Q54YT4 (MECR_DICDI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Trans-2-enoyl-CoA reductase, mitochondrial
EC=1.3.1.38

Gene names

Name:	mecr
ORF Names:	DDB_G0278095

Organism

Dictyostelium discoideum (Slime mold)

Taxonomic identifier

44689 [NCBI]

Taxonomic lineage

Eukaryota › Amoebozoa › Mycetozoa › Dictyosteliida › Dictyostelium

Protein attributes

Sequence length	350 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the reduction of trans-2-enoyl-CoA to acyl-CoA. May have a role in the mitochondrial synthesis of fatty acids By similarity.
Catalytic activity	Acyl-CoA + NADP+ = trans-2,3-dehydroacyl-CoA + NADPH.
Subunit structure	Homodimer By similarity.
Subcellular location	Mitochondrion By similarity.
Sequence similarities	Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.

Ontologies

Keywords
Biological process	Fatty acid biosynthesis Lipid synthesis
Cellular component	Mitochondrion
Domain	Transit peptide
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	fatty acid biosynthetic process Inferred from sequence or structural similarity. Source: dictyBase
Cellular component	mitochondrion Inferred from sequence or structural similarity. Source: dictyBase
Molecular function	nucleotide binding Inferred from electronic annotation. Source: InterPro trans-2-enoyl-CoA reductase (NADPH) activity Inferred from sequence or structural similarity. Source: dictyBase zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Transit peptide	1 – 14	14	Mitochondrion Potential
	Chain	15 – 350	336	Trans-2-enoyl-CoA reductase, mitochondrial		PRO_0000328319

Sequences

	Sequence		Length	Mass (Da)
	Q54YT4 [UniParc]. Last modified May 24, 2005. Version 1. Checksum: D68461685025F443	FASTA	350	38,735
	10 20 30 40 50 60 MNSTRNIISL VRRYSTSRSV KIASHGSPST ALKIENENIT DKISNKDVLV EMLHAPINPA 70 80 90 100 110 120 DLNIIQGTYG TNVQVGGVAG MEGVGVVKKV GSGVTGLKEN DLVVPSMKQH FGSWRSKGVW 130 140 150 160 170 180 SEQQLFKVPS DIPTEYLSTI SINPTTAYLL LNDFVKLQQG DVIIQNASNS MVGLSVIQLA 190 200 210 220 230 240 KARGIKTINV IRDGSEFEDN VQRLKQLGGD IVVSEEYVRT PAFRKLISDL PSPKLALNAV 250 260 270 280 290 300 GGQSATELSR ILADNGTLVT YGGMSREPVT IPTSQLIFRN IQIRGFWLNK WFEQHTDSEK 310 320 330 340 350 QSVYDAIFDL IRKKQFKLLI EKHKFSEFDQ ALLKSQQSGH GRKIVLDLQL

References

[1]

"The genome of the social amoeba Dictyostelium discoideum." Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N. , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A. Nature 435:43-57(2005) [PubMed: 15875012] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AX4.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AAFI02000023 Genomic DNA. Translation: EAL68220.1.
RefSeq	XP_642118.1. XM_637026.1.
3D structure databases
HSSP	HSSP built from PDB template 1ZSY based on UniProtKB Q9BV79.
ProteinModelPortal	Q54YT4.
ModBase	Search...
Protein-protein interaction databases
STRING	Q54YT4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblProtists	DDB0235198; DDB0235198; DDB_G0278095.
GeneID	8621327.
GenomeReviews	Gene locus mecr in contig CM000152_GR.
KEGG	ddi:DDB_G0278095.
Organism-specific databases
dictyBase	DDB_G0278095. mecr.
Phylogenomic databases
eggNOG	KOG0025.
GeneTree	EPrGT00060000009877.
HOGENOM	HBG753318.
OMA	RGFWMTR.
PhylomeDB	Q54YT4.
ProtClustDB	CLSZ2430754.
Family and domain databases
InterPro	IPR013149. ADH_C. IPR013154. ADH_GroES-like. IPR002085. ADH_SF_Zn-type. IPR011032. GroES-like. IPR016040. NAD(P)-bd_dom. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KO	K07512.
PANTHER	PTHR11695. ADH_Sf_Zn. 1 hit.
Pfam	PF08240. ADH_N. 1 hit. PF00107. ADH_zinc_N. 1 hit. [Graphical view]
SUPFAM	SSF50129. GroES_like. 1 hit.
ProtoNet	Search...

Entry information

Entry name

MECR_DICDI

Accession

Primary (citable) accession number: Q54YT4

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 8, 2008
Last sequence update:	May 24, 2005
Last modified:	December 14, 2011
This is version 50 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)