Reviewed, UniProtKB/Swiss-Prot Q54XF2 (KGUA_DICDI)

Names and origin

Protein names

Recommended name:
    Guanylate kinase
    EC=2.7.4.8
Alternative name(s):
    GMP kinase

Gene names

Name:	guk1
Synonyms:	gmkA
ORF Names:	DDB_G0279001

Organism

Dictyostelium discoideum (Slime mold) [Complete proteome]

Taxonomic identifier

44689 [NCBI]

Taxonomic lineage

Eukaryota › Amoebozoa › Mycetozoa › Dictyosteliida › Dictyostelium

Protein attributes

Sequence length	202 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Essential for recycling GMP and indirectly, cGMP By similarity.
Catalytic activity	ATP + GMP = ADP + GDP.
Subunit structure	Monomer By similarity.
Sequence similarities	Belongs to the guanylate kinase family. Contains 1 guanylate kinase-like domain.

Ontologies

Keywords
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	purine nucleotide metabolic process Inferred from sequence or structural similarity. Source: UniProtKB
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW guanylate kinase activity Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 202	202	Guanylate kinase		PRO_0000328180
Regions
	Domain	9 – 191	183	Guanylate kinase-like
	Nucleotide binding	16 – 23	8	ATP By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q54XF2-1 [UniParc]. Last modified May 24, 2005. Version 1. Checksum: D61578E09A74C4A9	FASTA	202	22,600
	10 20 30 40 50 60 MDNNSVDSLI PIIITGPSGV GKGTLIDKLR KEYEGSFGHI VSHTTRKPRE GEINGVHYHF 70 80 90 100 110 120 TDIPTMTEGI KNGDFIEHAN VHGNFYGTSK KALKDVSDKN KICILDIDVQ GCESVKKANI 130 140 150 160 170 180 PCKFIFISPP TFETLQERLI GRGTENEETL KKRLETAKKE MVYRDIPGFF DHVIVNNVLD 190 200 VAYGELKSII SPFISFQSKS NK

References

[1]

"The genome of the social amoeba Dictyostelium discoideum." Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N. , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A. Nature 435:43-57(2005) [PubMed: 15875012] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AX4.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AAFI02000026 Genomic DNA. Translation: EAL67922.1.
RefSeq	XP_641898.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q54XF2.
Genome annotation databases
GeneID	3392990.
GenomeReviews	Gene locus guk1 in contig CM000152_GR.
KEGG	ddi:DDB_0230100.
Organism-specific databases
dictyBase	DDB_G0279001. guk1.
Phylogenomic databases
OMA	DDLDKAY.
Enzyme and pathway databases
BRENDA	2.7.4.8. 424.
Family and domain databases
InterPro	IPR008144. Guanylate_kin. IPR020590. Guanylate_kinase_CS. IPR017665. Guanylate_kinase_sub. IPR008145. Guanylt/Ca. [Graphical view]
Pfam	PF00625. Guanylate_kin. 1 hit. [Graphical view]
SMART	SM00072. GuKc. 1 hit. [Graphical view]
TIGRFAMs	TIGR03263. guanyl_kin. 1 hit.
PROSITE	PS00856. GUANYLATE_KINASE_1. 1 hit. PS50052. GUANYLATE_KINASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

KGUA_DICDI

Accession

Primary (citable) accession number: Q54XF2

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 8, 2008
Last sequence update:	May 24, 2005
Last modified:	November 3, 2009
This is version 31 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)