Q54XF2 (KGUA_DICDI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Guanylate kinase
EC=2.7.4.8

Alternative name(s):
GMP kinase

Gene names

Name:	guk1
Synonyms:	gmkA
ORF Names:	DDB_G0279001

Organism

Dictyostelium discoideum (Slime mold) [Reference proteome]

Taxonomic identifier

44689 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Amoebozoa › Mycetozoa › Dictyosteliida › Dictyostelium

Protein attributes

Sequence length	202 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Essential for recycling GMP and indirectly, cGMP By similarity.
Catalytic activity	ATP + GMP = ADP + GDP.
Subunit structure	Monomer By similarity.
Sequence similarities	Belongs to the guanylate kinase family. Contains 1 guanylate kinase-like domain.

Ontologies

Keywords
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	GMP metabolic process Inferred from sequence or structural similarity. Source: dictyBase
Cellular_component	cytoplasm Inferred from sequence or structural similarity. Source: dictyBase
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW guanylate kinase activity Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 202	202	Guanylate kinase		PRO_0000328180
Regions
	Domain	9 – 191	183	Guanylate kinase-like
	Nucleotide binding	16 – 23	8	ATP By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q54XF2 [UniParc]. Last modified May 24, 2005. Version 1. Checksum: D61578E09A74C4A9	FASTA	202	22,600
	10 20 30 40 50 60 MDNNSVDSLI PIIITGPSGV GKGTLIDKLR KEYEGSFGHI VSHTTRKPRE GEINGVHYHF 70 80 90 100 110 120 TDIPTMTEGI KNGDFIEHAN VHGNFYGTSK KALKDVSDKN KICILDIDVQ GCESVKKANI 130 140 150 160 170 180 PCKFIFISPP TFETLQERLI GRGTENEETL KKRLETAKKE MVYRDIPGFF DHVIVNNVLD 190 200 VAYGELKSII SPFISFQSKS NK

References

[1]

"The genome of the social amoeba Dictyostelium discoideum." Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N. , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A. Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AX4.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AAFI02000026 Genomic DNA. Translation: EAL67922.1.
RefSeq	XP_641898.1. XM_636806.1.
3D structure databases
HSSP	HSSP built from PDB template 1GKY based on UniProtKB P15454.
ProteinModelPortal	Q54XF2.
ModBase	Search...
Protein-protein interaction databases
STRING	44689.DDB_0230100.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblProtists	DDB0230100; DDB0230100; DDB_G0279001.
GeneID	8621824.
KEGG	ddi:DDB_G0279001.
Organism-specific databases
dictyBase	DDB_G0279001. gmkA.
Phylogenomic databases
eggNOG	COG0194.
KO	K00942.
OMA	EWAEFAG.
ProtClustDB	CLSZ2430725.
Family and domain databases
InterPro	IPR008144. Guanylate_kin. IPR008145. Guanylate_kin/L-typ_Ca_channel. IPR020590. Guanylate_kinase_CS. IPR017665. Guanylate_kinase_sub. [Graphical view]
Pfam	PF00625. Guanylate_kin. 1 hit. [Graphical view]
SMART	SM00072. GuKc. 1 hit. [Graphical view]
TIGRFAMs	TIGR03263. guanyl_kin. 1 hit.
PROSITE	PS00856. GUANYLATE_KINASE_1. 1 hit. PS50052. GUANYLATE_KINASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

KGUA_DICDI

Accession

Primary (citable) accession number: Q54XF2

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 8, 2008
Last sequence update:	May 24, 2005
Last modified:	May 1, 2013
This is version 52 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)