Q54YW4 (Y8045_DICDI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable poly [ADP-ribose] polymerase DDB_G0278045
EC=2.4.2.30

Gene names

ORF Names:

DDB_G0278045

Organism

Dictyostelium discoideum (Slime mold)

Taxonomic identifier

44689 [NCBI]

Taxonomic lineage

Eukaryota › Amoebozoa › Mycetozoa › Dictyosteliida › Dictyostelium

Protein attributes

Sequence length	337 AA.
Sequence status	Complete.
Protein existence	Predicted

General annotation (Comments)

Catalytic activity	NAD+ + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor.
Sequence similarities	Contains 1 PARP catalytic domain.
Sequence caution	The sequence EAL68195.2 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
Ligand	NAD
Molecular function	Glycosyltransferase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Molecular function	NAD+ ADP-ribosyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 337	337	Probable poly [ADP-ribose] polymerase DDB_G0278045		PRO_0000369249
Regions
	Domain	21 – 231	211	PARP catalytic

Sequences

	Sequence		Length	Mass (Da)
	Q54YW4 [UniParc]. Last modified April 14, 2009. Version 3. Checksum: 42056911F3AA9A02	FASTA	337	39,384
	10 20 30 40 50 60 MGRVKMSETF SYWIEDNIYP KKWDIIYKQR ENQVFLIKIN KGSSEYIIVS ERFNETMSNS 70 80 90 100 110 120 FEIIKIERIQ NKSLWRNFDE SRKRLNEKYQ VSNLDFLEST LFHGTRANDP KLIFSSKVGF 130 140 150 160 170 180 DIGKSSFGNY GIGLYFALNA SYSNNYSFEE SPTSGCKQMF LCRVLLGNSA PPTQKELKND 190 200 210 220 230 240 STQDSIKGPG GEMFILKSNH TAYPDYLISY RQKVIVNNNT NNNNKNKNKN NNKNNNKNIK 250 260 270 280 290 300 IQNENKNENK IENKNENENQ FDNYGFNTNF SQNLYDKYGL KYPSQEKPKP GFFTPNKELE 310 320 330 YEIFPLLFEK NEKEEELEEL EDYQLALLLS TSSLGSK

References

[1]

"The genome of the social amoeba Dictyostelium discoideum." Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N. , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A. Nature 435:43-57(2005) [PubMed: 15875012] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AX4.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AAFI02000023 Genomic DNA. Translation: EAL68195.2. Sequence problems.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblProtists	DDB0304590; DDB0304590; DDB_G0278045.
Organism-specific databases
dictyBase	DDB_G0278045.
Phylogenomic databases
GeneTree	EPrGT00050000002666.
Family and domain databases
InterPro	IPR012317. Poly(ADP-ribose)pol_cat_dom. [Graphical view]
Pfam	PF00644. PARP. 1 hit. [Graphical view]
PROSITE	PS51059. PARP_CATALYTIC. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Y8045_DICDI

Accession

Primary (citable) accession number: Q54YW4

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 14, 2009
Last sequence update:	April 14, 2009
Last modified:	September 21, 2011
This is version 25 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)