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Q54Y32

- MPL3_DICDI

UniProt

Q54Y32 - MPL3_DICDI

Protein

MAP kinase phosphatase with leucine-rich repeats protein 3

Gene

mpl3

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 68 (01 Oct 2014)
      Sequence version 1 (24 May 2005)
      Previous versions | rss
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    Functioni

    Probable phosphatase with dual specificity toward Ser/Thr and Tyr-containing proteins.By similarity

    Catalytic activityi

    Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation
    [a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei717 – 7171Phosphocysteine intermediatePROSITE-ProRule annotation

    GO - Molecular functioni

    1. protein tyrosine/serine/threonine phosphatase activity Source: RefGenome
    2. protein tyrosine phosphatase activity Source: UniProtKB-EC

    GO - Biological processi

    1. protein dephosphorylation Source: RefGenome

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    MAP kinase phosphatase with leucine-rich repeats protein 3 (EC:3.1.3.16, EC:3.1.3.48)
    Gene namesi
    Name:mpl3
    ORF Names:DDB_G0278445
    OrganismiDictyostelium discoideum (Slime mold)
    Taxonomic identifieri44689 [NCBI]
    Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
    ProteomesiUP000002195: Chromosome 3, UP000002195: Unassembled WGS sequence

    Organism-specific databases

    dictyBaseiDDB_G0278445. mpl3.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedSequence Analysis
    Chaini2 – 856855MAP kinase phosphatase with leucine-rich repeats protein 3PRO_0000332957Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Lipidationi2 – 21N-myristoyl glycineSequence Analysis

    Keywords - PTMi

    Lipoprotein, Myristate

    Interactioni

    Protein-protein interaction databases

    STRINGi44689.DDBDRAFT_0205459.

    Structurei

    3D structure databases

    ProteinModelPortaliQ54Y32.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati344 – 36522LRR 1Add
    BLAST
    Repeati370 – 39122LRR 2Add
    BLAST
    Repeati392 – 41322LRR 3Add
    BLAST
    Repeati416 – 43722LRR 4Add
    BLAST
    Repeati439 – 46123LRR 5Add
    BLAST
    Repeati462 – 48423LRR 6Add
    BLAST
    Repeati485 – 50622LRR 7Add
    BLAST
    Repeati507 – 52822LRR 8Add
    BLAST
    Domaini632 – 772141Tyrosine-protein phosphataseAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi14 – 2512Poly-GlyAdd
    BLAST
    Compositional biasi93 – 10715Poly-AsnAdd
    BLAST
    Compositional biasi116 – 13015Poly-ThrAdd
    BLAST
    Compositional biasi137 – 1426Poly-Gln
    Compositional biasi223 – 2308Poly-Gln
    Compositional biasi563 – 58321Poly-AsnAdd
    BLAST
    Compositional biasi815 – 8206Poly-Asn
    Compositional biasi837 – 85014Poly-SerAdd
    BLAST

    Sequence similaritiesi

    Contains 8 LRR (leucine-rich) repeats.Curated

    Keywords - Domaini

    Leucine-rich repeat, Repeat

    Phylogenomic databases

    eggNOGiCOG4886.
    OMAiELNIRDN.

