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Q54Y32

- MPL3_DICDI

UniProt

Q54Y32 - MPL3_DICDI

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Protein

MAP kinase phosphatase with leucine-rich repeats protein 3

Gene

mpl3

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Probable phosphatase with dual specificity toward Ser/Thr and Tyr-containing proteins.By similarity

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation
[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei717 – 7171Phosphocysteine intermediatePROSITE-ProRule annotation

GO - Molecular functioni

  1. protein tyrosine/serine/threonine phosphatase activity Source: RefGenome
  2. protein tyrosine phosphatase activity Source: UniProtKB-EC

GO - Biological processi

  1. protein dephosphorylation Source: RefGenome
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Names & Taxonomyi

Protein namesi
Recommended name:
MAP kinase phosphatase with leucine-rich repeats protein 3 (EC:3.1.3.16, EC:3.1.3.48)
Gene namesi
Name:mpl3
ORF Names:DDB_G0278445
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
ProteomesiUP000002195: Chromosome 3, UP000002195: Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0278445. mpl3.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedSequence Analysis
Chaini2 – 856855MAP kinase phosphatase with leucine-rich repeats protein 3PRO_0000332957Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi2 – 21N-myristoyl glycineSequence Analysis

Keywords - PTMi

Lipoprotein, Myristate

Interactioni

Protein-protein interaction databases

STRINGi44689.DDBDRAFT_0205459.

Structurei

3D structure databases

ProteinModelPortaliQ54Y32.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati344 – 36522LRR 1Add
BLAST
Repeati370 – 39122LRR 2Add
BLAST
Repeati392 – 41322LRR 3Add
BLAST
Repeati416 – 43722LRR 4Add
BLAST
Repeati439 – 46123LRR 5Add
BLAST
Repeati462 – 48423LRR 6Add
BLAST
Repeati485 – 50622LRR 7Add
BLAST
Repeati507 – 52822LRR 8Add
BLAST
Domaini632 – 772141Tyrosine-protein phosphataseAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi14 – 2512Poly-GlyAdd
BLAST
Compositional biasi93 – 10715Poly-AsnAdd
BLAST
Compositional biasi116 – 13015Poly-ThrAdd
BLAST
Compositional biasi137 – 1426Poly-Gln
Compositional biasi223 – 2308Poly-Gln
Compositional biasi563 – 58321Poly-AsnAdd
BLAST
Compositional biasi815 – 8206Poly-Asn
Compositional biasi837 – 85014Poly-SerAdd
BLAST

Sequence similaritiesi

Contains 8 LRR (leucine-rich) repeats.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGiCOG4886.
InParanoidiQ54Y32.
OMAiELNIRDN.

