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Protein

MAP kinase phosphatase with leucine-rich repeats protein 3

Gene

mpl3

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Probable phosphatase with dual specificity toward Ser/Thr and Tyr-containing proteins.By similarity

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation
[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei717Phosphocysteine intermediatePROSITE-ProRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase, Protein phosphatase

Names & Taxonomyi

Protein namesi
Recommended name:
MAP kinase phosphatase with leucine-rich repeats protein 3 (EC:3.1.3.16, EC:3.1.3.48)
Gene namesi
Name:mpl3
ORF Names:DDB_G0278445
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyostelidsDictyostelialesDictyosteliaceaeDictyostelium
Proteomesi
  • UP000002195 Componentsi: Chromosome 3, Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0278445 mpl3

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedSequence analysis
ChainiPRO_00003329572 – 856MAP kinase phosphatase with leucine-rich repeats protein 3Add BLAST855

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi2N-myristoyl glycineSequence analysis1

Keywords - PTMi

Lipoprotein, Myristate

Proteomic databases

PaxDbiQ54Y32
PRIDEiQ54Y32

Interactioni

Protein-protein interaction databases

STRINGi44689.DDB0238874

Structurei

3D structure databases

ProteinModelPortaliQ54Y32
SMRiQ54Y32
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati344 – 365LRR 1Add BLAST22
Repeati370 – 391LRR 2Add BLAST22
Repeati392 – 413LRR 3Add BLAST22
Repeati416 – 437LRR 4Add BLAST22
Repeati439 – 461LRR 5Add BLAST23
Repeati462 – 484LRR 6Add BLAST23
Repeati485 – 506LRR 7Add BLAST22
Repeati507 – 528LRR 8Add BLAST22
Domaini632 – 772Tyrosine-protein phosphataseAdd BLAST141

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi14 – 25Poly-GlyAdd BLAST12
Compositional biasi93 – 107Poly-AsnAdd BLAST15
Compositional biasi116 – 130Poly-ThrAdd BLAST15
Compositional biasi137 – 142Poly-Gln6
Compositional biasi223 – 230Poly-Gln8
Compositional biasi563 – 583Poly-AsnAdd BLAST21
Compositional biasi815 – 820Poly-Asn6
Compositional biasi837 – 850Poly-SerAdd BLAST14

Sequence similaritiesi

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGiKOG0619 Eukaryota
KOG1716 Eukaryota
COG2453 LUCA
COG4886 LUCA
InParanoidiQ54Y32
OMAiELNIRDN

Family and domain databases

CDDicd00127 DSPc, 1 hit
Gene3Di3.80.10.10, 2 hits
3.90.190.10, 1 hit
InterProiView protein in InterPro
IPR000340 Dual-sp_phosphatase_cat-dom
IPR024950 DUSP
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
IPR029021 Prot-tyrosine_phosphatase-like
IPR016130 Tyr_Pase_AS
IPR003595 Tyr_Pase_cat
IPR000387 TYR_PHOSPHATASE_dom
IPR020422 TYR_PHOSPHATASE_DUAL_dom
PANTHERiPTHR10159 PTHR10159, 2 hits
PfamiView protein in Pfam
PF00782 DSPc, 1 hit
PF13855 LRR_8, 1 hit
SMARTiView protein in SMART
SM00195 DSPc, 1 hit
SM00369 LRR_TYP, 6 hits
SM00404 PTPc_motif, 1 hit
SUPFAMiSSF52799 SSF52799, 1 hit
PROSITEiView protein in PROSITE
PS51450 LRR, 9 hits
PS00383 TYR_PHOSPHATASE_1, 1 hit
PS50056 TYR_PHOSPHATASE_2, 1 hit
PS50054 TYR_PHOSPHATASE_DUAL, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q54Y32-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGNSHSSENG GNSGSGGGSG GGGSGYSGVS ENMIIDLEGR YHIDYKNRNY
60 70 80 90 100
KKLKPQMFST FFEHYEIVQA DSLINSDFIK NKTVKKNRDN SSNNNSNNNS
110 120 130 140 150
NNNNNNNTLN NSTIITTTTT TTTTSTPTTT IMITPPQQQQ QQRTSLDLTN
160 170 180 190 200
RDISESSTPN EQQIRLAQEE TENQEIVESS FLKSSPVPSP SSSVLKSFES
210 220 230 240 250
DFQLNTDLTT ETFDDNSAEK KRQQQQQQQQ NEDSKQSSQQ QTQKSKDKDE
260 270 280 290 300
SAKIVNNKSS STTNIKPILA AAQTSRSTSI PAFNRNKTKE PTKQKIKKEH
310 320 330 340 350
STLRKNSLSS SNIITPNNTT NTNAKDGASY FNENSLMSVK SDIKIFSLDL
360 370 380 390 400
SINRLENITN DILSIMARFE IQELTLSTNF FQIIPDLQLV KSLTTVNLTR
410 420 430 440 450
NKLSKLQTSV FIELPSLTSL ILDRNFISSI PDDIDQIKNL KYLSIKHNAL
460 470 480 490 500
EYLPNSLSNL SQLISLDLSQ NKLKTLPPNF DDLINLRMVW LSYNQITSLP
510 520 530 540 550
SMRKLVNLVT FDISSNKLLS LPKDFAYLVP SRIKQSYSDI DIDEYDENIN
560 570 580 590 600
TCNNINSNNN DSNNSNNNNN NNNDNNNNCN KNNILEMINS TELEGGGLGC
610 620 630 640 650
LKELNIRDNR ELISLPVEYK QVESLMTLVT SIPSEIIPGI FLGGLDSANN
660 670 680 690 700
APILQTLGIT HILLAIGDCE PFFPKTFKYY SIDDARDAPQ YDISQHFEQT
710 720 730 740 750
NCFIESGRKS GGVLVHCRAG ISRSSTLVIS YLMKYQRMTF KQAMDLVQSK
760 770 780 790 800
RPQIQPNPGF KDQLLKYEAK LFCTNILNIS SHNSNNKNNN SSNNRKSINN
810 820 830 840 850
RKSNNIIITI NNSSNSNNNN STDNSNNSST STTPNLSSLS SDSSSSASLS

KLSISK
Length:856
Mass (Da):95,418
Last modified:May 24, 2005 - v1
Checksum:iFA899072865A6CEA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000023 Genomic DNA Translation: EAL68395.1
RefSeqiXP_642370.1, XM_637278.1

Genome annotation databases

EnsemblProtistsiEAL68395; EAL68395; DDB_G0278445
GeneIDi8621575
KEGGiddi:DDB_G0278445

Entry informationi

Entry nameiMPL3_DICDI
AccessioniPrimary (citable) accession number: Q54Y32
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: May 24, 2005
Last modified: May 23, 2018
This is version 88 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health