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Q54XS6

- UBE2C_DICDI

UniProt

Q54XS6 - UBE2C_DICDI

Protein

Probable ubiquitin-conjugating enzyme E2 C

Gene

ube2c

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 71 (01 Oct 2014)
      Sequence version 1 (24 May 2005)
      Previous versions | rss
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    Functioni

    Catalyzes the covalent attachment of ubiquitin to other proteins. Acts as an essential factor of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis. Acts by initiating polyubiquitin chains on APC/C substrates, leading to the degradation of APC/C substrates by the proteasome and promoting mitotic exit By similarity.PROSITE-ProRule annotation

    Catalytic activityi

    ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine.PROSITE-ProRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei90 – 901Glycyl thioester intermediatePROSITE-ProRule annotation

    GO - Molecular functioni

    1. acid-amino acid ligase activity Source: InterPro
    2. ATP binding Source: UniProtKB-KW

    GO - Biological processi

    1. protein ubiquitination Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Ubl conjugation pathway

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    ReactomeiREACT_204065. APC/C:Cdc20 mediated degradation of Cyclin B.
    REACT_205940. Inactivation of APC/C via direct inhibition of the APC/C complex.
    REACT_208834. APC/C:Cdc20 mediated degradation of mitotic proteins.
    REACT_209924. Regulation of APC/C activators between G1/S and early anaphase.
    REACT_221036. Separation of Sister Chromatids.
    REACT_223655. Phosphorylation of the APC/C.
    REACT_224585. Senescence-Associated Secretory Phenotype (SASP).
    REACT_225025. APC/C:Cdc20 mediated degradation of Securin.
    REACT_225545. Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase.
    REACT_226311. APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1.
    REACT_226712. Autodegradation of Cdh1 by Cdh1:APC/C.
    UniPathwayiUPA00143.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable ubiquitin-conjugating enzyme E2 C (EC:6.3.2.19)
    Alternative name(s):
    Ubiquitin carrier protein C
    Ubiquitin-protein ligase C
    Gene namesi
    Name:ube2c
    Synonyms:ubch10
    ORF Names:DDB_G0278775
    OrganismiDictyostelium discoideum (Slime mold)
    Taxonomic identifieri44689 [NCBI]
    Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
    ProteomesiUP000002195: Chromosome 3, UP000002195: Unassembled WGS sequence

    Organism-specific databases

    dictyBaseiDDB_G0278775. ube2c.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 153153Probable ubiquitin-conjugating enzyme E2 CPRO_0000328509Add
    BLAST

    Post-translational modificationi

    Autoubiquitinated by the APC/C complex, leading to its degradation by the proteasome.By similarity

    Keywords - PTMi

    Ubl conjugation

    Interactioni

    Subunit structurei

    Component of the APC/C complex.By similarity

    Protein-protein interaction databases

    STRINGi44689.DDBDRAFT_0206182.

    Structurei

    3D structure databases

    ProteinModelPortaliQ54XS6.
    SMRiQ54XS6. Positions 3-151.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ubiquitin-conjugating enzyme family.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG5078.
    KOiK06688.
    OMAiAELWDKD.
    PhylomeDBiQ54XS6.

    Family and domain databases

    Gene3Di3.10.110.10. 1 hit.
    InterProiIPR000608. UBQ-conjugat_E2.
    IPR023313. UBQ-conjugating_AS.
    IPR016135. UBQ-conjugating_enzyme/RWD.
    [Graphical view]
    PfamiPF00179. UQ_con. 1 hit.
    [Graphical view]
    SUPFAMiSSF54495. SSF54495. 1 hit.
    PROSITEiPS00183. UBIQUITIN_CONJUGAT_1. 1 hit.
    PS50127. UBIQUITIN_CONJUGAT_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q54XS6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSQDHSVSKR LQSELMNLMM GPSPGISAFP DGDNIFNWIG TIQGAKDTVY    50
    EQMEFKMSLK FPTDYPYKPP TVKFETQCFH PNVDNNGNIC LDILKDKWSP 100
    VYNVRSLLIS IQSLLGEPNN ESPLNSYAAS LWSNQDEYKK VLDKRYQEAT 150
    SRP 153
    Length:153
    Mass (Da):17,473
    Last modified:May 24, 2005 - v1
    Checksum:i4ACE8F6E07C6E6C9
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AAFI02000024 Genomic DNA. Translation: EAL67989.1.
    RefSeqiXP_641954.1. XM_636862.1.

    Genome annotation databases

    EnsemblProtistsiDDB0304925; DDB0304925; DDB_G0278775.
    GeneIDi8621686.
    KEGGiddi:DDB_G0278775.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AAFI02000024 Genomic DNA. Translation: EAL67989.1 .
    RefSeqi XP_641954.1. XM_636862.1.

    3D structure databases

    ProteinModelPortali Q54XS6.
    SMRi Q54XS6. Positions 3-151.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 44689.DDBDRAFT_0206182.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblProtistsi DDB0304925 ; DDB0304925 ; DDB_G0278775 .
    GeneIDi 8621686.
    KEGGi ddi:DDB_G0278775.

    Organism-specific databases

    dictyBasei DDB_G0278775. ube2c.

    Phylogenomic databases

    eggNOGi COG5078.
    KOi K06688.
    OMAi AELWDKD.
    PhylomeDBi Q54XS6.

    Enzyme and pathway databases

    UniPathwayi UPA00143 .
    Reactomei REACT_204065. APC/C:Cdc20 mediated degradation of Cyclin B.
    REACT_205940. Inactivation of APC/C via direct inhibition of the APC/C complex.
    REACT_208834. APC/C:Cdc20 mediated degradation of mitotic proteins.
    REACT_209924. Regulation of APC/C activators between G1/S and early anaphase.
    REACT_221036. Separation of Sister Chromatids.
    REACT_223655. Phosphorylation of the APC/C.
    REACT_224585. Senescence-Associated Secretory Phenotype (SASP).
    REACT_225025. APC/C:Cdc20 mediated degradation of Securin.
    REACT_225545. Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase.
    REACT_226311. APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1.
    REACT_226712. Autodegradation of Cdh1 by Cdh1:APC/C.

    Miscellaneous databases

    PROi Q54XS6.

    Family and domain databases

    Gene3Di 3.10.110.10. 1 hit.
    InterProi IPR000608. UBQ-conjugat_E2.
    IPR023313. UBQ-conjugating_AS.
    IPR016135. UBQ-conjugating_enzyme/RWD.
    [Graphical view ]
    Pfami PF00179. UQ_con. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54495. SSF54495. 1 hit.
    PROSITEi PS00183. UBIQUITIN_CONJUGAT_1. 1 hit.
    PS50127. UBIQUITIN_CONJUGAT_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome of the social amoeba Dictyostelium discoideum."
      Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N.
      , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
      Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: AX4.

    Entry informationi

    Entry nameiUBE2C_DICDI
    AccessioniPrimary (citable) accession number: Q54XS6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 8, 2008
    Last sequence update: May 24, 2005
    Last modified: October 1, 2014
    This is version 71 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Dictyostelium discoideum
      Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3