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Protein

Guanylate kinase

Gene

guk1

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Essential for recycling GMP and indirectly, cGMP.By similarity

Catalytic activityi

ATP + GMP = ADP + GDP.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi16 – 23ATPPROSITE-ProRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-DDI-499943. Synthesis and interconversion of nucleotide di- and triphosphates.

Names & Taxonomyi

Protein namesi
Recommended name:
Guanylate kinase (EC:2.7.4.8)
Alternative name(s):
GMP kinase
Gene namesi
Name:guk1
Synonyms:gmkA
ORF Names:DDB_G0279001
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
Proteomesi
  • UP000002195 Componentsi: Chromosome 3, Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0279001. gmkA.

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003281801 – 202Guanylate kinaseAdd BLAST202

Proteomic databases

PaxDbiQ54XF2.

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

STRINGi44689.DDB0230100.

Structurei

3D structure databases

ProteinModelPortaliQ54XF2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini9 – 191Guanylate kinase-likePROSITE-ProRule annotationAdd BLAST183

Sequence similaritiesi

Belongs to the guanylate kinase family.Curated

Phylogenomic databases

eggNOGiKOG0707. Eukaryota.
COG0194. LUCA.
InParanoidiQ54XF2.
KOiK00942.
OMAiAFIEHAQ.
PhylomeDBiQ54XF2.

Family and domain databases

Gene3Di3.40.50.300. 3 hits.
InterProiView protein in InterPro
IPR008145. GK/Ca_channel_bsu.
IPR008144. Guanylate_kin-like_dom.
IPR017665. Guanylate_kinase.
IPR020590. Guanylate_kinase_CS.
IPR027417. P-loop_NTPase.
PfamiView protein in Pfam
PF00625. Guanylate_kin. 1 hit.
SMARTiView protein in SMART
SM00072. GuKc. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR03263. guanyl_kin. 1 hit.
PROSITEiView protein in PROSITE
PS00856. GUANYLATE_KINASE_1. 1 hit.
PS50052. GUANYLATE_KINASE_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q54XF2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDNNSVDSLI PIIITGPSGV GKGTLIDKLR KEYEGSFGHI VSHTTRKPRE
60 70 80 90 100
GEINGVHYHF TDIPTMTEGI KNGDFIEHAN VHGNFYGTSK KALKDVSDKN
110 120 130 140 150
KICILDIDVQ GCESVKKANI PCKFIFISPP TFETLQERLI GRGTENEETL
160 170 180 190 200
KKRLETAKKE MVYRDIPGFF DHVIVNNVLD VAYGELKSII SPFISFQSKS

NK
Length:202
Mass (Da):22,600
Last modified:May 24, 2005 - v1
Checksum:iD61578E09A74C4A9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000026 Genomic DNA. Translation: EAL67922.1.
RefSeqiXP_641898.1. XM_636806.1.

Genome annotation databases

EnsemblProtistsiEAL67922; EAL67922; DDB_G0279001.
GeneIDi8621824.
KEGGiddi:DDB_G0279001.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000026 Genomic DNA. Translation: EAL67922.1.
RefSeqiXP_641898.1. XM_636806.1.

3D structure databases

ProteinModelPortaliQ54XF2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi44689.DDB0230100.

Proteomic databases

PaxDbiQ54XF2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsiEAL67922; EAL67922; DDB_G0279001.
GeneIDi8621824.
KEGGiddi:DDB_G0279001.

Organism-specific databases

dictyBaseiDDB_G0279001. gmkA.

Phylogenomic databases

eggNOGiKOG0707. Eukaryota.
COG0194. LUCA.
InParanoidiQ54XF2.
KOiK00942.
OMAiAFIEHAQ.
PhylomeDBiQ54XF2.

Enzyme and pathway databases

ReactomeiR-DDI-499943. Synthesis and interconversion of nucleotide di- and triphosphates.

Miscellaneous databases

PROiQ54XF2.

Family and domain databases

Gene3Di3.40.50.300. 3 hits.
InterProiView protein in InterPro
IPR008145. GK/Ca_channel_bsu.
IPR008144. Guanylate_kin-like_dom.
IPR017665. Guanylate_kinase.
IPR020590. Guanylate_kinase_CS.
IPR027417. P-loop_NTPase.
PfamiView protein in Pfam
PF00625. Guanylate_kin. 1 hit.
SMARTiView protein in SMART
SM00072. GuKc. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR03263. guanyl_kin. 1 hit.
PROSITEiView protein in PROSITE
PS00856. GUANYLATE_KINASE_1. 1 hit.
PS50052. GUANYLATE_KINASE_2. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiKGUA_DICDI
AccessioniPrimary (citable) accession number: Q54XF2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: May 24, 2005
Last modified: February 15, 2017
This is version 77 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.