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Protein

Probable cyclin-dependent serine/threonine-protein kinase DDB_G0278487

Gene

DDB_G0278487

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei93ATPPROSITE-ProRule annotation1
Active sitei184Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi70 – 78ATPPROSITE-ProRule annotation9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Probable cyclin-dependent serine/threonine-protein kinase DDB_G0278487 (EC:2.7.11.22)
Gene namesi
ORF Names:DDB_G0278487
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyostelidsDictyostelialesDictyosteliaceaeDictyostelium
Proteomesi
  • UP000002195 Componentsi: Chromosome 3, Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0278487

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003620641 – 636Probable cyclin-dependent serine/threonine-protein kinase DDB_G0278487Add BLAST636

Proteomic databases

PaxDbiQ54Y06
PRIDEiQ54Y06

Expressioni

Developmental stagei

Up-regulated in aspidocytes, a resistant cell type induced by a range of toxins including heavy metals and antibiotics.1 Publication

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi44689.DDB0229294

Structurei

3D structure databases

ProteinModelPortaliQ54Y06
SMRiQ54Y06
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini64 – 343Protein kinasePROSITE-ProRule annotationAdd BLAST280

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi15 – 25Poly-SerAdd BLAST11
Compositional biasi372 – 375Poly-Gln4
Compositional biasi487 – 490Poly-Gln4
Compositional biasi591 – 594Poly-Gln4
Compositional biasi617 – 628Poly-AsnAdd BLAST12

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0600 Eukaryota
ENOG410XPIR LUCA
InParanoidiQ54Y06
OMAiYCTSETE
PhylomeDBiQ54Y06

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

Sequencei

Sequence statusi: Complete.

Q54Y06-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPSQSNNVIT SSTASSSMSS SSNSSDASST SSSNTNNAHS SNNQFVSGQL
60 70 80 90 100
NLVGNTHTKI NDNYEIISKI GEGISGSVFK AIKKGTEEMV ALKNFKGWTE
110 120 130 140 150
GDRASKEECS LLQQLRHIPY ITPVIDIYTN FETSEYIIVF PYFEHDLSGL
160 170 180 190 200
LSEHRLSIPQ VKCYFKQLLE GINEIHNAGV MHRDIKAANL LVNNKGSLFI
210 220 230 240 250
GDLGTATSYT KRSVFSSKVV TLWYRAPELL LGSTQYGPEI DMWSIGCVLI
260 270 280 290 300
ELVTSRNFLP GSSEQQQLEA ICKLCGTPTD EIWPNVSQLQ NFNQISHLPV
310 320 330 340 350
YPSRLRTVFK NFSNDFIELL EGLLTLNPKK RLTAEQALQS PFFTNHPLPF
360 370 380 390 400
KPENMPGYQP IHVLEAVQKR VQQQQELEQQ KKQEEQKKQQ EEQKKLEDQK
410 420 430 440 450
KQEEQKKQED LLKRQRLLKR QQELKKQQDE QRQQELIKKQ QEQEQLRLKV
460 470 480 490 500
EHEKQRQEQE RLRLIQQEQE RLKRQQQEHE QRLQREQQQQ LNQLQQQKES
510 520 530 540 550
PLNNSYGKIN LKRSLDLVND IRNYCTSETE SEYESDEEDF YTEEEVEDYS
560 570 580 590 600
SDEEDDYYNA QSNKSLYTPI KAMIQQHNNN QQHQQQYPYS QQQQEPISSN
610 620 630
PFLQPPKKQR TASTGFNNNN GNNNNNNNLS TPLTIH
Length:636
Mass (Da):73,679
Last modified:May 24, 2005 - v1
Checksum:i96FCE039D9FB05D6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000023 Genomic DNA Translation: EAL68416.1
RefSeqiXP_642396.1, XM_637304.1

Genome annotation databases

EnsemblProtistsiEAL68416; EAL68416; DDB_G0278487
GeneIDi8621601
KEGGiddi:DDB_G0278487

Similar proteinsi

Entry informationi

Entry nameiY8487_DICDI
AccessioniPrimary (citable) accession number: Q54Y06
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 10, 2009
Last sequence update: May 24, 2005
Last modified: March 28, 2018
This is version 82 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health