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Protein

Probable cyclin-dependent serine/threonine-protein kinase DDB_G0278487

Gene

DDB_G0278487

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei93ATPPROSITE-ProRule annotation1
Active sitei184Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi70 – 78ATPPROSITE-ProRule annotation9

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Probable cyclin-dependent serine/threonine-protein kinase DDB_G0278487 (EC:2.7.11.22)
Gene namesi
ORF Names:DDB_G0278487
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
Proteomesi
  • UP000002195 Componentsi: Chromosome 3, Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0278487.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003620641 – 636Probable cyclin-dependent serine/threonine-protein kinase DDB_G0278487Add BLAST636

Proteomic databases

PaxDbiQ54Y06.
PRIDEiQ54Y06.

Expressioni

Developmental stagei

Up-regulated in aspidocytes, a resistant cell type induced by a range of toxins including heavy metals and antibiotics.1 Publication

Interactioni

Protein-protein interaction databases

STRINGi44689.DDB0229294.

Structurei

3D structure databases

ProteinModelPortaliQ54Y06.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini64 – 343Protein kinasePROSITE-ProRule annotationAdd BLAST280

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi15 – 25Poly-SerAdd BLAST11
Compositional biasi372 – 375Poly-Gln4
Compositional biasi487 – 490Poly-Gln4
Compositional biasi591 – 594Poly-Gln4
Compositional biasi617 – 628Poly-AsnAdd BLAST12

Sequence similaritiesi

Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0600. Eukaryota.
ENOG410XPIR. LUCA.
InParanoidiQ54Y06.
OMAiYCTSETE.
PhylomeDBiQ54Y06.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q54Y06-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPSQSNNVIT SSTASSSMSS SSNSSDASST SSSNTNNAHS SNNQFVSGQL
60 70 80 90 100
NLVGNTHTKI NDNYEIISKI GEGISGSVFK AIKKGTEEMV ALKNFKGWTE
110 120 130 140 150
GDRASKEECS LLQQLRHIPY ITPVIDIYTN FETSEYIIVF PYFEHDLSGL
160 170 180 190 200
LSEHRLSIPQ VKCYFKQLLE GINEIHNAGV MHRDIKAANL LVNNKGSLFI
210 220 230 240 250
GDLGTATSYT KRSVFSSKVV TLWYRAPELL LGSTQYGPEI DMWSIGCVLI
260 270 280 290 300
ELVTSRNFLP GSSEQQQLEA ICKLCGTPTD EIWPNVSQLQ NFNQISHLPV
310 320 330 340 350
YPSRLRTVFK NFSNDFIELL EGLLTLNPKK RLTAEQALQS PFFTNHPLPF
360 370 380 390 400
KPENMPGYQP IHVLEAVQKR VQQQQELEQQ KKQEEQKKQQ EEQKKLEDQK
410 420 430 440 450
KQEEQKKQED LLKRQRLLKR QQELKKQQDE QRQQELIKKQ QEQEQLRLKV
460 470 480 490 500
EHEKQRQEQE RLRLIQQEQE RLKRQQQEHE QRLQREQQQQ LNQLQQQKES
510 520 530 540 550
PLNNSYGKIN LKRSLDLVND IRNYCTSETE SEYESDEEDF YTEEEVEDYS
560 570 580 590 600
SDEEDDYYNA QSNKSLYTPI KAMIQQHNNN QQHQQQYPYS QQQQEPISSN
610 620 630
PFLQPPKKQR TASTGFNNNN GNNNNNNNLS TPLTIH
Length:636
Mass (Da):73,679
Last modified:May 24, 2005 - v1
Checksum:i96FCE039D9FB05D6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000023 Genomic DNA. Translation: EAL68416.1.
RefSeqiXP_642396.1. XM_637304.1.

Genome annotation databases

EnsemblProtistsiEAL68416; EAL68416; DDB_G0278487.
GeneIDi8621601.
KEGGiddi:DDB_G0278487.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000023 Genomic DNA. Translation: EAL68416.1.
RefSeqiXP_642396.1. XM_637304.1.

3D structure databases

ProteinModelPortaliQ54Y06.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi44689.DDB0229294.

Proteomic databases

PaxDbiQ54Y06.
PRIDEiQ54Y06.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsiEAL68416; EAL68416; DDB_G0278487.
GeneIDi8621601.
KEGGiddi:DDB_G0278487.

Organism-specific databases

dictyBaseiDDB_G0278487.

Phylogenomic databases

eggNOGiKOG0600. Eukaryota.
ENOG410XPIR. LUCA.
InParanoidiQ54Y06.
OMAiYCTSETE.
PhylomeDBiQ54Y06.

Miscellaneous databases

PROiQ54Y06.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiY8487_DICDI
AccessioniPrimary (citable) accession number: Q54Y06
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 10, 2009
Last sequence update: May 24, 2005
Last modified: November 2, 2016
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.