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Q54YD9

- FOL1_DICDI

UniProt

Q54YD9 - FOL1_DICDI

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Protein

Folic acid synthesis protein FOL1

Gene

fol1

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed - Annotation score: 5 out of 5- Protein inferred from homologyi

Functioni

Catalyzes three sequential steps of tetrahydrofolate biosynthesis.By similarity

Catalytic activityi

2-amino-4-hydroxy-6-(D-erythro-1,2,3-trihydroxypropyl)-7,8-dihydropteridine = 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine + glycolaldehyde.
ATP + 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine = AMP + (2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl diphosphate.
(2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl diphosphate + 4-aminobenzoate = diphosphate + dihydropteroate.

Cofactori

Binds 1 magnesium ion per subunit. Magnesium is required for activity, even if it interacts primarily with the substrate (By similarity).By similarity

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi340 – 3401MagnesiumBy similarity
Binding sitei348 – 3481SubstrateBy similarity
Binding sitei416 – 4161SubstrateBy similarity
Binding sitei435 – 4351SubstrateBy similarity
Binding sitei547 – 5471SubstrateBy similarity
Binding sitei583 – 5831SubstrateBy similarity
Binding sitei629 – 6291SubstrateBy similarity
Binding sitei631 – 6311SubstrateBy similarity

GO - Molecular functioni

  1. 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity Source: UniProtKB-EC
  2. ATP binding Source: UniProtKB-KW
  3. dihydroneopterin aldolase activity Source: UniProtKB-EC
  4. dihydropteroate synthase activity Source: UniProtKB-EC
  5. kinase activity Source: UniProtKB-KW
  6. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. folic acid biosynthetic process Source: UniProtKB-KW
  2. tetrahydrofolate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Lyase, Transferase

Keywords - Biological processi

Folate biosynthesis

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00077; UER00154.
UPA00077; UER00155.
UPA00077; UER00156.

Names & Taxonomyi

Protein namesi
Recommended name:
Folic acid synthesis protein FOL1
Including the following 3 domains:
Dihydroneopterin aldolase (EC:4.1.2.25)
Short name:
DHNA
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase (EC:2.7.6.3)
Alternative name(s):
6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase
Short name:
PPPK
7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase
Short name:
HPPK
Dihydropteroate synthase (EC:2.5.1.15)
Short name:
DHPS
Alternative name(s):
Dihydropteroate pyrophosphorylase
Gene namesi
Name:fol1
ORF Names:DDB_G0278283
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
ProteomesiUP000002195: Chromosome 3, UP000002195: Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0278283. fol1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 657657Folic acid synthesis protein FOL1PRO_0000328111Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi44689.DDB_0230139.

Structurei

3D structure databases

ProteinModelPortaliQ54YD9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini333 – 641309Pterin-bindingPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 116116DHNAAdd
BLAST
Regioni149 – 274126HPPKAdd
BLAST
Regioni325 – 657333DHPSAdd
BLAST
Regioni380 – 3812Substrate bindingBy similarity

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi303 – 3064Poly-Pro
Compositional biasi462 – 51655Asn-richAdd
BLAST
Compositional biasi485 – 50925Poly-AsnAdd
BLAST

Sequence similaritiesi

In the N-terminal section; belongs to the DHNA family.Curated
In the central section; belongs to the HPPK family.Curated
In the C-terminal section; belongs to the DHPS family.Curated
Contains 1 pterin-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0294.
InParanoidiQ54YD9.
KOiK13939.
OMAiWQIILDP.
PhylomeDBiQ54YD9.