    Family and domain databases

    Gene3Di3.90.190.10. 1 hit.
    InterProiIPR000340. Dual-sp_phosphatase_cat-dom.
    IPR020422. Dual-sp_phosphatase_subgr_cat.
    IPR024950. DUSP.
    IPR001611. Leu-rich_rpt.
    IPR003591. Leu-rich_rpt_typical-subtyp.
    IPR029021. Prot-tyrosine_phosphatase-like.
    IPR000387. Tyr/Dual-sp_Pase.
    IPR016130. Tyr_Pase_AS.
    [Graphical view]
    PANTHERiPTHR10159. PTHR10159. 1 hit.
    PfamiPF00782. DSPc. 1 hit.
    PF13855. LRR_8. 1 hit.
    [Graphical view]
    SMARTiSM00195. DSPc. 1 hit.
    SM00369. LRR_TYP. 1 hit.
    [Graphical view]
    SUPFAMiSSF52799. SSF52799. 1 hit.
    PROSITEiPS51450. LRR. 9 hits.
    PS00383. TYR_PHOSPHATASE_1. 1 hit.
    PS50056. TYR_PHOSPHATASE_2. 1 hit.
    PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q54Y32-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGNSHSSENG GNSGSGGGSG GGGSGYSGVS ENMIIDLEGR YHIDYKNRNY    50
    KKLKPQMFST FFEHYEIVQA DSLINSDFIK NKTVKKNRDN SSNNNSNNNS 100
    NNNNNNNTLN NSTIITTTTT TTTTSTPTTT IMITPPQQQQ QQRTSLDLTN 150
    RDISESSTPN EQQIRLAQEE TENQEIVESS FLKSSPVPSP SSSVLKSFES 200
    DFQLNTDLTT ETFDDNSAEK KRQQQQQQQQ NEDSKQSSQQ QTQKSKDKDE 250
    SAKIVNNKSS STTNIKPILA AAQTSRSTSI PAFNRNKTKE PTKQKIKKEH 300
    STLRKNSLSS SNIITPNNTT NTNAKDGASY FNENSLMSVK SDIKIFSLDL 350
    SINRLENITN DILSIMARFE IQELTLSTNF FQIIPDLQLV KSLTTVNLTR 400
    NKLSKLQTSV FIELPSLTSL ILDRNFISSI PDDIDQIKNL KYLSIKHNAL 450
    EYLPNSLSNL SQLISLDLSQ NKLKTLPPNF DDLINLRMVW LSYNQITSLP 500
    SMRKLVNLVT FDISSNKLLS LPKDFAYLVP SRIKQSYSDI DIDEYDENIN 550
    TCNNINSNNN DSNNSNNNNN NNNDNNNNCN KNNILEMINS TELEGGGLGC 600
    LKELNIRDNR ELISLPVEYK QVESLMTLVT SIPSEIIPGI FLGGLDSANN 650
    APILQTLGIT HILLAIGDCE PFFPKTFKYY SIDDARDAPQ YDISQHFEQT 700
    NCFIESGRKS GGVLVHCRAG ISRSSTLVIS YLMKYQRMTF KQAMDLVQSK 750
    RPQIQPNPGF KDQLLKYEAK LFCTNILNIS SHNSNNKNNN SSNNRKSINN 800
    RKSNNIIITI NNSSNSNNNN STDNSNNSST STTPNLSSLS SDSSSSASLS 850
    KLSISK 856
    Length:856
    Mass (Da):95,418
    Last modified:May 24, 2005 - v1
    Checksum:iFA899072865A6CEA
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AAFI02000023 Genomic DNA. Translation: EAL68395.1.
    RefSeqiXP_642370.1. XM_637278.1.

    Genome annotation databases

    EnsemblProtistsiDDB0238874; DDB0238874; DDB_G0278445.
    GeneIDi8621575.
    KEGGiddi:DDB_G0278445.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AAFI02000023 Genomic DNA. Translation: EAL68395.1 .
    RefSeqi XP_642370.1. XM_637278.1.

    3D structure databases

    ProteinModelPortali Q54Y32.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 44689.DDBDRAFT_0205459.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblProtistsi DDB0238874 ; DDB0238874 ; DDB_G0278445 .
    GeneIDi 8621575.
    KEGGi ddi:DDB_G0278445.

    Organism-specific databases

    dictyBasei DDB_G0278445. mpl3.

    Phylogenomic databases

    eggNOGi COG4886.
    OMAi ELNIRDN.

    Family and domain databases

    Gene3Di 3.90.190.10. 1 hit.
    InterProi IPR000340. Dual-sp_phosphatase_cat-dom.
    IPR020422. Dual-sp_phosphatase_subgr_cat.
    IPR024950. DUSP.
    IPR001611. Leu-rich_rpt.
    IPR003591. Leu-rich_rpt_typical-subtyp.
    IPR029021. Prot-tyrosine_phosphatase-like.
    IPR000387. Tyr/Dual-sp_Pase.
    IPR016130. Tyr_Pase_AS.
    [Graphical view ]
    PANTHERi PTHR10159. PTHR10159. 1 hit.
    Pfami PF00782. DSPc. 1 hit.
    PF13855. LRR_8. 1 hit.
    [Graphical view ]
    SMARTi SM00195. DSPc. 1 hit.
    SM00369. LRR_TYP. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52799. SSF52799. 1 hit.
    PROSITEi PS51450. LRR. 9 hits.
    PS00383. TYR_PHOSPHATASE_1. 1 hit.
    PS50056. TYR_PHOSPHATASE_2. 1 hit.
    PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome of the social amoeba Dictyostelium discoideum."
      Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N.
      , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
      Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: AX4.

    Entry informationi

    Entry nameiMPL3_DICDI
    AccessioniPrimary (citable) accession number: Q54Y32
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 29, 2008
    Last sequence update: May 24, 2005
    Last modified: October 1, 2014
    This is version 68 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Dictyostelium discoideum
      Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3