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Protein

Protein transport protein Sec61 subunit alpha

Gene

sec61a

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Appears to play a crucial role in the insertion of secretory and membrane polypeptides into the ER. It is required for assembly of membrane and secretory proteins. Found to be tightly associated with membrane-bound ribosomes, either directly or through adaptor proteins (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Protein transport, Translocation, Transport

Enzyme and pathway databases

ReactomeiR-DDI-381038. XBP1(S) activates chaperone genes.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein transport protein Sec61 subunit alpha
Alternative name(s):
Secretory 61 complex subunit alpha
Gene namesi
Name:sec61a
ORF Names:DDB_G0278885
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
Proteomesi
  • UP000002195 Componentsi: Chromosome 3, Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0278885. sec61a.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 32CytoplasmicSequence analysisAdd BLAST32
Transmembranei33 – 53HelicalSequence analysisAdd BLAST21
Topological domaini54 – 75LumenalSequence analysisAdd BLAST22
Transmembranei76 – 96HelicalSequence analysisAdd BLAST21
Topological domaini97 – 118CytoplasmicSequence analysisAdd BLAST22
Transmembranei119 – 139HelicalSequence analysisAdd BLAST21
Topological domaini140 – 145LumenalSequence analysis6
Transmembranei146 – 166HelicalSequence analysisAdd BLAST21
Topological domaini167 – 173CytoplasmicSequence analysis7
Transmembranei174 – 194HelicalSequence analysisAdd BLAST21
Topological domaini195 – 241LumenalSequence analysisAdd BLAST47
Transmembranei242 – 262HelicalSequence analysisAdd BLAST21
Topological domaini263 – 289CytoplasmicSequence analysisAdd BLAST27
Transmembranei290 – 310HelicalSequence analysisAdd BLAST21
Topological domaini311 – 353LumenalSequence analysisAdd BLAST43
Transmembranei354 – 374HelicalSequence analysisAdd BLAST21
Topological domaini375 – 411CytoplasmicSequence analysisAdd BLAST37
Transmembranei412 – 434HelicalSequence analysisAdd BLAST23
Topological domaini435 – 440LumenalSequence analysis6
Transmembranei441 – 461HelicalSequence analysisAdd BLAST21
Topological domaini462 – 475CytoplasmicSequence analysisAdd BLAST14

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003281851 – 475Protein transport protein Sec61 subunit alphaAdd BLAST475

Proteomic databases

PaxDbiQ54XK2.

Interactioni

Subunit structurei

Heterotrimeric complex composed of SEC61-alpha, SEC61-beta and SEC61-gamma.By similarity

Protein-protein interaction databases

STRINGi44689.DDB0235193.

Structurei

3D structure databases

ProteinModelPortaliQ54XK2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SecY/SEC61-alpha family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1373. Eukaryota.
COG0201. LUCA.
InParanoidiQ54XK2.
KOiK10956.
OMAiRYIPYVT.
PhylomeDBiQ54XK2.

Family and domain databases

Gene3Di1.10.3370.10. 1 hit.
InterProiIPR002208. SecY/SEC61-alpha.
IPR030659. SecY_CS.
IPR023201. SecY_su_dom.
IPR019561. Translocon_Sec61/SecY_plug_dom.
[Graphical view]
PANTHERiPTHR10906. PTHR10906. 1 hit.
PfamiPF10559. Plug_translocon. 1 hit.
PF00344. SecY. 1 hit.
[Graphical view]
PIRSFiPIRSF004557. SecY. 1 hit.
SUPFAMiSSF103491. SSF103491. 1 hit.
TIGRFAMsiTIGR00967. 3a0501s007. 1 hit.
PROSITEiPS00755. SECY_1. 1 hit.
PS00756. SECY_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q54XK2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGFRFLDIVK PFTSLVPEVG QPDRKIPFRE KVLWTAICLF IFLVCSQIPL
60 70 80 90 100
YGIRSTDSSD PFYWAKVIMA SNRGTLMELG ISPIVTSGMV MQLLAGAKLI
110 120 130 140 150
EIDQSVKADR DLFSAAQKLF GMLICVGQGV AYIWSGSYGD PAVLGFGNCF
160 170 180 190 200
LIVLQLFFAG IIVMLLDELL QKGYGIGSGI SLFIATNICE TIVWKTFSPT
210 220 230 240 250
TVSVGKGTEF EGAVIALFHL LLTRNDKVRA LKEAFYRQNL PNITNLLATV
260 270 280 290 300
LIFMVVIYFQ GFRVDLPVKS TRVSGQQGTY PIKLFYTSNI PIILQSALVS
310 320 330 340 350
NLYFISQLLY RRFPDNILVN LFGAWRTSEY SQQMIPVSGL TYYISSPNNM
360 370 380 390 400
SAVLADPFHA LFYITFMLTS CALFSKVWIE VSGSSARDVA KQLKDQQMTM
410 420 430 440 450
KGHRDTSVIK ELNRYIPTAA AFGGLCIGAL TVVADFMGAI GSGTGILLAV
460 470
TIIYQYFETF VKEQQELSGG IGGLF
Length:475
Mass (Da):52,490
Last modified:May 24, 2005 - v1
Checksum:i726D28922092B70A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000024 Genomic DNA. Translation: EAL68044.1.
RefSeqiXP_647801.1. XM_642709.1.

Genome annotation databases

EnsemblProtistsiEAL68044; EAL68044; DDB_G0278885.
GeneIDi8621759.
KEGGiddi:DDB_G0278885.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000024 Genomic DNA. Translation: EAL68044.1.
RefSeqiXP_647801.1. XM_642709.1.

3D structure databases

ProteinModelPortaliQ54XK2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi44689.DDB0235193.

Proteomic databases

PaxDbiQ54XK2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsiEAL68044; EAL68044; DDB_G0278885.
GeneIDi8621759.
KEGGiddi:DDB_G0278885.

Organism-specific databases

dictyBaseiDDB_G0278885. sec61a.

Phylogenomic databases

eggNOGiKOG1373. Eukaryota.
COG0201. LUCA.
InParanoidiQ54XK2.
KOiK10956.
OMAiRYIPYVT.
PhylomeDBiQ54XK2.

Enzyme and pathway databases

ReactomeiR-DDI-381038. XBP1(S) activates chaperone genes.

Miscellaneous databases

PROiQ54XK2.

Family and domain databases

Gene3Di1.10.3370.10. 1 hit.
InterProiIPR002208. SecY/SEC61-alpha.
IPR030659. SecY_CS.
IPR023201. SecY_su_dom.
IPR019561. Translocon_Sec61/SecY_plug_dom.
[Graphical view]
PANTHERiPTHR10906. PTHR10906. 1 hit.
PfamiPF10559. Plug_translocon. 1 hit.
PF00344. SecY. 1 hit.
[Graphical view]
PIRSFiPIRSF004557. SecY. 1 hit.
SUPFAMiSSF103491. SSF103491. 1 hit.
TIGRFAMsiTIGR00967. 3a0501s007. 1 hit.
PROSITEiPS00755. SECY_1. 1 hit.
PS00756. SECY_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSC61A_DICDI
AccessioniPrimary (citable) accession number: Q54XK2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: May 24, 2005
Last modified: November 2, 2016
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.