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Protein

Putative phosphopantothenoylcysteine decarboxylase

Gene

ppcdc

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Necessary for the biosynthesis of coenzyme A. Catalyzes the decarboxylation of 4-phosphopantothenoylcysteine to form 4'-phosphopantotheine (By similarity).By similarity

Catalytic activityi

N-((R)-4'-phosphopantothenoyl)-L-cysteine = pantotheine 4'-phosphate + CO2.

Cofactori

FMNBy similarityNote: Binds 1 FMN per subunit.By similarity

Pathwayi: coenzyme A biosynthesis

This protein is involved in step 3 of the subpathway that synthesizes CoA from (R)-pantothenate.
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. no protein annotated in this organism
  3. Putative phosphopantothenoylcysteine decarboxylase (ppcdc)
  4. no protein annotated in this organism
  5. no protein annotated in this organism
This subpathway is part of the pathway coenzyme A biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes CoA from (R)-pantothenate, the pathway coenzyme A biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei52FMNBy similarity1
Binding sitei139SubstrateBy similarity1
Active sitei174Proton donorBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi102 – 105FMNBy similarity4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDecarboxylase, Lyase
Biological processCoenzyme A biosynthesis
LigandFlavoprotein, FMN

Enzyme and pathway databases

ReactomeiR-DDI-196783. Coenzyme A biosynthesis.
UniPathwayiUPA00241; UER00354.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative phosphopantothenoylcysteine decarboxylase (EC:4.1.1.36)
Short name:
PPC-DC
Gene namesi
Name:ppcdc
ORF Names:DDB_G0278413
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
Proteomesi
  • UP000002195 Componentsi: Chromosome 3, Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0278413. ppcdc.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003672581 – 197Putative phosphopantothenoylcysteine decarboxylaseAdd BLAST197

Proteomic databases

PaxDbiQ54Y51.

Interactioni

Subunit structurei

Homotrimer.Curated

Protein-protein interaction databases

STRINGi44689.DDB0231515.

Structurei

3D structure databases

ProteinModelPortaliQ54Y51.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0672. Eukaryota.
COG0452. LUCA.
InParanoidiQ54Y51.
KOiK01598.
OMAiKHFYSPQ.
PhylomeDBiQ54Y51.

Family and domain databases

Gene3Di3.40.50.1950. 1 hit.
InterProiView protein in InterPro
IPR036551. Flavin_trans-like.
IPR003382. Flavoprotein.
PfamiView protein in Pfam
PF02441. Flavoprotein. 1 hit.
SUPFAMiSSF52507. SSF52507. 1 hit.

Sequencei

Sequence statusi: Complete.

Q54Y51-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTITINNYNN DKKNLILGLT GSVATIKAKL LVEQLIQHFN LIVIPTETSL
60 70 80 90 100
KFLSDQDFEF ISSKCKIYKD KDEWENVDLL KRSALHIDLR NWANSILISP
110 120 130 140 150
CSANTLGKIS NGLCDNLLTS LIRAWDYKNK SMILAPAMNT MMWENPFTFK
160 170 180 190
HIETLKSISP NVFIIDPIEK KLFCGDIGMG AMEQVPKIVD FTINNLK
Length:197
Mass (Da):22,383
Last modified:May 24, 2005 - v1
Checksum:i665B8A1A3C726B04
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000023 Genomic DNA. Translation: EAL68379.1.
RefSeqiXP_642351.1. XM_637259.1.

Genome annotation databases

EnsemblProtistsiEAL68379; EAL68379; DDB_G0278413.
GeneIDi8621556.
KEGGiddi:DDB_G0278413.

Similar proteinsi

Entry informationi

Entry nameiCOAC_DICDI
AccessioniPrimary (citable) accession number: Q54Y51
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: May 24, 2005
Last modified: October 25, 2017
This is version 72 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families