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Q54YC4 (MAND_DICDI) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 60. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Alpha-mannosidase D

EC=3.2.1.24
Gene names
Name:manD
ORF Names:DDB_G0278653
OrganismDictyostelium discoideum (Slime mold) [Reference proteome]
Taxonomic identifier44689 [NCBI]
Taxonomic lineageEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium

Protein attributes

Sequence length1222 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Hydrolysis of terminal, non-reducing alpha-D-mannose residues in alpha-D-mannosides.

Cofactor

Binds 1 zinc ion per subunit By similarity.

Subcellular location

Membrane; Single-pass type I membrane protein Potential.

Sequence similarities

Belongs to the glycosyl hydrolase 38 family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2121 Potential
Chain22 – 12221201Alpha-mannosidase D
PRO_0000327843

Regions

Topological domain22 – 11701149Extracellular Potential
Transmembrane1171 – 119121Helical; Potential
Topological domain1192 – 122231Cytoplasmic Potential
Compositional bias499 – 52224Poly-Asn
Compositional bias534 – 54310Poly-Ser
Compositional bias544 – 5485Poly-Asn
Compositional bias1114 – 11207Poly-Asn

Sites

Active site1851Nucleophile By similarity
Metal binding711Zinc By similarity
Metal binding731Zinc By similarity
Metal binding1851Zinc By similarity
Metal binding4531Zinc By similarity

Amino acid modifications

Glycosylation1751N-linked (GlcNAc...) Potential
Glycosylation4921N-linked (GlcNAc...) Potential
Glycosylation4961N-linked (GlcNAc...) Potential
Glycosylation5471N-linked (GlcNAc...) Potential
Glycosylation5511N-linked (GlcNAc...) Potential
Glycosylation5661N-linked (GlcNAc...) Potential
Glycosylation6131N-linked (GlcNAc...) Potential
Glycosylation6651N-linked (GlcNAc...) Potential
Glycosylation7681N-linked (GlcNAc...) Potential
Glycosylation7851N-linked (GlcNAc...) Potential
Glycosylation9521N-linked (GlcNAc...) Potential
Glycosylation9811N-linked (GlcNAc...) Potential
Glycosylation10691N-linked (GlcNAc...) Potential
Glycosylation10841N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
Q54YC4 [UniParc].

Last modified May 24, 2005. Version 1.
Checksum: FDA5A919C2C65880

FASTA1,222141,190
        10         20         30         40         50         60 
MESSKFVKII WVFGIWILVF TFLIIYNNYD YKSTFGINKF EKRSLKTINQ INNKENGDDK 

        70         80         90        100        110        120 
KLSVFLIPHS HCDGGWLQDY DGYYYNIVQY ILSGVVNELN LDKEKKFNWV EIGFFSRWWN 

       130        140        150        160        170        180 
DQNEIQKEIV RNLINNKQLS FISGGWVQND EATATIDDVI TQMTQGHQWL KDTLNYTVEY 

       190        200        210        220        230        240 
AWQIDPFGYS SSTPTIFSSM GIKGLVINRV SNDVKSYMKS VKEMEFIWKG SESLGEQSQM 

       250        260        270        280        290        300 
LVSTLNIHYD YPKHIDPKKD FSLNDRIKGF TKYLNDLSKT RESNILMIPL GDDFRYSNAK 

       310        320        330        340        350        360 
TEFSVSKEWV KALQDNKEYY NIKEIKYATL DEYFIALEDS FLRNNKFGKS RKQNVYTETF 

       370        380        390        400        410        420 
SDGDDEVSAL SLYNKDFFPY STGNLEYWTG YYTTRPLLKR LIRESSLLQK SSDILYTLAI 

       430        440        450        460        470        480 
GENSNNQIDI NNLQTLSNQL NENRNTIALV QHHDIVTGTS RSFVLNDNFQ RLQKSRISNY 

       490        500        510        520        530        540 
NIISNSLEYL LNKSNNKTNN NNNNNNKNNN NNNNNNNNNN NNLKNTNSIS TTGSSSSSGS 

