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Q54XS6

- UBE2C_DICDI

UniProt

Q54XS6 - UBE2C_DICDI

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Protein

Probable ubiquitin-conjugating enzyme E2 C

Gene
ube2c, ubch10, DDB_G0278775
Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the covalent attachment of ubiquitin to other proteins. Acts as an essential factor of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis. Acts by initiating polyubiquitin chains on APC/C substrates, leading to the degradation of APC/C substrates by the proteasome and promoting mitotic exit By similarity.

Catalytic activityi

ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei90 – 901Glycyl thioester intermediate By similarity

GO - Molecular functioni

  1. acid-amino acid ligase activity Source: InterPro
  2. ATP binding Source: UniProtKB-KW

GO - Biological processi

  1. protein ubiquitination Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Ubl conjugation pathway

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_204065. APC/C:Cdc20 mediated degradation of Cyclin B.
REACT_205940. Inactivation of APC/C via direct inhibition of the APC/C complex.
REACT_208834. APC/C:Cdc20 mediated degradation of mitotic proteins.
REACT_209924. Regulation of APC/C activators between G1/S and early anaphase.
REACT_221036. Separation of Sister Chromatids.
REACT_223655. Phosphorylation of the APC/C.
REACT_224585. Senescence-Associated Secretory Phenotype (SASP).
REACT_225025. APC/C:Cdc20 mediated degradation of Securin.
REACT_225545. Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase.
REACT_226311. APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1.
REACT_226712. Autodegradation of Cdh1 by Cdh1:APC/C.
UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable ubiquitin-conjugating enzyme E2 C (EC:6.3.2.19)
Alternative name(s):
Ubiquitin carrier protein C
Ubiquitin-protein ligase C
Gene namesi
Name:ube2c
Synonyms:ubch10
ORF Names:DDB_G0278775
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
ProteomesiUP000002195: Chromosome 3, UP000002195: Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0278775. ube2c.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 153153Probable ubiquitin-conjugating enzyme E2 CPRO_0000328509Add
BLAST

Post-translational modificationi

Autoubiquitinated by the APC/C complex, leading to its degradation by the proteasome By similarity.

Keywords - PTMi

Ubl conjugation

Interactioni

Subunit structurei

Component of the APC/C complex By similarity.

Protein-protein interaction databases

STRINGi44689.DDBDRAFT_0206182.

Structurei

3D structure databases

ProteinModelPortaliQ54XS6.
SMRiQ54XS6. Positions 3-151.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG5078.
KOiK06688.
OMAiAELWDKD.
PhylomeDBiQ54XS6.

Family and domain databases

Gene3Di3.10.110.10. 1 hit.
InterProiIPR000608. UBQ-conjugat_E2.
IPR023313. UBQ-conjugating_AS.
IPR016135. UBQ-conjugating_enzyme/RWD.
[Graphical view]
PfamiPF00179. UQ_con. 1 hit.
[Graphical view]
SUPFAMiSSF54495. SSF54495. 1 hit.
PROSITEiPS00183. UBIQUITIN_CONJUGAT_1. 1 hit.
PS50127. UBIQUITIN_CONJUGAT_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q54XS6-1 [UniParc]FASTAAdd to Basket

« Hide

MSQDHSVSKR LQSELMNLMM GPSPGISAFP DGDNIFNWIG TIQGAKDTVY    50
EQMEFKMSLK FPTDYPYKPP TVKFETQCFH PNVDNNGNIC LDILKDKWSP 100
VYNVRSLLIS IQSLLGEPNN ESPLNSYAAS LWSNQDEYKK VLDKRYQEAT 150
SRP 153
Length:153
Mass (Da):17,473
Last modified:May 24, 2005 - v1
Checksum:i4ACE8F6E07C6E6C9
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAFI02000024 Genomic DNA. Translation: EAL67989.1.
RefSeqiXP_641954.1. XM_636862.1.

Genome annotation databases

EnsemblProtistsiDDB0304925; DDB0304925; DDB_G0278775.
GeneIDi8621686.
KEGGiddi:DDB_G0278775.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAFI02000024 Genomic DNA. Translation: EAL67989.1 .
RefSeqi XP_641954.1. XM_636862.1.

3D structure databases

ProteinModelPortali Q54XS6.
SMRi Q54XS6. Positions 3-151.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 44689.DDBDRAFT_0206182.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblProtistsi DDB0304925 ; DDB0304925 ; DDB_G0278775 .
GeneIDi 8621686.
KEGGi ddi:DDB_G0278775.

Organism-specific databases

dictyBasei DDB_G0278775. ube2c.

Phylogenomic databases

eggNOGi COG5078.
KOi K06688.
OMAi AELWDKD.
PhylomeDBi Q54XS6.

Enzyme and pathway databases

UniPathwayi UPA00143 .
Reactomei REACT_204065. APC/C:Cdc20 mediated degradation of Cyclin B.
REACT_205940. Inactivation of APC/C via direct inhibition of the APC/C complex.
REACT_208834. APC/C:Cdc20 mediated degradation of mitotic proteins.
REACT_209924. Regulation of APC/C activators between G1/S and early anaphase.
REACT_221036. Separation of Sister Chromatids.
REACT_223655. Phosphorylation of the APC/C.
REACT_224585. Senescence-Associated Secretory Phenotype (SASP).
REACT_225025. APC/C:Cdc20 mediated degradation of Securin.
REACT_225545. Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase.
REACT_226311. APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1.
REACT_226712. Autodegradation of Cdh1 by Cdh1:APC/C.

Miscellaneous databases

PROi Q54XS6.

Family and domain databases

Gene3Di 3.10.110.10. 1 hit.
InterProi IPR000608. UBQ-conjugat_E2.
IPR023313. UBQ-conjugating_AS.
IPR016135. UBQ-conjugating_enzyme/RWD.
[Graphical view ]
Pfami PF00179. UQ_con. 1 hit.
[Graphical view ]
SUPFAMi SSF54495. SSF54495. 1 hit.
PROSITEi PS00183. UBIQUITIN_CONJUGAT_1. 1 hit.
PS50127. UBIQUITIN_CONJUGAT_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome of the social amoeba Dictyostelium discoideum."
    Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N.
    , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
    Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AX4.

Entry informationi

Entry nameiUBE2C_DICDI
AccessioniPrimary (citable) accession number: Q54XS6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: May 24, 2005
Last modified: September 3, 2014
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi