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Protein

UTP--glucose-1-phosphate uridylyltransferase 2

Gene

ugpB

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Plays a central role as a glucosyl donor in cellular metabolic pathways.1 Publication

Catalytic activityi

UTP + alpha-D-glucose 1-phosphate = diphosphate + UDP-glucose.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei128UTPBy similarity1
Binding sitei191UTPBy similarity1
Binding sitei220UTP; via amide nitrogenBy similarity1
Binding sitei221SubstrateBy similarity1
Binding sitei251UTPBy similarity1
Binding sitei390UTPBy similarity1

GO - Molecular functioni

  • UTP:glucose-1-phosphate uridylyltransferase activity Source: dictyBase

GO - Biological processi

  • autophagosome assembly Source: dictyBase
  • cellulose biosynthetic process Source: dictyBase
  • culmination involved in sorocarp development Source: dictyBase
  • glycogen metabolic process Source: dictyBase
  • UDP-glucose metabolic process Source: GO_Central

Keywordsi

Molecular functionNucleotidyltransferase, Transferase

Enzyme and pathway databases

ReactomeiR-DDI-173599 Formation of the active cofactor, UDP-glucuronate
R-DDI-3322077 Glycogen synthesis

Names & Taxonomyi

Protein namesi
Recommended name:
UTP--glucose-1-phosphate uridylyltransferase 2 (EC:2.7.7.9)
Alternative name(s):
UDP-glucose pyrophosphorylase 2
Short name:
UDPGP 2
Short name:
UGPase 2
Gene namesi
Name:ugpB
ORF Names:DDB_G0277879
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyostelidsDictyostelialesDictyosteliaceaeDictyostelium
Proteomesi
  • UP000002195 Componentsi: Chromosome 3, Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0277879 ugpB

Subcellular locationi

GO - Cellular componenti

Pathology & Biotechi

Disruption phenotypei

Cells undergo aberrant differentiation and development ending with small, gnarled fruiting bodies. They also have decreased spore viability and decreased levels of glycogen.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003279421 – 502UTP--glucose-1-phosphate uridylyltransferase 2Add BLAST502

Proteomic databases

PaxDbiQ54YZ0
PRIDEiQ54YZ0

Expressioni

Developmental stagei

Expressed in both prestalk and prespore cells. Expression becomes strong after 12 hours of development and peaks at 16 hours.1 Publication

Interactioni

Protein-protein interaction databases

STRINGi44689.DDB0214911

Structurei

3D structure databases

ProteinModelPortaliQ54YZ0
SMRiQ54YZ0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni114 – 117UTP bindingBy similarity4
Regioni116 – 117Substrate bindingBy similarity2
Regioni249 – 251Substrate bindingBy similarity3

Sequence similaritiesi

Belongs to the UDPGP type 1 family.Curated

Phylogenomic databases

eggNOGiKOG2638 Eukaryota
COG4284 LUCA
InParanoidiQ54YZ0
KOiK00963
OMAiMEIIPNG
PhylomeDBiQ54YZ0

Family and domain databases

CDDicd00897 UGPase_euk, 1 hit
Gene3Di3.90.550.10, 1 hit
InterProiView protein in InterPro
IPR029044 Nucleotide-diphossugar_trans
IPR002618 UDPGP_fam
IPR016267 UDPGP_trans
PfamiView protein in Pfam
PF01704 UDPGP, 1 hit
PIRSFiPIRSF000806 UDPGP, 1 hit
SUPFAMiSSF53448 SSF53448, 1 hit

Sequencei

Sequence statusi: Complete.

Q54YZ0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMKPDLNSPL PQSPQLQAFG SRSSDLATED LFLKKLEAIS QTAPNETVKN
60 70 80 90 100
EFLNKEIPSI NKLFTRFLKN RKKVIDWDKI NPPPADMVLN YKDLPAITEQ
110 120 130 140 150
RTSELASKLA VLKLNGGLGT TMGCTGPKSV IEVRSEKTFL DLSVQQIKEM
160 170 180 190 200
NERYNIKVPL VLMNSFNTHQ ETGKIIQKYK YSDVKIHSFN QSRFPRILKD
210 220 230 240 250
NLMPVPDKLF GSDSEWYPPG HGDVFFALQN SGLLETLINE GKEYLFISNV
260 270 280 290 300
DNLGAVVDFN ILEAMDKNKV EYIMEVTNKT RADVKGGTLI QYEGKAKLLE
310 320 330 340 350
IAQVPSSKVE EFKSIKKFKI FNTNNIWVNL KAMDRILKQN LLDDMDIIIN
360 370 380 390 400
PKVADGKNII QLEIAAGAAI EFFNNARGVN VPRSRFLPVK STSDLFIVQS
410 420 430 440 450
NLYSLEKGVL VMNKNRPFTT VPLVKLGDNF KKVSDYQARI KGIPDILELD
460 470 480 490 500
QLTVSGDITF GPNMVLKGTV IIVANHGSRI DIPEGSEFEN KVVSGNLHCG

AL
Length:502
Mass (Da):56,268
Last modified:May 24, 2005 - v1
Checksum:i3FC27BF59798F944
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti18A → S in AAD34028 (PubMed:12060658).Curated1
Sequence conflicti320I → V in AAA91057 (Ref. 3) Curated1
Sequence conflicti363 – 364EI → RL in AAA91057 (Ref. 3) Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF150929 mRNA Translation: AAD34028.1
AAFI02000023 Genomic DNA Translation: EAL68112.1
L28007 Genomic DNA Translation: AAA91057.1
RefSeqiXP_642062.1, XM_636970.1

Genome annotation databases

EnsemblProtistsiEAL68112; EAL68112; DDB_G0277879
GeneIDi8621274
KEGGiddi:DDB_G0277879

Similar proteinsi

Entry informationi

Entry nameiUGPA2_DICDI
AccessioniPrimary (citable) accession number: Q54YZ0
Secondary accession number(s): Q27566, Q9XZN2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: May 24, 2005
Last modified: May 23, 2018
This is version 84 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. SIMILARITY comments
    Index of protein domains and families

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