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Protein

Guanylate kinase

Gene

guk1

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Essential for recycling GMP and indirectly, cGMP.By similarity

Catalytic activityi

ATP + GMP = ADP + GDP.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi16 – 23ATPPROSITE-ProRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Guanylate kinase (EC:2.7.4.8)
Alternative name(s):
GMP kinase
Gene namesi
Name:guk1
Synonyms:gmkA
ORF Names:DDB_G0279001
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyostelidsDictyostelialesDictyosteliaceaeDictyostelium
Proteomesi
  • UP000002195 Componentsi: Chromosome 3, Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0279001 gmkA

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003281801 – 202Guanylate kinaseAdd BLAST202

Proteomic databases

PaxDbiQ54XF2

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

STRINGi44689.DDB0230100

Structurei

3D structure databases

ProteinModelPortaliQ54XF2
SMRiQ54XF2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini9 – 191Guanylate kinase-likePROSITE-ProRule annotationAdd BLAST183

Sequence similaritiesi

Belongs to the guanylate kinase family.Curated

Phylogenomic databases

eggNOGiKOG0707 Eukaryota
COG0194 LUCA
InParanoidiQ54XF2
KOiK00942
OMAiAGNYYGT
PhylomeDBiQ54XF2

Family and domain databases

InterProiView protein in InterPro
IPR008145 GK/Ca_channel_bsu
IPR008144 Guanylate_kin-like_dom
IPR017665 Guanylate_kinase
IPR020590 Guanylate_kinase_CS
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF00625 Guanylate_kin, 1 hit
SMARTiView protein in SMART
SM00072 GuKc, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR03263 guanyl_kin, 1 hit
PROSITEiView protein in PROSITE
PS00856 GUANYLATE_KINASE_1, 1 hit
PS50052 GUANYLATE_KINASE_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q54XF2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDNNSVDSLI PIIITGPSGV GKGTLIDKLR KEYEGSFGHI VSHTTRKPRE
60 70 80 90 100
GEINGVHYHF TDIPTMTEGI KNGDFIEHAN VHGNFYGTSK KALKDVSDKN
110 120 130 140 150
KICILDIDVQ GCESVKKANI PCKFIFISPP TFETLQERLI GRGTENEETL
160 170 180 190 200
KKRLETAKKE MVYRDIPGFF DHVIVNNVLD VAYGELKSII SPFISFQSKS

NK
Length:202
Mass (Da):22,600
Last modified:May 24, 2005 - v1
Checksum:iD61578E09A74C4A9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000026 Genomic DNA Translation: EAL67922.1
RefSeqiXP_641898.1, XM_636806.1

Genome annotation databases

EnsemblProtistsiEAL67922; EAL67922; DDB_G0279001
GeneIDi8621824
KEGGiddi:DDB_G0279001

Similar proteinsi

Entry informationi

Entry nameiKGUA_DICDI
AccessioniPrimary (citable) accession number: Q54XF2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: May 24, 2005
Last modified: March 28, 2018
This is version 84 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome