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Q54XM7 (PSA6_DICDI) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 67. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Proteasome subunit alpha type-6

EC=3.4.25.1
Gene names
Name:psmA6
ORF Names:DDB_G0278847
OrganismDictyostelium discoideum (Slime mold) [Reference proteome]
Taxonomic identifier44689 [NCBI]
Taxonomic lineageEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium

Protein attributes

Sequence length250 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity By similarity.

Catalytic activity

Cleavage of peptide bonds with very broad specificity.

Subunit structure

The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel By similarity.

Subcellular location

Cytoplasm By similarity. Nucleus By similarity.

Sequence similarities

Belongs to the peptidase T1A family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 250250Proteasome subunit alpha type-6
PRO_0000328487

Sequences

Sequence LengthMass (Da)Tools
Q54XM7 [UniParc].

Last modified May 24, 2005. Version 1.
Checksum: AD7410CB493C250C

FASTA25027,217
        10         20         30         40         50         60 
MSRSGTAGYD MSIIFSPQGK LYQIEYAFKA IKTGGLTSVG IRGKDCVVVA TQKKIPDKLI 

        70         80         90        100        110        120 
DPKSVTSLYK LTDYIGCVQT GIVPDSKSQA SRAIQECATF HHKFGYQIPP NVLAKRMADI 

       130        140        150        160        170        180 
AQLSTQHASA RPLGVAMILI GIDDELGPQL FKVDPAGVFT GYKATAAGEK EQESTNFLEK 

       190        200        210        220        230        240 
KFKSNPQLSK DETIQVSLIV MAISTLQSVL GADLKSSDLE IGICTMDNRK FVIMTDEDID 

       250 
SQLTKLAERD 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AAFI02000024 Genomic DNA. Translation: EAL68025.1.
RefSeqXP_642003.1. XM_636911.1.

3D structure databases

ProteinModelPortalQ54XM7.
SMRQ54XM7. Positions 2-249.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING44689.DDB_0232956.

Proteomic databases

PRIDEQ54XM7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsDDB0232956; DDB0232956; DDB_G0278847.
GeneID8621735.
KEGGddi:DDB_G0278847.

Organism-specific databases

dictyBaseDDB_G0278847. psmA6.

Phylogenomic databases

eggNOGCOG0638.
OMAMSRTSYD.
PhylomeDBQ54XM7.

Family and domain databases

Gene3D3.60.20.10. 1 hit.
InterProIPR029055. Ntn_hydrolases_N.
IPR000426. Proteasome_asu_N.
IPR023332. Proteasome_suA-type.
IPR001353. Proteasome_sua/b.
[Graphical view]
PfamPF00227. Proteasome. 1 hit.
PF10584. Proteasome_A_N. 1 hit.
[Graphical view]
SMARTSM00948. Proteasome_A_N. 1 hit.
[Graphical view]
SUPFAMSSF56235. SSF56235. 1 hit.
PROSITEPS51475. PROTEASOME_ALPHA_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

PROQ54XM7.

Entry information

Entry namePSA6_DICDI
AccessionPrimary (citable) accession number: Q54XM7
Entry history
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: May 24, 2005
Last modified: July 9, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries

Dictyostelium discoideum

Dictyostelium discoideum: entries, gene names and cross-references to dictyBase