Q54Y06 (Y8487_DICDI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable cyclin-dependent serine/threonine-protein kinase DDB_G0278487
EC=2.7.11.22

Gene names

ORF Names:

DDB_G0278487

Organism

Dictyostelium discoideum (Slime mold) [Reference proteome]

Taxonomic identifier

44689 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Amoebozoa › Mycetozoa › Dictyosteliida › Dictyostelium

Protein attributes

Sequence length	636 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Catalytic activity	ATP + a protein = ADP + a phosphoprotein.
Developmental stage	Up-regulated in aspidocytes, a resistant cell type induced by a range of toxins including heavy metals and antibiotics. Ref.2
Sequence similarities	Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. Contains 1 protein kinase domain.

Ontologies

Keywords
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Serine/threonine-protein kinase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cell cycle Inferred from electronic annotation. Source: GOC
Molecular_function	ATP binding Inferred from sequence or structural similarity. Source: dictyBase cyclin-dependent protein serine/threonine kinase activity Inferred from electronic annotation. Source: EC protein serine/threonine kinase activity Inferred from sequence or structural similarity. Source: dictyBase
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 636	636	Probable cyclin-dependent serine/threonine-protein kinase DDB_G0278487		PRO_0000362064
Regions
	Domain	64 – 343	280	Protein kinase
	Nucleotide binding	70 – 78	9	ATP By similarity
	Compositional bias	15 – 25	11	Poly-Ser
	Compositional bias	372 – 375	4	Poly-Gln
	Compositional bias	487 – 490	4	Poly-Gln
	Compositional bias	591 – 594	4	Poly-Gln
	Compositional bias	617 – 628	12	Poly-Asn
Sites
	Active site	184	1	Proton acceptor By similarity
	Binding site	93	1	ATP By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q54Y06 [UniParc]. Last modified May 24, 2005. Version 1. Checksum: 96FCE039D9FB05D6	FASTA	636	73,679
	10 20 30 40 50 60 MPSQSNNVIT SSTASSSMSS SSNSSDASST SSSNTNNAHS SNNQFVSGQL NLVGNTHTKI 70 80 90 100 110 120 NDNYEIISKI GEGISGSVFK AIKKGTEEMV ALKNFKGWTE GDRASKEECS LLQQLRHIPY 130 140 150 160 170 180 ITPVIDIYTN FETSEYIIVF PYFEHDLSGL LSEHRLSIPQ VKCYFKQLLE GINEIHNAGV 190 200 210 220 230 240 MHRDIKAANL LVNNKGSLFI GDLGTATSYT KRSVFSSKVV TLWYRAPELL LGSTQYGPEI 250 260 270 280 290 300 DMWSIGCVLI ELVTSRNFLP GSSEQQQLEA ICKLCGTPTD EIWPNVSQLQ NFNQISHLPV 310 320 330 340 350 360 YPSRLRTVFK NFSNDFIELL EGLLTLNPKK RLTAEQALQS PFFTNHPLPF KPENMPGYQP 370 380 390 400 410 420 IHVLEAVQKR VQQQQELEQQ KKQEEQKKQQ EEQKKLEDQK KQEEQKKQED LLKRQRLLKR 430 440 450 460 470 480 QQELKKQQDE QRQQELIKKQ QEQEQLRLKV EHEKQRQEQE RLRLIQQEQE RLKRQQQEHE 490 500 510 520 530 540 QRLQREQQQQ LNQLQQQKES PLNNSYGKIN LKRSLDLVND IRNYCTSETE SEYESDEEDF 550 560 570 580 590 600 YTEEEVEDYS SDEEDDYYNA QSNKSLYTPI KAMIQQHNNN QQHQQQYPYS QQQQEPISSN 610 620 630 PFLQPPKKQR TASTGFNNNN GNNNNNNNLS TPLTIH

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The genome of the social amoeba Dictyostelium discoideum." Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N. , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A. Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AX4.
[2]	"A new environmentally resistant cell type from Dictyostelium." Serafimidis I., Bloomfield G., Skelton J., Ivens A., Kay R.R. Microbiology 153:619-630(2007) [PubMed] [Europe PMC] [Abstract] Cited for: DEVELOPMENTAL STAGE.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AAFI02000023 Genomic DNA. Translation: EAL68416.1.
RefSeq	XP_642396.1. XM_637304.1.
3D structure databases
HSSP	HSSP built from PDB template 1E1X based on UniProtKB P24941.
ProteinModelPortal	Q54Y06.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblProtists	DDB0229294; DDB0229294; DDB_G0278487.
GeneID	8621601.
KEGG	ddi:DDB_G0278487.
Organism-specific databases
dictyBase	DDB_G0278487.
Phylogenomic databases
eggNOG	COG0515.
InParanoid	Q54Y06.
OMA	CTSETES.
Family and domain databases
InterPro	IPR011009. Kinase-like_dom. IPR000719. Prot_kinase_cat_dom. IPR017441. Protein_kinase_ATP_BS. IPR002290. Ser/Thr_dual-sp_kinase_dom. IPR008271. Ser/Thr_kinase_AS. [Graphical view]
Pfam	PF00069. Pkinase. 1 hit. [Graphical view]
SMART	SM00220. S_TKc. 1 hit. [Graphical view]
SUPFAM	SSF56112. Kinase_like. 1 hit.
PROSITE	PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Y8487_DICDI

Accession

Primary (citable) accession number: Q54Y06

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 10, 2009
Last sequence update:	May 24, 2005
Last modified:	May 1, 2013
This is version 57 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)