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Q54YS6 (PNPO_DICDI) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 64. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Pyridoxine-5'-phosphate oxidase

EC=1.4.3.5
Alternative name(s):
Pyridoxamine-phosphate oxidase
Gene names
Name:pnpo
ORF Names:DDB_G0278107
OrganismDictyostelium discoideum (Slime mold) [Reference proteome]
Taxonomic identifier44689 [NCBI]
Taxonomic lineageEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium

Protein attributes

Sequence length227 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) By similarity. HAMAP-Rule MF_01629

Catalytic activity

Pyridoxamine 5'-phosphate + H2O + O2 = pyridoxal 5'-phosphate + NH3 + H2O2. HAMAP-Rule MF_01629

Pyridoxine 5'-phosphate + O2 = pyridoxal 5'-phosphate + H2O2. HAMAP-Rule MF_01629

Cofactor

Binds 1 FMN per subunit By similarity. HAMAP-Rule MF_01629

Pathway

Cofactor biosynthesis; B6 vitamer interconversion; pyridoxal 5'-phosphate from pyridoxamine 5'-phosphate: step 1/1. HAMAP-Rule MF_01629

Cofactor biosynthesis; B6 vitamer interconversion; pyridoxal 5'-phosphate from pyridoxine 5'-phosphate: step 1/1.

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_01629

Sequence similarities

Belongs to the pyridoxamine 5'-phosphate oxidase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 227227Pyridoxine-5'-phosphate oxidase HAMAP-Rule MF_01629
PRO_0000331120

Regions

Nucleotide binding90 – 912FMN By similarity
Nucleotide binding153 – 1542FMN By similarity
Region203 – 2053Substrate binding By similarity

Sites

Binding site751FMN By similarity
Binding site781FMN; via amide nitrogen By similarity
Binding site801Substrate By similarity
Binding site971FMN By similarity
Binding site1351Substrate By similarity
Binding site1391Substrate By similarity
Binding site1431Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q54YS6 [UniParc].

Last modified May 24, 2005. Version 1.
Checksum: 3EBA15FAEED2A3FE

FASTA22726,850
        10         20         30         40         50         60 
MSINLDNEEL KNEDLVANMR KDYRMGELKE EGLLESPFKM FDMWLTQEIE LKNEGAEPNA 

        70         80         90        100        110        120 
FTLATCSIER KPSARVVLLK HFDHQGFVFY TNYNSRKSKE LSENPFASMT FLWTQKQVRI 

       130        140        150        160        170        180 
EGSVEKVDRL ESEKYFKSRP RSSQIGAWVS EFQSSEVTKQ HLEEKTIEME NKFKDQEVPL 

       190        200        210        220 
PPFWGGWRIK PYAFEFWQGK SGRIHDRFKY VPTDSNNDNW ITKRLSP 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AAFI02000023 Genomic DNA. Translation: EAL68226.1.
RefSeqXP_642126.1. XM_637034.1.

3D structure databases

ProteinModelPortalQ54YS6.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING44689.DDB_0231657.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsDDB0231657; DDB0231657; DDB_G0278107.
GeneID8621335.
KEGGddi:DDB_G0278107.

Organism-specific databases

dictyBaseDDB_G0278107.

Phylogenomic databases

eggNOGCOG0259.
OMARAVTTIS.
PhylomeDBQ54YS6.

Enzyme and pathway databases

UniPathwayUPA00190; UER00304.
UPA00190; UER00305.

Family and domain databases

Gene3D2.30.110.10. 1 hit.
HAMAPMF_01629. PdxH.
InterProIPR000659. Pyridox_Oxase.
IPR019740. Pyridox_Oxase_CS.
IPR011576. Pyridox_Oxase_FMN-bd.
IPR019576. Pyridoxamine_oxidase_dimer_C.
IPR012349. Split_barrel_FMN-bd.
[Graphical view]
PANTHERPTHR10851. PTHR10851. 1 hit.
PfamPF10590. PNPOx_C. 1 hit.
PF01243. Pyridox_oxidase. 1 hit.
[Graphical view]
PIRSFPIRSF000190. Pyd_amn-ph_oxd. 1 hit.
SUPFAMSSF50475. SSF50475. 1 hit.
TIGRFAMsTIGR00558. pdxH. 1 hit.
PROSITEPS01064. PYRIDOX_OXIDASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

PROQ54YS6.

Entry information

Entry namePNPO_DICDI
AccessionPrimary (citable) accession number: Q54YS6
Entry history
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: May 24, 2005
Last modified: July 9, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

Dictyostelium discoideum

Dictyostelium discoideum: entries, gene names and cross-references to dictyBase