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Protein

Probable ubiquitin-conjugating enzyme E2 C

Gene

ube2c

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the covalent attachment of ubiquitin to other proteins. Acts as an essential factor of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis. Acts by initiating polyubiquitin chains on APC/C substrates, leading to the degradation of APC/C substrates by the proteasome and promoting mitotic exit.PROSITE-ProRule annotation

Catalytic activityi

S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.PROSITE-ProRule annotationBy similarity

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.PROSITE-ProRule annotation
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei90Glycyl thioester intermediatePROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processUbl conjugation pathway
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-DDI-141430 Inactivation of APC/C via direct inhibition of the APC/C complex
R-DDI-174048 APC/C:Cdc20 mediated degradation of Cyclin B
R-DDI-174084 Autodegradation of Cdh1 by Cdh1:APC/C
R-DDI-174178 APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
R-DDI-174184 Cdc20:Phospho-APC/C mediated degradation of Cyclin A
R-DDI-176407 Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
R-DDI-176408 Regulation of APC/C activators between G1/S and early anaphase
R-DDI-176409 APC/C:Cdc20 mediated degradation of mitotic proteins
R-DDI-176412 Phosphorylation of the APC/C
R-DDI-179409 APC-Cdc20 mediated degradation of Nek2A
R-DDI-2559582 Senescence-Associated Secretory Phenotype (SASP)
R-DDI-8866652 Synthesis of active ubiquitin: roles of E1 and E2 enzymes
R-DDI-983168 Antigen processing: Ubiquitination & Proteasome degradation
UniPathwayiUPA00143

Names & Taxonomyi

Protein namesi
Recommended name:
Probable ubiquitin-conjugating enzyme E2 C (EC:2.3.2.23)
Alternative name(s):
E2 ubiquitin-conjugating enzyme C
Ubiquitin carrier protein C
Ubiquitin-protein ligase C
Gene namesi
Name:ube2c
Synonyms:ubch10
ORF Names:DDB_G0278775
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyostelidsDictyostelialesDictyosteliaceaeDictyostelium
Proteomesi
  • UP000002195 Componentsi: Chromosome 3, Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0278775 ube2c

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003285091 – 153Probable ubiquitin-conjugating enzyme E2 CAdd BLAST153

Post-translational modificationi

Autoubiquitinated by the APC/C complex, leading to its degradation by the proteasome.By similarity

Keywords - PTMi

Ubl conjugation

Proteomic databases

PaxDbiQ54XS6

Interactioni

Subunit structurei

Component of the APC/C complex.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi44689.DDB0304925

Structurei

3D structure databases

ProteinModelPortaliQ54XS6
SMRiQ54XS6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ubiquitin-conjugating enzyme family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0421 Eukaryota
ENOG4111IGV LUCA
InParanoidiQ54XS6
KOiK06688
OMAiAELWDKD
PhylomeDBiQ54XS6

Family and domain databases

CDDicd00195 UBCc, 1 hit
Gene3Di3.10.110.101 hit
InterProiView protein in InterPro
IPR000608 UBQ-conjugat_E2
IPR023313 UBQ-conjugating_AS
IPR016135 UBQ-conjugating_enzyme/RWD
PfamiView protein in Pfam
PF00179 UQ_con, 1 hit
SUPFAMiSSF54495 SSF54495, 1 hit
PROSITEiView protein in PROSITE
PS00183 UBIQUITIN_CONJUGAT_1, 1 hit
PS50127 UBIQUITIN_CONJUGAT_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q54XS6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSQDHSVSKR LQSELMNLMM GPSPGISAFP DGDNIFNWIG TIQGAKDTVY
60 70 80 90 100
EQMEFKMSLK FPTDYPYKPP TVKFETQCFH PNVDNNGNIC LDILKDKWSP
110 120 130 140 150
VYNVRSLLIS IQSLLGEPNN ESPLNSYAAS LWSNQDEYKK VLDKRYQEAT

SRP
Length:153
Mass (Da):17,473
Last modified:May 24, 2005 - v1
Checksum:i4ACE8F6E07C6E6C9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000024 Genomic DNA Translation: EAL67989.1
RefSeqiXP_641954.1, XM_636862.1

Genome annotation databases

EnsemblProtistsiEAL67989; EAL67989; DDB_G0278775
GeneIDi8621686
KEGGiddi:DDB_G0278775

Similar proteinsi

Entry informationi

Entry nameiUBE2C_DICDI
AccessioniPrimary (citable) accession number: Q54XS6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: May 24, 2005
Last modified: February 28, 2018
This is version 96 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome