Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q54YT4 (MECR_DICDI) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 65. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Trans-2-enoyl-CoA reductase, mitochondrial

EC=1.3.1.38
Gene names
Name:mecr
ORF Names:DDB_G0278095
OrganismDictyostelium discoideum (Slime mold) [Reference proteome]
Taxonomic identifier44689 [NCBI]
Taxonomic lineageEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium

Protein attributes

Sequence length350 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Oxidoreductase with a preference for short and medium chain substrates, including trans-2-hexenoyl-CoA (C6), trans-2-decenoyl-CoA (C10), and trans-2-hexadecenoyl-CoA (C16). May play a role in mitochondrial fatty acid synthesis By similarity.

Catalytic activity

Acyl-CoA + NADP+ = trans-2,3-dehydroacyl-CoA + NADPH.

Subunit structure

Homodimer By similarity.

Subcellular location

Mitochondrion By similarity.

Sequence similarities

Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – 1414Mitochondrion Potential
Chain15 – 350336Trans-2-enoyl-CoA reductase, mitochondrial
PRO_0000328319

Regions

Nucleotide binding169 – 1724NADP By similarity
Nucleotide binding192 – 1943NADP By similarity
Nucleotide binding261 – 2644NADP By similarity
Nucleotide binding286 – 2883NADP By similarity

Sites

Binding site1431NADP By similarity
Binding site3431NADP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q54YT4 [UniParc].

Last modified May 24, 2005. Version 1.
Checksum: D68461685025F443

FASTA35038,735
        10         20         30         40         50         60 
MNSTRNIISL VRRYSTSRSV KIASHGSPST ALKIENENIT DKISNKDVLV EMLHAPINPA 

        70         80         90        100        110        120 
DLNIIQGTYG TNVQVGGVAG MEGVGVVKKV GSGVTGLKEN DLVVPSMKQH FGSWRSKGVW 

       130        140        150        160        170        180 
SEQQLFKVPS DIPTEYLSTI SINPTTAYLL LNDFVKLQQG DVIIQNASNS MVGLSVIQLA 

       190        200        210        220        230        240 
KARGIKTINV IRDGSEFEDN VQRLKQLGGD IVVSEEYVRT PAFRKLISDL PSPKLALNAV 

       250        260        270        280        290        300 
GGQSATELSR ILADNGTLVT YGGMSREPVT IPTSQLIFRN IQIRGFWLNK WFEQHTDSEK 

       310        320        330        340        350 
QSVYDAIFDL IRKKQFKLLI EKHKFSEFDQ ALLKSQQSGH GRKIVLDLQL 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AAFI02000023 Genomic DNA. Translation: EAL68220.1.
RefSeqXP_642118.1. XM_637026.1.

3D structure databases

ProteinModelPortalQ54YT4.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING44689.DDBDRAFT_0204417.

Proteomic databases

PRIDEQ54YT4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsDDB0235198; DDB0235198; DDB_G0278095.
GeneID8621327.
KEGGddi:DDB_G0278095.

Organism-specific databases

dictyBaseDDB_G0278095. mecr.

Phylogenomic databases

eggNOGCOG0604.
OMAKDHSPAQ.
PhylomeDBQ54YT4.

Family and domain databases

Gene3D3.40.50.720. 1 hit.
3.90.180.10. 1 hit.
InterProIPR013149. ADH_C.
IPR013154. ADH_GroES-like.
IPR002085. ADH_SF_Zn-type.
IPR011032. GroES-like.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERPTHR11695. PTHR11695. 1 hit.
PfamPF08240. ADH_N. 1 hit.
PF00107. ADH_zinc_N. 1 hit.
[Graphical view]
SUPFAMSSF50129. SSF50129. 1 hit.
ProtoNetSearch...

Other

PROQ54YT4.

Entry information

Entry nameMECR_DICDI
AccessionPrimary (citable) accession number: Q54YT4
Entry history
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: May 24, 2005
Last modified: July 9, 2014
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families

Dictyostelium discoideum

Dictyostelium discoideum: entries, gene names and cross-references to dictyBase