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Protein

MAP kinase phosphatase with leucine-rich repeats protein 3

Gene

mpl3

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Probable phosphatase with dual specificity toward Ser/Thr and Tyr-containing proteins.By similarity

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation
[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei717Phosphocysteine intermediatePROSITE-ProRule annotation1

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Names & Taxonomyi

Protein namesi
Recommended name:
MAP kinase phosphatase with leucine-rich repeats protein 3 (EC:3.1.3.16, EC:3.1.3.48)
Gene namesi
Name:mpl3
ORF Names:DDB_G0278445
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
Proteomesi
  • UP000002195 Componentsi: Chromosome 3, Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0278445. mpl3.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedSequence analysis
ChainiPRO_00003329572 – 856MAP kinase phosphatase with leucine-rich repeats protein 3Add BLAST855

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi2N-myristoyl glycineSequence analysis1

Keywords - PTMi

Lipoprotein, Myristate

Proteomic databases

PaxDbiQ54Y32.

Interactioni

Protein-protein interaction databases

STRINGi44689.DDB0238874.

Structurei

3D structure databases

ProteinModelPortaliQ54Y32.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati344 – 365LRR 1Add BLAST22
Repeati370 – 391LRR 2Add BLAST22
Repeati392 – 413LRR 3Add BLAST22
Repeati416 – 437LRR 4Add BLAST22
Repeati439 – 461LRR 5Add BLAST23
Repeati462 – 484LRR 6Add BLAST23
Repeati485 – 506LRR 7Add BLAST22
Repeati507 – 528LRR 8Add BLAST22
Domaini632 – 772Tyrosine-protein phosphataseAdd BLAST141

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi14 – 25Poly-GlyAdd BLAST12
Compositional biasi93 – 107Poly-AsnAdd BLAST15
Compositional biasi116 – 130Poly-ThrAdd BLAST15
Compositional biasi137 – 142Poly-Gln6
Compositional biasi223 – 230Poly-Gln8
Compositional biasi563 – 583Poly-AsnAdd BLAST21
Compositional biasi815 – 820Poly-Asn6
Compositional biasi837 – 850Poly-SerAdd BLAST14

Sequence similaritiesi

Contains 8 LRR (leucine-rich) repeats.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGiKOG0619. Eukaryota.
KOG1716. Eukaryota.
COG2453. LUCA.
COG4886. LUCA.
InParanoidiQ54Y32.
OMAiELNIRDN.