Family and domain databases

Gene3Di3.90.190.10. 1 hit.
InterProiIPR000340. Dual-sp_phosphatase_cat-dom.
IPR020422. Dual-sp_phosphatase_subgr_cat.
IPR024950. DUSP.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
[Graphical view]
PANTHERiPTHR10159. PTHR10159. 1 hit.
PfamiPF00782. DSPc. 1 hit.
PF13855. LRR_8. 1 hit.
[Graphical view]
SMARTiSM00195. DSPc. 1 hit.
SM00369. LRR_TYP. 1 hit.
[Graphical view]
SUPFAMiSSF52799. SSF52799. 1 hit.
PROSITEiPS51450. LRR. 9 hits.
PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q54Y32-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGNSHSSENG GNSGSGGGSG GGGSGYSGVS ENMIIDLEGR YHIDYKNRNY
60 70 80 90 100
KKLKPQMFST FFEHYEIVQA DSLINSDFIK NKTVKKNRDN SSNNNSNNNS
110 120 130 140 150
NNNNNNNTLN NSTIITTTTT TTTTSTPTTT IMITPPQQQQ QQRTSLDLTN
160 170 180 190 200
RDISESSTPN EQQIRLAQEE TENQEIVESS FLKSSPVPSP SSSVLKSFES
210 220 230 240 250
DFQLNTDLTT ETFDDNSAEK KRQQQQQQQQ NEDSKQSSQQ QTQKSKDKDE
260 270 280 290 300
SAKIVNNKSS STTNIKPILA AAQTSRSTSI PAFNRNKTKE PTKQKIKKEH
310 320 330 340 350
STLRKNSLSS SNIITPNNTT NTNAKDGASY FNENSLMSVK SDIKIFSLDL
360 370 380 390 400
SINRLENITN DILSIMARFE IQELTLSTNF FQIIPDLQLV KSLTTVNLTR
410 420 430 440 450
NKLSKLQTSV FIELPSLTSL ILDRNFISSI PDDIDQIKNL KYLSIKHNAL
460 470 480 490 500
EYLPNSLSNL SQLISLDLSQ NKLKTLPPNF DDLINLRMVW LSYNQITSLP
510 520 530 540 550
SMRKLVNLVT FDISSNKLLS LPKDFAYLVP SRIKQSYSDI DIDEYDENIN
560 570 580 590 600
TCNNINSNNN DSNNSNNNNN NNNDNNNNCN KNNILEMINS TELEGGGLGC
610 620 630 640 650
LKELNIRDNR ELISLPVEYK QVESLMTLVT SIPSEIIPGI FLGGLDSANN
660 670 680 690 700
APILQTLGIT HILLAIGDCE PFFPKTFKYY SIDDARDAPQ YDISQHFEQT
710 720 730 740 750
NCFIESGRKS GGVLVHCRAG ISRSSTLVIS YLMKYQRMTF KQAMDLVQSK
760 770 780 790 800
RPQIQPNPGF KDQLLKYEAK LFCTNILNIS SHNSNNKNNN SSNNRKSINN
810 820 830 840 850
RKSNNIIITI NNSSNSNNNN STDNSNNSST STTPNLSSLS SDSSSSASLS

KLSISK
Length:856
Mass (Da):95,418
Last modified:May 24, 2005 - v1
Checksum:iFA899072865A6CEA
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAFI02000023 Genomic DNA. Translation: EAL68395.1.
RefSeqiXP_642370.1. XM_637278.1.

Genome annotation databases

EnsemblProtistsiDDB0238874; DDB0238874; DDB_G0278445.
GeneIDi8621575.
KEGGiddi:DDB_G0278445.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAFI02000023 Genomic DNA. Translation: EAL68395.1 .
RefSeqi XP_642370.1. XM_637278.1.

3D structure databases

ProteinModelPortali Q54Y32.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 44689.DDBDRAFT_0205459.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblProtistsi DDB0238874 ; DDB0238874 ; DDB_G0278445 .
GeneIDi 8621575.
KEGGi ddi:DDB_G0278445.

Organism-specific databases

dictyBasei DDB_G0278445. mpl3.

Phylogenomic databases

eggNOGi COG4886.
InParanoidi Q54Y32.
OMAi ELNIRDN.

Family and domain databases

Gene3Di 3.90.190.10. 1 hit.
InterProi IPR000340. Dual-sp_phosphatase_cat-dom.
IPR020422. Dual-sp_phosphatase_subgr_cat.
IPR024950. DUSP.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
[Graphical view ]
PANTHERi PTHR10159. PTHR10159. 1 hit.
Pfami PF00782. DSPc. 1 hit.
PF13855. LRR_8. 1 hit.
[Graphical view ]
SMARTi SM00195. DSPc. 1 hit.
SM00369. LRR_TYP. 1 hit.
[Graphical view ]
SUPFAMi SSF52799. SSF52799. 1 hit.
PROSITEi PS51450. LRR. 9 hits.
PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome of the social amoeba Dictyostelium discoideum."
    Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N.
    , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
    Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AX4.

Entry informationi

Entry nameiMPL3_DICDI
AccessioniPrimary (citable) accession number: Q54Y32
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: May 24, 2005
Last modified: October 29, 2014
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3