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Q54XF2

- KGUA_DICDI

UniProt

Q54XF2 - KGUA_DICDI

Protein

Guanylate kinase

Gene

guk1

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 61 (01 Oct 2014)
      Sequence version 1 (24 May 2005)
      Previous versions | rss
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    Functioni

    Essential for recycling GMP and indirectly, cGMP.By similarity

    Catalytic activityi

    ATP + GMP = ADP + GDP.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi16 – 238ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. guanylate kinase activity Source: UniProtKB

    GO - Biological processi

    1. GMP metabolic process Source: dictyBase
    2. nucleotide phosphorylation Source: GOC
    3. purine nucleotide metabolic process Source: UniProtKB

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    ReactomeiREACT_212905. Abacavir metabolism.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Guanylate kinase (EC:2.7.4.8)
    Alternative name(s):
    GMP kinase
    Gene namesi
    Name:guk1
    Synonyms:gmkA
    ORF Names:DDB_G0279001
    OrganismiDictyostelium discoideum (Slime mold)
    Taxonomic identifieri44689 [NCBI]
    Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
    ProteomesiUP000002195: Chromosome 3, UP000002195: Unassembled WGS sequence

    Organism-specific databases

    dictyBaseiDDB_G0279001. gmkA.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: dictyBase

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 202202Guanylate kinasePRO_0000328180Add
    BLAST

    Proteomic databases

    PRIDEiQ54XF2.

    Interactioni

    Subunit structurei

    Monomer.By similarity

    Protein-protein interaction databases

    STRINGi44689.DDB_0230100.

    Structurei

    3D structure databases

    ProteinModelPortaliQ54XF2.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini9 – 191183Guanylate kinase-likePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the guanylate kinase family.Curated
    Contains 1 guanylate kinase-like domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0194.
    KOiK00942.
    OMAiVELACDR.
    PhylomeDBiQ54XF2.

    Family and domain databases

    Gene3Di3.40.50.300. 3 hits.
    InterProiIPR008145. GK/Ca_channel_bsu.
    IPR008144. Guanylate_kin-like.
    IPR017665. Guanylate_kinase.
    IPR020590. Guanylate_kinase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF00625. Guanylate_kin. 1 hit.
    [Graphical view]
    SMARTiSM00072. GuKc. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    TIGRFAMsiTIGR03263. guanyl_kin. 1 hit.
    PROSITEiPS00856. GUANYLATE_KINASE_1. 1 hit.
    PS50052. GUANYLATE_KINASE_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q54XF2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDNNSVDSLI PIIITGPSGV GKGTLIDKLR KEYEGSFGHI VSHTTRKPRE    50
    GEINGVHYHF TDIPTMTEGI KNGDFIEHAN VHGNFYGTSK KALKDVSDKN 100
    KICILDIDVQ GCESVKKANI PCKFIFISPP TFETLQERLI GRGTENEETL 150
    KKRLETAKKE MVYRDIPGFF DHVIVNNVLD VAYGELKSII SPFISFQSKS 200
    NK 202
    Length:202
    Mass (Da):22,600
    Last modified:May 24, 2005 - v1
    Checksum:iD61578E09A74C4A9
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AAFI02000026 Genomic DNA. Translation: EAL67922.1.
    RefSeqiXP_641898.1. XM_636806.1.

    Genome annotation databases

    EnsemblProtistsiDDB0230100; DDB0230100; DDB_G0279001.
    GeneIDi8621824.
    KEGGiddi:DDB_G0279001.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AAFI02000026 Genomic DNA. Translation: EAL67922.1 .
    RefSeqi XP_641898.1. XM_636806.1.

    3D structure databases

    ProteinModelPortali Q54XF2.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 44689.DDB_0230100.

    Proteomic databases

    PRIDEi Q54XF2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblProtistsi DDB0230100 ; DDB0230100 ; DDB_G0279001 .
    GeneIDi 8621824.
    KEGGi ddi:DDB_G0279001.

    Organism-specific databases

    dictyBasei DDB_G0279001. gmkA.

    Phylogenomic databases

    eggNOGi COG0194.
    KOi K00942.
    OMAi VELACDR.
    PhylomeDBi Q54XF2.

    Enzyme and pathway databases

    Reactomei REACT_212905. Abacavir metabolism.

    Miscellaneous databases

    PROi Q54XF2.

    Family and domain databases

    Gene3Di 3.40.50.300. 3 hits.
    InterProi IPR008145. GK/Ca_channel_bsu.
    IPR008144. Guanylate_kin-like.
    IPR017665. Guanylate_kinase.
    IPR020590. Guanylate_kinase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF00625. Guanylate_kin. 1 hit.
    [Graphical view ]
    SMARTi SM00072. GuKc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    TIGRFAMsi TIGR03263. guanyl_kin. 1 hit.
    PROSITEi PS00856. GUANYLATE_KINASE_1. 1 hit.
    PS50052. GUANYLATE_KINASE_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome of the social amoeba Dictyostelium discoideum."
      Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N.
      , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
      Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: AX4.

    Entry informationi

    Entry nameiKGUA_DICDI
    AccessioniPrimary (citable) accession number: Q54XF2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 8, 2008
    Last sequence update: May 24, 2005
    Last modified: October 1, 2014
    This is version 61 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Dictyostelium discoideum
      Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3