Family and domain databases

Gene3Di3.20.20.20. 1 hit.
3.30.70.560. 1 hit.
InterProiIPR011005. Dihydropteroate_synth-like.
IPR006157. FolB_dom.
IPR000550. Hppk.
IPR000489. Pterin-binding.
[Graphical view]
PfamiPF02152. FolB. 1 hit.
PF01288. HPPK. 1 hit.
PF00809. Pterin_bind. 1 hit.
[Graphical view]
SMARTiSM00905. FolB. 1 hit.
[Graphical view]
SUPFAMiSSF51717. SSF51717. 2 hits.
SSF55083. SSF55083. 1 hit.
TIGRFAMsiTIGR00526. folB_dom. 1 hit.
TIGR01498. folK. 1 hit.
PROSITEiPS00792. DHPS_1. 1 hit.
PS00793. DHPS_2. 1 hit.
PS00794. HPPK. 1 hit.
PS50972. PTERIN_BINDING. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q54YD9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDKIIIKDLL IQAVIGVNPG ERIIKQNIII SVTAYKDLSK CGSSDNVIDT
60 70 80 90 100
VSYSSLSKSI CSYSESSHHY TLEALATGVA KICCLGFGIE RVKVLVQKPG
110 120 130 140 150
AIKLAKWPGV QIERTLDYFK SNSFVEIPSK LINNNKNSNN SNAGNNIVYL
160 170 180 190 200
AFGSNLGDKF QNILNSFKRL EKQCFIQSTS FMYESSPQYY REQDSFYNCA
210 220 230 240 250
CKVSTDLKPH DLLKFIKQIE NDMGRVETFR NGPRVIDIDI IYYNGLIIKT
260 270 280 290 300
DDLEIPHPLM WERDFVLLPL SDIAPNFIHP TLHITTNRMK LNLPNGGNIH
310 320 330 340 350
NIPPPPTATT TCNNIIEKVI RIGNLNYNWN DKTFIMGILN VTPDSFVDGG
360 370 380 390 400
KFNTLEKSIQ QATALIEQGA DIIDIGGQST YPGAQQISIE EEINRVVPTI
410 420 430 440 450
KKIREVLGND IPLSIDTLHH QVAKEAILAG CNIINDVSGE FRVPIILNHS
460 470 480 490 500
QPTTQYLQQK QNEQYLNNSN DSNSNSSINT NGEDNNNNNN NNNNNNNNNN
510 520 530 540 550
NNNNNNNNND DNDNDNRSKI KQKIDLSSPK IETCTKLGLF RWQIILDPGL
560 570 580 590 600
GFYKTYEQSI EILQRGKELM GLGFPVLIGP SRKGFIANTI ANAEKDKSLP
610 620 630 640 650
PPSPKSERRL WGTIACCCIG SMWGANIIRI HDIPEIRDAM LISDSVNKPQ

RRYQIQK
Length:657
Mass (Da):73,720
Last modified:May 24, 2005 - v1
Checksum:iC1CA4397EE959845
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAFI02000023 Genomic DNA. Translation: EAL68314.1.
RefSeqiXP_642263.1. XM_637171.1.

Genome annotation databases

EnsemblProtistsiDDB0230139; DDB0230139; DDB_G0278283.
GeneIDi8621472.
KEGGiddi:DDB_G0278283.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAFI02000023 Genomic DNA. Translation: EAL68314.1 .
RefSeqi XP_642263.1. XM_637171.1.

3D structure databases

ProteinModelPortali Q54YD9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 44689.DDB_0230139.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblProtistsi DDB0230139 ; DDB0230139 ; DDB_G0278283 .
GeneIDi 8621472.
KEGGi ddi:DDB_G0278283.

Organism-specific databases

dictyBasei DDB_G0278283. fol1.

Phylogenomic databases

eggNOGi COG0294.
InParanoidi Q54YD9.
KOi K13939.
OMAi WQIILDP.
PhylomeDBi Q54YD9.

Enzyme and pathway databases

UniPathwayi UPA00077 ; UER00154 .
UPA00077 ; UER00155 .
UPA00077 ; UER00156 .

Family and domain databases

Gene3Di 3.20.20.20. 1 hit.
3.30.70.560. 1 hit.
InterProi IPR011005. Dihydropteroate_synth-like.
IPR006157. FolB_dom.
IPR000550. Hppk.
IPR000489. Pterin-binding.
[Graphical view ]
Pfami PF02152. FolB. 1 hit.
PF01288. HPPK. 1 hit.
PF00809. Pterin_bind. 1 hit.
[Graphical view ]
SMARTi SM00905. FolB. 1 hit.
[Graphical view ]
SUPFAMi SSF51717. SSF51717. 2 hits.
SSF55083. SSF55083. 1 hit.
TIGRFAMsi TIGR00526. folB_dom. 1 hit.
TIGR01498. folK. 1 hit.
PROSITEi PS00792. DHPS_1. 1 hit.
PS00793. DHPS_2. 1 hit.
PS00794. HPPK. 1 hit.
PS50972. PTERIN_BINDING. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome of the social amoeba Dictyostelium discoideum."
    Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N.
    , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
    Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AX4.

Entry informationi

Entry nameiFOL1_DICDI
AccessioniPrimary (citable) accession number: Q54YD9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: May 24, 2005
Last modified: October 29, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3