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Q54Y06

- Y8487_DICDI

UniProt

Q54Y06 - Y8487_DICDI

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Protein

Probable cyclin-dependent serine/threonine-protein kinase DDB_G0278487

Gene

DDB_G0278487

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei93 – 931ATPPROSITE-ProRule annotation
Active sitei184 – 1841Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi70 – 789ATPPROSITE-ProRule annotation

GO - Molecular functioni

  1. ATP binding Source: dictyBase
  2. cyclin-dependent protein serine/threonine kinase activity Source: UniProtKB-EC
  3. protein serine/threonine kinase activity Source: dictyBase
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Probable cyclin-dependent serine/threonine-protein kinase DDB_G0278487 (EC:2.7.11.22)
Gene namesi
ORF Names:DDB_G0278487
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
ProteomesiUP000002195: Chromosome 3, UP000002195: Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0278487.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 636636Probable cyclin-dependent serine/threonine-protein kinase DDB_G0278487PRO_0000362064Add
BLAST

Expressioni

Developmental stagei

Up-regulated in aspidocytes, a resistant cell type induced by a range of toxins including heavy metals and antibiotics.1 Publication

Interactioni

Protein-protein interaction databases

STRINGi44689.DDB_0229294.

Structurei

3D structure databases

ProteinModelPortaliQ54Y06.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini64 – 343280Protein kinasePROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi15 – 2511Poly-SerAdd
BLAST
Compositional biasi372 – 3754Poly-Gln
Compositional biasi487 – 4904Poly-Gln
Compositional biasi591 – 5944Poly-Gln
Compositional biasi617 – 62812Poly-AsnAdd
BLAST

Sequence similaritiesi

Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0515.
InParanoidiQ54Y06.
OMAiYCTSETE.
PhylomeDBiQ54Y06.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q54Y06-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPSQSNNVIT SSTASSSMSS SSNSSDASST SSSNTNNAHS SNNQFVSGQL
60 70 80 90 100
NLVGNTHTKI NDNYEIISKI GEGISGSVFK AIKKGTEEMV ALKNFKGWTE
110 120 130 140 150
GDRASKEECS LLQQLRHIPY ITPVIDIYTN FETSEYIIVF PYFEHDLSGL
160 170 180 190 200
LSEHRLSIPQ VKCYFKQLLE GINEIHNAGV MHRDIKAANL LVNNKGSLFI
210 220 230 240 250
GDLGTATSYT KRSVFSSKVV TLWYRAPELL LGSTQYGPEI DMWSIGCVLI
260 270 280 290 300
ELVTSRNFLP GSSEQQQLEA ICKLCGTPTD EIWPNVSQLQ NFNQISHLPV
310 320 330 340 350
YPSRLRTVFK NFSNDFIELL EGLLTLNPKK RLTAEQALQS PFFTNHPLPF
360 370 380 390 400
KPENMPGYQP IHVLEAVQKR VQQQQELEQQ KKQEEQKKQQ EEQKKLEDQK
410 420 430 440 450
KQEEQKKQED LLKRQRLLKR QQELKKQQDE QRQQELIKKQ QEQEQLRLKV
460 470 480 490 500
EHEKQRQEQE RLRLIQQEQE RLKRQQQEHE QRLQREQQQQ LNQLQQQKES
510 520 530 540 550
PLNNSYGKIN LKRSLDLVND IRNYCTSETE SEYESDEEDF YTEEEVEDYS
560 570 580 590 600
SDEEDDYYNA QSNKSLYTPI KAMIQQHNNN QQHQQQYPYS QQQQEPISSN
610 620 630
PFLQPPKKQR TASTGFNNNN GNNNNNNNLS TPLTIH
Length:636
Mass (Da):73,679
Last modified:May 24, 2005 - v1
Checksum:i96FCE039D9FB05D6
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAFI02000023 Genomic DNA. Translation: EAL68416.1.
RefSeqiXP_642396.1. XM_637304.1.

Genome annotation databases

EnsemblProtistsiDDB0229294; DDB0229294; DDB_G0278487.
GeneIDi8621601.
KEGGiddi:DDB_G0278487.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAFI02000023 Genomic DNA. Translation: EAL68416.1 .
RefSeqi XP_642396.1. XM_637304.1.

3D structure databases

ProteinModelPortali Q54Y06.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 44689.DDB_0229294.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblProtistsi DDB0229294 ; DDB0229294 ; DDB_G0278487 .
GeneIDi 8621601.
KEGGi ddi:DDB_G0278487.

Organism-specific databases

dictyBasei DDB_G0278487.

Phylogenomic databases

eggNOGi COG0515.
InParanoidi Q54Y06.
OMAi YCTSETE.
PhylomeDBi Q54Y06.

Family and domain databases

InterProi IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view ]
Pfami PF00069. Pkinase. 1 hit.
[Graphical view ]
SMARTi SM00220. S_TKc. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The genome of the social amoeba Dictyostelium discoideum."
    Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N.
    , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
    Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AX4.
  2. "A new environmentally resistant cell type from Dictyostelium."
    Serafimidis I., Bloomfield G., Skelton J., Ivens A., Kay R.R.
    Microbiology 153:619-630(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: DEVELOPMENTAL STAGE.

Entry informationi

Entry nameiY8487_DICDI
AccessioniPrimary (citable) accession number: Q54Y06
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 10, 2009
Last sequence update: May 24, 2005
Last modified: October 29, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3