0.

Family and domain databases

Gene3Di 3.90.550.10. 1 hit.
InterProi IPR029044. Nucleotide-diphossugar_trans.
IPR016267. UDPGP_trans.
IPR002618. UDPGP_trans_fam.
[Graphical view ]
PANTHERi PTHR11952. PTHR11952. 1 hit.
PTHR11952:SF1. PTHR11952:SF1. 1 hit.
Pfami PF01704. UDPGP. 1 hit.
[Graphical view ]
PIRSFi PIRSF000806. UDPGP. 1 hit.
SUPFAMi SSF53448. SSF53448. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A second UDP-glucose pyrophosphorylase is required for differentiation and development in Dictyostelium discoideum."
    Bishop J.D., Moon B.C., Harrow F., Ratner D., Gomer R.H., Dottin R.P., Brazill D.T.
    J. Biol. Chem. 277:32430-32437(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, DEVELOPMENTAL STAGE, DISRUPTION PHENOTYPE.
    Strain: AX4.
  2. "The genome of the social amoeba Dictyostelium discoideum."
    Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N.
    , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
    Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AX4.
  3. "Null mutation of a UDPGP-glucose pyrophosphorylase gene by homologous recombination provides evidence for a second gene in Dictyostelium discoideum."
    Moon B.C., Haribabu B., Dottin R.P.
    Submitted (MAR-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 319-370.

Entry informationi

Entry nameiUGPA2_DICDI
AccessioniPrimary (citable) accession number: Q54YZ0
Secondary accession number(s): Q27566, Q9XZN2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: May 24, 2005
Last modified: September 3, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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