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Q54Y32 (MPL3_DICDI) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 65. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
MAP kinase phosphatase with leucine-rich repeats protein 3

EC=3.1.3.16
EC=3.1.3.48
Gene names
Name:mpl3
ORF Names:DDB_G0278445
OrganismDictyostelium discoideum (Slime mold) [Reference proteome]
Taxonomic identifier44689 [NCBI]
Taxonomic lineageEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium

Protein attributes

Sequence length856 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Probable phosphatase with dual specificity toward Ser/Thr and Tyr-containing proteins By similarity.

Catalytic activity

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Sequence similarities

Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.

Contains 8 LRR (leucine-rich) repeats.

Contains 1 tyrosine-protein phosphatase domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed Potential
Chain2 – 856855MAP kinase phosphatase with leucine-rich repeats protein 3
PRO_0000332957

Regions

Repeat344 – 36522LRR 1
Repeat370 – 39122LRR 2
Repeat392 – 41322LRR 3
Repeat416 – 43722LRR 4
Repeat439 – 46123LRR 5
Repeat462 – 48423LRR 6
Repeat485 – 50622LRR 7
Repeat507 – 52822LRR 8
Domain632 – 772141Tyrosine-protein phosphatase
Compositional bias14 – 2512Poly-Gly
Compositional bias93 – 10715Poly-Asn
Compositional bias116 – 13015Poly-Thr
Compositional bias137 – 1426Poly-Gln
Compositional bias223 – 2308Poly-Gln
Compositional bias563 – 58321Poly-Asn
Compositional bias815 – 8206Poly-Asn
Compositional bias837 – 85014Poly-Ser

Sites

Active site7171Phosphocysteine intermediate By similarity

Amino acid modifications

Lipidation21N-myristoyl glycine Potential

Sequences

Sequence LengthMass (Da)Tools
Q54Y32 [UniParc].

Last modified May 24, 2005. Version 1.
Checksum: FA899072865A6CEA

FASTA85695,418
        10         20         30         40         50         60 
MGNSHSSENG GNSGSGGGSG GGGSGYSGVS ENMIIDLEGR YHIDYKNRNY KKLKPQMFST 

        70         80         90        100        110        120 
FFEHYEIVQA DSLINSDFIK NKTVKKNRDN SSNNNSNNNS NNNNNNNTLN NSTIITTTTT 

       130        140        150        160        170        180 
TTTTSTPTTT IMITPPQQQQ QQRTSLDLTN RDISESSTPN EQQIRLAQEE TENQEIVESS 

       190        200        210        220        230        240 
FLKSSPVPSP SSSVLKSFES DFQLNTDLTT ETFDDNSAEK KRQQQQQQQQ NEDSKQSSQQ 

       250        260        270        280        290        300 
QTQKSKDKDE SAKIVNNKSS STTNIKPILA AAQTSRSTSI PAFNRNKTKE PTKQKIKKEH 

       310        320        330        340        350        360 
STLRKNSLSS SNIITPNNTT NTNAKDGASY FNENSLMSVK SDIKIFSLDL SINRLENITN 

       370        380        390        400        410        420 
DILSIMARFE IQELTLSTNF FQIIPDLQLV KSLTTVNLTR NKLSKLQTSV FIELPSLTSL 

       430        440        450        460        470        480 
ILDRNFISSI PDDIDQIKNL KYLSIKHNAL EYLPNSLSNL SQLISLDLSQ NKLKTLPPNF 

       490        500        510        520        530        540 
DDLINLRMVW LSYNQITSLP SMRKLVNLVT FDISSNKLLS LPKDFAYLVP SRIKQSYSDI 

       550        560        570        580        590        600 
DIDEYDENIN TCNNINSNNN DSNNSNNNNN NNNDNNNNCN KNNILEMINS TELEGGGLGC 

       610        620        630        640        650        660 
LKELNIRDNR ELISLPVEYK QVESLMTLVT SIPSEIIPGI FLGGLDSANN APILQTLGIT 

       670        680        690        700        710        720 
HILLAIGDCE PFFPKTFKYY SIDDARDAPQ YDISQHFEQT NCFIESGRKS GGVLVHCRAG 

       730        740        750        760        770        780 
ISRSSTLVIS YLMKYQRMTF KQAMDLVQSK RPQIQPNPGF KDQLLKYEAK LFCTNILNIS 

       790        800        810        820        830        840 
SHNSNNKNNN SSNNRKSINN RKSNNIIITI NNSSNSNNNN STDNSNNSST STTPNLSSLS 

       850 
SDSSSSASLS KLSISK 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AAFI02000023 Genomic DNA. Translation: EAL68395.1.

3D structure databases

ProteinModelPortalQ54Y32.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING44689.DDBDRAFT_0205459.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsDDB0238874; DDB0238874; DDB_G0278445.
KEGGddi:DDB_G0278445.

Organism-specific databases

dictyBaseDDB_G0278445. mpl3.

Phylogenomic databases

eggNOGCOG4886.
OMAELNIRDN.

Family and domain databases

InterProIPR000340. Dual-sp_phosphatase_cat-dom.
IPR020422. Dual-sp_phosphatase_subgr_cat.
IPR024950. DUSP.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
[Graphical view]
PANTHERPTHR10159. PTHR10159. 1 hit.
PfamPF00782. DSPc. 1 hit.
[Graphical view]
SMARTSM00195. DSPc. 1 hit.
SM00369. LRR_TYP. 1 hit.
[Graphical view]
PROSITEPS51450. LRR. 9 hits.
PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameMPL3_DICDI
AccessionPrimary (citable) accession number: Q54Y32
Entry history
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: May 24, 2005
Last modified: April 16, 2014
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families

Dictyostelium discoideum

Dictyostelium discoideum: entries, gene names and cross-references to dictyBase