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Q54Y06

- Y8487_DICDI

UniProt

Q54Y06 - Y8487_DICDI

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Protein
Probable cyclin-dependent serine/threonine-protein kinase DDB_G0278487
Gene
DDB_G0278487
Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei93 – 931ATP By similarity
Active sitei184 – 1841Proton acceptor By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi70 – 789ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: dictyBase
  2. cyclin-dependent protein serine/threonine kinase activity Source: UniProtKB-EC
  3. protein serine/threonine kinase activity Source: dictyBase
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    Kinase, Serine/threonine-protein kinase, Transferase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable cyclin-dependent serine/threonine-protein kinase DDB_G0278487 (EC:2.7.11.22)
    Gene namesi
    ORF Names:DDB_G0278487
    OrganismiDictyostelium discoideum (Slime mold)
    Taxonomic identifieri44689 [NCBI]
    Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
    ProteomesiUP000002195: Chromosome 3, UP000002195: Unassembled WGS sequence

    Organism-specific databases

    dictyBaseiDDB_G0278487.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 636636Probable cyclin-dependent serine/threonine-protein kinase DDB_G0278487
    PRO_0000362064Add
    BLAST

    Expressioni

    Developmental stagei

    Up-regulated in aspidocytes, a resistant cell type induced by a range of toxins including heavy metals and antibiotics.1 Publication

    Interactioni

    Protein-protein interaction databases

    STRINGi44689.DDB_0229294.

    Structurei

    3D structure databases

    ProteinModelPortaliQ54Y06.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini64 – 343280Protein kinase
    Add
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi15 – 2511Poly-Ser
    Add
    BLAST
    Compositional biasi372 – 3754Poly-Gln
    Compositional biasi487 – 4904Poly-Gln
    Compositional biasi591 – 5944Poly-Gln
    Compositional biasi617 – 62812Poly-Asn
    Add
    BLAST

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0515.
    InParanoidiQ54Y06.
    OMAiYCTSETE.
    PhylomeDBiQ54Y06.

    Family and domain databases

    InterProiIPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view]
    PfamiPF00069. Pkinase. 1 hit.
    [Graphical view]
    SMARTiSM00220. S_TKc. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 1 hit.
    PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q54Y06-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPSQSNNVIT SSTASSSMSS SSNSSDASST SSSNTNNAHS SNNQFVSGQL    50
    NLVGNTHTKI NDNYEIISKI GEGISGSVFK AIKKGTEEMV ALKNFKGWTE 100
    GDRASKEECS LLQQLRHIPY ITPVIDIYTN FETSEYIIVF PYFEHDLSGL 150
    LSEHRLSIPQ VKCYFKQLLE GINEIHNAGV MHRDIKAANL LVNNKGSLFI 200
    GDLGTATSYT KRSVFSSKVV TLWYRAPELL LGSTQYGPEI DMWSIGCVLI 250
    ELVTSRNFLP GSSEQQQLEA ICKLCGTPTD EIWPNVSQLQ NFNQISHLPV 300
    YPSRLRTVFK NFSNDFIELL EGLLTLNPKK RLTAEQALQS PFFTNHPLPF 350
    KPENMPGYQP IHVLEAVQKR VQQQQELEQQ KKQEEQKKQQ EEQKKLEDQK 400
    KQEEQKKQED LLKRQRLLKR QQELKKQQDE QRQQELIKKQ QEQEQLRLKV 450
    EHEKQRQEQE RLRLIQQEQE RLKRQQQEHE QRLQREQQQQ LNQLQQQKES 500
    PLNNSYGKIN LKRSLDLVND IRNYCTSETE SEYESDEEDF YTEEEVEDYS 550
    SDEEDDYYNA QSNKSLYTPI KAMIQQHNNN QQHQQQYPYS QQQQEPISSN 600
    PFLQPPKKQR TASTGFNNNN GNNNNNNNLS TPLTIH 636
    Length:636
    Mass (Da):73,679
    Last modified:May 24, 2005 - v1
    Checksum:i96FCE039D9FB05D6
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AAFI02000023 Genomic DNA. Translation: EAL68416.1.
    RefSeqiXP_642396.1. XM_637304.1.

    Genome annotation databases

    EnsemblProtistsiDDB0229294; DDB0229294; DDB_G0278487.
    GeneIDi8621601.
    KEGGiddi:DDB_G0278487.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AAFI02000023 Genomic DNA. Translation: EAL68416.1 .
    RefSeqi XP_642396.1. XM_637304.1.

    3D structure databases

    ProteinModelPortali Q54Y06.
    ModBasei Search...

    Protein-protein interaction databases

    STRINGi 44689.DDB_0229294.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblProtistsi DDB0229294 ; DDB0229294 ; DDB_G0278487 .
    GeneIDi 8621601.
    KEGGi ddi:DDB_G0278487.

    Organism-specific databases

    dictyBasei DDB_G0278487.

    Phylogenomic databases

    eggNOGi COG0515.
    InParanoidi Q54Y06.
    OMAi YCTSETE.
    PhylomeDBi Q54Y06.

    Family and domain databases

    InterProi IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view ]
    Pfami PF00069. Pkinase. 1 hit.
    [Graphical view ]
    SMARTi SM00220. S_TKc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 1 hit.
    PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    « Hide 'large scale' publications
    1. "The genome of the social amoeba Dictyostelium discoideum."
      Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N.
      , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
      Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: AX4.
    2. "A new environmentally resistant cell type from Dictyostelium."
      Serafimidis I., Bloomfield G., Skelton J., Ivens A., Kay R.R.
      Microbiology 153:619-630(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: DEVELOPMENTAL STAGE.

    Entry informationi

    Entry nameiY8487_DICDI
    AccessioniPrimary (citable) accession number: Q54Y06
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 10, 2009
    Last sequence update: May 24, 2005
    Last modified: May 14, 2014
    This is version 64 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Dictyostelium discoideum
      Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

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