       550        560        570        580        590        600 
GSSNNNNNTV NKSEPFNFEN AIDLSNESNN QYSLVFHNTL GWEVNQHVSF RIKVNKNDNQ 

       610        620        630        640        650        660 
LLESIQLVEA ISNKTIQIQI IPIQDDSNCQ SIENNYIVFA IINLPPLGLN TYYLSIANSE 

       670        680        690        700        710        720 
DSKSNFTYLS KPKLLKKGNE INFNNNRFKV EFESNGLISK ITDKNSNEIK TIEQTFHQYS 

       730        740        750        760        770        780 
TKKSGPYIFN VKGGKKHGFL ENPDKFIYHD GPLVSQLTML YGVDDYCNVT SIVVQRIYKN 

       790        800        810        820        830        840 
NNEINNSNSK SLITENYIET GYSINGDMNR ETTINYKVKD LENDDIFYTD NGLESRKRIY 

       850        860        870        880        890        900 
NHDRSVNQNY YPVLGYIKLK ETSENNNHQY TVYVDRSVGA TSPSDGEMEI MIHRTMDTDD 

       910        920        930        940        950        960 
WKGVNWPSKD IGRSDAKLYF NMDLVNNQLQ NEKRISLHIT NQPIMFVKKH NNQTGYLLKY 

       970        980        990       1000       1010       1020 
SPLSNQLPSN IHLQSLLTLK NNTVGLRLFN IHEVDSNTQS TTDTDKSTLF NELEISNFIE 

      1030       1040       1050       1060       1070       1080 
TGLSFLKLTK NNLIDKFSTR INKKFPIKCG ESEYSFINEK PSSIIFSNNG TNNIIDGENK 

      1090       1100       1110       1120       1130       1140 
GENNKTIETI QIKPHEIKSF TFNFNFQLDQ IIPNNNNNNN KYAINKELNN EYIEQSIENQ 

      1150       1160       1170       1180       1190       1200 
RYEYDFSFFP IKPTFYDDRG KYNRPNHLAL ILSLSIGIPA GILIIVIALV VTYKKRKNRK 

      1210       1220 
TLTSSNSSSN LIQQEDQTDY SP 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AAFI02000023 Genomic DNA. Translation: EAL68499.1.

3D structure databases

ProteinModelPortalQ54YC4.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING44689.DDB_0231614.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsDDB0231614; DDB0231614; DDB_G0278653.
KEGGddi:DDB_G0278653.

Organism-specific databases

dictyBaseDDB_G0278653. manD.

Phylogenomic databases

eggNOGCOG0383.
OMAFISGGWV.
PhylomeDBQ54YC4.
ProtClustDBCLSZ2430771.

Family and domain databases

Gene3D1.20.1270.50. 1 hit.
2.60.40.1180. 1 hit.
3.20.110.10. 1 hit.
InterProIPR011013. Gal_mutarotase_SF_dom.
IPR011330. Glyco_hydro/deAcase_b/a-brl.
IPR013780. Glyco_hydro_13_b.
IPR027291. Glyco_hydro_38/57_N.
IPR015341. Glyco_hydro_38_cen.
IPR000602. Glyco_hydro_38_N.
[Graphical view]
PfamPF09261. Alpha-mann_mid. 1 hit.
PF01074. Glyco_hydro_38. 1 hit.
[Graphical view]
SMARTSM00872. Alpha-mann_mid. 1 hit.
[Graphical view]
SUPFAMSSF74650. SSF74650. 2 hits.
SSF88713. SSF88713. 1 hit.
ProtoNetSearch...

Entry information

Entry nameMAND_DICDI
AccessionPrimary (citable) accession number: Q54YC4
Entry history
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: May 24, 2005
Last modified: April 16, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families

Glycosyl hydrolases

Classification of glycosyl hydrolase families and list of entries

Dictyostelium discoideum

Dictyostelium discoideum: entries, gene names and cross-references to dictyBase