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Protein

Protein transport protein Sec61 subunit alpha

Gene

sec61a

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Appears to play a crucial role in the insertion of secretory and membrane polypeptides into the ER. It is required for assembly of membrane and secretory proteins. Found to be tightly associated with membrane-bound ribosomes, either directly or through adaptor proteins (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Protein transport, Translocation, Transport

Enzyme and pathway databases

ReactomeiR-DDI-381038. XBP1(S) activates chaperone genes.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein transport protein Sec61 subunit alpha
Alternative name(s):
Secretory 61 complex subunit alpha
Gene namesi
Name:sec61a
ORF Names:DDB_G0278885
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
Proteomesi
  • UP000002195 Componentsi: Chromosome 3, Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0278885. sec61a.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3232CytoplasmicSequence analysisAdd
BLAST
Transmembranei33 – 5321HelicalSequence analysisAdd
BLAST
Topological domaini54 – 7522LumenalSequence analysisAdd
BLAST
Transmembranei76 – 9621HelicalSequence analysisAdd
BLAST
Topological domaini97 – 11822CytoplasmicSequence analysisAdd
BLAST
Transmembranei119 – 13921HelicalSequence analysisAdd
BLAST
Topological domaini140 – 1456LumenalSequence analysis
Transmembranei146 – 16621HelicalSequence analysisAdd
BLAST
Topological domaini167 – 1737CytoplasmicSequence analysis
Transmembranei174 – 19421HelicalSequence analysisAdd
BLAST
Topological domaini195 – 24147LumenalSequence analysisAdd
BLAST
Transmembranei242 – 26221HelicalSequence analysisAdd
BLAST
Topological domaini263 – 28927CytoplasmicSequence analysisAdd
BLAST
Transmembranei290 – 31021HelicalSequence analysisAdd
BLAST
Topological domaini311 – 35343LumenalSequence analysisAdd
BLAST
Transmembranei354 – 37421HelicalSequence analysisAdd
BLAST
Topological domaini375 – 41137CytoplasmicSequence analysisAdd
BLAST
Transmembranei412 – 43423HelicalSequence analysisAdd
BLAST
Topological domaini435 – 4406LumenalSequence analysis
Transmembranei441 – 46121HelicalSequence analysisAdd
BLAST
Topological domaini462 – 47514CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 475475Protein transport protein Sec61 subunit alphaPRO_0000328185Add
BLAST

Proteomic databases

PaxDbiQ54XK2.
PRIDEiQ54XK2.

Interactioni

Subunit structurei

Heterotrimeric complex composed of SEC61-alpha, SEC61-beta and SEC61-gamma.By similarity

Protein-protein interaction databases

STRINGi44689.DDB0235193.

Structurei

3D structure databases

ProteinModelPortaliQ54XK2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SecY/SEC61-alpha family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1373. Eukaryota.
COG0201. LUCA.
InParanoidiQ54XK2.
KOiK10956.
OMAiRYIPYVT.
PhylomeDBiQ54XK2.

Family and domain databases

Gene3Di1.10.3370.10. 1 hit.
InterProiIPR002208. SecY/SEC61-alpha.
IPR030659. SecY_CS.
IPR023201. SecY_su_dom.
IPR019561. Translocon_Sec61/SecY_plug_dom.
[Graphical view]
PANTHERiPTHR10906. PTHR10906. 1 hit.
PfamiPF10559. Plug_translocon. 1 hit.
PF00344. SecY. 1 hit.
[Graphical view]
PIRSFiPIRSF004557. SecY. 1 hit.
SUPFAMiSSF103491. SSF103491. 1 hit.
TIGRFAMsiTIGR00967. 3a0501s007. 1 hit.
PROSITEiPS00755. SECY_1. 1 hit.
PS00756. SECY_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q54XK2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGFRFLDIVK PFTSLVPEVG QPDRKIPFRE KVLWTAICLF IFLVCSQIPL
60 70 80 90 100
YGIRSTDSSD PFYWAKVIMA SNRGTLMELG ISPIVTSGMV MQLLAGAKLI
110 120 130 140 150
EIDQSVKADR DLFSAAQKLF GMLICVGQGV AYIWSGSYGD PAVLGFGNCF
160 170 180 190 200
LIVLQLFFAG IIVMLLDELL QKGYGIGSGI SLFIATNICE TIVWKTFSPT
210 220 230 240 250
TVSVGKGTEF EGAVIALFHL LLTRNDKVRA LKEAFYRQNL PNITNLLATV
260 270 280 290 300
LIFMVVIYFQ GFRVDLPVKS TRVSGQQGTY PIKLFYTSNI PIILQSALVS
310 320 330 340 350
NLYFISQLLY RRFPDNILVN LFGAWRTSEY SQQMIPVSGL TYYISSPNNM
360 370 380 390 400
SAVLADPFHA LFYITFMLTS CALFSKVWIE VSGSSARDVA KQLKDQQMTM
410 420 430 440 450
KGHRDTSVIK ELNRYIPTAA AFGGLCIGAL TVVADFMGAI GSGTGILLAV
460 470
TIIYQYFETF VKEQQELSGG IGGLF
Length:475
Mass (Da):52,490
Last modified:May 24, 2005 - v1
Checksum:i726D28922092B70A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000024 Genomic DNA. Translation: EAL68044.1.
RefSeqiXP_647801.1. XM_642709.1.

Genome annotation databases

EnsemblProtistsiDDB0235193; DDB0235193; DDB_G0278885.
GeneIDi8621759.
KEGGiddi:DDB_G0278885.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000024 Genomic DNA. Translation: EAL68044.1.
RefSeqiXP_647801.1. XM_642709.1.

3D structure databases

ProteinModelPortaliQ54XK2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi44689.DDB0235193.

Proteomic databases

PaxDbiQ54XK2.
PRIDEiQ54XK2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsiDDB0235193; DDB0235193; DDB_G0278885.
GeneIDi8621759.
KEGGiddi:DDB_G0278885.

Organism-specific databases

dictyBaseiDDB_G0278885. sec61a.

Phylogenomic databases

eggNOGiKOG1373. Eukaryota.
COG0201. LUCA.
InParanoidiQ54XK2.
KOiK10956.
OMAiRYIPYVT.
PhylomeDBiQ54XK2.

Enzyme and pathway databases

ReactomeiR-DDI-381038. XBP1(S) activates chaperone genes.

Miscellaneous databases

PROiQ54XK2.

Family and domain databases

Gene3Di1.10.3370.10. 1 hit.
InterProiIPR002208. SecY/SEC61-alpha.
IPR030659. SecY_CS.
IPR023201. SecY_su_dom.
IPR019561. Translocon_Sec61/SecY_plug_dom.
[Graphical view]
PANTHERiPTHR10906. PTHR10906. 1 hit.
PfamiPF10559. Plug_translocon. 1 hit.
PF00344. SecY. 1 hit.
[Graphical view]
PIRSFiPIRSF004557. SecY. 1 hit.
SUPFAMiSSF103491. SSF103491. 1 hit.
TIGRFAMsiTIGR00967. 3a0501s007. 1 hit.
PROSITEiPS00755. SECY_1. 1 hit.
PS00756. SECY_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The genome of the social amoeba Dictyostelium discoideum."
    Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N.
    , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
    Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AX4.

Entry informationi

Entry nameiSC61A_DICDI
AccessioniPrimary (citable) accession number: Q54XK2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: May 24, 2005
Last modified: December 9, 2015
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.