Family and domain databases

CDDicd00127. DSPc. 1 hit.
Gene3Di3.80.10.10. 3 hits.
3.90.190.10. 1 hit.
InterProiIPR000340. Dual-sp_phosphatase_cat-dom.
IPR024950. DUSP.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR016130. Tyr_Pase_AS.
IPR003595. Tyr_Pase_cat.
IPR000387. TYR_PHOSPHATASE_dom.
IPR020422. TYR_PHOSPHATASE_DUAL_dom.
[Graphical view]
PANTHERiPTHR10159. PTHR10159. 2 hits.
PfamiPF00782. DSPc. 1 hit.
PF13855. LRR_8. 1 hit.
[Graphical view]
SMARTiSM00195. DSPc. 1 hit.
SM00369. LRR_TYP. 6 hits.
SM00404. PTPc_motif. 1 hit.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 1 hit.
SSF52799. SSF52799. 1 hit.
PROSITEiPS51450. LRR. 9 hits.
PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q54Y32-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGNSHSSENG GNSGSGGGSG GGGSGYSGVS ENMIIDLEGR YHIDYKNRNY
60 70 80 90 100
KKLKPQMFST FFEHYEIVQA DSLINSDFIK NKTVKKNRDN SSNNNSNNNS
110 120 130 140 150
NNNNNNNTLN NSTIITTTTT TTTTSTPTTT IMITPPQQQQ QQRTSLDLTN
160 170 180 190 200
RDISESSTPN EQQIRLAQEE TENQEIVESS FLKSSPVPSP SSSVLKSFES
210 220 230 240 250
DFQLNTDLTT ETFDDNSAEK KRQQQQQQQQ NEDSKQSSQQ QTQKSKDKDE
260 270 280 290 300
SAKIVNNKSS STTNIKPILA AAQTSRSTSI PAFNRNKTKE PTKQKIKKEH
310 320 330 340 350
STLRKNSLSS SNIITPNNTT NTNAKDGASY FNENSLMSVK SDIKIFSLDL
360 370 380 390 400
SINRLENITN DILSIMARFE IQELTLSTNF FQIIPDLQLV KSLTTVNLTR
410 420 430 440 450
NKLSKLQTSV FIELPSLTSL ILDRNFISSI PDDIDQIKNL KYLSIKHNAL
460 470 480 490 500
EYLPNSLSNL SQLISLDLSQ NKLKTLPPNF DDLINLRMVW LSYNQITSLP
510 520 530 540 550
SMRKLVNLVT FDISSNKLLS LPKDFAYLVP SRIKQSYSDI DIDEYDENIN
560 570 580 590 600
TCNNINSNNN DSNNSNNNNN NNNDNNNNCN KNNILEMINS TELEGGGLGC
610 620 630 640 650
LKELNIRDNR ELISLPVEYK QVESLMTLVT SIPSEIIPGI FLGGLDSANN
660 670 680 690 700
APILQTLGIT HILLAIGDCE PFFPKTFKYY SIDDARDAPQ YDISQHFEQT
710 720 730 740 750
NCFIESGRKS GGVLVHCRAG ISRSSTLVIS YLMKYQRMTF KQAMDLVQSK
760 770 780 790 800
RPQIQPNPGF KDQLLKYEAK LFCTNILNIS SHNSNNKNNN SSNNRKSINN
810 820 830 840 850
RKSNNIIITI NNSSNSNNNN STDNSNNSST STTPNLSSLS SDSSSSASLS

KLSISK
Length:856
Mass (Da):95,418
Last modified:May 24, 2005 - v1
Checksum:iFA899072865A6CEA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000023 Genomic DNA. Translation: EAL68395.1.
RefSeqiXP_642370.1. XM_637278.1.

Genome annotation databases

EnsemblProtistsiEAL68395; EAL68395; DDB_G0278445.
GeneIDi8621575.
KEGGiddi:DDB_G0278445.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000023 Genomic DNA. Translation: EAL68395.1.
RefSeqiXP_642370.1. XM_637278.1.

3D structure databases

ProteinModelPortaliQ54Y32.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi44689.DDB0238874.

Proteomic databases

PaxDbiQ54Y32.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsiEAL68395; EAL68395; DDB_G0278445.
GeneIDi8621575.
KEGGiddi:DDB_G0278445.

Organism-specific databases

dictyBaseiDDB_G0278445. mpl3.

Phylogenomic databases

eggNOGiKOG0619. Eukaryota.
KOG1716. Eukaryota.
COG2453. LUCA.
COG4886. LUCA.
InParanoidiQ54Y32.
OMAiELNIRDN.

Miscellaneous databases

PROiQ54Y32.

Family and domain databases

CDDicd00127. DSPc. 1 hit.
Gene3Di3.80.10.10. 3 hits.
3.90.190.10. 1 hit.
InterProiIPR000340. Dual-sp_phosphatase_cat-dom.
IPR024950. DUSP.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR016130. Tyr_Pase_AS.
IPR003595. Tyr_Pase_cat.
IPR000387. TYR_PHOSPHATASE_dom.
IPR020422. TYR_PHOSPHATASE_DUAL_dom.
[Graphical view]
PANTHERiPTHR10159. PTHR10159. 2 hits.
PfamiPF00782. DSPc. 1 hit.
PF13855. LRR_8. 1 hit.
[Graphical view]
SMARTiSM00195. DSPc. 1 hit.
SM00369. LRR_TYP. 6 hits.
SM00404. PTPc_motif. 1 hit.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 1 hit.
SSF52799. SSF52799. 1 hit.
PROSITEiPS51450. LRR. 9 hits.
PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMPL3_DICDI
AccessioniPrimary (citable) accession number: Q54Y32
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: May 24, 2005
Last modified: November 30, 2016
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.