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Q54XF2 (KGUA_DICDI) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 57. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Guanylate kinase

EC=2.7.4.8
Alternative name(s):
GMP kinase
Gene names
Name:guk1
Synonyms:gmkA
ORF Names:DDB_G0279001
OrganismDictyostelium discoideum (Slime mold) [Reference proteome]
Taxonomic identifier44689 [NCBI]
Taxonomic lineageEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium

Protein attributes

Sequence length202 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Essential for recycling GMP and indirectly, cGMP By similarity.

Catalytic activity

ATP + GMP = ADP + GDP.

Subunit structure

Monomer By similarity.

Sequence similarities

Belongs to the guanylate kinase family.

Contains 1 guanylate kinase-like domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 202202Guanylate kinase
PRO_0000328180

Regions

Domain9 – 191183Guanylate kinase-like
Nucleotide binding16 – 238ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q54XF2 [UniParc].

Last modified May 24, 2005. Version 1.
Checksum: D61578E09A74C4A9

FASTA20222,600
        10         20         30         40         50         60 
MDNNSVDSLI PIIITGPSGV GKGTLIDKLR KEYEGSFGHI VSHTTRKPRE GEINGVHYHF 

        70         80         90        100        110        120 
TDIPTMTEGI KNGDFIEHAN VHGNFYGTSK KALKDVSDKN KICILDIDVQ GCESVKKANI 

       130        140        150        160        170        180 
PCKFIFISPP TFETLQERLI GRGTENEETL KKRLETAKKE MVYRDIPGFF DHVIVNNVLD 

       190        200 
VAYGELKSII SPFISFQSKS NK 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AAFI02000026 Genomic DNA. Translation: EAL67922.1.

3D structure databases

ProteinModelPortalQ54XF2.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING44689.DDB_0230100.

Proteomic databases

PRIDEQ54XF2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsDDB0230100; DDB0230100; DDB_G0279001.
KEGGddi:DDB_G0279001.

Organism-specific databases

dictyBaseDDB_G0279001. gmkA.

Phylogenomic databases

eggNOGCOG0194.
KOK00942.
OMARCILDIE.
PhylomeDBQ54XF2.
ProtClustDBCLSZ2430725.

Family and domain databases

Gene3D3.40.50.300. 3 hits.
InterProIPR008145. GK/Ca_channel_bsu.
IPR008144. Guanylate_kin-like.
IPR017665. Guanylate_kinase.
IPR020590. Guanylate_kinase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamPF00625. Guanylate_kin. 1 hit.
[Graphical view]
SMARTSM00072. GuKc. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
TIGRFAMsTIGR03263. guanyl_kin. 1 hit.
PROSITEPS00856. GUANYLATE_KINASE_1. 1 hit.
PS50052. GUANYLATE_KINASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

PROQ54XF2.

Entry information

Entry nameKGUA_DICDI
AccessionPrimary (citable) accession number: Q54XF2
Entry history
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: May 24, 2005
Last modified: April 16, 2014
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families

Dictyostelium discoideum

Dictyostelium discoideum: entries, gene names and cross-references to dictyBase