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Q54Y06 (Y8487_DICDI) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 63. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable cyclin-dependent serine/threonine-protein kinase DDB_G0278487

EC=2.7.11.22
Gene names
ORF Names:DDB_G0278487
OrganismDictyostelium discoideum (Slime mold) [Reference proteome]
Taxonomic identifier44689 [NCBI]
Taxonomic lineageEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium

Protein attributes

Sequence length636 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

ATP + a protein = ADP + a phosphoprotein.

Developmental stage

Up-regulated in aspidocytes, a resistant cell type induced by a range of toxins including heavy metals and antibiotics. Ref.2

Sequence similarities

Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.

Contains 1 protein kinase domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 636636Probable cyclin-dependent serine/threonine-protein kinase DDB_G0278487
PRO_0000362064

Regions

Domain64 – 343280Protein kinase
Nucleotide binding70 – 789ATP By similarity
Compositional bias15 – 2511Poly-Ser
Compositional bias372 – 3754Poly-Gln
Compositional bias487 – 4904Poly-Gln
Compositional bias591 – 5944Poly-Gln
Compositional bias617 – 62812Poly-Asn

Sites

Active site1841Proton acceptor By similarity
Binding site931ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q54Y06 [UniParc].

Last modified May 24, 2005. Version 1.
Checksum: 96FCE039D9FB05D6

FASTA63673,679
        10         20         30         40         50         60 
MPSQSNNVIT SSTASSSMSS SSNSSDASST SSSNTNNAHS SNNQFVSGQL NLVGNTHTKI 

        70         80         90        100        110        120 
NDNYEIISKI GEGISGSVFK AIKKGTEEMV ALKNFKGWTE GDRASKEECS LLQQLRHIPY 

       130        140        150        160        170        180 
ITPVIDIYTN FETSEYIIVF PYFEHDLSGL LSEHRLSIPQ VKCYFKQLLE GINEIHNAGV 

       190        200        210        220        230        240 
MHRDIKAANL LVNNKGSLFI GDLGTATSYT KRSVFSSKVV TLWYRAPELL LGSTQYGPEI 

       250        260        270        280        290        300 
DMWSIGCVLI ELVTSRNFLP GSSEQQQLEA ICKLCGTPTD EIWPNVSQLQ NFNQISHLPV 

       310        320        330        340        350        360 
YPSRLRTVFK NFSNDFIELL EGLLTLNPKK RLTAEQALQS PFFTNHPLPF KPENMPGYQP 

       370        380        390        400        410        420 
IHVLEAVQKR VQQQQELEQQ KKQEEQKKQQ EEQKKLEDQK KQEEQKKQED LLKRQRLLKR 

       430        440        450        460        470        480 
QQELKKQQDE QRQQELIKKQ QEQEQLRLKV EHEKQRQEQE RLRLIQQEQE RLKRQQQEHE 

       490        500        510        520        530        540 
QRLQREQQQQ LNQLQQQKES PLNNSYGKIN LKRSLDLVND IRNYCTSETE SEYESDEEDF 

       550        560        570        580        590        600 
YTEEEVEDYS SDEEDDYYNA QSNKSLYTPI KAMIQQHNNN QQHQQQYPYS QQQQEPISSN 

       610        620        630 
PFLQPPKKQR TASTGFNNNN GNNNNNNNLS TPLTIH 

« Hide

References

« Hide 'large scale' references
[1]"The genome of the social amoeba Dictyostelium discoideum."
Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N. expand/collapse author list , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: AX4.
[2]"A new environmentally resistant cell type from Dictyostelium."
Serafimidis I., Bloomfield G., Skelton J., Ivens A., Kay R.R.
Microbiology 153:619-630(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: DEVELOPMENTAL STAGE.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AAFI02000023 Genomic DNA. Translation: EAL68416.1.

3D structure databases

ProteinModelPortalQ54Y06.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING44689.DDB_0229294.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsDDB0229294; DDB0229294; DDB_G0278487.
KEGGddi:DDB_G0278487.

Organism-specific databases

dictyBaseDDB_G0278487.

Phylogenomic databases

eggNOGCOG0515.
InParanoidQ54Y06.
OMAYCTSETE.
PhylomeDBQ54Y06.

Family and domain databases

InterProIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMSSF56112. SSF56112. 1 hit.
PROSITEPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameY8487_DICDI
AccessionPrimary (citable) accession number: Q54Y06
Entry history
Integrated into UniProtKB/Swiss-Prot: February 10, 2009
Last sequence update: May 24, 2005
Last modified: April 16, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families

Dictyostelium discoideum

Dictyostelium discoideum: entries, gene names and cross-references to dictyBase