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Q54YT4

- MECR_DICDI

UniProt

Q54YT4 - MECR_DICDI

Protein

Trans-2-enoyl-CoA reductase, mitochondrial

Gene

mecr

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 67 (01 Oct 2014)
      Sequence version 1 (24 May 2005)
      Previous versions | rss
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    Functioni

    Oxidoreductase with a preference for short and medium chain substrates, including trans-2-hexenoyl-CoA (C6), trans-2-decenoyl-CoA (C10), and trans-2-hexadecenoyl-CoA (C16). May play a role in mitochondrial fatty acid synthesis By similarity.By similarity

    Catalytic activityi

    Acyl-CoA + NADP+ = trans-2,3-dehydroacyl-CoA + NADPH.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei143 – 1431NADPBy similarity
    Binding sitei343 – 3431NADPBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi169 – 1724NADPBy similarity
    Nucleotide bindingi192 – 1943NADPBy similarity
    Nucleotide bindingi261 – 2644NADPBy similarity
    Nucleotide bindingi286 – 2883NADPBy similarity

    GO - Molecular functioni

    1. trans-2-enoyl-CoA reductase (NADPH) activity Source: dictyBase
    2. zinc ion binding Source: InterPro

    GO - Biological processi

    1. fatty acid biosynthetic process Source: dictyBase

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism

    Keywords - Ligandi

    NADP

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Trans-2-enoyl-CoA reductase, mitochondrial (EC:1.3.1.38)
    Gene namesi
    Name:mecr
    ORF Names:DDB_G0278095
    OrganismiDictyostelium discoideum (Slime mold)
    Taxonomic identifieri44689 [NCBI]
    Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
    ProteomesiUP000002195: Chromosome 3, UP000002195: Unassembled WGS sequence

    Organism-specific databases

    dictyBaseiDDB_G0278095. mecr.

    Subcellular locationi

    Mitochondrion By similarity

    GO - Cellular componenti

    1. mitochondrion Source: dictyBase

    Keywords - Cellular componenti

    Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 1414MitochondrionSequence AnalysisAdd
    BLAST
    Chaini15 – 350336Trans-2-enoyl-CoA reductase, mitochondrialPRO_0000328319Add
    BLAST

    Proteomic databases

    PRIDEiQ54YT4.

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Protein-protein interaction databases

    STRINGi44689.DDBDRAFT_0204417.

    Structurei

    3D structure databases

    ProteinModelPortaliQ54YT4.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiCOG0604.
    KOiK07512.
    OMAiKDHSPAQ.
    PhylomeDBiQ54YT4.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    3.90.180.10. 1 hit.
    InterProiIPR013149. ADH_C.
    IPR013154. ADH_GroES-like.
    IPR002085. ADH_SF_Zn-type.
    IPR011032. GroES-like.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PANTHERiPTHR11695. PTHR11695. 1 hit.
    PfamiPF08240. ADH_N. 1 hit.
    PF00107. ADH_zinc_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF50129. SSF50129. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q54YT4-1 [UniParc]FASTAAdd to Basket

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    MNSTRNIISL VRRYSTSRSV KIASHGSPST ALKIENENIT DKISNKDVLV    50
    EMLHAPINPA DLNIIQGTYG TNVQVGGVAG MEGVGVVKKV GSGVTGLKEN 100
    DLVVPSMKQH FGSWRSKGVW SEQQLFKVPS DIPTEYLSTI SINPTTAYLL 150
    LNDFVKLQQG DVIIQNASNS MVGLSVIQLA KARGIKTINV IRDGSEFEDN 200
    VQRLKQLGGD IVVSEEYVRT PAFRKLISDL PSPKLALNAV GGQSATELSR 250
    ILADNGTLVT YGGMSREPVT IPTSQLIFRN IQIRGFWLNK WFEQHTDSEK 300
    QSVYDAIFDL IRKKQFKLLI EKHKFSEFDQ ALLKSQQSGH GRKIVLDLQL 350
    Length:350
    Mass (Da):38,735
    Last modified:May 24, 2005 - v1
    Checksum:iD68461685025F443
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AAFI02000023 Genomic DNA. Translation: EAL68220.1.
    RefSeqiXP_642118.1. XM_637026.1.

    Genome annotation databases

    EnsemblProtistsiDDB0235198; DDB0235198; DDB_G0278095.
    GeneIDi8621327.
    KEGGiddi:DDB_G0278095.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AAFI02000023 Genomic DNA. Translation: EAL68220.1 .
    RefSeqi XP_642118.1. XM_637026.1.

    3D structure databases

    ProteinModelPortali Q54YT4.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 44689.DDBDRAFT_0204417.

    Proteomic databases

    PRIDEi Q54YT4.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblProtistsi DDB0235198 ; DDB0235198 ; DDB_G0278095 .
    GeneIDi 8621327.
    KEGGi ddi:DDB_G0278095.

    Organism-specific databases

    dictyBasei DDB_G0278095. mecr.

    Phylogenomic databases

    eggNOGi COG0604.
    KOi K07512.
    OMAi KDHSPAQ.
    PhylomeDBi Q54YT4.

    Miscellaneous databases

    PROi Q54YT4.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    3.90.180.10. 1 hit.
    InterProi IPR013149. ADH_C.
    IPR013154. ADH_GroES-like.
    IPR002085. ADH_SF_Zn-type.
    IPR011032. GroES-like.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    PANTHERi PTHR11695. PTHR11695. 1 hit.
    Pfami PF08240. ADH_N. 1 hit.
    PF00107. ADH_zinc_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50129. SSF50129. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The genome of the social amoeba Dictyostelium discoideum."
      Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N.
      , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
      Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: AX4.

    Entry informationi

    Entry nameiMECR_DICDI
    AccessioniPrimary (citable) accession number: Q54YT4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 8, 2008
    Last sequence update: May 24, 2005
    Last modified: October 1, 2014
    This is version 67 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Dictyostelium discoideum
      Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3